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See detailComparative Pharmacokinetics of Two Intravenous Administration Regimens of Tiludronate in Healthy Adult Horses and Effects on the Bone Resorption Marker Ctx-1
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, J. et al

in Journal of Veterinary Pharmacology & Therapeutics (2008), 31(2), 108-16

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days ... [more ▼]

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX-1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX-1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX-1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses. [less ▲]

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See detailComparative pharmacokinetics of two intravenous dosage rates of tiludronate in healthy adult horses
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, Jérôme et al

Conference (2007)

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg ... [more ▼]

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg (group 2, n=6) in healthy adult horses. Plasma samples were collected at regular intervals for a period of 16 and 7 days in groups 1 and 2 respectively. Continuous urine collection for determination of cumulative urinary excretion of tiludronate was performed during 16 and 7 days in groups 1 and 2 respectively, and over 24-hour periods every 10 days until 60 days after the last tiludronate administration in both groups. Tiludronate concentrations were obtained in all plasma and urine samples using HPLC with UV detection. Plasma pharmacokinetic parameters were determined using a noncompartmental approach. Group 1 mean (± SD) AUCss was 3.76 (±0.698) mg.h.L-1 and group 2 mean (± SD) AUCtot was 39.07 (±3.699) mg.h.L-1. Mean (± SD) clearance (Cl) was 0.027 (±0.0042) and 0.026 (±0.0022) L.h-1.kg-1 in groups 1 and 2, respectively. Neither the dose corrected AUC (p=0.724) nor the Cl (p=0.528) were statistically different between groups. Relative plasma bioavailability (infusion versus bolus) was 103%. Cumulative urine tiludronic acid excretion could not be compared between groups due to analytical limitations (LOQ of 0.025 mg.L-1), which led to numerous missing data particularly in group 1, and an inability to conduct appropriate statistical and pharmacokinetic analyses. In conclusion, both dosage rates of tiludronate were considered bioequivalent with regards to plasma pharmacokinetics. [less ▲]

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See detailComparative Planetary Magnetotails
Bagenal, F.; Jackman, C.; Slavin, J. et al

Poster (2011)

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See detailThe comparative profitability of Romanian apiarian exploitations On Size Categories
Bodescu, Dan; Stefan, Gavril; Paveliuc Olariu, Codrin ULg

in Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture (2009), 66(2), 514

The aim of the work consists in determining the level of profitability in apiarian exploitations on the size categories: apiarian exploitations with a herd less than 50 bees families, apiarian ... [more ▼]

The aim of the work consists in determining the level of profitability in apiarian exploitations on the size categories: apiarian exploitations with a herd less than 50 bees families, apiarian exploitations with a herd of 50 to 100 bees families and apiarian exploitations with a herd larger than 100 bees families. The average size of the apiarian exploitation in the investigated sample was of 24,6 bees families per apiarian exploitation (NIS, 2008). The subjects category (the beekeepers in the apiarian exploitations) which hold the biggest share in the sample was the one with a herd smaller the 50 bees families with 81,0%. The field socio-economic research have been made as a part of the PN II 51-085/2007 Parteneriate research contract. The investigated sample has been comprised from the beekeepers in 6 apiarian exploitations from 21 counties. The analyzed period was 2006-2009. The apiarian exploitations with a size between 0-50 bees families have obtained in 2006 a honey production of 22,7 kg/family continuing in 2007 with a loss of 1,7 kg/family following in 2007 to obtain an increase of 4,9 kg/family from the previous year. In 2008, the honey production was of 24,9 kg/family in the case of apiarian exploitations with a size between 0-50 families, continuing with an increase of 5,2 kg/family in the case of exploitations with a size between 50 and 100 families and ending with an increase of 0,8 kg/family for the exploitations with over 100 bees families. The average expenditures value on the three types of apiarian exploitation was of 150,5 lei/family and the average of the gross profit was of 118,4 lei/bees family. The average of the gross profit on the three types of exploitation was of 8814,3 lei/exploitation and that of the profit rate was of 81,8%. [less ▲]

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See detailComparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone.
Roux, C.; Gennari, C.; Farrerons, J. et al

in Arthritis and Rheumatism (1995), 38(6), 851-8

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with ... [more ▼]

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with radiologic lesions characteristic of Paget's disease of bone and serum alkaline phosphatase (AP) concentrations at least twice the upper limit of normal, in a prospective, randomized, double-blind, multicenter clinical trial lasting 6 months. Patients were randomly allocated into 1 of 3 treatment groups: tiludronate for 3 months followed by placebo for 3 months, tiludronate for 6 months, or etidronate for 6 months. Serum AP levels and urinary hydroxyproline excretion were measured at baseline and after 3 months and 6 months. Patients with a reduction of at least 50% in the serum AP concentration were considered to be responders. RESULTS: After 3 months, the proportion of responders was higher in the tiludronate group (57.4%) than in the etidronate group (13.9%) (P < 0.0001). In the etidronate group, this percentage was lower among patients who had received previous treatment with a bisphosphonate (2.3%) than among those who had not (28.6%) (P < 0.01). Previous bisphosphonate treatment was not associated with response in the tiludronate group. After 6 months, the proportion of responders did not differ between the 2 tiludronate groups (60.3% and 70.1%), but was lower in the etidronate group (25.3%) (P < 0.0001). There was a higher proportion of patients with treatment-resistant disease (< 25% reduction of serum AP) in the etidronate group (51.9%) than in the tiludronate 3-month group (17.9%) or the tiludronate 6-month group (19.5%) (P < 0.0001). Gastrointestinal disturbances were more common, and occurred earlier, with tiludronate, but they were mostly mild, requiring no treatment. CONCLUSION: Tiludronate at 400 mg/day for 3 months or 6 months is more effective than the same dosage of etidronate for 6 months in the treatment of Paget's disease. [less ▲]

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See detailComparative responses to sodium selenite and organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Spring, P.; Andrieu, S. et al

in Livestock Science (2007), 111(3), 259-263

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed ... [more ▼]

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed. The goal of this trial was to compare the effects of different forms and concentrations of Se supplementation on Se status, health and performance in 60 pregnant Se-deficient BB cows. Cows were allocated to 3 experimental groups receiving selenized-yeast at 0.5 ppm Se on total ration (Y-Se 0.5), Na-selenite at 0.5 ppm Se on total ration (Na-Se 0.5) and Na-selenite at 0.1 ppm Se on total ration (Na-Se 0.1), respectively. Cows were supplemented from 2 months before calving until 2 months after calving. Data on performance, health and Se status of the dams and their calves were analyzed using a linear model, least squares means and logistic regression. At the end of the study, plasmatic Se (pSe) was significantly higher (P<0.01) in cows receiving Y-Se than in cows from other groups. Glutathion-peroxidase in erythrocytes (GSH-pxe) was higher in Y-Se and Na-Se 0.5 than Na-Se 0.1 group (P<0.01). Se content in colostrum and milk was significantly higher (P< 0.01) in Y-Se than other groups. At birth, Se status of calves from group Y-Se was significantly higher than those of other groups (P<0.01). Plasmatic Se in calves remained higher for 75 days after birth in Y-Se compared to other groups (P<0.01). Diarrhoea was the most commonly observed disease in the calves and, during the first 15 days of life, diarrhoea occurred in 6%, 21% and 35% of calves from groups Y-Se, Na-Se 0.5 and Na-Se 0.1, respectively. Over the whole 75 days trial period, incidence of diarrhoea was 19, 29 and 65%, respectively. Average daily gain (ADG) in calves born from Y-Se group of cows tended to be higher than in Na-Se 0.5 (P=0.06) and Na-Se 0.1 (P<0.05) but there was no difference between Na-Se 0.5 and Na-Se 0.1 (P>0.1). At the same dosage, Y-Se conferred better Se status in both dams and their calves than did Na-Se. Requirement of 0.1 ppm Se seems to be insufficient in BB to optimise health and performance. Regarding health status and ADG in calves, Y-Se seems also to result in better performance. (C) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailComparative responses to sodium selenite and Sel-Plex® organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Rollin, Frédéric ULg; Andrieu, Sylvie et al

in Nutritional Biotechnology in the Feed and Food Industries (Alltech’s 22nd Annual Symposium) (2006)

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See detailComparative semi-empirical and ab initio atomic structure calculations in Yb-like tungsten W4+
Enzonga Yoca, S; Quinet, Pascal ULg; Palmeri, P et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2012), 45

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See detailComparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
Paulsen, M.; Takada, S.; Youngson, N. A. et al

in Genome Research (2001), 11(12), 2085-94

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced ... [more ▼]

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced this conserved region in the mouse and sheep and included the human sequence in a three species comparison. This analysis resulted in a precise conservation map and identification of highly conserved sequence elements, some of which we have shown previously to be differentially methylated in the mouse. Additionally, this analysis facilitated identification of a CpG-rich tandem repeat array located approximately 13-15 kb upstream of Gtl2. Furthermore, we have identified a third imprinted transcript that overlaps with the last Dlk1 exon in the mouse. This transcript lacks a conserved open reading frame and is probably generated by cleavage of extended Dlk1 transcripts. Because Dlk1 and Gtl2 share many of the imprinting properties of the well-characterized Igf2-H19 domain, it has been proposed that the two regions may be regulated in the same way. Comparative genomic examination of the two domains indicates that although there are similarities, other features are very different, including the location of conserved CTCF-binding sites, and the level of conservation at regulatory regions. [less ▲]

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See detailComparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
Amarger, V.; Nguyen, Minh Ngoc ULg; Van Laere, Anne-Sophie ULg et al

in Mammalian Genome (2002), 13(7), 388-398

IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development. Here we report two sequence contigs together comprising almost ... [more ▼]

IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development. Here we report two sequence contigs together comprising almost 90 kb containing the INS-IGF2 and H19 genes. A comparative sequence analysis of the pig, human, and mouse genomic sequences was conducted to identify the exon/intros organization, all promoters, and other evolutionarily conserved elements. RT-PCR analysis showed that IGF2 transcripts originated from four different promoters and included various combinations of seven untranslated exons together with three coding exons, in agreement with previous findings in other mammals. The observed sequence similarity in intronic and intragenic regions among the three species is remarkable and is most likely explained by the complicated regulation of imprinting and expression of these genes. The general trend was, as expected, a higher sequence similarity between human and pig than between these species and the mouse, but a few exceptions to this rule were noted. This genomic region exhibits several striking features, including a very high GC content, many CpG islands, and a low amount of interspersed repeats. The high GC and CpG content were more pronounced in the pig than in the two other species. The results will facilitate the further characterization of this important QTL in the pig. [less ▲]

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See detailComparative studies for the serodiagnosis of Chlamydophila and Mycoplasma pneumoniae infections
Huynen, Pascale ULg; Goebel, Marie-Rose ULg; Meex, Cécile ULg et al

in ESCMID (Ed.) Abstract book of the 20th ECCMID (2010, April)

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See detailComparative studies of dispersant optimisation techniques for evaluating the stability of concentrated alumina slurries
Gaydardzhiev, Stoyan ULg; Ay, Peter; Janeczko, Marta

in Particle & Particle Systems Characterization (2006), 23

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See detailA comparative study between proximal radial morphology and the floating radial head prosthesis.
Popovic, Nebojsa; Djekic, Julien; Lemaire, Roger ULg et al

in Journal of Shoulder and Elbow Surgery (2005), 14(4), 433-40

A morphometric study of the proximal radius was performed with computed tomography scanning in 51 healthy adults. These dimensions were then compared with those of a commercially available floating radial ... [more ▼]

A morphometric study of the proximal radius was performed with computed tomography scanning in 51 healthy adults. These dimensions were then compared with those of a commercially available floating radial head prosthesis. Results were expressed as mean values, SD, and minimum and maximum values. The minimum and maximum diameters of the radial head were 21.9 +/- 1.9 mm and 22.9 +/- 1.9 mm, respectively. The minimum and maximum intramedullary diameters of the radial neck were 8.3 +/- 1.3 mm and 9.3 +/- 1.5 mm, respectively. The combined length of the radial head and neck was 22.47 +/- 2.84 mm. The implications for prosthetic design are as follows: the small floating cup (19 mm in diameter) is too small for the large majority of adults, the large floating cup (22 mm in diameter) is closer to the radial anatomy, the mean values are significantly different between male and female patients, and a single component would suffice for right and left elbows. [less ▲]

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