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See detailClinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg; Bellamy, Nicholas et al

in Rheumatology (2014), 53

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving ... [more ▼]

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving strontium ranelate 2 g/day (n = 454), 1 g/day (n = 445) or placebo (n = 472) in the Strontium Ranelate Efficacy in Knee Osteoarthritis Trial. Clinical response was evaluated using WOMAC subscores, minimal perceptible clinical improvement (MPCI), minimal clinically important improvement (MCII) and a modified OMERACT Osteoarthritis Research Society International (OARSI) responder definition. Patients who withdrew prematurely from the study were considered non-responders. Results. There was no significant effect on symptoms for strontium ranelate 1 g/day. At the dosage of 2 g/day, strontium ranelate was associated with greater response than placebo in terms of 520% improvement in WOMAC pain from baseline to the last visit (58% vs 47%, P = 0.002) and 550% improvement in WOMAC pain (42% vs 36%, P = 0.083). Significant differences were found in MPCI response for WOMAC pain (52% vs 40%, P<0.001), stiffness (47% vs 39%, P = 0.009) and physical function (46% vs 37%, P = 0.009) and in MCII response for WOMAC physical function (46% vs 37%, P = 0.013). There were also more OMERACT-OARSI-like responders with strontium ranelate (44% vs 35%, P = 0.004). The treatment placebo difference in MPCI response for WOMAC pain was significant after 6 months (P = 0.024), while that in MPCI and MCII response for WOMAC physical function reached significance after 12 months (P = 0.027 and P = 0.019, respectively). Conclusion. Treatment with strontium ranelate 2 g/day over 3 years is associated with a clinically meaningful improvement in pain from 6 months as well as physical function and stiffness as assessed by the number of responders above thresholds of clinical relevance. [less ▲]

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See detailA clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma.
Salvatori, Roberto; Daly, Adrian ULg; Quinones-Hinojosa, Alfredo et al

in Endocrinology, diabetes & metabolism case reports (2014), 2014

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated ... [more ▼]

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated pituitary adenoma syndrome, usually as somatotropinomas and prolactinomas. More recently, they have been found in a significant percentage of young patients presenting with pituitary macroadenoma without any apparent family history. We describe the case of a 19-year-old man who presented with a gigantic somatotropinoma. His family history was negative. His peripheral DNA showed a heterozygous AIP mutation (p.I13N), while tumor tissue only had the mutated allele, showing loss of heterozygosity (LOH) and suggesting that the mutation caused the disease. LEARNING POINTS: AIP mutations may be observed in sporadic somatotrope adenomas occurring in young patients.LOH is a strong indicator that an AIP variant is disease causing.Somatotrope adenomas in carriers of AIP mutations are generally larger and more difficult to cure. [less ▲]

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See detailClinico-pathological prognostic factors of IgA vasculitis
Bovy, Christophe ULg; Parotte, Marie-Christine ULg; Krzesinski, Jean-Marie ULg

in Acta Clinica Belgica (2007, October), 62(5), 369

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See detailA clinico-pathological report of SCA17 associated with a heterozygote small trinucleotide expansion
Garraux, Gaëtan ULg; Moonen, Gustave ULg; Deprez, Manuel ULg

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 12-12

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See detailClinicopathologic analysis of appendiceal tumors from 1,237 apendectomies
Tchanasato, V.; Laurent, S.; Thiry, Albert ULg et al

in Acta Gastro-Enterologica Belgica (2005, January), 68(1), 08

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See detailClinicopathologic and molecular analysis of a choroidal pigmented schwannoma in the context of a PTEN hamartoma tumor syndrome.
Venturini, Giulia; Moulin, Alexandre P.; DEPREZ, Manuel ULg et al

in Ophthalmology (2012), 119(4), 857-64

PURPOSE: To report the first case of choroidal schwannoma in a patient affected by PTEN hamartoma tumor syndrome (PHTS) and investigate the molecular involvement of the phosphatase and tensin homolog ... [more ▼]

PURPOSE: To report the first case of choroidal schwannoma in a patient affected by PTEN hamartoma tumor syndrome (PHTS) and investigate the molecular involvement of the phosphatase and tensin homolog (PTEN) and neurofibromin 2 (NF2) genes in this rare intraocular tumor. DESIGN: Observational case report. PARTICIPANT: A 10-year-old girl diagnosed with PHTS. METHODS: The enucleated specimen underwent histologic, immunohistochemical, and transmission electronic microscopy. The expression of PTEN and NF2 and their protein products were evaluated by reverse transcription-polymerase chain reaction and immunohistochemistry. Somatic mutations of PTEN and NF2, as well as allelic loss, were investigated by direct sequencing of DNA extracted from the tumor. PTEN epigenetic silencing was investigated by pyrosequencing. MAIN OUTCOME MEASURES: Histopathologic and molecular characterization of a choroidal pigmented schwannoma. RESULTS: Histopathologic, immunohistochemical, and electron microscopic analysis demonstrated features consistent with a pigmented cellular schwannoma of the choroid. We found no loss of heterozygosity at the genomic level for the PTEN germline mutation and no promoter hypermethylation or other somatic intragenic mutations. However, we observed an approximate 40% reduction of PTEN expression at both the mRNA and the protein level, indicating that the tumor was nonetheless functionally deficient for PTEN. Although DNA sequencing of NF2 failed to identify any pathologic variants, its expression was abolished within the tumor. CONCLUSIONS: We report the first description of a pigmented choroidal schwannoma in the context of a PHTS. This rare tumor showed a unique combination of reduction of PTEN and absence of NF2 expression. [less ▲]

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See detailClinicopathologic presentations of dermatomycoses in cancer patients.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Journal of the European Academy of Dermatology & Venereology (2008)

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged ... [more ▼]

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged and severe neutropenia is the main risk factor for the dramatic issue of fungal infections. The dermatomycoses in cancer patients can be classified in four broad groups: primary superficial dermatophytoses, primary superficial yeast infections, opportunistic mold infections with distinct potential for dissemination and secondary cutaneous manifestations of fungaemia. Occasionally, more than one fungus are found inside a given skin lesion. A special condition is represented by the mycotic colonization of mucosal squamous cell carcinomas. Angio-invasion by fungi accounts for the frequency of disseminated infections prevailing in immunocompromised cancer patients. In case of skin involvement, the dermatologist may assist by recognizing subtle semiological signs and performing biopsies for swift histological examination, molecular biology and/or culture. [less ▲]

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See detailClinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
Ben Gacem, Riadh; Hachana, Mohamed Ridha ULg; Ziadi, Sonia et al

in Human Pathology (2012)

DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze ... [more ▼]

DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a series of 94 Tunisian sporadic breast carcinomas. Results were correlated to clinicopathologic parameters and promoter methylation status of 8 tumor suppressor genes (BRCA1, BRCA2, RASSFA1, TIMP3, CDH1, P16, RARβ2, and DAPK). Overexpression of DNA methyltransferase 1, 3a, and 3b was detected in 46.8%, 32%, and 44.7% of cases, respectively. A significant correlation was found between DNA methyltransferase 1 overexpression and Scarff-Bloom-Richardson histologic grade III (P = .01). DNA methyltransferase 3a overexpression was significantly associated with menopausal status (P = .01), Scarff-Bloom-Richardson histologic grade III (P = .0001), estrogen (P = .04) and progesterone (P = .007) receptor negativity, and HER2 overexpression (P = .004). However, DNA methyltransferase 3a overexpression was found less frequently in the luminal A intrinsic breast cancer subtype (9.7%) than in luminal B (53%), HER2 (41%), and triple-negative (50%) subtypes (P = .001). DNA methyltransferase 3b overexpression shows significant correlation with promoter hypermethylation of BRCA1 (P = .03) and RASSFA1 (P = .04) and with the hypermethylator phenotype (more than 4 methylated genes, P = .01). These data suggest that overexpression of various DNA methyltransferases might represent a critical event responsible for the epigenetic inactivation of multiple tumor suppressor genes, leading to the development of aggressive forms of sporadic breast cancer. [less ▲]

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See detailClinicopathological data in equids suffering from ante-hepatic, hepatic and post-hepatic diseases
Amory, Hélène ULg; Perron, MF; Sandersen, Charlotte ULg et al

in Proceedings of the 42th Annual Congress of the British Equine Veterinary Association (BEVA) (2003)

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See detailClinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.
Deprez, Manuel ULg; Uffer, Sylvie

in American Journal of Dermatopathology (2009), 31(3), 256-62

Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors. In this retrospective study, we report the clinical and histological ... [more ▼]

Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors. In this retrospective study, we report the clinical and histological features of 5504 eyelid skin tumors diagnosed at the Laboratory of Ophthalmopathology of the Hopital Ophtalmique Jules Gonin, Lausanne, Switzerland, between January 1989 and December 2007. Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%). Basal cell carcinoma was the most frequent malignant tumor (86%), followed by squamous cell carcinoma (7%) and sebaceous carcinoma (3%). For several tumor subtypes, there was a poor correlation between clinical and histological diagnosis, stressing the numerous pitfalls in the diagnosis of eyelid tumors. We further discuss our results with reference to previously published series. [less ▲]

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See detailClinicopathological study of ninety cases of clinical stage I cutaneous malignant melanoma
Castermans, A.; Castermans-Elias, S.; Lapière, M. et al

in Chir. Plastica (1974), 2

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See detailLa clinique ambulatoire bovine de l'ULg
Guyot, Hugues ULg

Article for general public (2010)

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See detailLa Clinique Ambulatoire de l'ULg au service du praticien
Gaillot, Claire ULg; Guyot, Hugues ULg

Article for general public (2013)

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See detailLa clinique des traits de personnalité adaptée à l'enfance. L'apport de cette lecture dans le suivi thérapeutique
Scholl, Jean-Marc ULg

Conference given outside the academic context (2006)

Les présentations des traits de personnalité pour enfants et surtout leurs évaluations sont actuellement quasi inexistantes. La présentation qui sera ici exposée est le résultat d'une composition ... [more ▼]

Les présentations des traits de personnalité pour enfants et surtout leurs évaluations sont actuellement quasi inexistantes. La présentation qui sera ici exposée est le résultat d'une composition personnelle. Elle suit le schéma du DSM IV, avec des éléments surajoutés et des nuances apportées à partir du DSM III, du « Manuel de psychopathologie de l'enfant et de l'adolescent » de Robert Pelsser, et de la nomenclature CIM 10 ou ICD 10 (Classification Internationale de l'Organisme Mondial de la Santé). Ce travail reprend dans un continuum, en fondu enchaîné, des descriptions qui concernent à la fois l'enfant et l'adulte. Ce qui importe, c'est la compréhension clinique des formes générales de personnalité. La personnalité est organisée de façon moins stable et moins rigide au cours de l'enfance et de l'adolescence qu'à l'âge adulte. Les manifestations de troubles de personnalité deviennent plus clairement identifiables au fur et à mesure du développement. Par ailleurs, la capacité de l'enfant ou de l'adolescent à faire preuve d'introspection et de réaliser qu'il a des difficultés liées à sa personnalité (à partir de sa souffrance, d'expériences négatives, ou de ce qui lui est renvoyé par l'entourage) ne s'accroîtra qu'avec l'âge. Les traits de personnalité sont fluctuants : ils peuvent se résorber spontanément sans aucune intervention, se cristalliser au fur et à mesure du développement et s'organiser en un caractère pathologique à l'âge adulte ; ils peuvent également se transformer pour faire place à d'autres types de tableaux cliniques. Certains traits peuvent être marqués dès la petite enfance, d'autres n'apparaîtront que dans le décours de l'adolescence. Dans ce contexte, nous avons préféré ne pas donner de listes de critères pour chaque personnalité (comme le fait le DSM IV pour les adultes), mais plutôt donner un tableau clinique assez exhaustif pour chacune d'elles, en partant parfois d'aspects plus propres à l'enfant pour aboutir au tableau caricatural de l'adulte. Bien sûr, pour reconnaître des traits, il ne faut pas la présence du tableau caricatural exhaustif. Tenant compte de la réalité clinique, nous utilisons le terme de "traits" de personnalité et non de trouble. La réalité clinique nous confronte souvent à la présence simultanée de traits de différents types des personnalités. Il faut donc envisager pour chaque enfant un panaché de traits différents. Pour chaque trait, il faut alors cliniquement déterminer s'il est marqué ou faible chez l'enfant, c'est-à-dire l'envisager en termes de gradient d'intensité, l'enfant ayant peu, moyennement ou fortement ce trait. [less ▲]

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See detailClinique du Stress et du Traumatisme psychique - Approche cognitivo-comportementale
Blavier, Adelaïde ULg

Scientific conference (2013, December 13)

L’objectif de cette conférence est de décrire en quoi consiste l'approche cognitivo-comportementale, son origine et de préciser comment l'approche cognitivo-comportementale aborde la clinique du ... [more ▼]

L’objectif de cette conférence est de décrire en quoi consiste l'approche cognitivo-comportementale, son origine et de préciser comment l'approche cognitivo-comportementale aborde la clinique du traumatisme psychique. Seront également discutées les particularités de cette clinique du traumatisme psychique par rapport à d'autres cliniques ainsi que la position du praticien en victimologie. Le but est de permettre à l'étudiant de pouvoir prendre connaissance des enjeux cognitivo-comportementaux et de la clinique cognitivo-comportementale autour de la victime souffrant de psychotraumatisme. [less ▲]

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See detailClinique du sujet et hyperspécialisation du soin en hôpital de jour: quand la réalité dépasse la fiction
Massart, Nicolas ULg; Conraads, Valérie; Argento, Gino et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2007), 9

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See detailClinique et cytologie sputaire de l'asthme intrinseque
Bettiol, J.; Radermecker, Maurice ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2002), 57(4), 223-7

The diagnosis of intrinsic asthma is evoked in patients with clinical criteria of asthma but, who contrarily to atopic asthmatics, lack history of allergy, specific IgE and skin positive reaction towards ... [more ▼]

The diagnosis of intrinsic asthma is evoked in patients with clinical criteria of asthma but, who contrarily to atopic asthmatics, lack history of allergy, specific IgE and skin positive reaction towards common aeroallergens of the environment. While the bronchial cytology of these two types of asthma is comparable, the immunological mechanisms of intrinsic asthma remain poorly understood because the factors responsible for the bronchial inflammation are unknown. Intrinsic asthma normally begins in adulthood and carries often a more severe prognosis. This disease is more frequent in women and is often associated to nasal polyposis and/or aspirin hypersensitivity. In this work, we have retrospectively studied the demographic and clinical characteristics, as well as the lung function and the sputum cell counts of intrinsic asthmatic outpatients seen during the period of 1996 to 1998 in the Pneumology Department of the CHU Sart Tilman. [less ▲]

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See detailClinique phoniatrique
FINCK, Camille ULg

Scientific conference (2003, December)

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See detailLa clinique psychologique et logopédique : une approche intégrée du patient
Maillart, Christelle ULg; Catale, Corinne ULg

Conference given outside the academic context (2013)

Le travail en équipe multidisciplinaire permet d’envisager l’évaluation et la prise en charge d’un patient de manière intégrée : illustration de la collaboration entre neuropsychologue et logopède dans le ... [more ▼]

Le travail en équipe multidisciplinaire permet d’envisager l’évaluation et la prise en charge d’un patient de manière intégrée : illustration de la collaboration entre neuropsychologue et logopède dans le cadre de suivis d’enfants et d’adolescents. [less ▲]

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