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See detailA clinical lab experience with an automated HIV Antigen/Antibody (Ag/Ab) combined assay
HUYNEN, Pascale ULg; TOUSSAINT, Françoise ULg; GERARD, Christiane ULg et al

Poster (2014, May 11)

OBJECTIVES: To describe the diagnostic performance of a new fourth-generation HIV Ag/Ab chemiluminescent immunoassay, available on the new LIAISON® XL analyser, in a clinical setting. METHODS: Through ... [more ▼]

OBJECTIVES: To describe the diagnostic performance of a new fourth-generation HIV Ag/Ab chemiluminescent immunoassay, available on the new LIAISON® XL analyser, in a clinical setting. METHODS: Through February 2012-October 2013, 12,438 samples of serum, received at our laboratory for screening for HIV infection were routinely tested with LIAISON® XL Murex HIV Ab/Ag assay (HIV-XL), which employs HIV-1, HIV-1 group O, and HIV-2 antigens and anti-p24 monoclonal antibodies in two coupled reagent cartridges, providing information of the overall Ab/Ag reactivity and detail of the specific reactivity for anti-HIV/HIV p24 antigen. Each serum with positive result or with negative result displaying a value close to the cut-off were sent to the regional AIDS-Reference Laboratory (RefLab) to perform confirmatory assays (PCR, Immunoblot). A previous verification of the HIV-XL demonstrated 100% sensitivity with a challenge panel of hundred positive sera provided by the RefLab. Performed external quality control was from United-Kingdom National External Quality Assessment Service (NEQAS). RESULTS: Out of the clinical samples, 12,312 non-reactive samples (including 6 negative results displaying a value close to the cut-off further confirmed true HIV negative), 64 Ab HIV reactive samples (all confirmed HIV-1 positive by immunoblot), including 4 samples reactive also for Ag HIV (confirmed positive by Ag assay/PCR), 42 Ab HIV reactive samples tested negative by immunoblot, and 20 Ag HIV reactive samples tested negative by the kit used for the Ag p24 detection in our HIV Reference Lab, have been found. All the 43 NEQAS specimens tested, 16 reactive and 27 non-reactive, were correctly classified. These results, considered all together, provide a calculated positive predictive value of 57.5% with an estimated specificity of 99.5% (with 95% confidence interval of 99.36-99.62%), and a calculated negative predictive value of 100% with an estimated sensitivity of 100.0% (with 95% confidence interval of 95.49-100%). CONCLUSIONS: In our experience HIV-XL showed excellent performance associated to all the advantages of a fully automated/random access instrument. [less ▲]

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See detailClinical Management and Resource Utilisation for Postmenopausal Hormone-Receptor-Positive HER2-Negative (HR+ HER2-) Advanced Breast Cancer (BC) in Europe
JERUSALEM, Guy ULg; MARINSEK, Nina; RICCI, Jean-François et al

Poster (2012)

Objective: To understand treatment patterns and quantify resource utilisation of HR+ HER2– Advanced BC, with the overall aim of comparing costs and disease burden as patients progress from hormonal ... [more ▼]

Objective: To understand treatment patterns and quantify resource utilisation of HR+ HER2– Advanced BC, with the overall aim of comparing costs and disease burden as patients progress from hormonal therapy (HT) to chemotherapy (CT). Methods: We conducted a chart audit in France, Germany, The Netherlands, Belgium, and Sweden of 399 living and deceased postmenopausal female patients (target, 75 per country) diagnosed with HR+ HER2– advanced BC in the past 4 years. Patients were required to have progressed on ≥ 1 line of prior HT either in the adjuvant or advanced setting and to have completed ≥ 1 line of CT (minimum 2 full cycles) in the advanced BC setting. The chart audit was completed online using a standardised form developed with the assistance of European academic physicians, pharmacy directors, and hospital administrators. Participation was sought from 25 oncologists per country, except in Germany (15 oncologists and 10 gynecologists to reflect local clinical practice). Study was compliant with European and country market research regulations. Results: Our report details the patient care pathway, CT side effects, and resource utilisation in the inpatient and outpatient settings throughout the continuum of advanced BC care. In the study sample 55% of HR+ HER2– advanced BC patients are first treated with HT and switch to CT after an average of 1.5 lines of HT. This switch is primarily influenced by the extent (56%) and progression rate (36%) of metastases. The switch from HT to CT is associated with increased resource utilisation of treating advanced BC. Conclusions: Our results highlight the increased resource utilisation for postmenopausal HR+ HER2– advanced BC patients treated with CT versus HT. [less ▲]

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See detailClinical neurophysiology and neurotransmitters
MAERTENS DE NOORDHOUT, Alain ULg; Wang, Wei; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1995), 15(4), 301-9

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional ... [more ▼]

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional evaluation of neurotransmission at the neuromuscular junction, in some spinal interneurons and intracortical circuits as well as evaluation of pharmacological modulation of some electrophysiological tests. These investigations are carried out to help our understanding of the pathophysiology of brain diseases. Finally, we discuss possible relationships between electrophysiological tests (evoked/event-related potentials and exteroceptive suppression of temporalis muscle activity) and neurotransmitter function in headache. [less ▲]

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See detailClinical neurophysiology in headache: use and abuse
Schoenen, Jean ULg

in Olesen, J.; Schmidt, R. E. (Eds.) Pathophysiological Mechanisms of Migraine (1993)

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See detailClinical Neurophysiology of Headache
Schoenen, Jean ULg

in Neurologic Clinics (1997), 15(1), 85-105

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches ... [more ▼]

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches. They are traumatic, able to explore simple or more complex neural activities, and to some extent capable of reflecting activity in certain neurotransmitter systems as well as the action of pharmacologic agents on the CNS. This article reviews the interest and limits of electroencephalography, evoked potentials, electromyography, and nocifensive reflexes in primary headaches. Because neurophysiologic methods are no more than indirect means of looking into the "black box," their results need to be interpreted with caution and, whenever possible, should be compared in the same study with clinical behavioral and biochemical data. [less ▲]

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See detailClinical Neurophysiology Studies in Headache: A Review of Data and Pathophysiological Hints
Schoenen, Jean ULg

in Functional Neurology (1992), 7(3, May-Jun), 191-204

In migraine between attacks EMG studies are normal. Recordings during attacks need to be performed. Temporalis exteroceptive silent period is useful in the differential diagnosis of headaches and sheds ... [more ▼]

In migraine between attacks EMG studies are normal. Recordings during attacks need to be performed. Temporalis exteroceptive silent period is useful in the differential diagnosis of headaches and sheds some light on the pathophysiology of tension-type headache. [less ▲]

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See detailClinical outcome following combination of cutting balloon angioplasty and coronary β-radiation for in-stent restenosis: A report from the RENO registry
Coucke, Philippe ULg; Roguelov; Eeckhout

in Journal of Invasive Cardiology (The) (2003), 15(12), 706-709

At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the ... [more ▼]

At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary β-radiation with the Beta-Cath System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary β-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes of patients at 6 months were compared with those of patients treated by conventional angioplasty and coronary β-radiation (group 2, n = 712). At 6-month follow-up, there was a significant difference between groups 1 and 2 in target vessel revascularization (10.2% versus 16.6% respectively; p = 0.04) and in the incidence of major adverse clinical events (MACE) including death, myocardial infarction, and revascularization (10.8% versus 19.2%; p = 0.01). This observation was confirmed by a multivariate analysis indicating a lower risk for MACE at 6 months (odds ratio: 0.49; confidence intervals: 0.27-0.88; p = 0.02). Compared to conventional angioplasty, cutting balloon angioplasty prior to coronary beta-radiation with the Beta-Cath System seems to improve the 6-month clinical outcome in patients with in-stent restenosis. [less ▲]

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See detailClinical outcome in asymptomatic severe aortic stenosis: Insights from the new proposed aortic stenosis grading classification
Lancellotti, Patrizio ULg; Magne, Julien ULg; Donal, E. et al

in Journal of the American College of Cardiology (2012), 59(3), 235-243

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See detailClinical outcomes of a new cognitive-behaviour bibliotherapy for premature ejaculation
Kempeneers, Philippe ULg; Andrianne, Robert ULg; Bauwens, Sabrina et al

Conference (2010, October 08)

INTRODUCTION. Premature ejaculation (PE) is a common sexual disorder. However, only few affected people consult clinicians in order to overcome this problem. Although no definitive consensus about its ... [more ▼]

INTRODUCTION. Premature ejaculation (PE) is a common sexual disorder. However, only few affected people consult clinicians in order to overcome this problem. Although no definitive consensus about its aetiology emerges, some mechanisms of PE are now well known. This allows more precise and efficient treatments, both at pharmacological as well as cognitive-behavioural levels. Further, studies have shown that reading didactical documents about their PE problem might be useful to men. Such approach is called “bibliotherapy”. AIM. The aim of the present study was to improve the bibliotherapy approach on the basis of up to date knowledge and techniques. The expected benefits were: (1) an efficient manual shorter than previous ones, (2) therapeutic principles easier to assimilate and (3) a method thereby made accessible to a large public which usually does not consult for this type of sexual problem. METHOD. A short bibliotherapy named Practical Guide of PE [in French] was tested among 421 PE subjects (DSM-IV diagnosis criteria). Self-reported anxiety, sexual satisfaction, ejaculatory latency time, feeling of control and distress were measured: (1) at baseline, (2) at 4-8 months and (3) at 10-14 months after reading the Practical guide of PE. A control condition was composed by 67 subjects left on a waiting-list for two months after baseline. RESULTS. Significant improvements were found for all the self-reported parameters, either at 4-8 and at 10-14 months after the bibliotherapy. The improvements were associated with an adjustment of sexual cognitions (SIQ, McCormick & Jordan). The response to treatment seemed better when the severity of PE was moderate, but did not seem related to variables such as age, educational level and personality traits (TCI-R, Cloninger; STAI Y-B, Spielberger.) CONCLUSION: Its cost/benefit ratio makes the Practical Guide an ideal first line therapeutic tool. Its large diffusion might be useful in order to improve sexual health in populations [less ▲]

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See detailClinical outcomes of a new self-help booklet for premature ejaculation
Kempeneers, Philippe ULg; ANDRIANNE, Robert ULg; Bauwens, Sabrina et al

in Journal of Sexual Medicine (2012), 9

INTRODUCTION. Premature ejaculation (PE) is quite common. Although effective treatments do exist, only a few affected people consult a practitioner in order to overcome their problem. At the same time ... [more ▼]

INTRODUCTION. Premature ejaculation (PE) is quite common. Although effective treatments do exist, only a few affected people consult a practitioner in order to overcome their problem. At the same time, studies have shown that reading didactical documents about their PE problem (bibliotherapy) can be useful to men. AIM. The aim of this study was to improve the bibliotherapy approach using up to date knowledge and techniques. The expected benefits were: (1) an effective manual shorter than previous ones, (2) easier to assimilate therapeutic principles and (3) a method thereby made accessible to a broad population most of whom usually do not consult for this type of sexual problem. METHOD. A short bibliotherapy titled The Practical Guide of PE [in French] was tested among PE subjects who were diagnosed with PE according to DSM-IV-TR criteria. Assessments were made at baseline (N = 421), at 4-8 months (N = 120) and at 10-14 months (N = 79) after they read The Practical Guide. A control group of 66 subjects was left on a waiting list and was assessed two months after baseline. MAIN OUTCOME MEASURES. Self-reported ejaculatory latency time, feeling of control upon ejaculation, sexual satisfaction, distress related to PE, anxiety experienced during sexual intercourse and sexual cognitions (SIQ). RESULTS. Significant improvements were found for all the self-reported parameters, both at 4-8 and at 10-14 months after the bibliotherapy. The improvements were associated with an adjustment of sexual cognitions. The response to treatment seemed better for those subjects with moderate PE. Although the severity criteria used in this study did not precisely meet the ISSM criteria for lifelong PE, they were likely related. The response did not seem to be affected by variables such as age, education or personality. CONCLUSION. Its cost/benefit ratio makes The Practical Guide a valuable therapeutic tool. [less ▲]

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See detailClinical pathology tests for assessment of liver disease in dogs & cats
Ramery, Eve ULg; Papakonstantinou, Stratos; O’Brien, Peter J

in Northern Ireland Veterinary Today (2010)

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See detailClinical pattern characterisation of cattle naturally infected by BTV-8 - Clinical characterisation of BTV-8 infected cattle
Zanella, G; Martinelle, Ludovic ULg; Guyot, Hugues ULg et al

in Transboundary and Emerging Diseases (in press)

Detailed reference viewed: 41 (12 ULg)
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See detailClinical Pattern of Corticosteroid Dependent Crohn's Disease
Franchimont, D. P.; Louis, Edouard ULg; Croes, F. et al

in European Journal of Gastroenterology & Hepatology (1998), 10(10), 821-5

OBJECTIVES: Corticosteroid dependency in Crohn's disease (CD) is characterized by the need for chronic use of corticosteroids to maintain clinical remission. Several definitions have been used. Depending ... [more ▼]

OBJECTIVES: Corticosteroid dependency in Crohn's disease (CD) is characterized by the need for chronic use of corticosteroids to maintain clinical remission. Several definitions have been used. Depending on the definition, 10-30% of the patients are considered as corticosteroid dependent. The aim of the study was to define a clinical pattern of corticosteroid dependent CD patients. PATIENTS AND METHODS: Epidemiological and clinical characteristics were retrospectively compared between 20 corticosteroid dependent CD patients and 248 non-corticosteroid dependent CD patients by using univariate and multivariate analyses. Corticosteroid dependency was defined either by two successive relapses during the 2 months after discontinuing glucocorticoids (n=5) or by two successive relapses at dose tapering, after successful treatment of a flare-up by using glucocorticoids (n=15). RESULTS: Corticosteroid dependent CD patients were younger at diagnosis (P < 0.001), and were characterized by a higher frequency of colonic location (P< 0.05), but lower frequency of ileal location (P < 0.01), and higher ano-perineal location (P < 0.05). They were also more frequently smokers (P< 0.05) and users of contraceptive pills (P< 0.01). The inflammatory type of the disease was increased (P < 0.01), while the fibrostenotic type was decreased (P < 0.001) in corticosteroid dependent CD patients. By multivariate analysis, a smoking habit (P < 0.01), a colonic location (P < 0.05), a non-fibrostenotic type (P< 0.05) and a younger age at diagnosis (P< 0.05) were shown to be independently associated with corticosteroid dependency. CONCLUSIONS: This study suggests a clinical pattern associated with corticosteroid dependency. Whether this clinical pattern is simply associated with the dependency, or whether a primary decrease of corticosensitivity produces this clinical pattern, is not known. Further prospective studies will have to determine whether the presence of these clinical characteristics is predictive of corticosteroid dependency and whether this prediction will be useful for the management of this condition. [less ▲]

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See detailClinical performance of the C-PET camera.
SMITH, RJ.; HUSTINX, Roland ULg; ADAM, LE. et al

in Journal of Nuclear Medicine (The) (1999), 40

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See detailClinical Perspectives in Emotional Intelligence
Hansenne, Michel ULg

in Emotional intelligence: New perspectives and applications (2012)

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See detailClinical PET in Oncology
Hustinx, Roland ULg; Paulus, Danusia ULg; Rigo, Pierre ULg et al

Book published by GE Medical Systems (1996)

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See detailClinical PET in oncology
Rigo, P.; Paulus, P.; Bury, Thierry ULg et al

in Radioactive Isotopes in Clinical Medicine Research XXII (1997)

Detailed reference viewed: 11 (5 ULg)