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See detailThe Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.
Kuchnio, Anna; Moens, Stijn; Bruning, Ulrike et al

in Cell Reports (2015), 12(6), 992-1005

Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model ... [more ▼]

Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficiency reduced metastasis without affecting tumor growth. Second, it is unknown whether PHD2 regulates cancer by affecting cancer-associated fibroblasts (CAFs). We show that PHD2 haplodeficiency reduced metastasis via two mechanisms: (1) by decreasing CAF activation, matrix production, and contraction by CAFs, an effect that surprisingly relied on PHD2 deletion in cancer cells, but not in CAFs; and (2) by improving tumor vessel normalization. Third, the effect of concomitant PHD2 inhibition in malignant and stromal cells (mimicking PHD2 inhibitor treatment) is unknown. We show that global PHD2 haplodeficiency, induced not only before but also after tumor onset, impaired metastasis. These findings warrant investigation of PHD2's therapeutic potential. [less ▲]

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See detailLe cancer colo-rectal en imagerie : dépistage, stadification et suivi post-opératoire immédiat. Rôle de l’imagerie médicale dans le dépistage du cancer colo-rectal.
HOCK, DANIELLE; OUHADI, ROXANNE; MATERNE, R. et al

in Le cancer colo-rectal en imagerie : dépistage, stadification et suivi post-opératoire immédiat. Rôle de l’imagerie médicale dans le dépistage du cancer colo-rectal. (2010)

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See detailCancer de la parathyroïde
Beckers, Albert ULg

Scientific conference (2009, December 17)

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See detailCancer du canal anal: identification de deux sous-types distincts
Herfs, Michael ULg

Conference (2016, September)

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See detailCancer du col de l'utérus: analyse du coût-bénéfice et de l'efficacité du dépistage opportuniste versus le dépistage organisé
Castronovo, Vincenzo ULg; Foidart, Jean-Michel ULg; Boniver, Jacques ULg

in Revue Médicale de Liège (1998), 53(5), 305-7

Cervical cancer is the fourth cancer in women. It is the first malignancy for which mass population screening has been demonstrated to significantly reduce the mortality due to this disease. In Belgium ... [more ▼]

Cervical cancer is the fourth cancer in women. It is the first malignancy for which mass population screening has been demonstrated to significantly reduce the mortality due to this disease. In Belgium, the mortality associated to cervical cancer decreased from 6 to 4 per 100,000 women-years from 1955-1959 to 1985-1989. European recommendations regarding cervical cancer screening are to perform a cervical smear each three years in women aged 25 to 65 years. In Belgium, while the Flemish region has decided to organize the cervical cancer screening according to the European recommendations, the screening in the French part of the country is essentially opportunistic. In this short review, the cost/benefit of the organized screening versus the opportunistic screening is discussed. [less ▲]

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See detailLe cancer du col de l'utérus: du virus au traitement
Delvenne, Philippe ULg; Goffin, Frédéric ULg; Kridelka, Frédéric ULg et al

in Revue Médicale de Liège (2007), 62(S1)

Squamous cell cancer of the uterine cervix is associated with a high morbidity and mortality worldwide and in Belgium. New therapeutic approaches have been recently proposed. The development of this ... [more ▼]

Squamous cell cancer of the uterine cervix is associated with a high morbidity and mortality worldwide and in Belgium. New therapeutic approaches have been recently proposed. The development of this cancer is related to the infection by oncogenic human papillomavirus (HPV) types. The link between cervical cancer and HPV has, in recent years, generated, a great interest for studies aiming to better understand the role of the immune system in the control of these infections and for the development of prophylactic anti-HPV vaccines. [less ▲]

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See detailCancer du pancréas et vertèbre d'ivoire
Guillaume, Thierry ULg; Krzesinski, Jean-Marie ULg; Lambinet, Nadine ULg

in Revue Médicale de Liège (2004), 59(12), 685-687

En résumé, nous avons donc objectivé un adénocarcinome de la tête pancréatique cliniquement asymptomatique suite à la mise en évidence d’une lésion osseuse métastatique condensante douloureuse. Le cas ... [more ▼]

En résumé, nous avons donc objectivé un adénocarcinome de la tête pancréatique cliniquement asymptomatique suite à la mise en évidence d’une lésion osseuse métastatique condensante douloureuse. Le cas d’un adénocarcinome pancréatique révélé par une métastase osseuse surtout condensante, étant relativement rare, nous a paru intéressant à rapporter. [less ▲]

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See detailCancer du pancréas exocrine. Traité de Radiodiagnostic IV - Appareil digestif de l’EMC
NCHIMI LONGANG, Alain ULg; BRISBOIS, Denis ULg; MATERNE, R et al

in Cancer du pancréas exocrine. Traité de Radiodiagnostic IV - Appareil digestif de l’EMC (2006)

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See detailLe cancer du poumon. Epidemiologie et facteurs etiologiques.
Frusch, Nicolas ULg; Bosquee, Léon ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2007), 62(9), 548-53

Lung cancer is the most frequent cause of death by cancer worldwide. Despite improvements in the treatment the vital prognosis remains poor with an estimated 5-year survival rate of 15 % all stages ... [more ▼]

Lung cancer is the most frequent cause of death by cancer worldwide. Despite improvements in the treatment the vital prognosis remains poor with an estimated 5-year survival rate of 15 % all stages together. Even if some environmental exposure may favour apparition of the disease, tobacco smoking is by far the greatest risk factor for developing lung cancer. Recent progresses have been made on the identification of cellular mechanisms and genetic abnormalities that make the patients more prone to develop lung cancer. [less ▲]

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See detailLe cancer du sein "triple négatif"
Freres, Pierre; Collignon, Joëlle ULg; Gennigens, Christine ULg et al

in Revue Médicale de Liège (2010), 65(3), 120-126

Le cancer du sein touche une femme sur huit dans les pays occidentaux. Son incidence a considérablement augmenté au cours de ces deux dernières décennies mais, en même temps, le niveau de mortalité ... [more ▼]

Le cancer du sein touche une femme sur huit dans les pays occidentaux. Son incidence a considérablement augmenté au cours de ces deux dernières décennies mais, en même temps, le niveau de mortalité spécifique est resté stable et a même diminué en Europe et aux Etats-Unis, notamment, grâce à l’apport de nouvelles armes thérapeutiques, aux changements dans l’utilisation du traitement hormonal substitutif à la ménopause et à un diagnostic plus précoce. Malgré cela, le cancer du sein reste la première cause de décès par cancer chez la femme de moins de 65 ans. Le cancer du sein «triple négatif», un sous-type représentant environ 10 % des cancers du sein, est caractérisé par l’absence de récepteurs hormonaux aux oestrogènes et à la progestérone et l’absence d’expression du facteur de croissance HER-2 en étude d’immunohistochimie. Ce type de cancer du sein est associé à un profil clinique défavorable avec un haut risque de rechute métastatique précoce. De plus, le cancer du sein «triple négatif» ne présente aucune cible thérapeutique propre et son pronostic est donc particulièrement mauvais. La définition de facteurs prédictifs de la réponse tumorale aux différents traitements et l’apport des thérapies ciblées sont deux pistes susceptibles d’améliorer la prise en charge et la survie des patients atteints par ce type de cancer extrêmement agressif. [less ▲]

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See detailCancer du sein : de la thérapie ciblée à la médecine personnalisée
JERUSALEM, Guy ULg; COLLIGNON, Joëlle ULg; Josse, Claire ULg et al

in Revue Médicale de Liège (2015), 70(5-6), 269-276

Dans cet article, les auteurs passent en revue les grands principes de prise en charge du traitement systémique du cancer du sein et posent la question suivante : jusqu'où réellement aujourd'hui ce ... [more ▼]

Dans cet article, les auteurs passent en revue les grands principes de prise en charge du traitement systémique du cancer du sein et posent la question suivante : jusqu'où réellement aujourd'hui ce traitement est-il individualisé ? Les nouvelles technologies permettent une analyse détaillée des anomalies génomiques au niveau des cellules cancéreuses. Malheureusement, nous n'avons pas encore compris comment utiliser au mieux ces données au bénéfice du patient. La majorité des modifications du génome sont des évènements relativement rares compliquant le développement de nouveaux médicaments dans le cadre d'une médecine de précision. De plus, les tumeurs présentent une grande hétérogénéité temporelle et spatiale dont il faudra tenir compte lors de ce développement. Une collaboration internationale intensive est en cours pour tenter de confirmer que la médecine de précision permet d'optimiser les résultats du traitement systémique dans le cancer du sein. [less ▲]

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See detailCancer du sein : Yoga, hypnose, et support psychologique classique en groupe
Bragard, Isabelle ULg

Scientific conference (2014, November 07)

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See detailLe cancer du sein chez la femme jeune
ANDRE, Chantal ULg; COLLIGNON, Joëlle ULg; RORIVE, Andrée ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 397-399

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See detailLe cancer du sein de la femme âgée
MARTIN, Marie; COLLIGNON, Joëlle ULg; RORIVE, Andrée ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 400-408

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See detailLe cancer du sein en Belgique: pourquoi sommes-nous les premiers en Europe?
DESREUX, Joëlle ULg; Gaspard, Ulysse ULg; BLERET, Valerie ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 231-7

Breast cancer incidence in Belgium is on the top of European countries, with 9.697 new cases in 2008 and 106/100.000 women/year. The explanation of this high incidence in our country is probably the ... [more ▼]

Breast cancer incidence in Belgium is on the top of European countries, with 9.697 new cases in 2008 and 106/100.000 women/year. The explanation of this high incidence in our country is probably the accumulation of risk factors (many of them are linked to lifestyle), and the impact of screening and registration of cases. The relative impact of each of theses factors is less clear because we don't have powerful statistical studies. Belgium is slightly above the European mean for breast cancer mortality, with 19,4/100.000 women/year and an all stages 15-year survival of 75%. Breast cancers are responsible for around 3% of all-cause mortality in Belgian women. This article discusses the causes of this high Belgian incidence and of current decrease of incidence in western countries, and reviews known and less known risk factors of breast cancers, with a special focus on menopause hormonal treatments. [less ▲]

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See detailCancer du sein et métastases cérébrales
RORIVE, Andrée ULg; COLLIGNON, Joëlle ULg; MARTIN, Marie et al

in Revue Médicale de Liège (2011), 66(5-6), 299-305

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See detailCancer du sein et retour au travail
Schippers, Nathalie ULg; Van Hoof, Elke; Mairiaux, Philippe ULg

Poster (2014, December 17)

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See detailCancer du sein inflammatoire: aspects épidemiologique, anatomopathologique, moléculaire et viral à propos de 219 cas colligés à l'Institut National d'Oncologie (Rabat/Maroc)
Zoure, Abdou Azaque ULg

Master's dissertation (2012)

Inflammatory breast cancer represents a special clinical entity characterized by its rarity, rapid evolutionary pace and poor prognosis. We conducted a retrospective study over 6 years (2005-2010) and we ... [more ▼]

Inflammatory breast cancer represents a special clinical entity characterized by its rarity, rapid evolutionary pace and poor prognosis. We conducted a retrospective study over 6 years (2005-2010) and we identified 219 cases of inflammatory breast cancer (IBC) diagnosed and treated at the National Institute of Oncology (INO) Hospital Sidi Mohamed Ben Abdellah, Rabat. The diagnosis was clinical as defined by AJCC (American Joint Cancer Committee). Thus, we found an incidence of 4.09% of IBC. All patients were female. The mean age was 47.31 years (26-75 years) and 60.72% of the patients were younger than 50 years. The rate of non-menopausal women is 51.14% and 69.58% were multiparous. Over 60% of patients were either obese (body mass index or BMI ≥ 30 kg/m2) or overweight (25 <BMI <30). On histology, invasive ductal carcinoma is predominant representing 93.23% of cases. SBR Grade I SBR (Scarff Bloom Richardson) was encountered in only 7, 11% of cases. Estrogen receptor (ER) and progesterone receptor (PR) were negative in respectively 44.78% and 30.50%, and HER2 was positive in 33.07%. Molecular classification showed 41.60% luminal A subtype, 19.46% grouped in the luminal B subtype, 17.70% HER2 + subtype and 21.24% Triple negative subtype. Lymph node infiltration was clinical in 60.85% and histological in 85.19% of the cases 28.77% were initially metastatic. Vascular emboli were found in 72.67% cases. The preliminary study of MMTV-like virus detection focused on 37 cases including 31 cases of IBC and 6 cases of non-inflammatory breast cancer (NIBC). One PCR was used for the detection of MMTV-like in paraffin embedded tissues. The results show the presence of DNA sequences of the Env region of MMTV-like virus in 64.51% of IBC cases and 50% of NIBC cases. [less ▲]

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