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See detailCheckpoints modulation by the human T-lymphotropic virus type 1 (HTLV-1) Tax protein : towards new therapeutic approaches
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

Poster (2015, May 13)

HTLV-1 infects approximately 15 million people worldwide and causes several diseases. This virus is responsible for the adult T-cell leukemia (ATL) and for a chronic neuropathology (TSP/HAM). There is ... [more ▼]

HTLV-1 infects approximately 15 million people worldwide and causes several diseases. This virus is responsible for the adult T-cell leukemia (ATL) and for a chronic neuropathology (TSP/HAM). There is currently no satisfactory treatment for these diseases. Among the proteins encoded by HTLV-1, Tax appears to play an important role in the mechanisms leading to pathogenicity. We are interested in the mechanisms of cell transformation by the Tax viral oncoprotein. In particular, we aim at understanding the interplay between Tax and the DNA damage response (DDR). We show that transient expression of Tax results in DNA damage, cell cycle arrest and activation of the DDR. In fibroblasts, cell cycle arrest occurs at the G1 and G2 phases depending on the p53 background. In contrast, HTLV-1 infected lymphocytes proliferate continuously and appear to be adapted to the checkpoints. This mechanism of checkpoint adaptation thus allows ongoing proliferation despite the presence of genomic lesions. Quantification of the rates of NHEJ and homologous recombination indicates that HTLV-1 infected cells require very efficient DNA repair for survival. Therefore, we propose a novel therapeutic approach based on the principle of synthetic lethality using inhibitors of DNA repair. [less ▲]

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See detailCheckpoints modulation by the Human T-lymphotropic virus type 1 Tax protein
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Boxus, Mathieu et al

in Retrovirology (2014), 11(S1), 90

HTLV-1 is responsible for two main diseases, Adult T-cell Leukemia/Lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis, for which there is currently no satisfactory treatment. Among the ... [more ▼]

HTLV-1 is responsible for two main diseases, Adult T-cell Leukemia/Lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis, for which there is currently no satisfactory treatment. Among the proteins encoded by HTLV-1, Tax appears to play an important role in the mechanisms leading to pathogenicity. We are interested in the mechanisms of cell transformation by Tax and more particularly in the interplay between the viral Tax oncoprotein and the DNA damage response (DDR). We demonstrated that transient expression of Tax results in DNA damage, cell cycle arrest and activation of the DDR. In fibroblasts, cell cycle arrest occurs at the G1 and G2 phases depending on the p53 background. Although Tax induces apoptosis and senescence in fibroblasts, HTLV-1 infected lymphocytes proliferate continuously and appear to be adapted to the checkpoint control. This mechanism allows infected lymphocytes to proliferate despite the presence of genomic lesions. With these observations, we propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

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See detailLe "cheetah-look". Le phénotype guépart, face cachée de la pigmentation mélanique innée du visage.
Hermanns-Lê, Trinh ULg; AL RUSTOM, Kamil; FRANCHIMONT, Claudine ULg et al

in Dermatologie Actualité (2012), 131

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See detail"Le chef de saint Jean Baptiste sur un plat", Jan van Steffeswert, 1508
Van den Bossche, Benoît ULg

in Delfosse, Annick; Glesener, Thomas (Eds.) Lire, écrire et éduquer à la Renaissance. Mélanges en l'honneur de Franz Bierlaire (2013)

Rédigé dès 2010 pour faire honneur au professeur Franz Bierlaire, cet article a été publié une première fois en 2012 sous une forme légèrement amendée à l'occasion d'une exposition consacrée au patrimoine ... [more ▼]

Rédigé dès 2010 pour faire honneur au professeur Franz Bierlaire, cet article a été publié une première fois en 2012 sous une forme légèrement amendée à l'occasion d'une exposition consacrée au patrimoine déposé au Musée Curtius (Liège) par la COmpagnie de Charité pour le Secours des Pauvres et des Prisonniers (Liège). [less ▲]

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See detailChefs-d'oeuvre de la Renaissance italienne. La collection de peintures de François Ier
Fagnart, Laure ULg

Scientific conference (2006, March 01)

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See detailCheloide et cicatrice hypertrophique
Mostinckx, S.; Vanhooteghem, Olivier ULg; Richert, Bertrand ULg et al

in Annales de Dermatologie et de Vénéréologie (2005), 132(4), 384-7

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See detailChemical abundances in 43 metal-poor stars
Gustafsson, Bengt; Asplund, Martin; Edvardsson, Bengt et al

in Hill, V.; François, P.; Primas, F. (Eds.) From Lithium to Uranium: Elemental Tracers of Early Cosmic Evolution (2005)

We have derived abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Fe, Ni and Ba for 43 metal-poor field stars, mostly stars at the turn-off point and on the subgiant branch, in the interval {-}3.0{[Fe/H ... [more ▼]

We have derived abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Fe, Ni and Ba for 43 metal-poor field stars, mostly stars at the turn-off point and on the subgiant branch, in the interval {-}3.0{[Fe/H]{. The analysis is differential relative to the Sun. Oxygen abundances, with consideration of NLTE effects, were derived from the OI 777.4 nm triplet lines. We find [O/Fe] to gradually increase with decreasing [Fe/H], though considerably slower than has earlier been obtained from OH lines in the UV. A scatter in [O,Mg,Ca,Ti/Fe] at a given [Fe/H] is found and we argue that this scatter is partly real. The deviations from the mean trends of abundance ratios vs [Fe/H] are found to correlate in non-trivial ways for different abundances. Similar trends are found from results of accurate studies by other groups. This seems to give further evidence for the hypothesis that the stars once formed in different subsystems, with different star-formation rates.The paper is in press in A&A, may be obtained as astro-ph/0505118. [less ▲]

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See detailChemical abundances in 43 metal-poor stars
Jonsell, K.; Edvardsson, B.; Gustafsson, B. et al

in Astronomy and Astrophysics (2005), 440

We have derived abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Fe, Ni, and Ba for 43 metal-poor field stars in the solar neighbourhood, most of them subgiants or turn-off-point stars with iron ... [more ▼]

We have derived abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Fe, Ni, and Ba for 43 metal-poor field stars in the solar neighbourhood, most of them subgiants or turn-off-point stars with iron abundances [Fe/H] ranging from -0.4 to -3.0. About half of this sample has not been spectroscopically analysed in detail before. Effective temperatures were estimated from uvby photometry, and surface gravities primarily from Hipparcos parallaxes. The analysis is differential relative to the Sun, and was carried out with plane-parallel MARCS models. Various sources of error are discussed and found to contribute a total error of about 0.1-0.2 dex for most elements, while relative abundances, such as [Ca/Fe], are most probably more accurate. For the oxygen abundances, determined in an NLTE analysis of the 7774 Å triplet lines, the errors may be somewhat larger. We made a detailed comparison with similar studies and traced the reasons for the, in most cases, relatively small differences. Among the results we find that [O/Fe] possibly increases beyond [Fe/H] = -1.0, though considerably less so than in results obtained by others from abundances based on OH lines. We did not trace any tendency toward strong overionization of iron, and find the excesses, relative to Fe and the Sun, of the alpha elements Mg, Si, and Ca to be smaller than those of O. We discuss some indications that also the abundances of different alpha elements relative to Fe vary and the possibility that some of the scatter around the trends in abundances relative to iron may be real. This may support the idea that the formation of Halo stars occurred in smaller systems with different star formation rates. We verify the finding by Gratton et al. (2003b, A&A, 406, 131) that stars that do not participate in the rotation of the galactic disk show a lower mean and larger spread in [ alpha/Fe] than stars participating in the general rotation. The latter stars also seem to show some correlation between [ alpha/Fe] and rotation speed. We trace some stars with peculiar abundances, among these two Ba stars, <ASTROBJ>HD 17072</ASTROBJ> and <ASTROBJ>HD 196944</ASTROBJ>, the second already known to be rich in s elements. Finally we advocate that a spectroscopic study of a larger sample of halo stars with well-defined selection criteria is very important, in order to add to the very considerable efforts that various groups have already made. [less ▲]

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See detailChemical abundances of fast-rotating OB stars
Cazorla, Constantin ULg; Morel, Thierry ULg; Nazé, Yaël ULg et al

in Proceedings of the International Astronomical Union - New windows on massive stars: asteroseismology, interferometry, and spectropolarimetry (2014)

Fast rotation in massive stars is predicted to induce mixing in their interior, but a population of fast-rotating stars with normal nitrogen abundances at their surface has recently been revealed (Hunter ... [more ▼]

Fast rotation in massive stars is predicted to induce mixing in their interior, but a population of fast-rotating stars with normal nitrogen abundances at their surface has recently been revealed (Hunter et al. 2009; Brott et al. 2011, but see Maeder et al. 2014). However, as the binary fraction of these stars is unknown, no definitive statements about the ability of single-star evolutionary models including rotation to reproduce these observations can be made. Our work combines for the first time a detailed surface abundance analysis with a radial-velocity monitoring for a sample of bright, fast-rotating Galactic OB stars to put strong constraints on stellar evolutionary and interior models. [less ▲]

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See detailChemical abundances of fast-rotating OB stars
Cazorla, Constantin ULg; Morel, Thierry ULg; Nazé, Yaël ULg et al

Poster (2014, June 23)

Fast rotation in massive stars is predicted to induce mixing in their interior, but recent observations have challenged this concept by revealing a population of fast-rotating stars with normal nitrogen ... [more ▼]

Fast rotation in massive stars is predicted to induce mixing in their interior, but recent observations have challenged this concept by revealing a population of fast-rotating stars with normal nitrogen abundances at their surface (Hunter et al. 2009, A&A, 496, 841; Brott et al. 2011, A&A, 530, A116, but see Maeder et al. 2014, A&A, 565, A39). However, as the binary fraction of these stars is unknown, the importance of mass-transfer processes cannot be quantified. As a result, no definitive statements about the ability of single-star evolutionary models including rotation to reproduce these observations can be made. Our work combines for the first time a detailed surface abundance analysis with a radial-velocity monitoring for a sample of bright, fast-rotating Galactic OB stars to put strong constraints on stellar evolutionary and interior models. [less ▲]

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See detailChemical analyses of the seeds from Prunella vulgaris: A chemotaxonomic approach
Paul, Aman ULg; Frederich, Michel ULg; Cieckiewicz, Ewa ULg et al

Poster (2014, April)

Common self-heal (Prunella vulgaris) plants are traditionally sown along the border of crops to enhance the biodiversity. Besides enhancing the biodiversity, they can also be a source of interesting ... [more ▼]

Common self-heal (Prunella vulgaris) plants are traditionally sown along the border of crops to enhance the biodiversity. Besides enhancing the biodiversity, they can also be a source of interesting compounds which could be important for food, pharmaceutical and cosmetic industries. The seeds of Common self-heal were investigated for proteins, fatty acid compositions and polyphenolic compounds. The protein content was analyzed according to Dumas method, the extraction of oil was done using a cold extraction technique employing 2:1 chloroform/methanol as solvent, the fatty acid composition was determined using the gas chromatography and the amount of polyphenolic compounds were estimated using the method as described in European Pharmacopoeia, 8th edition. Common self-heal seeds can be of great commercial importance. [less ▲]

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See detailChemical anatomy of the spinal cord
Schoenen, Jean ULg

in Neurologic Clinics (1991), 9

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See detailChemical and biological evaluation of the nutritive value of Algerian green seaweed Ulva lactuca using in vitro gas production technique fior ruminant animals
Zitouni, Hind; Arhab, Rabah; Boudry, Christelle ULg et al

in International Journal of Advanced Research (2014), 2(4), 916-925

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to ... [more ▼]

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to vetch-oat hay (control), using in vitro gas production technique. Seaweed and control were incubated with rumen liquor taken from fistulated and non lactating cows. Gas production was recorded at: 2, 4, 6, 8, 12, 24, 48 and 72h. The in vitro rumen fermentation parameters were measured after 24h and 72h of fermentation. Proteins degradability was investigated by the enzymatic technique using a protease extracted from Streptomyces griseus. The results showed a wide variation between the chemical components of seaweed and conventional fodder used as control. The main constituents in Ulva lactuca were ashes (39.1% DM), fibers (22.8 % DM) and proteins (15.3% DM). The gas production profile of seaweed during 72h of incubation showed a slow and low gas production. Cumulative gas production obtained after 24h for seaweed (42 ml/g OM) was significantly lower than control (128.4 ml/g OM) (P<0.001). pH, ammonia, volatile fatty acids (VFAs), apparent digestibility of dry matter (DDM), organic matter digestibility (OMD) and metabolizable energy (ME) were significantly different between seaweed and vetch-oat hay (6.86, 290.1 mg/ml, 1.25 mmol/g DM, 38.3%, 29.2%, 3.81MJ/Kg DM respectively for seaweed). Protein degradability measurement indicates the weak hydrolysis of seaweed crude protein which is beneficial for ruminants. This study showed that the use of Ulva lactuca as non conventional feed in ruminant nutrition can be considered under certain conditions. [less ▲]

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See detailChemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp montana
Karangwa, Charles; Esters, Virginie ULg; Frederich, Michel et al

in Journal of Ethnopharmacology (2006), 103(3), 433-438

Magnistipida butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mg ... [more ▼]

Magnistipida butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mg/kg) of its aqueous extract, administered orally to adult Wistar rats. This study demonstrated that the freeze-dried aqueous extract (5%, w/w) possesses high toxicity. The extract caused hypothermia, neurological disorders, including extensor reflex of maximal convulsive induced-seizures at about 2h after the administered dose, and death occurred (LD50 = 370 mg/kg) in a dose dependent manner. Blood parameter evaluation revealed slight variations, but these might not have clinical relevance. Histological examination of internal organs (lungs, liver, heart and kidneys) did not reveal any abnormality in the treated group compared to the control. Therefore, it can be concluded that Magnistipida butayei subsp. montana aqueous extract, given orally, is toxic and that its target is the central nervous system. General phytochemical screening revealed that the plant did not contain significant amounts of products known to be toxic, such as alkaloids or cardioactive glycosides, but only catechic tannins, amino acids, saponins and other aphrogen principles in the three parts of the species (fruit, leave and bark). (c) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailChemical and enzymatical modifications of sugar derived from lignocellulose
Richard, Gaetan ULg; Laurent, Pascal ULg; Nott, Katherine ULg et al

Poster (2009, January)

Actually, biorefinery is increasingly considered as a promising alternative to petroleum chemistry, since it aims at not only the replacement of fossil energy but also the development of chemicals from ... [more ▼]

Actually, biorefinery is increasingly considered as a promising alternative to petroleum chemistry, since it aims at not only the replacement of fossil energy but also the development of chemicals from biomass, with applications such as detergents, phytopharmaceutics, solvents, plastics, etc. The valorisation of carbohydrates from renewable raw materials is currently the subject of numerous researches. In this context, the synthesis of new surfactants derived from the sugars issued from the lignocellulose hydrolysis was undertaken by chemical or enzymatic routes. In this poster, the examples of glucose, cellobiose and uronic acids will be discussed. Whatever the way used, the reaction conditions (use of a catalyst, protection/deprotection steps, type of solvent, presence of co-solvent, reactant concentrations, etc) were optimized to yield a panel of carbohydrate derivatives (some examples of the structures obtained are given above). These differ by the nature of the alkyl chain (in length and in degree of saturation), the type of chemical bond (amide, ester, thioester, acetal), and the position of substitution. The impact of these differences on the techno-functional properties of these modified sugars will be evaluated. [less ▲]

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See detailChemical and physical factors involved in the aggregation behaviour of Harmonia axyridis Pallas
Durieux, Delphine ULg; Fischer, Christophe ULg; Deneubourg, Jean-Louis et al

Conference (2011, July 27)

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See detailThe chemical biomarkers C2C, Coll2-1, and Coll2-1NO(2) provide complementary information on type II collagen catabolism in healthy and osteoarthritic mice
Ameye, L. G.; Deberg, Michelle ULg; Oliveira, M. et al

in Arthritis and Rheumatism (2007), 56(10), 3336-3346

Objective. Compared with wild-type (WT) mice, biglycan/fibromodulin double-deficient mice develop severe knee osteoarthritis. We undertook this study to compare type 11 collagen catabolism in the 2 ... [more ▼]

Objective. Compared with wild-type (WT) mice, biglycan/fibromodulin double-deficient mice develop severe knee osteoarthritis. We undertook this study to compare type 11 collagen catabolism in the 2 genotypes and to compare the usefulness of 3 biomarkers of collagen degradation (C2C [also known as Col23/4C(long mono)] as well as the peptide Coll2-1 and its nitrated form, Coll2-1NO(2)) for evaluating collagen catabolism in vivo. Methods. In 15 WT mice and 15 biglycan/ fibromodulin double-deficient mice, we determined serum levels of C2C at ages 66 and 141 days, and we determined serum levels of Coll2-1 and Coll2-1NO(2) at ages 49, 81, 95, and 141 days. Expression of the biomarkers in knee sections was examined using immunohistochemistry. Results. The mean concentrations of C2C and Coll2-1 were higher in biglycan/fibromodulin double-deficient mice at all time points. For C2C and Coll2-1, the ratio of the serum concentration in biglycan/ fibromodulin double-deficient mice to that in WT mice (the double-deficient:WT ratio) was constant over time and was similar to 1.63 and similar to 1.15, respectively. In contrast, the double-deficient:WT ratio for Coll2-1NO(2) varied and, depending on age, was >1 or <1. No significant correlation was found between the expression of the different biomarkers, except for a weak, negative correlation between Coll2-1NO(2) and C2C. In both genotypes, antibodies to each biomarker labeled some fibroblasts in the tendons and menisci as well as chondrocytes above the tidemark in articular cartilage. Growth plates were unstained. For each biomarker, extracellular staining was limited to fibrocartilage areas in the tendons and menisci in all mice and was limited to some focal lesions of the cartilage in biglyean/fibromodulin double-deficient mice. Conclusion. The different double-deficient:WT ratios observed with C2C, Coll2-1, and Coll2-1NO(2) in the absence of any correlation between the expression of the 3 biomarkers indicate that these biomarkers give complementary, rather than redundant, information about in vivo type 11 collagen catabolism. [less ▲]

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See detailChemical changes and influences of rapeseed antinutritional factors on gestating and lactating ewes 1. Animal performances and plasma hormones and glucose
Mandiki, S. N. M.; Derycke, G.; Bister, J. L. et al

in Animal Feed Science & Technology (2002), 98(1-2), 25-35

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating ... [more ▼]

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating hormones (progesterone-P4, estradiol-E2,-prolactin-PRL, cortisol, insulin, tri-iodothyronin-T3, thyroxin-T4) and glucose. On the 100th day of gestation, 90 ewes bearing at least two foetuses were divided into 3 groups. Control, Apex and Synergy groups received concentrates with 0, 40 and 40% of LG-rapeseed meal obtained with either Apex (13.77 mumol of glucosinolates/g DM seed) or Synergy (18.19 mumol) variety. Apart from the distribution of pasture hay ad libitum, the ewes received 500 and 1200 g of concentrates/animal per day during gestation and lactation, respectively. Concentrates were offered till the 47th day of lactation, and thereafter, the ewes were fed only with hay during 3 weeks. The lambs received ad libitum concentrates without rapeseed meal from 10 days of age till slaughtering. They were weaned at 65 days of age and were slaughtered when their fattening state was optimal. The performances of ewes (food intake and liveweight profiles) and of lambs (birth liveweight, mortality at birth, weight gains, slaughtering parameters) were not reduced by 40% of LG-rapeseed meal except a decrease in the liveweight for ewes in the Apex group after lambing. The profiles and levels of plasma metabolic (T3, T4, cortisol, insulin) and reproductive (PRL, P4) hormones were not modified by the rapeseed meal. In contrast, the estradiol concentration was lower (P < 0.05) in the two groups of ewes which received rapeseed meal than in the controls as an index of an eventual disturbance in the reproductive functions. In conclusion, large amounts of LG-rapeseed meal may be used as protein supplement in the diet of ewes at the end of gestation and during lactation without negative effects on animal performances and physiology. (c( 2002 Published by Elsevier Science B.V. [less ▲]

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