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See detailCancer parathyroïdien et immunothérapie
Beckers, Albert ULg

Scientific conference (2005, November 25)

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See detailCancer patient's qaulity of life : importance of goal's and hierarchy's adjustement
Etienne, Anne-Marie ULg; Dupuis, G.; Conradt, S. et al

in Psycho-oncology (2010, May), 19(Suppl.2)(1-313), 151

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See detailCancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families.
De Brakeleer, Sylvia; De Greve, Jacques; Loris, Remy et al

in Human Mutation (2010), 31(3), 1175-85

Fifteen years ago BRCA1 and BRCA2 were reported as high penetrant breast cancer predisposing genes. However, mutations in these genes are found in only a fraction of high risk families. BARD1 is a ... [more ▼]

Fifteen years ago BRCA1 and BRCA2 were reported as high penetrant breast cancer predisposing genes. However, mutations in these genes are found in only a fraction of high risk families. BARD1 is a candidate breast cancer gene, but only a limited number of missense mutations with rather unclear pathogenic consequences have been reported.We screened 196 high risk breast cancer families for the occurrence of BARD1 variants. All genetic variants were analyzed using clinical information as well as IN SILICO predictive tools, including protein modeling. We found three candidate pathogenic mutations in seven families including a first case of a protein truncating mutation (p.Glu652fs) removing the entire second BRCT domain of BARD1. In conclusion, we provide evidence for an increased breast cancer risk associated to specific BARD1 germline mutations. However, these BARD1 mutations occur in a minority of hereditary breast cancer families. [less ▲]

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See detailCancer risk and bariatric surgery
De Roover, Arnaud ULg; Desaive, Claude; Detry, Olivier ULg et al

in Obesity Surgery (2006), 16

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See detailCancer risk in immune-mediated inflammatory diseases (IMID).
Beyaert, Rudi; Beaugerie, Laurent; Van Assche, Gert et al

in Molecular cancer (2013), 12(1), 98

Inflammation and cancer have a profound yet ambiguous relationship. Inflammation - especially chronic inflammation - has protumorigenic effects, but inflammatory cells also mediate an immune response ... [more ▼]

Inflammation and cancer have a profound yet ambiguous relationship. Inflammation - especially chronic inflammation - has protumorigenic effects, but inflammatory cells also mediate an immune response against the tumor and immunosuppression is known to increase the risk for certain tumors.This article reviews current literature on the role of inflammation in cancer and the cancer risk in immune-mediated inflammatory diseases (IMIDs). We discuss the effect on cancer risk of different drug classes used in the treatment of IMIDs treatment, including biologicals such as tumor necrosis factor (TNF) inhibitors.Overall cancer incidence and mortality risk are similar to the general population in inflammatory bowel disease (IBD), and slightly increased for rheumatoid arthritis and psoriasis, with risk profiles differing for different tumor types. Increased risk for non-melanoma skin cancer is associated with thiopurine treatment in IBD, with the combination of anti-TNF and methotrexate in rheumatoid arthritis and with PUVA, cyclosporine and anti-TNF treatment in psoriasis. Data on the safety of using biologic or immunosuppressant therapy in IMID patients with a history of cancer are scarce.This review provides clinicians with a solid background to help them in making decisions about treatment of immune-mediated diseases in patients with a tumor history.This article is related to another review article in Molecular Cancer: http://www.molecular-cancer.com/content/12/1/86. [less ▲]

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See detailThe cancer screening controversy
CUSUMANO, Giuseppe ULg; LIFRANGE, Eric ULg

in European Journal of Cancer Prevention (2011), Suppl 1(S1),

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See detailCancer thyroïdien familial non médullaire : actualités cliniques et génétiques
VALDES SOCIN, Hernan Gonzalo ULg; Gonon Rodrigues Palmeira, Leonor ULg; Burlacu, MC et al

in Revue Médicale de Liège (2016), 71(12), 557-561

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See detailLe cancer thyroïdien papillaire familial (FNMTC): études cliniques et génétiques chez 8 familles
VALDES SOCIN, Hernan Gonzalo ULg; Daly, Adrian ULg; Burlacu, C et al

in Abstract book - Annales d'Endocrinologie : 31ème Congrès de la Société Française d'Endocrinologie, Lyon 5-8 novembre 2014 (2014, October)

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See detailCancérologie
Lambert, Philippe; Noël, Agnès ULg; Coucke, Philippe ULg

Article for general public (2010)

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See detailCancers cutanés après transplantation d'organe, un revers de médaille.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2007), 62(11), 663-8

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most ... [more ▼]

Drug-induced immunosuppression is the necessary corollary of organ transplantation. This situation is responsible for an increased risk of both infection and neoplasia. Cutaneous carcinomas are the most frequent malignancies developing after organ transplantation. The usual squamous to basal cell carcinoma ratio is increased and reversed compared to the general population. Carcinomas primarily result from the combination of cumulative sun exposure, fair skin phototype and effects of immunosuppressive drugs. These treatments impair the systemic immunosurveillance and may exert a direct carcinogenic effect. The severity of these carcinomas is due to their multiplicity and to the occurrence of more aggressive lesions. Prevention relies on a strict adherence to sun protection after transplantation, and on refined immunosuppressive strategies. The treatment of the neoplastic lesions is based on their early and complete excision with histological control of the nature of the neoplasm, the safety surgical margins, and the determination of prognostic factors. [less ▲]

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See detailCancers cutanés photo induits en 3D, version spécialiste
PIERARD, Gérald ULg; Andre, J.; Brochez, L. et al

Book (2009)

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See detailCancers du pancréas exocrine
DURAN, Unal ULg; brisbois, d; marterne, R. et al

in Encyclopédie Médico-Chirurgicale (2016)

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See detailCancers épithéliaux de l'ovaire. Acquisitions récentes
van den Brule, F. A.; Lambotte, René ULg; Castronovo, Vincenzo ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1995), 24(3), 241-52

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by ... [more ▼]

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by the lack of a well defined precursor lesion, the lack of knowledge about tumour progression, and by the relative inaccessibility of the ovaries in the abdominal cavity. Recent studies using experimental models allow us to better define the fundamental mechanisms of carcinogenesis from the serous ovarian cells and of invasion of the abdominopelvic cavity by proximity. This review article tries to update on epidemiology, genetic syndromes, biology, screening, and therapy of these epithelial tumours, and about the new directions taken by basic and clinical research. We will present data concerning oncogenes and tumour suppressor genes involved in epithelial ovarian tumours, regulation of tumour cells by growth factors, genes involved in tumour invasion, and mechanisms used by the cancer cell to resist to therapies. Non-epithelial ovarian tumours will not be examined in this manuscript. [less ▲]

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See detailLes cancers hématologiques en 1987. Chimiothérapie et immunothérapie.
Fillet, Georges ULg; Bury, J.; Beguin, Yves ULg et al

in Revue Médicale de Liège (1987), 42(10), 496-502

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See detailCancers hématologiques et qualité de vie
Fillet, Georges ULg; Bury, J.

in Revue Médicale de Liège (1986), 41

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See detailCancers secondaires après allogreffe de cellules souches hématopoïétiques
Hafraoui, Kaoutar ULg; Beguin, Yves ULg; Baron, Frédéric ULg

in Revue Médicale de Liège (2009), 64(10), 496-499

This article reviews the incidence, risk factors and prevention of secondary malignancies after allogeneic hematopoietic cell transplantation.

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See detailCancers thyroidiens radio-induits
Lemaire, Michelle ULg; Lejeune, Georges ULg; Lambermont, Bernard ULg

in Acta Oto-Rhino-Laryngologica Belgica (1988), 42(5), 606-11

We describe thyroid carcinomas observed in two male patients after cervical irradiation in infancy. In the first case, irradiation was given for cervical angioma and in the second case, for enlarged ... [more ▼]

We describe thyroid carcinomas observed in two male patients after cervical irradiation in infancy. In the first case, irradiation was given for cervical angioma and in the second case, for enlarged thymus. A long time interval (16 and 43 years) elapsed between irradiation and the detection of the epitheliomas. The anatomopathological diagnosis was, for the first patient, papillo-vesicular epithelioma and for the second one, anaplastic carcinoma. [less ▲]

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See detailLes cancers viro-induits: interrelations genetique-environnement
Delvenne, Philippe ULg; Renoux, V. M.; Arafa, M. et al

in Revue Médicale de Liège (2012), 67(5-6), 381-9

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the ... [more ▼]

Among cancers diagnosed worldwide on a yearly basis, 20% are thought to be associated with a viral infection. The viruses involved are, by order of decreasing incidence, the hepatitis viruses, the papillomaviruses and the Epstein-Barr virus. These virus-induced cancers generate a high level of interest not only for the study of mechanisms involved in the neoplastic transformation, but also for the set-up of specific immunotherapies including prophylactic and therapeutic antitumor vaccination. [less ▲]

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See detailCandida albicans cheilitis in guinea pig may be caused by commensal strains carried in the lower genital tract
Mignon, Bernard ULg; Symoens, F.; Losson, Bertrand ULg

in Veterinary Dermatology (2003), 14(5), 242

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg

Scientific conference (2011, November)

Detailed reference viewed: 16 (6 ULg)