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See detailCardiac Transplantation Beyond 55 Years of Age
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Beaujean, M. A. et al

in Transplant International (1990), 3(2), 59-61

Between January 1985 and December 1988, 20 patients over the age of 55 years (extremes 56-63 years; 15 men and 5 women) underwent cardiac transplantation. The cause of cardiopathy was ischemic in 70% of ... [more ▼]

Between January 1985 and December 1988, 20 patients over the age of 55 years (extremes 56-63 years; 15 men and 5 women) underwent cardiac transplantation. The cause of cardiopathy was ischemic in 70% of the cases. The immunosuppressive regimen consisted of cyclosporin A, corticoids, and azathioprine. Rejection episodes were monitored by endomyocardial biopsies and treated by pulses of corticoids or monoclonal antibodies (OKT3). The operative mortality was 10% (n = 2). The 1-year survival rate was 70%. The 1-year incidence of infection and/or rejection episodes was 1 and 1.53 episodes/patient, respectively. One patient was successfully retransplanted after 9 months because of intractable rejection. Age beyond 55 years is no longer a contraindication to cardiac transplantation. This change in recipient selection policy should lead to parallel changes in donor selection criteria. [less ▲]

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See detailCardiac Transplantation in Patients Older Than 55 Years
Defraigne, Jean-Olivier ULg; Demoulin, J.C.; VAN DAMME, Hendrik ULg et al

in Acta Chirurgica Belgica (1991), 91(1), 38-42

From 1985 to 1990, 27 patients older than 55 years (extremes 55-65 years; 21 men and 6 women) received a cardiac transplant. The cause of cardiopathy was ischemic in 70%. Postoperative immunosuppressive ... [more ▼]

From 1985 to 1990, 27 patients older than 55 years (extremes 55-65 years; 21 men and 6 women) received a cardiac transplant. The cause of cardiopathy was ischemic in 70%. Postoperative immunosuppressive therapy consisted of Cyclosporin A, steroids, azathioprine and antilymphocytic serum. Rejection episodes were monitored by endomyocardial biopsies and treated by pulses of steroids or monoclonal antibodies (OKT3). The operative mortality is 7.4% (n = 2). The one and two year survivals are 71% and 62% respectively. The incidence of infection and/or rejection were 0.71 +/- 0.4 and 1.4 +/- 0.7 episodes/patient year. Age beyond 55 years does not contraindicate heart transplantation. This change in recipient selection policy should lead to parallel changes in donor selection criteria. [less ▲]

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See detailCardiac troponin and natriuretic peptide in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, I.; Garcia, Alexandra ULg et al

in Proceedings of 21st ECVIM Meeting (2011, September 06)

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See detailCardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers
Chapelle, Jean-Paul ULg

in Clinical Chemistry & Laboratory Medicine (1999), 37(1), 11-20

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the ... [more ▼]

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in noncardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intense physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage: therefore they have found new clinical applications, in particular risk stratification in patients with unstable angina. In spite of the possible reexpression of cTnT in human skeletal muscles, and of the lack of standardization of cTnI assays, Tn subunits are not far to meet the criteria of ideal markers for acute myocardial injury. Only an insufficient sensitivity in the first hours following the acute coronary syndroms requiries to maintain an early myocardial marker in the cardiac panel for routine laboratory testing. [less ▲]

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See detailCardiac troponins and natriuretic peptides in runners: useful for cardiac risk screening ?
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Fillet, Marianne ULg et al

in British Journal of Sports Medicine (2014, April), 48(7), 173

Background Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. Objective Our aim was to compare ... [more ▼]

Background Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. Objective Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Design Prospective, cohort study. Setting Amateur marathon runners and ultrarunners. Patients 28 subjects (26 men, 42.5±11 yrs) were enrolled. Interventions Subjects ran the Maasmarathon (42.195 kilometers) and 33 subjects (33 men, 45.7±9.3 yrs) ran the Ultratour of Liège (Belgium; 67 km). All subjects gave their informed consent. We took blood sample before (T0), just after (T1) and 3 hours after the race (T3). Main outcome measurements cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. All statistical analyses were performed using Medcalc version 8.1 for Windows. P-value <.01 was regarded as statistically significant. Results A significant difference between hsTnT concentrations at T0 and T1 (P<.001), and between T0 and T3 (P<.001) for NT-proBNP have been observed, but not between T1 and T3. This observation appeared only after a strenuous exercise. However, up to now this type of exercise is not reproducible easily in a laboratory. Moreover, nobody knows if these observations would have cardiac consequences at long terms. Conclusion Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death. [less ▲]

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See detailCardiac troponins in patients with chronic renal failure
Chapelle, Jean-Paul ULg

Conference (2001, June 19)

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See detailCardiac ultrasound in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, Isabelle; Garcia, Alexandra et al

Poster (2012, October 19)

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See detailCardiac ultrasound in canine emergencies with a systemic inflammatory response syndrome
Gommeren, Kris ULg; Desmas, Isabelle; Garcia, Alexandra et al

in Proceedings of the 22nd ECVIM-CA Congress (2012, September)

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See detailCardio-pulmonary function values in double-muscled cattle during muscular exercise.
Gustin, Pascal ULg; Dhem, A. R.; Lomba, F. et al

in Veterinary Research Communications (1988), 12(4-5), 407-416

Eleven double-muscled calves of the Belgian White and Blue breed and eleven Friesian calves have been investigated at rest, during exercise on a treadmill (11% incline; speed 1.3 m.sec-1) and 10 and 30 ... [more ▼]

Eleven double-muscled calves of the Belgian White and Blue breed and eleven Friesian calves have been investigated at rest, during exercise on a treadmill (11% incline; speed 1.3 m.sec-1) and 10 and 30 minutes after the end of this exercise. Blood gases and acid-base status were determined in mixed venous and arterial blood sampled from the pulmonary and the carotid artery respectively. Expired gases were collected in a balloon. The time of collection, volume of expired gases and fractional O2 and CO2 concentrations in expired gases were measured. In double-muscled calves, inadequate oxygen intake and carbon dioxide elimination were demonstrated by the increase in the carbon dioxide tension (PaCO2) and in the hydrogen ion concentration [H+]a and the decrease in the oxygen tension (PaO2) in arterial blood during exercise. In Friesian calves, an adequate increase in oxygen intake occurred and no acidosis was recorded. A metabolic acidosis explained by only a 1.5-fold increase in the cardiac output and by the small increase in haemoglobin concentration was recorded in double-muscled calves. It was concluded that some aspects of the cardio-pulmonary and metabolic responses to exercise in double-muscled calves can be related to their inability to greatly increase their O2 consumption. [less ▲]

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2016, March 04)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in 14th Belgian Day on Biomedical Engineering (2016, March 04)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

Poster (2015, November 26)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Proceedings of the IEEE-EMBS Benelux chapter 2015 meeting (2015, November 26)

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See detailCardio-pulmonary mechanics and minimal modelling in critical care
de Bournonville, Sébastien ULg

Master's dissertation (2015)

Positive pressure ventilation is a widely used support for patients in intensive care units.Their weak respiratory condition is often accompanied by a weak cardiac status and haemodya-mical instability ... [more ▼]

Positive pressure ventilation is a widely used support for patients in intensive care units.Their weak respiratory condition is often accompanied by a weak cardiac status and haemodya-mical instability. This ventilation support has significant impacts on the cardiovascular systemthat are known but not predicted nor taken into account when varying the respiratory para-meters such as the positive end-expiratory pressure. The fact is that positive end-expiratorypressure increases the intrathoracic pressure. Ultimately, this will lead to decreases in cardiacoutput and stroke volume of the left ventricle. The good parametrization of such ventilator istherefore of primary importance for the critically ill patient cares.This master’s thesis seeks to develop a new minimal model of the cardiovascular and therespiratory system that is new in terms of its cardiovascular lumped model representationand the fact that it takes into account the cardiopulmonary interactions. This new model isaimed to be implemented at bedside for real time monitoring of the patients’ cardiac status asfunction of the respiratory inputs. Its ultimate use will be prediction and active control of thisstatus to improve the work of clinicians.The physiological knowledge in terms of cardiopulmonary interactions was investigated toselect the specific behaviour that will be modelled. The mathematical representation of themodel was precisely described and was designed as a function of physiological relevancy, com-putational weight and data availability. These factors lead to the design of a three chambermodel of the cardiovascular system, focused on the left ventricle, the aorta and the vena cavawhich represent the common available data in ICUs. This three chamber model was coupledto a single compartment model of the lung to compute the intrathoracic pressure that actson intrathoracic structures. Porcine measurements performed with the chest closed were usedto build patient specific models by fitting the model outputs to these measurements. Theconstruction of patient specific models was performed by identifying the patient-specific pa-rameter values of the model. For this purpose, the data were first processed to compute andidentify many parameters. Then an iterative optimization process was implemented to fit themodel to the specific datasets.This model was validated against the aforementioned porcine datasets. It showed physiolo-gical behaviours and reactions in a cardiovascular point of view as well as in a cardiopulmonaryinteractions point of view. By analysing the several identified parameters on the PEEP levelof each pigs, correlations between haemodynamical parameters and the PEEP level applied tothe patients were identified. It also allowed the confirmation that linear ESPVR models arenot appropriated for relatively high levels of PEEPs. The model showed the expected beha-viour of decreasing cardiac output for an increasing PEEP although not in the expected ranges.Eventually, this work opens many research hypotheses and questions in this field. Thequestion of implementing the model at bedside for real-time monitoring should be investigated.A modelling of the correlation between haemodynamic parameters and PEEP based on theresult of this work should also be investigated. [less ▲]

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailCardio-respiratory, haematological and biochemical parameter adjustments to exercise: effect of a probiotic in horses during training
Art, Tatiana ULg; Votion, Dominique ULg; Mc Entee, Kathleen ULg et al

in Veterinary Research (1994), 25(4), 361-370

Two randomly distributed groups of thoroughbred horses were compared during a 12-week period for their cardio-respiratory and metabolic adjustment to strenuous exercise, training and detraining. The ... [more ▼]

Two randomly distributed groups of thoroughbred horses were compared during a 12-week period for their cardio-respiratory and metabolic adjustment to strenuous exercise, training and detraining. The horses were trained following the same standardized schedule and were regularly investigated using standardized treadmill exercise tests (SET) of increasing speed. After the first SET and during the whole experimental period, a group of 6 horses received a probiotic (Bioracing) once a day while a group of 5 horses received a placebo. All other conditions were similar for both groups. During each SET, the oxygen uptake, carbon dioxide output, tidal volume (inspired volume), respiratory rate and expired minute volume were obtained using 2 ultrasonic pneumotachographs and a mass spectrometer. All the parameters were the mean of the values calculated during the last 20 s of the SET. Heart rate was continuously measured with a polar horse tester. Venous blood was sampled before and after the test and analyzed for various biochemical parameters. In both groups, training induced significant modification in most of the cardio-respiratory parameters, ie peak oxygen uptake, peak carbon dioxide output, respiratory exchange ratio, ventilation/min to oxygen-uptake ratio and oxygen-uptake to heart-rate ratio. After the 3-week detraining period, most of the values were again similar to the pre-training values in both groups. However, the training-induced modifications of most of the cardio-respiratory parameters occurred earlier and were proportionally greater in the probiotic-treated group than in the control. The respiratory coefficient decreased in the control but not in the treated group. All other parameters changed similarly in both groups. This suggests that Bioracing could modify the physiological effects of training by improving some aerobic metabolic capacities for carbohydrate utilization, but that this effect occurs only during training and not during periods of physical inactivity [less ▲]

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See detailCardiographe
Fredericq, Léon ULg

in Richet, Charles (Ed.) Dictionnaire de physiologie. 003. Tome III (1898)

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See detailCardiological and general health status in preschool- and school-age children after neonatal arterial switch operation
Hovels-Gurich, H. H.; SEGHAYE, Marie-Christine ULg; Dabritz, S. et al

in European Journal of Cardio - Thoracic Surgery (1997), 12(4), 593-601

OBJECTIVE: Cardiological and general health status 3-9 years after neonatal arterial switch operation for transposition of the great arteries should be evaluated by non-invasive methods. METHODS: A total ... [more ▼]

OBJECTIVE: Cardiological and general health status 3-9 years after neonatal arterial switch operation for transposition of the great arteries should be evaluated by non-invasive methods. METHODS: A total of 77 unselected children with intact ventricular septum (75.3%) or ventricular septal defect (24.7%) without or with aortic isthmic stenosis (5.2%) were prospectively examined 3.2-9.4 years (5.4 +/- 1.6) after neonatal switch. Clinical pediatric and cardiological examination, standard and 24 h Holter electrocardiogram, M-mode, 2D-, Doppler and colour Doppler echocardiography were performed. Outcome data were compared to published normals. RESULTS: Reoperation rate was 2.6%, 96.1% were without limitation of physical activity and 98.7% without medication. Compared to normals, growth was adequate, weight and head circumference were slightly reduced. After median sternotomy, 23.4% had abnormal thoracic configuration (16.9% asymmetry, 6.5% funnel chest). ECG and Holter: 93.5% were in sinus, 6.5% in ectopic atrial or junctional rhythm. Incidence of complete right bundle branch block was 15.8% in patients with ventricular septal defect and 5.2% in those without. Ischemic ST-T changes during exercise due to coronary artery occlusion and evidence of old myocardial infarction were found in 1 patient (1.3%) each. Occasional atrial ectopy was found in 27.4%, ventricular ectopy in 15.3%: occasional in 12.5% and frequent (> 30/h) in 2.8% presenting bigemini, couplets and short runs of ventricular tachycardia at rest and during exercise. Echocardiography: Left ventricular function was normal in all. Endsystolic diameter of neoaortic valve annulus was beyond 90% confidence interval for controls in 79.2%, neoaortic root diameter in 100%. Mild aortic insufficiency was seen in 10.4%. No correlation was found between aortic insufficiency and aortic dilatation. Neoaortic stenosis was not seen, mild residual coarctation after end-to-end-anastomosis was found in 2.6%, native coarctation corrected later on in 1.3%. Supravalvular pulmonary stenosis was seen in 29.9% (19.5% trivial, 7.8% mild, 2.6% moderate), mild subvalvular pulmonary stenosis in 1.3%, pulmonary insufficiency in 2.6%. CONCLUSION: The study confirms good midterm results after neonatal arterial switch operation for transposition with or without ventricular septal defect. Long-term observation is necessary to assess rhythm, coronary artery and myocardial function as well as development of neo-aorta and pulmonary artery system. [less ▲]

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See detailCardiologie des équidés
Amory, Hélène ULg; Sandersen, Charlotte ULg

Learning material (2010)

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