Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailCombinatorics, Automata and Number Theory 2006
Berthé, Valérie; Lecomte, Pierre ULg; Rigo, Michel ULg

in Theoretical Computer Science (2008), 391

Detailed reference viewed: 18 (5 ULg)
See detailCombine pedigree and marker information into a single estimator for the calculation of relationships
Bömcke, Elisabeth ULg; Gengler, Nicolas ULg

Poster (2009, May)

Relationship coefficients are particularly useful to improve genetic management of endangered populations. Estimation of relationships was traditionally based on pedigree data but, today, numerous methods ... [more ▼]

Relationship coefficients are particularly useful to improve genetic management of endangered populations. Estimation of relationships was traditionally based on pedigree data but, today, numerous methods already exist to replace pedigrees by molecular data. However, genotyping a complete population for a sufficient number of markers can be impossible, e.g., in case of local and/or rare breeds. The idea was therefore to develop a new method to estimate relationship by combining molecular with pedigree data into a single estimator. Originally developed for the management of an endangered horse population, it will be useful for specific situations, where neither pedigree nor molecular data are complete. Two questions appeared: What and how to combine? Following the principle that things have to be similar to be combined, we compared two coefficients that have the advantage to be similarly defined: the additive relationship coefficient (axy) calculated from pedigrees and the total allelic relationship (taxy) obtained from markers. Wright relationship coefficient (rped,xy) were also compared to taxy, transformed into rmol,xy, to highlight the influence of inbreeding. The results showed the influence of inbreeding, of marker quality and the tendency of molecular coefficients to overestimate the relationship among individuals. The method to combine the selected coefficients was also determined. Various parameters were taken into account in the model: number of markers and quality (e.g. marker informativeness), mutation rate, pedigree quality (e.g. generation-equivalents), … The combined estimator has several advantages. Especially, negative relationship values obtained in literature with molecular-based estimators in case of small inbred populations can be avoided. [less ▲]

Detailed reference viewed: 34 (5 ULg)
Full Text
Peer Reviewed
See detailCombined (hormonal and microsurgical) therapy in infertile women with endometriosis.
Donnez, J.; Lemaire-Rubbers, M.; Karaman, Y. et al

in Fertility and Sterility (1987), 48(2), 239-42

Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. A significant regression of the ovarian and peritoneal implants was observed in 72 ... [more ▼]

Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. A significant regression of the ovarian and peritoneal implants was observed in 72% of the cases after progestative treatment, but the presence of residual epithelium in all cases made surgical resection necessary. After preoperative medical treatment and microsurgery, intrauterine (living births) pregnancy rates of 60 and 47% were obtained in cases of moderate and severe endometriosis, respectively. The following prognostic factors were found in this series: the degree of endometriosis, the concomitant male factors, the decrease of endometriotic lesions after treatment, and the unilaterality of ovarian endometriosis. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailCombined 10pter-->P11 and 18pter-->Q11 Trisomy in a 7-Year-Old Child
Lapiere, J. C.; Verloes, Alain ULg; Herens, Christian ULg et al

in Genetic Counseling (Geneva, Switzerland) (1992), 3(3), 155-9

We report a severely mentally retarded, dysmorphic girl aged 7 years with a 47,XX, +der(18), t(10;18)(p11.2;q11.2)mat. The phenotype of our patient is compared with 6 cases of trisomy 10p and 10 cases of ... [more ▼]

We report a severely mentally retarded, dysmorphic girl aged 7 years with a 47,XX, +der(18), t(10;18)(p11.2;q11.2)mat. The phenotype of our patient is compared with 6 cases of trisomy 10p and 10 cases of trisomy 18q- from the literature. The short trisomic segment 10pter-10p11 appears to affect more the phenotype than the trisomic segment 18qter-q11. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailCombined action of diazepam and d-amphetamine on fixed-interval performance in cats
Richelle, Marc ULg

in Journal of the Experimental Analysis of Behavior (1969), 12(6), 989-998

Cats trained under a fixed-interval 5-min schedule of milk presentation were injected with diazepam, amphetamine, and combinations of amphetamine and diazepam. Diazepam increased overall reponse rate as a ... [more ▼]

Cats trained under a fixed-interval 5-min schedule of milk presentation were injected with diazepam, amphetamine, and combinations of amphetamine and diazepam. Diazepam increased overall reponse rate as a function of the dose and disrupted the temporal pattern of responding. Low doses of amphetamine (0.5mg/kg) usually increased the response rate; higher doses (1 to 2 mg/kg) either decreased the response rate or had little effect. Amphetamine always disrupted the temporal pattern of responding, even though it did not affect the overall rate. When doses of amphetamine that increased the response rate or left it unchanged were combined with diazepam, a potential increase in response rate occured. When doses of amphetamine that decreased the response rate were combined with diazepam, the amphetamine-induced rate decreases were reversed at least partially. Less clear potentiation of disruption of the temporal pattern of responding was observed when amphetamine and diazepam were combined. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailCombined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
McQueen, M. B.; Devlin, B.; Faraone, S. V. et al

in American Journal of Human Genetics (2005), 77(4), 582-95

Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is ... [more ▼]

Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficulty and potential pitfalls of the implementation. We conducted a combined analysis using the original genotype data from 11 BP genomewide linkage scans comprising 5,179 individuals from 1,067 families. Heterogeneity among studies was minimized in our analyses by using uniform methods of analysis and a common, standardized marker map and was assessed using novel methods developed for meta-analysis of genome scans. To date, this collaboration is the largest and most comprehensive analysis of linkage samples involving a psychiatric disorder. We demonstrate that combining original genome-scan data is a powerful approach for the elucidation of linkage regions underlying complex disease. Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches. [less ▲]

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailCombined analysis of fourteen nuclear genes refines the Ursidae phylogeny
Pagès, Marie ULg; Calvignac, Sébastien; Klein, Catherine et al

Poster (2007, August)

To definitively solve the last the ambiguities concerning the evolutionary history of Ursidae, we sequenced ten nuclear genes for all the eight extant bear species. By combining these new sequences with ... [more ▼]

To definitively solve the last the ambiguities concerning the evolutionary history of Ursidae, we sequenced ten nuclear genes for all the eight extant bear species. By combining these new sequences with those of four other recently published nuclear markers, we provide new insights into the phylogenetic relationships of the Ursidae family members. The hypothesis that the giant panda was the first species to diverge among ursids is definitively confirmed and the branching order within the Ursus genus is clarified for the first time. Moreover, these analyses indicate that the American and the Asiatic black bears do not cluster as sister taxa, as had been previously hypothesised. Sun and sloth bears undoubtedly appear as the most basal ursine species but uncertainties about their exact relationships remain. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailCombined analysis of fourteen nuclear genes refines the Ursidae phylogeny
Pagès, Marie ULg; Calvignac, Sébastien; Klein, Catherine et al

in Molecular Phylogenetics & Evolution (2008), 47

Despite numerous studies, questions remain about the evolutionary history of Ursidae and additional independent genetic markers were needed to elucidate these ambiguities. For this purpose, we sequenced ... [more ▼]

Despite numerous studies, questions remain about the evolutionary history of Ursidae and additional independent genetic markers were needed to elucidate these ambiguities. For this purpose, we sequenced ten nuclear genes for all the eight extant bear species. By combining these new sequences with those of four other recently published nuclear markers, we provide new insights into the phylogenetic relationships of the Ursidae family members. The hypothesis that the giant panda was the first species to diverge among ursids is definitively confirmed and the precise branching order within the Ursus genus is clarified for the first time. Moreover, our analyses indicate that the American and the Asiatic black bears do not cluster as sister taxa, as had been previously hypothesised. Sun and sloth bears clearly appear as the most basal ursine species but uncertainties about their exact relationships remain. Since our larger dataset did not enable us to clarify this last question, identifying rare genomic changes in bear genomes could be a promising solution for further studies. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailCombined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma.
Ernoux-Neufcoeur, P.; Arafa, M.; Decaestecker, C. et al

in Journal of Cancer Research & Clinical Oncology (2011), 137(1), 173-81

PURPOSE: We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal ... [more ▼]

PURPOSE: We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal squamous cell carcinoma (HSCC). METHODS: Paraffin-embedded tumours from HSCC patients (n = 75) were evaluated for p16, p21 and p53 expression by immunohistochemistry. HPV DNA was detected by GP5+/6+ consensus PCR and subsequent genotyping by E6/E7 type-specific PCR for HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. RESULTS: Among the 61 specimens that tested positive for the beta-globin, HPV typing identified 50 patients with high-risk (hr) HPV types. HPV 16E7 DNA was detected in 74% (37 cases) of these specimens. Twelve patients were found to be infected with multiple HPV types. However, the presence of hrHPV DNA was not found to correlate with the proportion of disease-free patients. The 5-year disease-free survival rate was 73% in p53- tumours versus 48% in p53+ tumours (P = 0.008). CONCLUSION: In our series of patients with stage IV HSCC, the hrHPV+ subgroup had a similar prognosis (in terms of recurrence risk) as the HPV- subgroup. p53 overexpression was associated with a worse prognosis. [less ▲]

Detailed reference viewed: 40 (6 ULg)
Full Text
Peer Reviewed
See detailThe combined bone forming capacity of human periosteal derived cells and calcium phosphates.
Roberts, Scott J; Geris, Liesbet ULg; Kerckhofs, Greet ULg et al

in Biomaterials (2011), 32(19), 4393-405

Current knowledge suggests that the periosteum, a fibrous tissue which covers the surface of all bones, contains a population of progenitor cells which mediate the repair of bone defects. In an effort to ... [more ▼]

Current knowledge suggests that the periosteum, a fibrous tissue which covers the surface of all bones, contains a population of progenitor cells which mediate the repair of bone defects. In an effort to optimise the utilisation of this source of cells for bone engineering, herein we describe the rational selection of calcium phosphate (CaP) containing materials, based on biomaterial properties, and evaluation of their combined bone forming capacity. Five different commercially available orthopaedic 3D matrices composed of CaP particles in an open collagen network (NuOss, CopiOs, Bio-Oss((R)), Collagraft and Vitoss((R))) were evaluated in vitro and in vivo with human periosteal derived cells (hPDCs). It was found that the cell-material combinations behaved quite differently in vivo, despite apparent in vitro similarities in gene expression profiles. Bone formation was highest within the NuOss/hPDC implant at 13.03%, which also contained the highest incidence of bone marrow formation. The bone formed in this implant was chimeric with approximately 65% originating from implanted cells. Upon analysis of human specific gene expression, although it was found that predominantly osteogenic differentiation was observed within NuOss/hPDC implants, a lesser induction of chondrogenic genes was also observed. The formation of a cartilage intermediate was confirmed by histology. Additionally the NuOss/hPDC implant integrated into the mouse environment with apparent active scaffold resorption. This study demonstrates the importance of matching a cell support/biological matrix with a cell type and subsequently has outlined parameters which can be used for the rational selection of biomaterials for bone engineering. [less ▲]

Detailed reference viewed: 39 (0 ULg)
Full Text
Peer Reviewed
See detailCombined detailed and quasi steady-state time simulations for large-disturbance analysis
Van Cutsem, Thierry ULg; Grenier, Marie-Eve; Lefebvre, Daniel

(2005, August)

This paper deals with the simulation of long-term power system responses to large disturbances in the presence of discrete events. A method combining detailed and quasi steady-state time simulations is ... [more ▼]

This paper deals with the simulation of long-term power system responses to large disturbances in the presence of discrete events. A method combining detailed and quasi steady-state time simulations is presented, the former being used for accuracy and the latter for ef ciency reasons. Detailed time simulation is used to analyze the short-term period following a large disturbance and identify the discrete controls triggered. Next, quasi steady-state simulation is used to simulate the same time interval with the discrete controls imposed as external events, before letting the system evolve as usual in the long term. This simple method has been successfully tested on the Hydro-Québec system. [less ▲]

Detailed reference viewed: 76 (8 ULg)
Full Text
Peer Reviewed
See detailCombined detailed and quasi steady-state time simulations for large-disturbance analysis
Van Cutsem, Thierry ULg; Grenier, Marie-Eve; Lefebvre, Daniel

in International Journal of Electrical Power & Energy Systems (2006), 28(9), 634-642

This paper deals with the simulation of long-term responses of power systems to large disturbances in the presence of discrete events. After outlining the power system model under the quasi steady-state ... [more ▼]

This paper deals with the simulation of long-term responses of power systems to large disturbances in the presence of discrete events. After outlining the power system model under the quasi steady-state (QSS) approximation, a method combining detailed and QSS time simulations is presented, the former being used for accuracy and the latter for efficiency reasons. Detailed time simulation is used to analyze the short-term period following a large disturbance and identify the discrete controls triggered. Next, QSS simulation is used to simulate the same time interval with the discrete controls imposed as external events, before letting the system evolve as usual in the long-term. This simple method has been successfully tested on the Hydro-Quebec system. (C) 2006 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 84 (9 ULg)
Peer Reviewed
See detailCombined diagnostic value of biochemical markers in acute pancreatitis.
Viel, J F; Foucault, P; Bureau, F et al

in Clinica Chimica Acta (1990), 189(2), 191-8

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailCombined distortional and overall flexural-torsional buckling of cold-formed stainless steel sections: Design
Rossi, Barbara ULg; Jaspart, Jean-Pierre ULg; Rasmussen, Kim J.R.

in Journal of Structural Engineering (2010), 136(4), 361-369

This paper provides a critical summary of the European standards and design methods available for calculating the strength of cold-formed stainless steel compression members. The standards considered (so ... [more ▼]

This paper provides a critical summary of the European standards and design methods available for calculating the strength of cold-formed stainless steel compression members. The standards considered (so far mainly applied to columns failing by flexural buckling) are applied to the case of lipped channel section columns failing by combined distortional and overall flexural-torsional buckling. As observed during the tests presented in a companion paper, distortional buckling is found to have a considerable effect on the cross-section resistance and is prone to interact with the global flexural-torsional mode. It is investigated how the different formulations account for the two buckling modes and their interaction and how accurate strength predictions they provide. A new Direct Strength Method taking into account these failure modes is then presented and compared to the tests results. [less ▲]

Detailed reference viewed: 96 (32 ULg)
Full Text
Peer Reviewed
See detailCombined distortional and overall flexural-torsional buckling of cold-formed stainless steel sections: Experimental investigations
Rossi, Barbara ULg; Jaspart, Jean-Pierre ULg; Rasmussen, Kim J.R.

in Journal of Structural Engineering (2010), 136(4), 354-360

This paper presents a series of 48 full-scale tests on press-braked stainless steel lipped channel section columns subjected to concentric compression. The tests were carried out between fixed ends in the ... [more ▼]

This paper presents a series of 48 full-scale tests on press-braked stainless steel lipped channel section columns subjected to concentric compression. The tests were carried out between fixed ends in the Structures Laboratory of the University of Liège and the test specimens were designed such that distortional buckling developed in the section prior to overall flexural-torsional buckling. The stainless steel alloy was 1.4003 chromium weldable steel, popularly known as 3Cr12. Three different geometries were tested using the same experimental set-up. A critical summary of the standards and methods for calculating the carrying capacity of cold-formed stainless steel compression members is presented in a companion paper by the same authors. [less ▲]

Detailed reference viewed: 77 (20 ULg)
Full Text
Peer Reviewed
See detailCombined Effect of Web 2086 (Paf Antagonist) and Ketoprofen (Nsaid) on Paf-Induced Ex Vivo Platelet Aggregation in Bovine
Bastos da Silva, Miriam; Herion, Francine ULg; Raskinet, Renée ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1997), 44(2), 65-71

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich ... [more ▼]

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich plasma (PRP). WEB 2086 was infused intravenously over 1 min followed immediately by ketoprofen administration over 1 s (both drugs = 3 mg/kg), in a group of six healthy male Friesian calves. Depending on the PAF concentration, a reversible (10(-8)-10(-9) mol/l) and irreversible (10(-5)-10(-7) mol/l) platelet aggregation was observed. The reversible aggregation was completely blocked by pretreatment of the animal with WEB 2086 and ketoprofen. The inhibitory effects observed during the irreversible aggregation were 47.22%, 54.00% and 88.00% at 10(-5), 10(-6) and 10(-7) mol/l PAF, respectively. Moreover, the aggregation obtained in these condition became reversible. Maximal inhibitory effect of WEB 2086 and ketoprofen on PAF-induced platelet aggregation in calves was observed within 30 min after administration of both drugs. This inhibition persisted even after 24 h and was significantly different from control with P < 0.05. The combined effect of both drugs exceeded the sum of the individual effects (synergism). It was concluded that WEB 2086 and ketoprofen very effectively blocked PAF-induced bovine platelet aggregation in platelet-rich plasma. The study also suggested a synergism between both substances. [less ▲]

Detailed reference viewed: 104 (0 ULg)
Full Text
Peer Reviewed
See detailCombined effects of climate warming and plant diversity loss on above- and below-ground grassland productivity
De Boeck, H. J.; Lemmens, CMHM; Gielen, B. et al

in Environmental and Experimental Botany (2007), 60(1), 95-104

Projections of global change predict both increases of the surface temperature and decreases of biodiversity, but studies on the combined impact of both on terrestrial ecosystems are lacking. We assessed ... [more ▼]

Projections of global change predict both increases of the surface temperature and decreases of biodiversity, but studies on the combined impact of both on terrestrial ecosystems are lacking. We assessed the impact of these two global changes on above- and below-ground productivity of grassland communities. Experimental ecosystems containing one, three or nine grassland species were grown in 12 sunlit, climate-controlled chambers in Wilrijk, Belgium. Half of these chambers were exposed to ambient air temperatures, while the other half were warmed by 3 degrees C. Equal amounts of water were added to heated and unheated communities, so that any increases in evapotranspiration due to warmer conditions would result in a drier soil. Warming led to a decreased productivity of both above-ground plant parts (-18%) and roots (-23%), which coincided with a significantly lower soil water content. Complementarity in resource use and/or facilitation slightly enhanced above-ground productivity in multi-species communities, regardless of the induced warming. Interactive effects between temperature treatment and species richness level were found below-ground, however, where warming nullified the positive effect of richness on root productivity. Future warmer conditions could further increase losses of productivity associated with declining species numbers. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 58 (5 ULg)
Full Text
Peer Reviewed
See detailCombined effects of climate, resource availability, and plant traits on biomass produced in a Mediterranean rangeland
Chollet, Simon; Rambal, Serge; Fayolle, Adeline ULg et al

in Ecology (2014), 95(3), 737-748

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities ... [more ▼]

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities. However, the combined effects of these different factors remain largely unknown. The aim of the present study was to unravel the causes of variations in the standing biomass of plant communities using a long-term experiment conducted in a Mediterranean rangeland of Southern France. Two management regimes, sheep grazing and grazing associated with mineral fertilization, were applied to different areas of the study site over the past 25 years. Abiotic (temperature, available water, nutrients) and biotic (components of the functional structure communities) factors were considered to explain interannual and spatial variations in standing biomass in these rangelands. Standing biomass was highly predictable, with the best model explaining ;80% of variations in the amount of biomass produced, but the variation explained by abiotic and biotic factors was dependent on the season and on the management regime. Abiotic factors were found to have comparable effects in both management regimes: The amount of biomass produced in the spring was limited by cold temperatures, while it was limited by water availability and high temperatures in the summer. In the fertilized community, the progressive change in the functional structure of the communities had significant effects on the amount of biomass produced: the dominance of few productive species which were functionally close led to higher peak standing biomass in spring. [less ▲]

Detailed reference viewed: 33 (5 ULg)