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See detailComparative Morphometric Study of Eruptive Puva-Induced and Chronic Sun-Induced Lentigines of the Skin
Nikkels, Arjen ULg; Ben Mosbah, T.; Pierard-Franchimont, Claudine ULg et al

in Analytical and Quantitative Cytology and Histology (1991), 13(1), 23-26

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by ... [more ▼]

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different. [less ▲]

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See detailComparative Nationality Law - Selected Questions (2012)
Wautelet, Patrick ULg

Learning material (2012)

These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and ... [more ▼]

These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. Reference is also made to the European Convention on Nationality (1997) as well as to other relevant international instruments dealing with nationality law. [less ▲]

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See detailComparative Nationality Law - Selected Questions (2014)
Wautelet, Patrick ULg

Learning material (2013)

This collection of ppt presentation was used as support for a course taught in English (in 2013) which provides an overview of the major questions arising in the field of nationality law. The course ... [more ▼]

This collection of ppt presentation was used as support for a course taught in English (in 2013) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. Reference is also made to the European Convention on Nationality (1997) as well as to other relevant international instruments dealing with nationality law. [less ▲]

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See detailComparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
JOURET, François ULg; Igarashi, Takashi; Gofflot, Francoise et al

in Kidney International (2004), 65(1), 198-208

BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the ... [more ▼]

BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the mature kidney. Neonatal cases of Dent's disease suggest that ClC-5 distribution must be acquired before birth. However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown. METHODS: Immunoblotting, real-time polymerase chain reaction (RT-PCR), immunostaining, and deglycosylation studies were used to investigate the expression, distribution, and maturation of ClC-5 during mouse and human nephrogenesis, in comparison with H+-ATPase, type II carbonic anhydrase (CAII), and aquaporin-1 (AQP1). RESULTS: An early induction (E13.5-E14.5) of ClC-5 was observed in mouse kidney, with persistence at high levels through late nephrogenesis. This pattern contrasted with the progressive expression of H+-ATPase and AQP1, and the postnatal upregulation of CAII. Immunostaining showed expression of ClC-5 in ureteric buds and, from E14.5, its location in developing PT. From E15.5, ClC-5 codistributed with H+-ATPase in PT cells and alpha-type IC. In the human kidney, ClC-5 was detected from 12 gestation weeks; its distribution was similar to that observed in mouse, except for a later detection in IC. Although mouse and human ClC-5 proteins are glycosylated, biochemical differences between fetal and adult proteins were observed in both species. CONCLUSION: The segmental expression of ClC-5 and H+-ATPase is essentially achieved during early nephrogenesis, in parallel with the onset of glomerular filtration. These data give insight into PT and IC maturation, and explain early phenotypic variants of Dent's disease. [less ▲]

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See detailComparative Pathogenesis of Acute and Latent Infections of Calves with Bovine Herpesvirus Types 1 and 5
Meyer, Gilles; Lemaire, Mylène; Ros, C. et al

in Archives of Virology (2001), 146(4), 633-52

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves ... [more ▼]

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves were inoculated intranasally with BHV-1 or BHV-5. Although BHV-1 and BHV-5 similarly replicate in the nasal mucosa after inoculation, both viruses differ markedly in their ability to cause disease, BHV-5 being responsible of some fatal encephalitis while BHV-1 inducing rhinotracheitis. Virus isolation and immunohistochemistry demonstrated that BHV-5 replicates extensively in neurons of the central nervous system (CNS) and in respiratory cells of lungs, tracheal and nasal mucosae. Invasion of the CNS likely occurs through the trigeminal and olfactory pathways. Both groups developed cross-neutralising antibodies during this experiment suggesting partial clinical cross-protection afforded by the two infections. Three months after primary infection, experimental reactivation showed that BHV-5 was able to establish latency in the trigeminal ganglia but also the CNS of surviving calves. Moreover, laboratory findings suggested that BHV-5 could also persist in the tracheal and nasal mucosae. These results indicate that, after primary infection, BHV-1 and BHV-5 displayed similar biological features and consequently need to be considered together for the control of BHV-1 infection. [less ▲]

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See detailThe comparative performance of for-profit, public and third sector providers. The case of the "service-vouchers" field in Belgium".
Defourny, Jacques ULg; Henry, Arnaud

E-print/Working paper (2011)

Within the Belgian service-voucher system, various types of organizations can provide services (house cleaning, ironing and various types of help to vulnerable persons). Based on a detailed survey ... [more ▼]

Within the Belgian service-voucher system, various types of organizations can provide services (house cleaning, ironing and various types of help to vulnerable persons). Based on a detailed survey covering 50 providers of different types, this paper examines their comparative performance based on three different specifications of the latter and by using Data Envelopment Analysis. [less ▲]

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See detailComparative performance study of postal services: a productive efficiency approach
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Annales d'Economie et de Statistique (1994), (33), 187-202

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It ... [more ▼]

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It then presents an empirical efficiency study of postal services which is aimed at comparing productive performance indicators across countries and at testing the effect of competition and regulation on these indicators. [less ▲]

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See detailComparative Pharmacokinetics of Two Intravenous Administration Regimens of Tiludronate in Healthy Adult Horses and Effects on the Bone Resorption Marker Ctx-1
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, J. et al

in Journal of Veterinary Pharmacology & Therapeutics (2008), 31(2), 108-16

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days ... [more ▼]

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX-1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX-1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX-1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses. [less ▲]

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See detailComparative pharmacokinetics of two intravenous dosage rates of tiludronate in healthy adult horses
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, Jérôme et al

Conference (2007)

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg ... [more ▼]

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg (group 2, n=6) in healthy adult horses. Plasma samples were collected at regular intervals for a period of 16 and 7 days in groups 1 and 2 respectively. Continuous urine collection for determination of cumulative urinary excretion of tiludronate was performed during 16 and 7 days in groups 1 and 2 respectively, and over 24-hour periods every 10 days until 60 days after the last tiludronate administration in both groups. Tiludronate concentrations were obtained in all plasma and urine samples using HPLC with UV detection. Plasma pharmacokinetic parameters were determined using a noncompartmental approach. Group 1 mean (± SD) AUCss was 3.76 (±0.698) mg.h.L-1 and group 2 mean (± SD) AUCtot was 39.07 (±3.699) mg.h.L-1. Mean (± SD) clearance (Cl) was 0.027 (±0.0042) and 0.026 (±0.0022) L.h-1.kg-1 in groups 1 and 2, respectively. Neither the dose corrected AUC (p=0.724) nor the Cl (p=0.528) were statistically different between groups. Relative plasma bioavailability (infusion versus bolus) was 103%. Cumulative urine tiludronic acid excretion could not be compared between groups due to analytical limitations (LOQ of 0.025 mg.L-1), which led to numerous missing data particularly in group 1, and an inability to conduct appropriate statistical and pharmacokinetic analyses. In conclusion, both dosage rates of tiludronate were considered bioequivalent with regards to plasma pharmacokinetics. [less ▲]

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See detailComparative Planetary Magnetotails
Bagenal, F.; Jackman, C.; Slavin, J. et al

Poster (2011)

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See detailThe comparative profitability of Romanian apiarian exploitations On Size Categories
Bodescu, Dan; Stefan, Gavril; Paveliuc Olariu, Codrin ULg

in Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture (2009), 66(2), 514

The aim of the work consists in determining the level of profitability in apiarian exploitations on the size categories: apiarian exploitations with a herd less than 50 bees families, apiarian ... [more ▼]

The aim of the work consists in determining the level of profitability in apiarian exploitations on the size categories: apiarian exploitations with a herd less than 50 bees families, apiarian exploitations with a herd of 50 to 100 bees families and apiarian exploitations with a herd larger than 100 bees families. The average size of the apiarian exploitation in the investigated sample was of 24,6 bees families per apiarian exploitation (NIS, 2008). The subjects category (the beekeepers in the apiarian exploitations) which hold the biggest share in the sample was the one with a herd smaller the 50 bees families with 81,0%. The field socio-economic research have been made as a part of the PN II 51-085/2007 Parteneriate research contract. The investigated sample has been comprised from the beekeepers in 6 apiarian exploitations from 21 counties. The analyzed period was 2006-2009. The apiarian exploitations with a size between 0-50 bees families have obtained in 2006 a honey production of 22,7 kg/family continuing in 2007 with a loss of 1,7 kg/family following in 2007 to obtain an increase of 4,9 kg/family from the previous year. In 2008, the honey production was of 24,9 kg/family in the case of apiarian exploitations with a size between 0-50 families, continuing with an increase of 5,2 kg/family in the case of exploitations with a size between 50 and 100 families and ending with an increase of 0,8 kg/family for the exploitations with over 100 bees families. The average expenditures value on the three types of apiarian exploitation was of 150,5 lei/family and the average of the gross profit was of 118,4 lei/bees family. The average of the gross profit on the three types of exploitation was of 8814,3 lei/exploitation and that of the profit rate was of 81,8%. [less ▲]

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See detailComparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone.
Roux, C.; Gennari, C.; Farrerons, J. et al

in Arthritis and Rheumatism (1995), 38(6), 851-8

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with ... [more ▼]

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with radiologic lesions characteristic of Paget's disease of bone and serum alkaline phosphatase (AP) concentrations at least twice the upper limit of normal, in a prospective, randomized, double-blind, multicenter clinical trial lasting 6 months. Patients were randomly allocated into 1 of 3 treatment groups: tiludronate for 3 months followed by placebo for 3 months, tiludronate for 6 months, or etidronate for 6 months. Serum AP levels and urinary hydroxyproline excretion were measured at baseline and after 3 months and 6 months. Patients with a reduction of at least 50% in the serum AP concentration were considered to be responders. RESULTS: After 3 months, the proportion of responders was higher in the tiludronate group (57.4%) than in the etidronate group (13.9%) (P < 0.0001). In the etidronate group, this percentage was lower among patients who had received previous treatment with a bisphosphonate (2.3%) than among those who had not (28.6%) (P < 0.01). Previous bisphosphonate treatment was not associated with response in the tiludronate group. After 6 months, the proportion of responders did not differ between the 2 tiludronate groups (60.3% and 70.1%), but was lower in the etidronate group (25.3%) (P < 0.0001). There was a higher proportion of patients with treatment-resistant disease (< 25% reduction of serum AP) in the etidronate group (51.9%) than in the tiludronate 3-month group (17.9%) or the tiludronate 6-month group (19.5%) (P < 0.0001). Gastrointestinal disturbances were more common, and occurred earlier, with tiludronate, but they were mostly mild, requiring no treatment. CONCLUSION: Tiludronate at 400 mg/day for 3 months or 6 months is more effective than the same dosage of etidronate for 6 months in the treatment of Paget's disease. [less ▲]

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See detailComparative responses to sodium selenite and organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Spring, P.; Andrieu, S. et al

in Livestock Science (2007), 111(3), 259-263

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed ... [more ▼]

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed. The goal of this trial was to compare the effects of different forms and concentrations of Se supplementation on Se status, health and performance in 60 pregnant Se-deficient BB cows. Cows were allocated to 3 experimental groups receiving selenized-yeast at 0.5 ppm Se on total ration (Y-Se 0.5), Na-selenite at 0.5 ppm Se on total ration (Na-Se 0.5) and Na-selenite at 0.1 ppm Se on total ration (Na-Se 0.1), respectively. Cows were supplemented from 2 months before calving until 2 months after calving. Data on performance, health and Se status of the dams and their calves were analyzed using a linear model, least squares means and logistic regression. At the end of the study, plasmatic Se (pSe) was significantly higher (P<0.01) in cows receiving Y-Se than in cows from other groups. Glutathion-peroxidase in erythrocytes (GSH-pxe) was higher in Y-Se and Na-Se 0.5 than Na-Se 0.1 group (P<0.01). Se content in colostrum and milk was significantly higher (P< 0.01) in Y-Se than other groups. At birth, Se status of calves from group Y-Se was significantly higher than those of other groups (P<0.01). Plasmatic Se in calves remained higher for 75 days after birth in Y-Se compared to other groups (P<0.01). Diarrhoea was the most commonly observed disease in the calves and, during the first 15 days of life, diarrhoea occurred in 6%, 21% and 35% of calves from groups Y-Se, Na-Se 0.5 and Na-Se 0.1, respectively. Over the whole 75 days trial period, incidence of diarrhoea was 19, 29 and 65%, respectively. Average daily gain (ADG) in calves born from Y-Se group of cows tended to be higher than in Na-Se 0.5 (P=0.06) and Na-Se 0.1 (P<0.05) but there was no difference between Na-Se 0.5 and Na-Se 0.1 (P>0.1). At the same dosage, Y-Se conferred better Se status in both dams and their calves than did Na-Se. Requirement of 0.1 ppm Se seems to be insufficient in BB to optimise health and performance. Regarding health status and ADG in calves, Y-Se seems also to result in better performance. (C) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailComparative responses to sodium selenite and Sel-Plex® organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Rollin, Frédéric ULg; Andrieu, Sylvie et al

in Nutritional Biotechnology in the Feed and Food Industries (Alltech’s 22nd Annual Symposium) (2006)

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