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See detailZisterzienser, Zisterzienserinnen
Henneau, Marie-Elisabeth ULg

in Lexikon des Mittelalters IV Alte Niederlandse t. IX (1998)

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See detailZn(Ii) Dependence of the Aeromonas Hydrophila Ae036 Metallo-Beta-Lactamase Activity and Stability
Hernandez Valladares, M.; Felici, A.; Weber, Georges ULg et al

in Biochemistry (1997), 36(38), 11534-41

Two Zn2+ binding sites were found in the Aeromonas hydrophila AE036 metallo-beta-lactamase. The affinity of the first binding site for Zn2+ ions is so high that the dissociation constant could not be ... [more ▼]

Two Zn2+ binding sites were found in the Aeromonas hydrophila AE036 metallo-beta-lactamase. The affinity of the first binding site for Zn2+ ions is so high that the dissociation constant could not be determined, but it is significantly lower than 20 nM. The mono-Zn2+ form of the enzyme exhibits a maximum activity against its carbapenem substrates. The presence of a Zn2+ ion in the second lower affinity binding site results in a loss of enzymatic activity with a Ki value of 46 microM at pH 6.5. The kinetic analysis is in agreement with a noncompetitive inhibition mechanism. The Zn content of the A. hydrophila enzyme is also strongly pH-dependent. With an external Zn2+ ion concentration of 0.4 microM, occupancy of the higher affinity site by metal ions is lower than 10% at pH 5 and 10. The affinity for the second binding site seems to increase from pH 6 to 7.5. Fluorescence emission and circular dichroism spectra revealed slight conformational changes upon titration of the apoenzyme by Zn2+ ions, resulting in the successive saturation of the first and second binding sites. Differential scanning calorimetry transitions and intrinsic fluorescence emission spectra in the presence of increasing concentrations of urea demonstrate that the catalytic zinc strongly stabilizes the conformation of the enzyme whereas the di-Zn enzyme is even more resistant to thermal and urea denaturation than the mono-Zn enzyme. The Zn2+ dependency of the activity of this metallo-beta-lactamase thus appears to be very different from that of the homologous Bacteroides fragilis enzyme for which the presence of two Zn2+ ions per molecule of protein appears to result in maximum activity. [less ▲]

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See detailZn, Cu, Cd and Hg Binding to Metallothioneins in Harbour Porpoises Phocoena Phocoena from the Southern North Sea
Das, Krishna ULg; De Groof, Arnaud; Jauniaux, Thierry ULg et al

in BMC Ecology (2006), 6

BACKGROUND: Harbour porpoises Phocoena phocoena from the southern North Sea are known to display high levels of Zn and Hg in their tissues linked to their nutritional status (emaciation). The question ... [more ▼]

BACKGROUND: Harbour porpoises Phocoena phocoena from the southern North Sea are known to display high levels of Zn and Hg in their tissues linked to their nutritional status (emaciation). The question arises regarding a potential role of metallothioneins (MTs) with regard to these high metal levels. In the present study, metallothionein detection and associated Zn, Cd, Cu and Hg concentrations were investigated in the liver and kidney of 14 harbour porpoises collected along the Belgian coast. RESULTS: Metallothioneins seemed to play a key role in essential metal homeostasis, as they were shown to bind 50% of the total hepatic Zn and 36% of the total hepatic Cu concentrations. Renal MTs also participated in Cd detoxification, as they were shown to bind 56% of the total renal Cd. Hg was mainly found in the insoluble fraction of both liver and kidney. Concomitant increases in total Zn concentration and Zn bound to MTs were observed in the liver, whereas Zn concentration bound to high molecular weight proteins remained constant. Cu, Zn and Cd were accumulated preferentially in the MT fraction and their content in this fraction increased with the amount in the hepatocytosol. CONCLUSION: MTs have a key role in Zn and Cu homeostasis in harbour porpoises. We demonstrated that increasing hepatic Zn concentration led to an increase in Zn linked to MTs, suggesting that these small proteins take over the Zn overload linked to the poor body condition of debilitated harbour porpoises. [less ▲]

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See detailZnaczenie inżynierii powierzchni w naprawach betonu
Garbacz, Andrzej; Piotrowski, Tomasz; Courard, Luc ULg

in Kaminski, M.; Jasiczak, J.; Buczkowski, W. (Eds.) et al Współczesne metody naprawcze w obiektach budowlanych (2009)

Recently, an efficiency of concrete repair is treated as the civilizing challenge. This was also the genesis to elaborate family of European standards EN 1504. The part 10 of this standard gives ... [more ▼]

Recently, an efficiency of concrete repair is treated as the civilizing challenge. This was also the genesis to elaborate family of European standards EN 1504. The part 10 of this standard gives requirements for substrate condition before and during application including structural stability, storage, the preparation and application of products and systems for the protection and repair of concrete structures including quality control, maintenance, health and safety, and the environment. According to this standard a suitable preparation of concrete substrate prior a repair is considered as the one of the important factors affecting durability of concrete repair. Recently, experiences in this filed is ordered in the framework of scientific approach called concrete surface engineering. The main goal of this approach is analysis of qualitative and quantitative relationships between surface quality and repair durability. The aim of this paper is to analyze an effect of surface treatment on surface quality and adhesion in repair system using concrete surface engineering approach. [less ▲]

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See detailZnO/PVA Macroscopic Fibers Bearing Anisotropic Photonic Properties
Kinadjian, Natacha ULg; Achard, Marie-France; Julian-Lopez, Beatriz et al

Poster (2012, November 25)

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of ... [more ▼]

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of the ZnO nanorods along the main axis of the PVA fiber. This photonic anisotropy is triggered by a synergistic interaction between the PVA matrix, stretched above the glass transition temperature (Tg), and cooled down under strain. Compared with non-elongated fibers that present an isotropic emission, composite fibers previously submitted to a tensile stress absorb selectively UV emission when the polarized laser beam is parallel to the main axis of the fiber. In addition, their photolumincescence is also anisotropic, with a waveguide behavior along the main axis of the fiber. Mechanical properties of these composite fibers are also drastically improved, compared with pure PVA fibers: the longitudinal Young modulus of these fibers is increased from 2 to 6 GPa upon ZnO addition, a value similar to those already observed for composite fibers, prepared either with carbon nanotubes, or V2O5 macroscopic fibers. [less ▲]

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See detailZnO/PVA Macroscopic Fibers Bearing Anisotropic Photonic Properties
Kinadjian, Natacha ULg; Achard, Marie-France; Julian-Lopez, Beatriz et al

Conference (2013, August 30)

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See detailZnO/PVA Macroscopic Fibers Bearing Anisotropic Photonic Properties
Kinadjian, Natacha ULg; Achard, Marie-France; Julian-Lopez, Beatriz et al

Conference (2013, March)

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of ... [more ▼]

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of the ZnO nanorods along the main axis of the PVA fiber. This photonic anisotropy is triggered by a synergistic interaction between the PVA matrix, stretched above the glass transition temperature (Tg), and cooled down under strain. Compared with non-elongated fibers that present an isotropic emission, composite fibers previously submitted to a tensile stress absorb selectively UV emission when the polarized laser beam is parallel to the main axis of the fiber. In addition, their photolumincescence is also anisotropic, with a waveguide behavior along the main axis of the fiber. Mechanical properties of these composite fibers are also drastically improved, compared with pure PVA fibers: the longitudinal Young modulus of these fibers is increased from 2 to 6 GPa upon ZnO addition, a value similar to those already observed for composite fibers, prepared either with carbon nanotubes, or V2O5 macroscopic fibers. [less ▲]

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See detailZnO/PVA Macroscopic Fibers Bearing Anisotropic Photonic Properties
Kinadjian, Natacha ULg; Achard, Marie-France; Julian-lopez, Beatriz et al

in Advanced Functional Materials (2012)

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of ... [more ▼]

Composite PVA/ZnO-nanorods fibers, synthesized through co-axial flux extrusion exhibit higher anisotropic photonic properties, both in absorption and emission, as a result of the collective alignment of the ZnO nanorods along the main axis of the PVA fiber. This photonic anisotropy is triggered by a synergistic interaction between the PVA matrix, stretched above the glass transition temperature (Tg), and cooled down under strain. Compared with non-elongated fibers that present an isotropic emission, composite fibers previously submitted to a tensile stress absorb selectively UV emission when the polarized laser beam is parallel to the main axis of the fiber. In addition, their photolumincescence is also anisotropic, with a waveguide behavior along the main axis of the fiber. Mechanical properties of these composite fibers are also drastically improved, compared with pure PVA fibers: the longitudinal Young modulus of these fibers is increased from 2 to 6 GPa upon ZnO addition, a value similar to those already observed for composite fibers, prepared either with carbon nanotubes, or V2O5 macroscopic fibers. [less ▲]

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See detailHet zoekgeraakte bijproduct. Over literaire prijzen
Spinoy, Erik ULg

in Freespace Nieuwzuid (2008), 8(32), 6-23

This article reflects on the growing importance of literary prizes, while other literary institutions are rapidly losing ground and influence.

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See detailZoektocht naar een levende prothese
De Gersem, Hilde; Geris, Liesbet ULg

in Het Ingenieursblad (2003), 72(8/9), 54-60

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen ... [more ▼]

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen, of zorgt de behandeling niet voor volledig herstel van de functionaliteit. Vooral bij grote botdefecten is de vraag naar een permanente, biologische en patiëntvriendelijkere oplossing groot. Dit artikel kadert in het onderzoek naar een behandeling met behulp van met botcellen ingezaaide poreuze draagstructuren. [less ▲]

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See detailZola et l'invention du roman naturaliste
Bertrand, Jean-Pierre ULg

in Saint-Amand, Denis (Ed.) La Préface. Formes et enjeux d'un discours d'escorte (2016)

Le concept d'invention escorte l'émergence de la littérature au XIXe siècle parallèlement à ce qui l'a transformé dans les sciences et les techniques. Cela signifie que la littérature peut aussi être ... [more ▼]

Le concept d'invention escorte l'émergence de la littérature au XIXe siècle parallèlement à ce qui l'a transformé dans les sciences et les techniques. Cela signifie que la littérature peut aussi être saisie comme un champ de production du nouveau, et qu'elle a à voir avec les notions de découverte, de crise, de progrès, de technique. La préface sert de laboratoire réflexif aux expérimentations romanesques, que l'auteur des Rougon-Macquart est appelé à justifier, expliquer, négocier, voire vulgariser. [less ▲]

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See detailZola ethnographe ?
Ledent, David ULg

in Cahiers Naturalistes : Bulletin officiel de la Société Littéraire des Amis d'Emile Zola (2014), 88

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See detailZola face aux émotions
Ledent, David ULg

Conference (2014, March 30)

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See detailZola in Sciascia. Una nota su Candido
Curreri, Luciano ULg

E-print/Working paper (2014)

Detailed reference viewed: 117 (4 ULg)
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See detailZola in Sciascia: Una nota su Candido (1977) e sul corpo
Curreri, Luciano ULg

in Baldassarri, Guido (Ed.) I cantieri dell’italianistica. Ricerca, didattica e organizzazione agli inizi del XXI secolo. (2016)

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See detailZola sociologue du quotidien
Ledent, David ULg

Conference (2010, November 06)

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See detailZoledronate inhibits alpha v beta 3 and alpha v beta 5 integrin cell surface expression in endothelial cells
Bellahcene, Akeila ULg; Chaplet, Michael; Bonjean, K. et al

in Endothelium : Journal of Endothelial Cell Research (2007), 14(2), 123-130

Zoledronate exhibits antiangiogenic properties in vitro and in vivo. Integrins alpha v beta 3 and alpha v beta 5 are involved in angiogenesis. Because zoledronate inhibits endothelial cell adhesion, the ... [more ▼]

Zoledronate exhibits antiangiogenic properties in vitro and in vivo. Integrins alpha v beta 3 and alpha v beta 5 are involved in angiogenesis. Because zoledronate inhibits endothelial cell adhesion, the authors explored the hypothesis that it could alter these integrins recruitment to focal adhesion sites. Human umbilical vein endothelial cells ( HUVECs) were treated with zoledronate or with mevalonate pathway intermediates geranylgeraniol ( GGOH) and farnesol (FOH). Zoledronate generated a significant decrease in alpha v beta 3 and alpha v beta 5 expression at HUVEC cell surface using flow cytometry and immunofluorescence. This inhibition was reversed by GGOH but not by FOH. Cells cotreated with zoledronate and GGOH were able to attach to vitronectin through alpha v beta 3 and alpha v beta 5, as confirmed by the use of specific function-blocking antibodies. The authors showed that zoledronate alters endothelial cell integrin-mediated adhesion. This effect is likely to contribute to the previously demonstrated antiangiogenic effect of zoledronate. Whether this mechanism of action also applies to metastatic tumor cells is under investigation. [less ▲]

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See detailZoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial.
Reid, David M; Devogelaer, Jean-Pierre; Saag, Kenneth et al

in Lancet (2009), 373(9671), 1253-63

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral ... [more ▼]

BACKGROUND: Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral fractures, but are associated with poor compliance and adherence. We aimed to assess whether one intravenous infusion of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. METHODS: This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. 833 patients were randomised 1:1 to receive zoledronic acid (n=416) or risedronate (n=417). Patients were stratified by sex, and allocated to prevention or treatment subgroups dependent on duration of glucocorticoid use immediately preceding the study. The treatment subgroup consisted of those treated for more than 3 months (272 patients on zoledronic acid and 273 on risedronate), and the prevention subgroup of those treated for less than 3 months (144 patients on each drug). 62 patients did not complete the study because of adverse events, withdrawal of consent, loss to follow-up, death, misrandomisation, or protocol deviation. The primary endpoint was percentage change from baseline in lumbar spine bone mineral density. Drug efficacy was assessed on a modified intention-to-treat basis and safety was assessed on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov, number NCT00100620. FINDINGS: Zoledronic acid was non-inferior and superior to risedronate for increase of lumbar spine bone mineral density in both the treatment (least-squares mean 4.06% [SE 0.28] vs 2.71% [SE 0.28], mean difference 1.36% [95% CI 0.67-2.05], p=0.0001) and prevention (2.60% [0.45] vs 0.64% [0.46], 1.96% [1.04-2.88], p<0.0001) subgroups at 12 months. Adverse events were more frequent in patients given zoledronic acid than in those on risedronate, largely as a result of transient symptoms during the first 3 days after infusion. Serious adverse events were worsening rheumatoid arthritis for the treatment subgroup and pyrexia for the prevention subgroup. INTERPRETATION: A single 5 mg intravenous infusion of zoledronic acid is non-inferior, possibly more effective, and more acceptable to patients than is 5 mg of oral risedronate daily for prevention and treatment of bone loss that is associated with glucocorticoid use. [less ▲]

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See detailZoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
Chaplet, Michaël; Deroanne, Christophe ULg; Fisher, Larry W. et al

in Biochemical Journal (2004), 384(Pt 3), 591-598

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these ... [more ▼]

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these beneficial effects of BPs are still poorly understood. We hypothesized that ZOL (zoledronic acid), a potent third-generation BP, may induce the expression of proteins associated with the bone-forming potential of osteoblastic cells such as BSP (bone sialoprotein). Expression of BSP gene is up-regulated by hormones that promote bone formation and has been associated with de novo bone mineralization. Using real-time reverse transcriptase-PCR and Western-blot analysis, we demonstrated that ZOL increased BSP expression in Saos-2 osteoblast-like cells. Nuclear run-on and mRNA decay assays showed no effect at the transcriptional level but a stabilization of BSP transcripts in ZOL-treated cells. ZOL effect on BSP expression occurred through an interference with the mevalonate pathway since it was reversed by either mevalonate pathway intermediates or a Rho GTPase activator. We showed that ZOL impaired membrane localization of RhoA in Saos-2 cells indicating reduced prenylation of this protein. By the use of small interfering RNAs directed to RhoA and Rac1, we identified both Rho GTPases as negative regulators of BSP expression in Saos-2 cells. Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity. [less ▲]

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