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See detailLa cathédrale gothique Saint-Lambert à Liège. Une église et son contexte
Van den Bossche, Benoît ULg

Book published by ULg-Service d'Histoire de l'Art et Archéologie du Moyen Age (2005)

Actes du colloque international consacré à la cathédrale gothique de Liège - la cathédrale Saint-Lambert -, disparue suite à la Révolution liégeoise de la fin du XVIIIe siècle.

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See detailLa cathédrale Saint-Paul et la maquette de Liège par Gustave Ruhl: numérisation du patrimoine
Billen, Roland ULg

Conference given outside the academic context (2013)

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See detailCathédrale, églises, châsses, ivoires, châteaux-forts ...
Nekrassoff, Serge ULg

in Province de Liège (1997)

Notices descriptives du patrimoine médiéval de la province de Liège

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See detailCathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: Study of their antiangiogenic properties and physiological relevance
Piwnica, David; Touraine, Philippe; Struman, Ingrid ULg et al

in Molecular Endocrinology (2004), 18(10), 2522-2542

16K prolactin (PRL) is the name given to the 16-kDa N-terminal fragment obtained by proteolysis of rat PRL by tissue extracts or cell lysates, in which cathepsin D was identified as the candidate protease ... [more ▼]

16K prolactin (PRL) is the name given to the 16-kDa N-terminal fragment obtained by proteolysis of rat PRL by tissue extracts or cell lysates, in which cathepsin D was identified as the candidate protease. Based on its antiangiogenic activity, 16K PRL is potentially a physiological inhibitor of tumor growth. Full-length human PRL ( hPRL) was reported to be resistant to cathepsin D, suggesting that antiangiogenic 16K PRL may be physiologically irrelevant in humans. In this study, we show that hPRL can be cleaved by cathepsin D or mammary cell extracts under the same conditions as described earlier for rat PRL, although with lower efficiency. In contrast to the rat hormone, hPRL proteolysis generates three 16K-like fragments, which were identified by N-terminal sequencing and mass spectrometry as corresponding to amino acids 1 - 132 ( 15 kDa), 1 - 147 (16.5 kDa), and 1 - 150 ( 17 kDa). Biochemical and mutagenetic studies showed that the species-specific digestion pattern is due to subtle differences in primary and tertiary structures of rat and human hormones. The antiangiogenic activity of N-terminal hPRL fragments was assessed by the inhibition of growth factor-induced thymidine uptake and MAPK activation in bovine umbilical endothelial cells. Finally, an N-terminal hPRL fragment comigrating with the proteolytic 17-kDa fragment was identified in human pituitary adenomas, suggesting that the physiological relevance of antiangiogenic N-terminal hPRL fragments needs to be reevaluated in humans. [less ▲]

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See detailA cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
Hilfiker-Kleiner, D.; Kaminski, K.; Podewski, E. et al

in Cell (2007), 128(3), 589-600

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 ... [more ▼]

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and proapoptotic 16 kDa form of the nursing hormone prolactin. Treatment with bromocriptine, an inhibitior of prolactin secretion, prevents the development of PPCM, whereas forced myocardial generation of 16 kDa prolactin impairs the cardiac capillary network and function, thereby recapitulating the cardiac phenotype of PPCM. Myocardial STAT3 protein levels are reduced and serum levels of activated CD and 16 kDa prolactin are elevated in PPCM patients. Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM. [less ▲]

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See detailA cathepsin K inhibitor reduces breast cancer-induced osteolysis and skeletal tumor burden
Le Gall, C.; Bellahcene, Akeila ULg; Bonnelye, E. et al

in Cancer Research (2007), 67(20), 9894-9902

Osteoclasts mediate bone destruction in breast cancer skeletal metastases. Cathepsin K is a proteinase that is secreted by osteoclasts and degrades bone. Here, immohistochemistry revealed that cathepsin K ... [more ▼]

Osteoclasts mediate bone destruction in breast cancer skeletal metastases. Cathepsin K is a proteinase that is secreted by osteoclasts and degrades bone. Here, immohistochemistry revealed that cathepsin K was expressed not only by osteoclasts but also by breast cancer cells that metastasize to bone. Following intratibial injection with cathepsin K-expressing human BT474 breast cancer cells, tumor-bearing mice treated with a clinical dosing regimen of cathepsin K inhibitor (CKI; 50 mg/kg, twice daily) had osteolytic lesions that were 79% smaller than those of tumor-bearing mice treated with the vehicle. The effect of CKI was also studied in a mouse model in which the i.v. inoculation of human B02 breast cancer cells expressing cathepsin K leads to bone metastasis formation. Drug administration was started before (preventive protocol) or after (treatment protocol) the occurrence of osteolytic lesions. In treatment protocols, CKI (50 mg/kg, twice daily) or a single clinical dose of 100 mu g/kg zoledronic acid (osteoclast inhibitor) reduced the progression of osteolytic lesions by 59% to 66%. CKI therapy also reduced skeletal tumor burden by 62% compared with vehicle, whereas zoledronic acid did not decrease the tumor burden. The efficacy of CKI at inhibiting skeletal tumor burden was similar in the treatment and preventive protocols. By contrast, CKI did not block the growth of s.c. B02 tumor xenografts in animals. Thus, CKI may render the bone a less favorable microenvironment for tumor growth by inhibiting bone resorption. These findings raise the possibility that cathepsin K could be a therapeutic target for the treatment of bone metastases. [less ▲]

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See detailCathepsin L in eggs and larvae of perch Perca fluviatilis: variations with developpement stage and spawning
Kestemont, Patrick; Cooremens, J.; Abi-Ayad, A. et al

in Fish Physiology and Biochemistry (1999), 21

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See detailCatherine Remy. La fin des bêtes. Une ethnographie de la mise à mort des animaux
Servais, Véronique ULg

in Annales : Histoire, Sciences Sociales (2010), 4

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See detailCatherine Seret: plus de cent cinquante ans de guérison
Baiwir, Esther ULg; de Marneffe-Laurent, Annette

in Neuberg, André (Ed.) Guérisseurs d'hier et d'Aujourd'hui (2003)

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See detailCathéter épicutanéo-cave double voie versus simple voie: une étude randomisée chez le nouveau-né prémature
Marion, W.; Anthopoulou, N.; François, A. et al

Conference (2007)

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See detailCatheter tip position as a risk factor for thrombosis associated with the use of subcutaneous infusion ports.
Caers, Jo ULg; Fontaine, Christel; Vinh-Hung, Vincent et al

in Supportive Care in Cancer (2005), 13((5)), 325-31

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See detailCatheter-related Infections - Belgian epidemiological data
Melin, Pierrette ULg

Conference (2003, November 20)

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See detailLe catheterisme d'intervention.
Legrand, Victor ULg; Collignon, P.

in Revue medicale de Liege (1987), 42(9), 375-89

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See detailLe catheterisme intermittent, methode de choix dans la prise en charge des dysfonctionnements neurologiques vesico-sphincteriens : notre experience a propos de 154 patients atteints d'une sclerose en plaques.
Keppenne, Véronique; Sanjurjo, Sylvia; Bottin, Christiane et al

in Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (2014), 24(13), 842-3

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See detailCathéters pour instillation moins invasive de SURFACTANT : une étude de simulation
RIGO, Vincent ULg; Debauche, Christian; Maton, Pierre et al

in Baud, Olivier; Saliba, Elie (Eds.) Congrès JFN-JFRN 2016, livre des communications (2016, December 15)

Introduction et objectifs : l’instillation trachéale de surfactant par un cathéter fin (Less invasive surfactant therapy- LIST) chez le prématuré sous CPAP permet de diminuer la morbidité respiratoire ... [more ▼]

Introduction et objectifs : l’instillation trachéale de surfactant par un cathéter fin (Less invasive surfactant therapy- LIST) chez le prématuré sous CPAP permet de diminuer la morbidité respiratoire. Plusieurs cathéters sont décrits à cette fin : une sonde oro-gastrique insérée avec (LISA-Köln, K) ou sans pince de Maggil (Take Care- Ankara, A), un cathéter veineux de 13 cm (MIST- Hobart, H), un cathéter d’angiographie de 30 cm (Stockholm, S) ou un cathéter ombilical fixé à un stylet d’intubation utilisé localement (Liège, L). L’objectif de l’étude est d’évaluer l’efficacité de ces techniques en prenant l’INSURE (Intubation-Surfactant-Extubation) comme référence. Intervention : 20 néonatologues travaillant dans 4 services ayant des stratégies d’administration du surfactant différentes ont participé. Ils ont simulé ces 6 techniques sur deux têtes d’intubation de difficulté croissante. L’efficacité de l’intervention est évaluée par le taux d’échec et la durée de procédure mesurée sur vidéo. Chaque intervenant apprécie la facilité d’utilisation sur une échelle de 1 à 9 (Difficile> facile). Résultats : Pour le premier modèle, les durées médianes de procédure pour Köln et Ankara sont allongées [K: 21s (IQR 17-24); A: 23s (15-42); H: 10s (8-16); S: 12s (10-22); L (10-20); INSURE: 14s (11-21); p<.0001]. Pour le second modèle, seul Liège permet une durée de procédure similaire à l’INSURE [K: 32s (25-44); A: 39s (27-95); H: 34s (27-46); S: 37s (29-42); L: 24s (15-35); INSURE: 24s (17-32); p<.002]. Les taux d’échec des méthodes LIST sont similaires entre eux (de 3 à 8/ 40 essais), mais supérieurs à celui de l’INSURE (0/40). Köln et Ankara sont considérés comme plus difficiles [scores de facilité : K: 5 (4-6); A: 3 (2-4); H: 6,5 (6-7); S: 7 (4-8); L: 8 (6,5-8); INSURE: 7 (6-8); p<.001]. Conclusions : les cathéters plus rigides sont plus efficaces et perçus comme plus simples d’utilisation. L’insertion d’un cathéter guidé et incurvé pourrait être plus rapide dans les cas difficiles. [less ▲]

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See detailCathodic electrografting of acrylics: From fundamentals to functional coatings
Gabriel, Sabine ULg; Jérôme, Robert ULg; Jérôme, Christine ULg

in Progress in Polymer Science (2010), 35

Promoting permanent adhesion between so dissimilar materials as polymers and metals is a very challenging target and a severe brake to the implementation of many potential applications. However, synthetic ... [more ▼]

Promoting permanent adhesion between so dissimilar materials as polymers and metals is a very challenging target and a severe brake to the implementation of many potential applications. However, synthetic polymers can now be chemisorbed onto a variety of conducting surfaces by cathodic electrografting of acrylic monomers. The first part of this review will focus on the fundamental aspects of this emerging technology, thus from the historical discovery to experimental and theoretical developments, with the purpose to better comprehend the electrografting phenomenon. Once firmly established, this concept has been exploited in order to make polymeric coatings with specific functionality chemisorbed onto more diversified substrates in more convenient liquid media. This remarkable progress that largely relies on advanced controlled polymerization processes will be the topic of the second part of the review, with a special emphasis on the more recent development of smart coatings, particularly stimuli responsive coatings very well-suited to nanotechnologies. [less ▲]

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See detailLe catholicisme baroque : historiographie et nouveaux enjeux
Delfosse, Annick ULg

Conference (2007, October 26)

Detailed reference viewed: 24 (2 ULg)