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See detailCanine eosinophilic bronchopneumopathy
Clercx, Cécile ULg; Peeters, Dominique ULg

in Veterinary Clinics of North America. Small Animal Practice (2007)

Eosinophilic bronchopneumopathy (EBP) is a disease characterized by eosinophilic infiltration of the lung and bronchial mucosa, as demonstrated by examination of bronchoalveolar lavage fluid cytologic ... [more ▼]

Eosinophilic bronchopneumopathy (EBP) is a disease characterized by eosinophilic infiltration of the lung and bronchial mucosa, as demonstrated by examination of bronchoalveolar lavage fluid cytologic preparations or histologic examination of the bronchial mucosa. Although the precise cause of EBP is unknown, a hypersensitivity to aeroallergens is suspected. The diagnosis relies on typical history and clinical signs, demonstration of bronchopulmonary eosinophilia by cytology or histopathologic examination, and exclusion of known causes of lower airway eosinophilia. Most dogs display an excellent response to oral corticosteroid therapy; however, side effects of this treatment can be limiting. New therapeutic approaches are being studied, including the use of aerosol therapy, cyclosporine, or drugs interfering with T helper 2 immune response. [less ▲]

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See detailCanine herpesvirus-1 (CHV-1): clinical, serological and virological patterns in breeding colonies
Ronsse, Veerle; Verstegen, John; Thiry, Etienne ULg et al

in Theriogenology (2005), 64(1), 61-74

Canine herpesvirus-1 (CHV-1) is presumed to be enzootic in the dog population and is associated with reproductive disorders and neonatal mortality. To advise dog breeders towards an effective management ... [more ▼]

Canine herpesvirus-1 (CHV-1) is presumed to be enzootic in the dog population and is associated with reproductive disorders and neonatal mortality. To advise dog breeders towards an effective management of CHV-1 infected colonies, 27 breeding bitches were studied during one reproductive cycle in field conditions: the effect of cycle stage, kennel size, initial antibody titre, mating and gestation on serologic and viral excretion patterns was evaluated, while the association between reproductive disorders and CHV-1 antibody titres and viral excretion was also analysed. All initially seronegative bitches seroconverted, while 40% of the initially seropositive bitches became seronegative at one or two occasions. No difference in antibody patterns was observed between mated and unmated bitches. Of the mated bitches, 40% experienced infertility, foetal resorption or mummification. No difference in antibody patterns was observed depending on the occurrence of reproductive disorders even if a decrease in antibody titres during early or late-di-oestrus was often present. Significantly higher titres were observed at all cycle stages in large kennels. None of the vaginal and nasal samples or buffy coats tested positive for CHV-1 DNA. The mixed image of clinical and subclinical carriage in this study demonstrated CHV-1 has a complex and difficult to predict clinical behavior. Preventive management with vaccination of reproducing bitches in kennels with reproductive disorders should therefore be advised. (c) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailCanine idiopathic pulmonary fibrosis : improvement of the phenotype characterization and search for biomarkers and for etiologic agents
Roels, Elodie ULg

Doctoral thesis (2016)

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive parenchymal lung disease of unknown origin, mainly described in old-aged West Highland white terriers (WHWTs). It is characterized by exercise ... [more ▼]

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive parenchymal lung disease of unknown origin, mainly described in old-aged West Highland white terriers (WHWTs). It is characterized by exercise intolerance, cough and dyspnoea/tachypnea with a progressive deterioration until death from respiratory insufficiency. CIPF shares clinical features with human idiopathic pulmonary fibrosis (IPF), while tomodensitometric and histopathological findings do not appear to be exactly the same. Over the past 10 years, several studies have been performed to improve our knowledge about CIPF. However, this disease is still misunderstood and clinicians are dealing with several challenges including the absence of clinical or biological markers for estimating the presence, severity or progression of the disease and related comorbidities such as pulmonary hypertension, the absence of etiologic agent, and the absence of targeted therapy. Consequently, the aims of the present project were (1) to investigate whether high-resolution computed tomography (HRCT) of the lungs obtained under sedation can be used for the diagnosis and for the follow-up of the disease, (2) to study a new echocardiographic parameter for the diagnosis of precapillary pulmonary hypertension induced by CIPF, (3) to study the potential roles of 2 chemokines of interest, CCL2 and CXCL8, as biomarkers of fibrosis and as actors in the pathogenesis of the disease, (4) to determine breed variation of basal blood concentrations of the same chemokines, vascular endothelial growth factor (VEGF), and serotonin, and (5) to search for the presence of herpesvirus as a possible etiologic agent. [less ▲]

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See detailCanine idiopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015)

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See detailCanine idopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015, October)

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See detailCanine leishmaniasis in Algeria: true prevalence and diagnostic test characteristics in groups of dogs of different functional type.
Adel, Amel; Saegerman, Claude ULg; Speybroeck, Niko et al

in Veterinary Parasitology (2010), 172(3-4), 204-13

A Bayesian approach was used to assess the prevalence of Canine leishmaniasis and evaluate three serological diagnostic tests: indirect fluorescent antibody test (IFAT), direct agglutination test, and ... [more ▼]

A Bayesian approach was used to assess the prevalence of Canine leishmaniasis and evaluate three serological diagnostic tests: indirect fluorescent antibody test (IFAT), direct agglutination test, and particle gel immuno-assay (PaGIA) for Canine leishmaniasis (CL) in Algiers. Four hundred and sixty-two dogs were involved in this study and divided in four groups according to their functional type: stray dogs, farm dogs, national guard dogs and pet dogs. The stray dog group showed the highest prevalence of leishmaniasis (11.7%), followed by the national guard dogs (9.7%) and the farm dogs (5.9%). IFAT was shown to be the most sensitive test in all groups. However, IFAT specificity was considerably lowered in the farm dog group: 65.2% versus 94.5% for the stray dogs. A considerable drop in PaGIA specificity was noted in the stray dogs group. The results of the current study demonstrate the variability of test characteristics in different situations and underline the danger of using standard values, without verifying their appropriateness for the specific purposes. [less ▲]

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See detailCanine nasal aspergillosis : CT findings in 25 patients
Sanders, J.; Zonderland, J. L.; Gielen, I. et al

in 43rd BSAVA Annual Congress (2000, April)

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See detailCanine Rhinitis
Peeters, Dominique ULg

in Proceedings of the 31st Internationaler Fortbildungskurs Kleintierkrankheiten (2010, March)

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See detailCanine sino-nasal aspergillosis
Peeters, Dominique ULg

in Proceedings of the 31st Internationaler Fortbildungskurs Kleintierkrankheiten (2010, March)

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See detailCanine sino-nasal aspergillosis
Peeters, Dominique ULg

in Proceedings of the 30th Internationaler Fortbildungskurs Kleintierkrankheiten (2009, March)

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See detailCanine sino-nasal aspergillosis and penicilliosis
Day, M. J.; Peeters, Dominique ULg; Clercx, Cécile ULg

in Greene, Craig (Ed.) Infectious Diseases of the Dog and Cat 4th Edition (2012)

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See detailCanine sino-nasal aspergillosis: treatment with intranasal infusion of enilconazole
Stork, Christoph; Zonderland, Jean-Luc; Saunders, Jimmy et al

Poster (2003, April)

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See detailCanister free videogrammetry system for thermal vacuum and space applications
Roose, Stéphane ULg; Stockman, Yvan ULg; Bolsee, Jean-Christophe et al

in Decker, J.; Brown, N. (Eds.) Proceedings of the Conference on Recent Developments in Traceable Dimensional Measurements, (2003, November 20)

The development of a canister-free videogrammetry system is presented. Applications in view, are coordinate measurements during thermal vacuum test and on-baord space flight metrology of mechanical ... [more ▼]

The development of a canister-free videogrammetry system is presented. Applications in view, are coordinate measurements during thermal vacuum test and on-baord space flight metrology of mechanical structures, reflectors and antenna's. The paper presents the breadboard system architecture. Two breadboards have been developed. One is based on a space-qualified micro-imager camera. Lenses and flashers are all commercial components and have been made vacuum compatible. Results of accuracy (typically 50ppm) and resolution (typically 25 ppm) tests, in ambient and in vacuum are also presented. [less ▲]

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See detailCannabinoid-1 receptor antagonists in type-2 diabetes.
Scheen, André ULg

in Best practice & research. Clinical endocrinology & metabolism (2007), 21(4), 535-53

Type-2 diabetes is closely related to abdominal obesity and is generally associated with other cardiometabolic risk factors, resulting in a risk of major cardiovascular disease. Several animal and human ... [more ▼]

Type-2 diabetes is closely related to abdominal obesity and is generally associated with other cardiometabolic risk factors, resulting in a risk of major cardiovascular disease. Several animal and human observations suggest that the endocannabinoid system is over-active in the presence of abdominal obesity and/or diabetes. Both central and peripheral endocannabinoid actions, via the activation of CB1 receptors, promote weight gain and associated metabolic changes. Rimonabant, the first selective CB(1) receptor blocker in clinical use, has been shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance index and C-reactive protein levels, and to increase high-density lipoprotein (HDL) cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients. In addition, a 0.5-0.7% reduction in HbA1c levels was observed in metformin- or sulphonylurea-treated patients with type-2 diabetes and in drug-naive diabetic patients. Almost half of the metabolic changes, including HbA1c reduction, could not be explained by weight loss, suggesting that there are direct peripheral effects. Rimonabant was generally well-tolerated, and the safety profile was similar in diabetic and non-diabetic patients, with a higher incidence of depressed mood disorders, nausea and dizziness. In conclusion, the potential role of rimonabant in overweight/obese patients with type-2 diabetes and at high risk of cardiovascular disease deserves much consideration. [less ▲]

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See detailCannabis d'hier et d'aujourd'hui. Evolution de la composition en principes actifs au cour du temps
CHARLIER, Corinne ULg

Scientific conference (2010, October 26)

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See detailLe cannabis dans la vie de l'adolescent normal, un invité encombrant?
Malchair, Alain ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2006), (51-52), 109-113

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