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See detail18fdg-Pet for the Assessment of Primary Head and Neck Tumors: Clinical, Computed Tomography, and Histopathological Correlation in 38 Patients
Paulus, Patrick; Sambon, A.; Vivegnis, Danielle et al

in Laryngoscope (1998), 108(10), 1578-83

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck ... [more ▼]

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck cancer. STUDY DESIGN: Retrospective review of 38 patients with biopsy-proven head and neck cancers who underwent clinical, computed tomography (CT), and FDG-PET examinations. Twenty-five patients were studied prior to therapy and 13 patients were evaluated for disease recurrence. METHODS: All patients were operated and clinical data, CT, and FDG-PET results were correlated with histopathological findings. RESULTS: All primary tumors in 25 patients were detected, with the exception of one small superficial localization of the epiglottis. Histopathological examination showed lymph node involvement in 10 patients; PET detected lymph node involvement in five. FDG-PET found one case of nodal disease not identified by clinical and CT examination. With so few cases, this could be anecdotal. Five false-negative results (microscopic lymph node involvement) and two false positives were noted. Twelve of 13 patients with recurrent disease were correctly identified with FDG-PET. FDG-PET was the only imaging technique to identify local recurrence in two patients and lymph node involvement in two others. One false-positive result occurred in a patient with a foreign body granuloma. CONCLUSIONS: FDG-PET is a useful diagnostic modality for the detection of recurrent tumors and, in selected cases, precise lymph node involvement. The best way to further investigate the utility of clinical FDG-PET is in the follow-up of treated patients. [less ▲]

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See detail(19) F NMR in vivo spectroscopy reflects the effectiveness of perfusion - enhancing vascular modifiers for improving gemcitabine chemotheraypy
Cron, Greg O.; Ansiaux; MARTINIVE, Philippe ULg et al

in Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine (2008)

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of ... [more ▼]

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of fluorine-19 ((19)F NMR) has proven useful for evaluating kinetics of fluorinated chemotherapy drugs in tumors in vivo. This work investigated how three perfusion-enhancing vascular modifiers (BQ123, thalidomide, and Botulinum neurotoxin type A [BoNT-A]) would affect the chemotherapeutic efficacy of gemcitabine, a fluorinated drug widely used in human cancer treatment. Murine tumor growth experiments demonstrated that only BoNT-A showed a strong trend to enhance tumor growth inhibition by gemcitabine (1.7 days growth delay, P = 0.052, Student t-test). In accord with these results, (19)F NMR experiments showed that only BoNT-A increased significantly the uptake of gemcitabine in tumors (50% increase, P = 0.0008, Student t-test). Further experiments on gemcitabine kinetics (NMR vs time) and distribution ((19)F MRI) confirmed the uptake-enhancing properties of BoNT-A. The results of this study demonstrate that (19)F NMR can monitor modulation of the pharmacokinetics of fluorinated chemotherapy drugs in tumors. The results also show that (19)F NMR data can give a strong indication of the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy in murine tumors. (19)F NMR is a promising tool for preclinical evaluation of such vascular modifiers and may ultimately be used in the clinic to monitor how these modifiers affect chemotherapy. 2007 Wiley-Liss, Inc PMID: 18050344 [PubMed - indexed for MEDLINE] [less ▲]

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See detailThe 19-27 Amino-Acid Segment Of Gp51 Adopts An Amphiphilic Structure And Plays A Key Role In The Fusion Events Induced By Bovine Leukemia-Virus
Voneche, V.; Callebaut, I.; Kettmann, Richard ULg et al

in Journal of Biological Chemistry (1992), 267(21),

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S ... [more ▼]

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S., Portetelle, D., Berte, C., Franssen, J. D., Herion, P., and Burny, A. (1982) Virology 122, 342-352; Voneche, V., Portetelle., D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3810-3814) and suggest that a region encompassing residues 23 and 25 of gp51 is involved in this process (Portetelle, D., Couez, D., Bruck, C., Kettmann, R., Mammerickx, M., Van der Maaten, M., Brasseur, R., and Burny, A. (1989) Virology 169, 27-33; Mamoun, R., Morisson, M., Rebeyrotte, N., Busetta, B., Couez, D., Kettmann, R., Hospital, M., and Guillemain, B. (1990) J. Virol. 64, 4180-4188). X-ray diffraction studies performed on envelope glycoproteins of influenza virus indicate that the NH2-terminal part of the external glycoprotein lies very close to the fusion peptide. The same overall structure seems to exist in human immunodeficiency virus as suggested by site-directed mutagenesis followed by syncytia induction assays. Our theoretical studies indicate that a segment expanding between residues 19 and 27 of gp51 probably adopts an amphipathic beta-strand structure. We hypothesize that the amphipathic 19-27 structure of gp51 plays an important role in the process of membrane fusion by interacting with the fusion peptide or with another region of gp30. Mutational analysis disrupting the amphipathy of the 19-27 region strongly altered the fusogenic capacity of the gp51-gp30 complex. [less ▲]

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See detail19. Oiseaux
Lougbegnon, Toussaint; Libois, Roland ULg

in Neuenschwander, Peter; Sinsin, Brice; Goergen, Georg (Eds.) Protection de la nature en Afrique de l'Ouest: une liste rouge pour le Bénin (2011)

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See detail1903-2003. Cent ans de géographie à l’Université de Liège : changements et permanences
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (2004), (44), 125-127

Address of the 100th anniversary of the Institute of Geography, University of Liege

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See detail1905-2005 : de la tuberculose au sida
Jaminon, Martine ULg; Brouwir, Christine ULg; Dumont, Pascal

Learning material (2005)

plaquette de l'exposition " 1905- 2005 : de la tuberculose au sida"

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See detail1910 : Solitudini e seduzioni fatali. Leila e Forse che sì forse che no
Curreri, Luciano ULg

in Neiger, Ada (Ed.) All'insegna della femme fatale (1994)

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See detail1914-1918, La Grande Guerre vue de la Province de Liège et de Belgique
Pirot, Pascal ULg; Province de Liège, Enseignement

Learning material (2014)

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See detail192-Ir or 125-I Prostate Brachytherapy as a Boost to External Beam Radiotherapy in Locally Advanced Prostatic Cancer: A Dosimetric Point of View
Nickers, Philippe ULg; Thissen, Benedicte ULg; Jansen, Nicolas ULg et al

in Radiotherapy & Oncology (2006), 78(1), 47-52

PURPOSE: This work aims at comparing the dosimetric possibilities of 125I or 192Ir prostate brachytherapy (Bt) as a boost to external beam radiotherapy in the treatment of locally advanced adenocarcinoma ... [more ▼]

PURPOSE: This work aims at comparing the dosimetric possibilities of 125I or 192Ir prostate brachytherapy (Bt) as a boost to external beam radiotherapy in the treatment of locally advanced adenocarcinoma. METHODS AND MATERIALS: From 1/1997 to 12/2002, 260 patients were treated. Until 12/2001 a low dose rate (LDR) treatment with 192Ir wires was used, later replaced by a high dose rate (HDR) delivered with an 192Ir stepping source technology. For the present work, we selected 40 patients including the last 20 treated, respectively, by LDR and HDR. The planning CT Scans of all these 40 patients were transferred into the 3D Prowess system for 125I permanent implants design according to the Seattle method. The reference data for dosimetric comparisons were the V100 and the prescribed dose for 192Ir as well as the dose delivered with 125I techniques to the 192Ir V100. We compared V100-150 data as well as doses to the organs at risks (OR) and cold spots (CS). RESULTS: The V100 is 85.3+/-8% for 192Ir LDR and 96+/-2% for HDR techniques (P < 0.0001). In comparison with 125I, the 192Ir LDR mode induces higher hyperdosage volumes inside the CTV but also more CS, while maximal doses to urethra and rectum are, respectively, 17 and 39% less with 125I (P < 0.0001). In comparison with the 192Ir HDR mode, 125I Bt induces higher hyperdosage volumes and slightly more CS deliberately planned around the bladder neck. If delivered doses to urethra are identical, those to the 20% anterior part of the rectum are 33% less with 125I (P < 0,0001). The 125I Bt technique was only possible in 24 out of the 40 patients studied due to pelvic bone arch interference. CONCLUSIONS: At the present time, there is no evident dosimetric superiority of one Bt method when all the criteria are taken into account. However, improving Bt techniques to implant any prostatic size could found the superiority of the 125I or permanent implants. 125I indeed allows large hyperdosage volumes inside the CTV in comparison with 192Ir HDR techniques while lowering doses to OR and minimizing CS. [less ▲]

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See detail1924 : Marcel Thiry publie Toi qui pâlis au nom de Vancouver. « Docteur, j’ai un pied dans le XIXe neuvième siècle »
Purnelle, Gérald ULg

in Bertrand, Jean-Pierre; Biron, Michel; Denis, Benoît (Eds.) et al Histoire de la littérature belge francophone : 1830-2000 (2003)

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See detail192ir Low Dose Rate Brachytherapy for Boosting Locally Advanced Prostate Cancers after External Beam Radiotherapy: A Phase Ii Trial
Nickers, Philippe ULg; Coppens, Luc ULg; De Leval, Jean ULg et al

in Radiotherapy & Oncology (2006), 79(3), 329-34

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir ... [more ▼]

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir low dose rate brachytherapy (Bt) (40-45 Gy). PATIENTS AND METHODS: Sixty-four patients were included in the intermediate prognosis group with only one of the following adverse factors (PSA > 10 ng/ml, Gleason score > or = 7 or clinical stage > or =T2b) and 137 in the unfavourable group when at least two of these factors were present. RESULTS: The actuarial 4 years biochemical no evidence of disease is 82.8% for the entire population. It is, respectively, 97 and 76% in the intermediate and unfavourable prognosis groups (P < 0.0001). Grade > or =3 late urinary complications occurred in 13 patients (6.5%). Eight patients (4%) presented late grade 2 rectal complications but no grades 3-5 was observed. CONCLUSIONS: Even if an alpha/beta of 1.5-3 Gy theoretically favours the use of a high dose rate mode of irradiation, the early results presented here are as good as those reported for similar groups of patients with high dose rate treatments. Late toxicity is identical but our urinary toxicity is within the less favourable and rectal toxicity within the most favourable results. We can postulate that while inducing very high hyperdosage regions (V150) mainly focused on the peripheral zone, most of the Bt techniques consist of a more ablative treatment. Many of the radiobiological studies on Bt did not in fact take into account the heterogeneity of irradiation inside the CTV. This study highlights the need to explore pulsed dose rate therapies, permanent implant and new available radioisotopes such as (169)Ytterbium that will offer the safety of low and lower dose rates. The actual late toxicity of the different Bt techniques is not yet inexistent indeed. [less ▲]

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See detail1936-1940. Roman, reportage, théâtre, cinéma, BD au service du fascisme italien
Curreri, Luciano ULg

in Cahiers Internationaux de Symbolisme (2009), 122-123-124

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See detail1944-1945: tournant ou césure dans les relations franco-belges?
Lanneau, Catherine ULg

Scientific conference (2009, February 25)

L’imaginaire collectif réserve une place particulière à la "France éternelle", fer de lance de la civilisation européenne, fière de l’héritage de son passé comme des "principes de 89". Le devenir, le rôle ... [more ▼]

L’imaginaire collectif réserve une place particulière à la "France éternelle", fer de lance de la civilisation européenne, fière de l’héritage de son passé comme des "principes de 89". Le devenir, le rôle voire la mission de la "France nouvelle", celle du rédempteur de Gaulle, font débat en 1944-45. Dans une Europe en ruines, elle est l’inconnue de l’heure, celle dont le futur peut être fait du meilleur comme du pire. À la fois proches et différents d'elle, les francophones de Belgique, pétris de la même culture, oscilleront cependant entre amour et haine, entre la proclamation d’une parenté spirituelle et ethnique, et le souci d’affirmer une identité propre, la future belgitude. Pour eux aussi, la période 1944-45, entre les stigmates de la guerre et les déchirements de la Question Royale, n’est qu’une suite d’interrogations. Pour la première fois, le mouvement wallon se montre plus actif et revendicatif qu’un flamingantisme contraint par ses mauvais choix à une courbe rentrante. Craintes ou espoirs, étayés par le mythe de cette France résistante et novatrice, tant en politique intérieure qu’extérieure, agitent au besoin l’hypothèse d’un rattachement. Mais, très rapidement, le mythe fait place au malaise entre Bruxelles et Paris, d’autant que, désormais, la France doit affronter, sur tous les terrains, la fascination exercée par ses concurrents Anglo-Américains. [less ▲]

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See detailThe 1958-2008 Greenland ice sheet surface mass balance variability simulated by the regional climate model MAR
Fettweis, Xavier ULg

Poster (2009, April 24)

Results made with the regional climate model MAR over 1958-2008 show a very high interannual variability of the Greenland ice sheet (GrIS) surface mass balance (SMB) modelled in average to be 330 +/- 130 ... [more ▼]

Results made with the regional climate model MAR over 1958-2008 show a very high interannual variability of the Greenland ice sheet (GrIS) surface mass balance (SMB) modelled in average to be 330 +/- 130 km^3/yr. To a first approximation, the SMB variability is driven by the annual precipitation anomaly minus the meltwater run-off rate variability. Sensitivity experiments carried out by the MAR model evaluate the impacts on the surface melt of (i) the summer SST around the Greenland, (ii) the snow pack temperature at the beginning of the spring, (iii) the winter snow accumulation, (iv) the solid and liquid summer precipitations and (v) the summer atmospheric circulation. This last one, by forcing the summer air temperature above the ice sheet, explains mainly the surface melt anomalies. [less ▲]

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See detailThe 1958-2008 Greenland ice sheet surface melt and the mid-tropospheric atmospheric circulation
Fettweis, Xavier ULg

Conference (2009, April 23)

With the aim to study the impact of the mid-tropospheric circulation on the Greenland ice sheet (GrIS) surface melt simulated by the regional climate model MAR, we developed an automatic Circulation Type ... [more ▼]

With the aim to study the impact of the mid-tropospheric circulation on the Greenland ice sheet (GrIS) surface melt simulated by the regional climate model MAR, we developed an automatic Circulation Type Classification (CTC) based on the 500hPa geopotential height from reanalyses over the period 1958-2008. This CTC shows that the dominant mode of the regional atmospheric summer variability around the GrIS is linked to the North Atlantic Oscillation (NAO) and that the surface melt anomalies are highly correlated to the general circulation. It explains notably why a record surface melt was observed during the summers 2007 and 2008. In addition, the climate conditions occurring the 27th August of 2003, where the GrIS temperature was 10°C higher than the normal, were the consequence of an almost unique 500 hPa circulation in the 50 last years. [less ▲]

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See detailThe 1958–2009 Greenland ice sheet surface melt and the mid-tropospheric atmospheric circulation
Fettweis, Xavier ULg; Mabille, Georges; Erpicum, Michel ULg et al

in Climate Dynamics (2011), 36(1 (2011)), 139-159

In order to assess the impact of the mid-tropospheric circulation over the Greenland ice sheet (GrIS) on surface melt, as simulated by the regional climate model MAR, an automatic Circulation type ... [more ▼]

In order to assess the impact of the mid-tropospheric circulation over the Greenland ice sheet (GrIS) on surface melt, as simulated by the regional climate model MAR, an automatic Circulation type classification (CTC) based on 500 hPa geopotential height from reanalyses is developed. General circulation correlates significantly with the surface melt anomalies for the summers in the period 1958–2009. The record surface melt events observed during the summers of 2007–2009 are linked to the exceptional persistence of atmospheric circulations favouring warm air advection. The CTC emphasizes that summer 500 hPa circulation patterns have changed since the beginning of the 2000s; this process is partly responsible for the recent warming observed over the GrIS. [less ▲]

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See detail195au Biokinetics and Dosimetry
Brihaye, C.; Guillaume, Marcel

in European Journal of Nuclear Medicine (1990), 16(4-6), 369-71

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