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See detailCombined spastic paresis of both gastrocnemius and femoral quadriceps muscles in Belgian blue calves
Janda, Jozef; Uyttenhoef, Aude; Vandeputte, Sébastien ULg et al

Conference (2006)

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See detailCombined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Salmon, Eric ULg; Grégoire, M. C.; Delfiore, Guy et al

in Journal of Cerebral Blood Flow & Metabolism (1996), 16(3), 399-408

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result ... [more ▼]

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result from local neuronal loss or from a decrease of synaptic activity. We measured in vivo [11C]methionine accumulation into proteins with positron emission tomography (PET) to assess cortical tissue loss in AD. Both global regional activity and compartmental analysis were used to express [11C]methionine accumulation into brain tissue. Glucose metabolism was measures with [18F]fluorodeoxyglucose and autoradiographic method. Combined studies were performed in 10 patients with probable AD, compared to age-matched healthy volunteers. There was a significant 45% decrease of temporo-parietal glucose metabolism in patients with AD, and frontal metabolism was lowered in most patients. Temporo-parietal metabolism correlated to dementia severity. [11C]methionine incorporation into temporo-parietal and frontal cortices was not significantly decreased in AD. There was no correlation with clinical symptoms. Data suggest that regional tissue loss, assessed by the decrease of [11C]methionine accumulation, is not sufficient to explain cortical glucose hypometabolism, which reflects, rather, reduced synaptic connectivity. [less ▲]

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See detailCombined Suicide and Cytokine Gene Therapy for Peritoneal Carcinomatosis
Lechanteur, Chantal ULg; Delvenne, Philippe ULg; Princen, Frédéric et al

in Gut (2000), 47(3), 343-8

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of ... [more ▼]

BACKGROUND: Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. AIMS: The efficacy of a therapy combining a suicide gene (herpes simplex virus type I thymidine kinase (HSV-TK)) and cytokine genes was investigated in a model of peritoneal carcinomatosis induced by colon carcinoma cells in syngeneic rats. MATERIAL AND METHODS: Pre-established macroscopic tumours in BDIX rats were treated by intraperitoneal injections of retrovirus producing cells (FLYA13 TK, FLYA13 granulocyte macrophage-colony stimulating factor (GM-CSF), FLYA13 interleukin 12 (IL-12)) and ganciclovir (GCV). RESULTS: TK/GCV treated animals showed a slight increase in survival time (72 days) compared with the control group (63 days) while the association of cytokine and TK/GCV gene therapy resulted in significantly improved survival, with a large proportion of animals remaining tumour free on day 480 (60% and 40% for TK/GCV/GM-CSF and TK/GCV/IL-12 treated animals, respectively). Histological analysis of treated animals showed that the remaining tumour nodes were infiltrated by mononuclear cells but no major differences were observed between the various treatments. Immunohistochemical analysis revealed that lymphoid CD4(+) and CD8(+) T cells as well as macrophages accumulated outside untreated tumour nodes while CD8(+) and CD25(+) activated T cells and macrophages heavily infiltrated the tumours after the different treatments. CONCLUSIONS: Our data indicate that combined suicide and cytokine gene therapy is a powerful approach for the treatment of macroscopic peritoneal carcinomatosis. [less ▲]

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See detailA combined theoretical and experimental study of the electrochemically induced chemisorption of acrylonitrile on nickel, copper, and zinc
Fredriksson, C.; Lazzaroni, Roberto; Brédas, Jean-Luc et al

in Chemical Physics Letters (1996), 258(3-4), 356-362

We report a combined theoretical and experimental study of the interaction between a series of transition metals (Ni, Cu, Zn) and acrylonitrile. We demonstrate experimentally that the transition metal has ... [more ▼]

We report a combined theoretical and experimental study of the interaction between a series of transition metals (Ni, Cu, Zn) and acrylonitrile. We demonstrate experimentally that the transition metal has a selective role in the grafting of electropolymerized acrylonitrile. Nickel and copper substrates support the formation of a polyacrylonitrile film, while zinc does not. Quantum chemical calculations indicate that acrylonitrile molecules form π-d bonds with Ni and Cu atoms, but do not react chemically with a Zn atom, in qualitative agreement with the experiment. Computational results also show that the electron affinity is significantly increased upon chemisorption, promoting radical anion species at the metal surface as initiators for polymerization. [less ▲]

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See detailCombined treatment of liver failure and hepatorenal syndrome with orthotopic liver transplantation
Detroz, Bernard ULg; Honore, Pierre ULg; Monami, B. et al

in Acta Gastro-Enterologica Belgica (1992), 55(4), 350-357

Hepatorenal syndrome (HRS) is a severe complication of liver failure with high mortality. The pathogenesis of this reversible functional renal failure is not yet clearly understood. Diagnosis is based ... [more ▼]

Hepatorenal syndrome (HRS) is a severe complication of liver failure with high mortality. The pathogenesis of this reversible functional renal failure is not yet clearly understood. Diagnosis is based upon the association of clinical and biological criteria. A patient was admitted to our institution for severe liver failure secondary to an exacerbation of cirrhosis, where he developed a fulminant hepatorenal syndrome. Both, the renal and hepatic failure were successfully treated by orthotopic liver transplantation. Special attention was paid to the immunosuppressive treatment with Cyclosporine whose use, we believe, should be delayed until function has partially recovered. [less ▲]

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See detailCombined use of bacteriocin-producing strains to control Listeria monocytogenes regrowth in raw pork meat.
Kouakou, P.; Ghalfi, H.; Dortu, C. et al

in International Journal of Food Science & Technology (2010), 45

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See detailCombined use of Bispectral Index (TM) and A-Line (TM) Autoregressive Index (TM) to assess anti-nociceptive component of balanced anaesthesia during lumbar arthrodesis
Bonhomme, Vincent ULg; Llabres, V.; Dewandre, Pierre-Yves et al

in British Journal of Anaesthesia (2006), 96(3), 353-360

BACKGROUND: This study evaluated the A-Line Autoregressive Index (AAI) response to surgical stimulation during lumbar arthrodesis, as an estimate of the anti-nociceptive component of a Bispectral Index ... [more ▼]

BACKGROUND: This study evaluated the A-Line Autoregressive Index (AAI) response to surgical stimulation during lumbar arthrodesis, as an estimate of the anti-nociceptive component of a Bispectral Index (BIS) guided anaesthesia combined with epidural analgesia. METHODS: An epidural catheter was inserted in 23 patients allocated randomly to receive ropivacaine plus clonidine (Group R) or normal saline (Group S) epidurally. General anaesthesia was induced with propofol, cis-atracurium and a remifentanil infusion that was stopped 3 min after tracheal intubation, and maintained using sevoflurane to keep BIS at 50 (range 40-60). Mean arterial pressure, heart rate, end-tidal sevoflurane, BIS and AAI were analysed from 2 min before to 17 min after surgical incision. RESULTS: While BIS was maintained at 50, AAI significantly increased from a 2 min averaged value of 12 (4) to 21 (7) in Group S within the first 5 min after surgical incision, but did not change in Group R. Maximum AAI values reached during the study period were significantly higher in Group S than in Group R [38 (12) and 27 (10), respectively]. Binary logistic regression analysis allowed the calculation of AAI threshold values above which the probability of predominant nociception over anti-nociception was higher than 95%. At 1 MAC sevoflurane concentration, a 2 min averaged AAI of 35 or an AAI peak value of 62 were associated with such a probability. CONCLUSIONS: During a BIS-guided constant level of hypnosis, AAI response to the onset of surgical stimulation significantly differs according to the analgesic regimen. Further studies are needed to refine the estimation of sensitivity and specificity of this variable in assessing the balance between nociception and anti-nociception during general anaesthesia. [less ▲]

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See detailCombined uses of supervised classification and Normalized Difference Vegetation Index techniques to monitor land degradation in the Saloum saline estuary system
Dieng, Ndeye Maguette ULg; Dinis, Joel; Faye, Serigne et al

in Diop, Salif; Barusseau, Jean-Paul; Descamp, Cyr (Eds.) The Land/Ocean Interactions in the Coastal Zone of West and Central Africa, Estuaries of the World (2014)

Saltwater contamination constitutes a serious problem in Saloumestuary, due to the intermittent and reverse tide flows of the Saloum River. This phenomenon is caused by the runoff deficit, which forces ... [more ▼]

Saltwater contamination constitutes a serious problem in Saloumestuary, due to the intermittent and reverse tide flows of the Saloum River. This phenomenon is caused by the runoff deficit, which forces the advance of saltwater 60 km upstream, contaminating surface water and thus causing the degradation of biodiversity and large areas of agricultural soils in this region. The present study aims to evaluate the consequences of saltwater contamination in the last three decades in this estuary by assessing the land-cover dynamics. Thus, latter consists of tracking the landscape-changing process over time to identify land-cover transitions. These transitions are closely related to the ecosystem-setting condition and can be used to assess the combined impacts of both natural and human-induced phenomena over a given period of time. In this study, special attention was given to mangrove degradation and to temporal progression of the salty barren soils locally called ‘‘tan’’. The loss of mangrove areas to tan and the general increase in salty barren soil areas can reflect the increase in the level of salinization in the study area over the time period under consideration. To fulfill this objective, four Landsat satellite images from the same season in the years 1984, 1992, 1999, and 2010 were used to infer time series land-use and land-cover maps of the Saloumestuary area. In addition to satellite imagery, rainfall records were used to evaluate climatic variation in terms of high-to-low precipitation during the time span considered. Spectral analysis indicated that from 1984 to 2010, mangroves and savanna/ rain-fed agriculture are converted to ‘‘tan’’ (denuded and salty soils). In addition, these results showed that significant changes in land use/land cover occur within the whole estuary system and reflecting therefore environmental degradation, such as land desertification and salinization, and vegetation degradation which reflect the advanced of salinity [less ▲]

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See detailCombined utilization of DGTs and bioindicators to trace chemical contamination threats on coastal ecosystems
Richir, Jonathan ULg; Luy, Nicolas; Serpe, Pierre et al

Conference (2011, May 03)

Trace metal monitoring in marine organisms and their living habitats permit to trace chronic or acute contaminations of marine ecosystems due to human activities. While dissolved trace metal ... [more ▼]

Trace metal monitoring in marine organisms and their living habitats permit to trace chronic or acute contaminations of marine ecosystems due to human activities. While dissolved trace metal concentrations give us an overall and punctual view over biota contamination status, bioindicator species put their bioavailable and possible toxic fraction in an obvious. However, difficulties mainly inherent to metal measurements in seawater lead field ecotoxicologists to study marine pollution essentially through the use of bioindicators alone. The technique of diffusive gradients in thin films (DGT) for the measurement of trace metals in aqueous solutions was introduced in the mid-ninetieth by Davison and Zhang. This passive probe accumulates labile trace metal species in proportion to their bulk environmental concentrations by maintaining a negative gradient between the environment and an ion-exchange resin (Chelex). DGTs average natural water trace metal concentrations over the deployment period, concentrate them and avoid matrix interferences, notably due to dissolved salts in seawater. Their deployment in passive and experimental monitoring studies permits to reliably measure labile trace metal concentrations and, jointly analysed with bioindicators, to estimate their bioavailability to marine organisms. This combined approach DGT-bioindicator was investigated in Calvi Bay (Corsica) through three monitoring studies. (1) DGTs were deployed in Posidonia oceanica bed, a Mediterranean seagrass forming dense meadows from the surface down to 40 meters depth, to study seasonal, spatial and bathymetrical variations of labile trace metal concentrations within this meadow. These concentrations were analysed jointly with Posidonia trace metal contents in order to quantify their bioaccumulation towards this primary producer, taking into account the seagrass biological cycle. (2) Portions of Posidonia meadow were also in situ experimentally contaminated with a mix of dissolved metals to study seagrass kinetics of pollutant accumulation and decontamination. Thanks to DGTs deployed inside contaminated mesocosms throughout experiments, Posidonia responses to known metal concentrations could be precisely quantified. (3) The blue mussel Mytilus galloprovincialis is widely used in trace metal monitoring programs. Mussels, stored in conchylicultural pouches, were transplanted for 3 months in contrasted stations of Calvi Bay (e.g. aquaculture farm, sewer, etc.) in parallel with DGTs. Such as for Posidonia, the complementary utilization of DGTs and mussels permitted to describe water contamination levels at the scale of the Bay, and their bioaccumulation towards mussels. These 3 studies demonstrate the usefulness of DGTs to monitor labile trace metals in an ecological and ecosystemic approach, in parallel with marine organisms, both indicators furnishing different and complementary informations about ecosystem functioning. [less ▲]

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See detailCombiner les mesures métaboliques cérébrales et neuropsychologiques permet une meilleure prédiction de la conversion vers une maladie d’Alzheimer chez les patients MCI
Bastin, Christine ULg; Adam, Stéphane ULg; LEKEU, Françoise ULg et al

in Revue Neurologique (2009), 165

Introduction. Une voie de recherche neurologique importante concerne la capacité de prédire sur base de l’évaluation initiale des patients avec Mild Cognitive Impairment (MCI) ceux qui vont développer une ... [more ▼]

Introduction. Une voie de recherche neurologique importante concerne la capacité de prédire sur base de l’évaluation initiale des patients avec Mild Cognitive Impairment (MCI) ceux qui vont développer une maladie d’Alzheimer (MA). Parmi les tests neuropsychologiques, le rappel indicé avec indiçage congruent lors de l’encodage et du rappel (RI48) apparaît comme le meilleur prédicteur du devenir des patients MCI (Ivanoiu et al., 2005). D’autre part, on a montré que les mesures métaboliques cérébrales (TEP-FDG), plus particulièrement l’hypométabolisme du cortex temporopariétal, prédit le déclin cognitif global dans le MCI mieux que des mesures neuropsychologiques (Chételat et al., 2005). Le but de notre étude était d’évaluer le pouvoir de prédiction pour la conversion du MCI vers une MA de deux prédicteurs robustes (performance au RI48 et métabolisme cérébral) pris soit isolément soit ensemble. Méthode. 50 patients MCI ont subi un examen en TEP-FDG au repos et ont réalisé le test de rappel indicé RI48 et le MMSE. Au terme d’un suivi neuropsychologique de 36 mois, 28 patients ont évolué vers une MA et 22 sont restés stables. Le métabolisme cérébral et les performances cognitives ont été comparés entre « convertisseurs » et MCI-stables. Des analyses discriminantes ont ensuite permis d’évaluer la capacité de classification de l’âge, du MMSE et des mesures métaboliques et mnésiques considérés individuellement ou selon diverses combinaisons. Résultat. Par comparaison avec les MCI-stables, les « convertisseurs » montraient un hypométabolisme du cortex temporal moyen bilatéralement, du cortex pariétal inférieur droit et du précuneus droit, et de plus faibles performances initiales au RI48. Prises individuellement, les différentes mesures permettaient le même taux de classification correcte (métabolisme cérébral = 76%, RI48 = 76%). L’âge et le MMSE étaient de faibles prédicteurs (exactitude de classification = 62% et 66% respectivement). Par contre, la combinaison des mesures métaboliques et des scores au RI48 prédisaient le mieux la progression vers la MA (88%). Conclusion. Les résultats suggèrent que la stratégie optimale pour identifier quels patients MCI ont plus de risque de développer une MA est de combiner les mesures métaboliques cérébrales et la performance à un test de mémoire très sensible. [less ▲]

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See detailCombiner sport et études. Comment cela est-il vécu ?
Cloes, Marc ULg

Scientific conference (2004, October 16)

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See detailCombining a stability and a performance-oriented control in power systems
Glavic, M.; Ernst, Damien ULg; Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (2005), 20(1), 525-526

This paper suggests that the appropriate combination of a stability-oriented and a performance-oriented control technique is a promising way to implement advanced control schemes in power systems. The ... [more ▼]

This paper suggests that the appropriate combination of a stability-oriented and a performance-oriented control technique is a promising way to implement advanced control schemes in power systems. The particular approach considered combines control Lyapunov functions (CLF) and reinforcement learning. The capabilities of the resulting controller are illustrated on a control problem involving a thyristor-controlled series capacitor (TCSC) device for damping oscillations in a four-machine power system. [less ▲]

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See detailCombining Active Learning and Reactive Control for Robot Grasping
Kroemer, Oliver; Detry, Renaud ULg; Piater, Justus ULg et al

in Robotics and Autonomous Systems (2010)

Detailed reference viewed: 57 (4 ULg)