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See detailLe cancer thyroïdien papillaire familial (FNMTC): études cliniques et génétiques chez 8 familles
VALDES SOCIN, Hernan Gonzalo ULg; Daly, Adrian ULg; Burlacu, C et al

in Abstract book - Annales d'Endocrinologie : 31ème Congrès de la Société Française d'Endocrinologie, Lyon 5-8 novembre 2014 (2014, October)

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See detailCancérologie
Lambert, Philippe; Noël, Agnès ULg; Coucke, Philippe ULg

Article for general public (2010)

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See detailCancers cutanés après transplantation d'organe, un revers de médaille.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2007), 62(11), 663-8

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most ... [more ▼]

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most frequent malignancies developing after organ transplantation. The usual squamous to basal cell carcinoma ratio is increased and reversed compared to the general population. Carcinomas primarily result from the combination of cumulative sun exposure, fair skin phototype and effects of immunosuppressive drugs. These treatments impair the systemic immunosurveillance and may exert a direct carcinogenic effect. The severity of these carcinomas is due to their multiplicity and to the occurrence of more aggressive lesions. Prevention relies on a strict adherence to sun protection after transplantation, and on refined immunosuppressive strategies. The treatment of the neoplastic lesions is based on their early and complete excision with histological control of the nature of the neoplasm, the safety surgical margins, and the determination of prognostic factors. [less ▲]

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See detailCancers cutanés photo induits en 3D, version spécialiste
PIERARD, Gérald ULg; Andre, J.; Brochez, L. et al

Book (2009)

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See detailCancers du pancréas exocrine
DURAN, Unal ULg; brisbois, d; marterne, R. et al

in Encyclopédie Médico-Chirurgicale (2016)

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See detailCancers épithéliaux de l'ovaire. Acquisitions récentes
van den Brule, F. A.; Lambotte, René ULg; Castronovo, Vincenzo ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1995), 24(3), 241-52

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by ... [more ▼]

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by the lack of a well defined precursor lesion, the lack of knowledge about tumour progression, and by the relative inaccessibility of the ovaries in the abdominal cavity. Recent studies using experimental models allow us to better define the fundamental mechanisms of carcinogenesis from the serous ovarian cells and of invasion of the abdominopelvic cavity by proximity. This review article tries to update on epidemiology, genetic syndromes, biology, screening, and therapy of these epithelial tumours, and about the new directions taken by basic and clinical research. We will present data concerning oncogenes and tumour suppressor genes involved in epithelial ovarian tumours, regulation of tumour cells by growth factors, genes involved in tumour invasion, and mechanisms used by the cancer cell to resist to therapies. Non-epithelial ovarian tumours will not be examined in this manuscript. [less ▲]

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See detailLes cancers hématologiques en 1987. Chimiothérapie et immunothérapie.
Fillet, Georges ULg; Bury, J.; Beguin, Yves ULg et al

in Revue Médicale de Liège (1987), 42(10), 496-502

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See detailCancers hématologiques et qualité de vie
Fillet, Georges ULg; Bury, J.

in Revue Médicale de Liège (1986), 41

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See detailCancers secondaires après allogreffe de cellules souches hématopoïétiques
Hafraoui, Kaoutar ULg; Beguin, Yves ULg; Baron, Frédéric ULg

in Revue Médicale de Liège (2009), 64(10), 496-499

This article reviews the incidence, risk factors and prevention of secondary malignancies after allogeneic hematopoietic cell transplantation.

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See detailCancers thyroidiens radio-induits
Lemaire, Michelle ULg; Lejeune, Georges ULg; Lambermont, Bernard ULg

in Acta Oto-Rhino-Laryngologica Belgica (1988), 42(5), 606-11

We describe thyroid carcinomas observed in two male patients after cervical irradiation in infancy. In the first case, irradiation was given for cervical angioma and in the second case, for enlarged ... [more ▼]

We describe thyroid carcinomas observed in two male patients after cervical irradiation in infancy. In the first case, irradiation was given for cervical angioma and in the second case, for enlarged thymus. A long time interval (16 and 43 years) elapsed between irradiation and the detection of the epitheliomas. The anatomopathological diagnosis was, for the first patient, papillo-vesicular epithelioma and for the second one, anaplastic carcinoma. [less ▲]

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See detailLes cancers viro-induits: interrelations genetique-environnement
Delvenne, Philippe ULg; Renoux, V. M.; Arafa, M. et al

in Revue Médicale de Liège (2012), 67(5-6), 381-9

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the ... [more ▼]

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the papillomaviruses and the Epstein-Barr virus. These virus-induced cancers generate a high level of interest not only for the study of mechanisms involved in the neoplastic transformation, but also for the set-up of specific immunotherapies including prophylactic and therapeutic antitumor vaccination. [less ▲]

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See detailCandida albicans cheilitis in guinea pig may be caused by commensal strains carried in the lower genital tract
Mignon, Bernard ULg; Symoens, F.; Losson, Bertrand ULg

in Veterinary Dermatology (2003), 14(5), 242

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg

Scientific conference (2011, November)

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg

Conference (2012, March)

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See detailCandidate gene markers associated with somatotropic axis and milk selection
Parmentier, I.; Portetelle, Daniel ULg; Gengler, Nicolas ULg et al

in Domestic Animal Endocrinology (1999), 17(2-3), 139-148

One of the obstacles to progress in dairy cattle selection is that milk production traits are only expressed after the first calving. However, the use of the quantitative trait loci (QTL) technology will ... [more ▼]

One of the obstacles to progress in dairy cattle selection is that milk production traits are only expressed after the first calving. However, the use of the quantitative trait loci (QTL) technology will improve the efficiency of dairy industry with a positive image for the consumers. QTL are part of the genome showing a preponderant action and explaining the major part of variation of the trait production. At the present time, the two major strategies developed to detect such QTL are the candidate gene approach and the positional genetics approach. The somatotropic axis contains the most promising candidates in this respect, as it strongly regulates milk production. Then, the identification of favorable QTL associated with the somatotropic axis that are significantly correlated with genetic merits for milk production could lead to more effective selection programs. (C) 1999 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailCandidate locus for familial abdominal aortic aneurysms by genome-wide DNA linkage analysis
Shibamura, H.; Buxbaum, S.; Olson, J. M. et al

in Circulation (2002), 106(19, Suppl. S), 168

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See detailThe candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.
Franzoso, G.; Bours, Vincent ULg; Park, S. et al

in Nature (1992), 359(6393), 339-42

The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias. The protein Bcl-3 contains seven so-called ... [more ▼]

The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias. The protein Bcl-3 contains seven so-called ankyrin repeats. Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in I kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-kappa B activity. No biological function has yet been described for Bcl-3, but it was noted recently that Bcl-3 interferes with DNA-binding of the p50 subunit of NF-kappa B in vitro. Here we demonstrate that Bcl-3 can aid kappa B site-dependent transcription in vivo by counteracting the inhibitory effects of p50/NF-kappa B homodimers. Bcl-3 may therefore aid activation of select NF-kappa B-regulated genes, including those of the human immunodeficiency virus. [less ▲]

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See detailCandidate VLTI Configurations for the GENIE Nulling Experiment
Absil, Olivier ULg; Gondoin, P.; Erd, C. et al

in Deming, Drake; Seager, Sara (Eds.) Scientific Frontiers in Research on Extrasolar Planets (2003)

The European Space Agency (ESA) and the European Southern Observatory (ESO) initiate a definition study for a Ground-based European Nulling Interferometer Experiment (Darwin-GENIE). The experiment will ... [more ▼]

The European Space Agency (ESA) and the European Southern Observatory (ESO) initiate a definition study for a Ground-based European Nulling Interferometer Experiment (Darwin-GENIE). The experiment will use the Very Large Telescope Interferometer (VLTI) operating on Mount Paranal (Chile). The objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer using a design concept and technology representative of the ESA IRSI-Darwin space mission. GENIE will prepare the IRSI-Darwin science program through a systematic search for exozodiacal dust clouds around IRSI-Darwin candidate targets. GENIE also aims to perform IRSI-Darwin related science achievable from ground including the detection of low-mass companions (if possible, hot jupiters) around nearby stars. Among the variety of telescope sizes and positions on the VLTI site, candidate interferometric configurations have been identified for GENIE, taking into account the limitation imposed by the Earth's atmosphere. They include a Bracewell interferometer for exozodiacal clouds detection in the N band and a double Bracewell configuration with internal modulation for extrasolar jupiter detection in the L' band. The present paper presents the prospective performance of these configurations in light of current specifications of major VLTI subsystems. [less ▲]

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See detailLes candidats d’ouverture : où, qui, comment, pourquoi ?
Audrey, Vandeleene; Dodeigne, Jérémy ULg; Valentin, Jaminet

in Dandoy, Régis; Dodeigne, Jérémy; Matagne, Geoffroy (Eds.) et al Les élections communales de 2012 en Wallonie (2013)

L’idée d’« ouverture » est une notion répandue dans la rhétorique politique et c’est une tendance à laquelle le scrutin communal du 14 octobre 2012 n’échappe pas. Au lendemain des élections, il n’est pas ... [more ▼]

L’idée d’« ouverture » est une notion répandue dans la rhétorique politique et c’est une tendance à laquelle le scrutin communal du 14 octobre 2012 n’échappe pas. Au lendemain des élections, il n’est pas rare que la liste sortie gagnante du scrutin décide malgré tout d’ouvrir sa majorité absolue à un autre groupe du conseil communal. La stratégie d’ouverture peut également intervenir en amont du scrutin lors de la composition des listes, avec la sélection de candidats extérieurs aux partis politiques. Nous retrouvons alors sur ces listes des candidats – officiellement non membres du parti – mais présents en signe d’ouverture de la liste aux membres actifs de la vie associative communale, à des dissidents d’un autre parti ou à des membres d’un parti qui ne se présente pas lors de ces élections. La présence de ces candidats constitue un argument électoral durant la campagne pour démontrer la dynamique « citoyenne » d’une liste, sa volonté de faire de la politique autrement, son ancrage dans la communauté locale, ou permet plus pragmatiquement de combler les places vacantes d’une liste incomplète. Si le recrutement de candidats d’ouverture s’impose comme une stratégie électorale évidente pour de nombreux leaders locaux, comme en témoignent la rhétorique de campagne et le contenu des tracts électoraux, le concept de candidat d’ouverture revêt toutefois un caractère singulier dans le cadre du scrutin communal. Ce dernier est effet caractérisé par la forte présence de listes locales et quasi-locales, où la notion d’ouverture vis-à-vis des partis politiques est plus ambiguë (compte tenu de la nature intrinsèquement locale et non partisane de ces listes). Dans ce chapitre, nous revenons donc dans un premier temps sur le concept de candidat d’ouverture lors du scrutin communal et ciblons en particulier les données à analyser pour étudier ce type de candidats. Après avoir scruté les statuts des partis et les règles spécifiques applicables à ce type de candidats, nous analysons en détails les contextes électoraux, communaux et partisans expliquant le recrutement de candidats d’ouverture. Comme nous le verrons, la présence de ces candidats varie fortement en fonction du type de liste, des partis, de la taille des communes, du nombre de listes en présence et des figures politiques supra-locales qui se portent candidates. Enfin, nous analysons brièvement dans quelle mesure cette stratégie électorale peut être considérée comme politiquement et électoralement gagnante tant du point de vue des candidats que des listes. [less ▲]

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