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See detailZnO/PVA Macroscopic Fibers Bearing Anisotropic Photonic Properties
Kinadjian, Natacha ULiege; Achard, Marie-France; Julian-lopez, Beatriz et al

in Advanced Functional Materials (2012)

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of ... [more ▼]

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of the ZnO nanorods along the main axis of the PVA fiber. This photonic anisotropy is triggered by a synergistic interaction between the PVA matrix, stretched above the glass transition temperature (Tg), and cooled down under strain. Compared with non-elongated fibers that present an isotropic emission, composite fibers previously submitted to a tensile stress absorb selectively UV emission when the polarized laser beam is parallel to the main axis of the fiber. In addition, their photolumincescence is also anisotropic, with a waveguide behavior along the main axis of the fiber. Mechanical properties of these composite fibers are also drastically improved, compared with pure PVA fibers: the longitudinal Young modulus of these fibers is increased from 2 to 6 GPa upon ZnO addition, a value similar to those already observed for composite fibers, prepared either with carbon nanotubes, or V2O5 macroscopic fibers. [less ▲]

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See detailHet zoekgeraakte bijproduct. Over literaire prijzen
Spinoy, Erik ULiege

in Freespace Nieuwzuid (2008), 8(32), 6-23

This article reflects on the growing importance of literary prizes, while other literary institutions are rapidly losing ground and influence.

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See detailZoektocht naar een levende prothese
De Gersem, Hilde; Geris, Liesbet ULiege

in Het Ingenieursblad (2003), 72(8/9), 54-60

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen ... [more ▼]

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen, of zorgt de behandeling niet voor volledig herstel van de functionaliteit. Vooral bij grote botdefecten is de vraag naar een permanente, biologische en patiëntvriendelijkere oplossing groot. Dit artikel kadert in het onderzoek naar een behandeling met behulp van met botcellen ingezaaide poreuze draagstructuren. [less ▲]

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See detailZola et l'invention du roman naturaliste
Bertrand, Jean-Pierre ULiege

in Saint-Amand, Denis (Ed.) La Préface. Formes et enjeux d'un discours d'escorte (2016)

Le concept d'invention escorte l'émergence de la littérature au XIXe siècle parallèlement à ce qui l'a transformé dans les sciences et les techniques. Cela signifie que la littérature peut aussi être ... [more ▼]

Le concept d'invention escorte l'émergence de la littérature au XIXe siècle parallèlement à ce qui l'a transformé dans les sciences et les techniques. Cela signifie que la littérature peut aussi être saisie comme un champ de production du nouveau, et qu'elle a à voir avec les notions de découverte, de crise, de progrès, de technique. La préface sert de laboratoire réflexif aux expérimentations romanesques, que l'auteur des Rougon-Macquart est appelé à justifier, expliquer, négocier, voire vulgariser. [less ▲]

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See detailZola ethnographe ?
Ledent, David ULiege

in Cahiers Naturalistes : Bulletin officiel de la Société Littéraire des Amis d'Emile Zola (2014), 88

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See detailZola face aux émotions
Ledent, David ULiege

Conference (2014, March 30)

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See detailZola in Sciascia. Una nota su Candido
Curreri, Luciano ULiege

E-print/Working paper (2014)

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See detailZola in Sciascia: Una nota su Candido (1977) e sul corpo
Curreri, Luciano ULiege

in Baldassarri, Guido (Ed.) I cantieri dell’italianistica. Ricerca, didattica e organizzazione agli inizi del XXI secolo. (2016)

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See detailZola sociologue du quotidien
Ledent, David ULiege

Conference (2010, November 06)

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See detailZoledronate inhibits alpha v beta 3 and alpha v beta 5 integrin cell surface expression in endothelial cells
Bellahcene, Akeila ULiege; Chaplet, Michael; Bonjean, K. et al

in Endothelium : Journal of Endothelial Cell Research (2007), 14(2), 123-130

Zoledronate exhibits antiangiogenic properties in vitro and in vivo. Integrins alpha v beta 3 and alpha v beta 5 are involved in angiogenesis. Because zoledronate inhibits endothelial cell adhesion, the ... [more ▼]

Zoledronate exhibits antiangiogenic properties in vitro and in vivo. Integrins alpha v beta 3 and alpha v beta 5 are involved in angiogenesis. Because zoledronate inhibits endothelial cell adhesion, the authors explored the hypothesis that it could alter these integrins recruitment to focal adhesion sites. Human umbilical vein endothelial cells ( HUVECs) were treated with zoledronate or with mevalonate pathway intermediates geranylgeraniol ( GGOH) and farnesol (FOH). Zoledronate generated a significant decrease in alpha v beta 3 and alpha v beta 5 expression at HUVEC cell surface using flow cytometry and immunofluorescence. This inhibition was reversed by GGOH but not by FOH. Cells cotreated with zoledronate and GGOH were able to attach to vitronectin through alpha v beta 3 and alpha v beta 5, as confirmed by the use of specific function-blocking antibodies. The authors showed that zoledronate alters endothelial cell integrin-mediated adhesion. This effect is likely to contribute to the previously demonstrated antiangiogenic effect of zoledronate. Whether this mechanism of action also applies to metastatic tumor cells is under investigation. [less ▲]

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See detailZoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial.
Reid, David M; Devogelaer, Jean-Pierre; Saag, Kenneth et al

in Lancet (2009), 373(9671), 1253-63

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral ... [more ▼]

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral fractures, but are associated with poor compliance and adherence. We aimed to assess whether one intravenous infusion of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. METHODS: This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. 833 patients were randomised 1:1 to receive zoledronic acid (n=416) or risedronate (n=417). Patients were stratified by sex, and allocated to prevention or treatment subgroups dependent on duration of glucocorticoid use immediately preceding the study. The treatment subgroup consisted of those treated for more than 3 months (272 patients on zoledronic acid and 273 on risedronate), and the prevention subgroup of those treated for less than 3 months (144 patients on each drug). 62 patients did not complete the study because of adverse events, withdrawal of consent, loss to follow-up, death, misrandomisation, or protocol deviation. The primary endpoint was percentage change from baseline in lumbar spine bone mineral density. Drug efficacy was assessed on a modified intention-to-treat basis and safety was assessed on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov, number NCT00100620. FINDINGS: Zoledronic acid was non-inferior and superior to risedronate for increase of lumbar spine bone mineral density in both the treatment (least-squares mean 4.06% [SE 0.28] vs 2.71% [SE 0.28], mean difference 1.36% [95% CI 0.67-2.05], p=0.0001) and prevention (2.60% [0.45] vs 0.64% [0.46], 1.96% [1.04-2.88], p<0.0001) subgroups at 12 months. Adverse events were more frequent in patients given zoledronic acid than in those on risedronate, largely as a result of transient symptoms during the first 3 days after infusion. Serious adverse events were worsening rheumatoid arthritis for the treatment subgroup and pyrexia for the prevention subgroup. INTERPRETATION: A single 5 mg intravenous infusion of zoledronic acid is non-inferior, possibly more effective, and more acceptable to patients than is 5 mg of oral risedronate daily for prevention and treatment of bone loss that is associated with glucocorticoid use. [less ▲]

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See detailZoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
Chaplet, Michaël; Deroanne, Christophe ULiege; Fisher, Larry W. et al

in Biochemical Journal (2004), 384(Pt 3), 591-598

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these ... [more ▼]

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these beneficial effects of BPs are still poorly understood. We hypothesized that ZOL (zoledronic acid), a potent third-generation BP, may induce the expression of proteins associated with the bone-forming potential of osteoblastic cells such as BSP (bone sialoprotein). Expression of BSP gene is up-regulated by hormones that promote bone formation and has been associated with de novo bone mineralization. Using real-time reverse transcriptase-PCR and Western-blot analysis, we demonstrated that ZOL increased BSP expression in Saos-2 osteoblast-like cells. Nuclear run-on and mRNA decay assays showed no effect at the transcriptional level but a stabilization of BSP transcripts in ZOL-treated cells. ZOL effect on BSP expression occurred through an interference with the mevalonate pathway since it was reversed by either mevalonate pathway intermediates or a Rho GTPase activator. We showed that ZOL impaired membrane localization of RhoA in Saos-2 cells indicating reduced prenylation of this protein. By the use of small interfering RNAs directed to RhoA and Rac1, we identified both Rho GTPases as negative regulators of BSP expression in Saos-2 cells. Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity. [less ▲]

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See detailZolmitriptan (Zomig, 311c90), a Novel Dual Central and Peripheral 5ht1b/1d Agonist: An Overview of Efficacy
Schoenen, Jean ULiege; Sawyer, J.

in Cephalalgia : An International Journal of Headache (1997), 17(Suppl 18), 28-40

The efficacy of zolmitriptan (Zomig, 311C90), a 5-hydroxytryptamine (5HT)1B/1D receptor agonist, in the acute oral treatment of migraine was evaluated in an extensive clinical trial program. Four ... [more ▼]

The efficacy of zolmitriptan (Zomig, 311C90), a 5-hydroxytryptamine (5HT)1B/1D receptor agonist, in the acute oral treatment of migraine was evaluated in an extensive clinical trial program. Four randomized, placebo-controlled studies (total 2480 patients) were performed; data from two of these trials established that a 2.5 mg dose was on the shoulder of the dose-response curve (2-h headache response rate 64%), showing similar efficacy to the 5 mg dose (67%). In this program, the efficacy of zolmitriptan was not influenced by the pretreatment headache duration; the presence of aura preceding the headache, migraine associated with menses or migraine upon awakening; or by concomitant use of oral contraceptives or antidepressants. In addition, zolmitriptan 5 mg proved consistently effective in the treatment of multiple migraine attacks for up to 1 year. Zolmitriptan reduced the incidence of nausea, photophobia and phonophobia, reduced impairment of normal activity and demonstrated positive effects on patients' quality of life. Thus, zolmitriptan is a highly effective acute oral antimigraine therapy, with 2.5 mg providing the optimal balance between efficacy and tolerability. [less ▲]

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See detailZolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study.
Dahlof, C.; Diener, H. C.; Goadsby, P. J. et al

in European Journal of Neurology (1998), 5(6), 535-543

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral ... [more ▼]

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the treatment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similar across the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reported at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose, 39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Most adverse events were of mild or moderate intensity and were transient. The frequency of adverse events was dose-related. Although, zolmitriptan 5 mg exhibited the most favourable efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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See detailZombies Go to Toronto: Zombifying Shame in Nalo Hopkinson's Brown Girl in the Ring
Romdhani, Rebecca ULiege

in Research in African Literatures (2015), 16(4), 72-89

Caribbean-Canadian Nalo Hopkinson's speculative fiction novel Brown Girl in the Ring (1998) is set in a near future dystopian Toronto and contains many African and Caribbean supernatural and folkloric ... [more ▼]

Caribbean-Canadian Nalo Hopkinson's speculative fiction novel Brown Girl in the Ring (1998) is set in a near future dystopian Toronto and contains many African and Caribbean supernatural and folkloric characters. This article focuses on the zombie, which traditionally functions as a symbol of powerlessness, and argues that Hopkinson's book expands the relations of power that this figure is commonly employed to probe. More specifically, the essay suggests that, in Brown Girl in the Ring, the zombie symbolizes black people's history of oppression, exploitation, and demonization. Furthermore, through reading the novel alongside emotion discourse and Vodou psychology, the article contends that the zombie in Hopkinson's book can be understood as being symbolic of the consequential shame that members of the African-Caribbean diaspora may experience from a legacy of oppression, which, significantly, includes internalizing a white Western perception of their African and Caribbean cultural inheritance. [less ▲]

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See detailLe zona chez l'enfant
Nikkels, Arjen ULiege; Tassoudji, Nazli ULiege; Pierard, Gérald ULiege

in Skin (1999), 2(1), 7-8

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See detailLe zonage de l’insécurité alimentaire du Système d’Alerte Précoce au Niger : l’indice de vulnérabilité
Andres, Ludovic ULiege; Lebailly, Philippe ULiege

in Actes du Premier Colloque de l'université de Parakou (2013, November 27)

La République du Niger a mis en place à partir de 1989 le Système d’Alerte Précoce (SAP) à cause des crises alimentaires récurrentes. L’objectif du SAP vise à prévenir et gérer les crises alimentaires. La ... [more ▼]

La République du Niger a mis en place à partir de 1989 le Système d’Alerte Précoce (SAP) à cause des crises alimentaires récurrentes. L’objectif du SAP vise à prévenir et gérer les crises alimentaires. La prévention des crises alimentaires est réalisée en décrivant l’état de l’insécurité alimentaire par département. Il est évalué par un indice composite construit à partir de données secondaires récoltées par des fiches d’identification durant le mois d’octobre. L’objectif de l’article est de décrire la méthode d’évaluation de l’indice et d’étudier l’évolution de l’indice de vulnérabilité. L’étude de l’évolution de l’indice de vulnérabilité du SAP est réalisée grâce à l’étude d’une série chronologique. Les tendances évolutives seront caractérisées pour la période allant de 1992 à 2011, soit l’évolution de l’indice sur vingt ans. L’étude de l’indice du SAP nous permettra de valider les observations que nous avons déjà réalisées dans certains articles abordant les méthodes d’évaluation de la vulnérabilité alimentaire. Le zonage géographique des indices des 37 départements du Niger montre une différence entre les départements pastoraux, agropastoraux et agricoles (Andres L. et Lebailly Ph., 2011a ; Andres L. et Lebailly Ph., 2011b ; Andres L. et Lebailly Ph., 2012 ; Andres L., 2012). En outre, nos résultats démontreront l’aspect conjoncturel des crises alimentaires sans montrer une tendance générale en fonction des départements et des systèmes de production même si les départements présentent une résilience. [less ▲]

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See detailZonage écologique et propriété. Compensation et indemnisation
Pâques, Michel ULiege

in Le zonage écologique (2002)

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See detailZonage phénoclimatique et caractérisation des parcours naturels du Sénégal avec les données de télédétection satellitaire
Diouf, Abdoul Aziz ULiege; Faye, G.; Minet, Julien ULiege et al

in XXVIIIème Colloque de l’Association Internationale de Climatologie, Liège 1-5 juillet 2015 (2015, July 02)

Les métriques phénologiques qui expriment certains événements du cycle de vie des plantes, tels que l'émergence, la croissance et la sénescence, principalement liées aux conditions météorologiques et au ... [more ▼]

Les métriques phénologiques qui expriment certains événements du cycle de vie des plantes, tels que l'émergence, la croissance et la sénescence, principalement liées aux conditions météorologiques et au climat, ont été utilisées afin : (i) de déterminer, à travers les parcours naturels du Sénégal, des entités "phénoclimatiques" homogènes ou phénorégions par classification non-supervisée des images de la série temporelle (1999-2013); (ii) d’analyser l’homogénéité des phénorégions en comparant l’évolution interannuelle de l’indice et des quantités de précipitation et (iii) de donner leurs principales caractéristiques biophysiques. Les résultats obtenus montrent que le domaine pastoral sénégalais peut être subdivisé en trois phénorégions à partir de la grande intégrale du NDVIS10 qui donne les entités spatiales les plus homogènes dans lesquelles les paramètres biophysiques comportent une variation latitudinale caractéristique du Sahel [less ▲]

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