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See detail17β-estradiol levels in male zebra finch brain: combining Palkovits punch and an ultrasensitive radioimmunoassay
Charlier, Thierry ULg; Po, Kevin WL; Newman, Amy EM et al

in General and Comparative Endocrinology (2010), 167

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See detail18 F-labeled analogues of anti-tumor agent calixarene 0118
Läppchen, Tilman; Rossin, Raffaella; van Mourik, Tiemen et al

Conference (2013, May 14)

Calix[4]arene compound 0118 , a topomimetic of the antiangiogenic amphipathic peptide anginex targeting galectin-1, is currently in Phase I clinical trials with terminal cancer patients. Radiolabelled ... [more ▼]

Calix[4]arene compound 0118 , a topomimetic of the antiangiogenic amphipathic peptide anginex targeting galectin-1, is currently in Phase I clinical trials with terminal cancer patients. Radiolabelled analogues of compound 0118 may serve as a development tool in PK/PD studies of this class of calix[4]arene compounds, and may prove highly valuable for patient stratification and therapy monitoring. So far, such radiotracers have not been described. In this work, we have designed compound 0118 analogues containing a terminal alkyne functional group for introduction of an F-18 label via Cu(I)-catalyzed 1,3-dipolar cycloaddition of 2-[18F]fluoroethylazide. [less ▲]

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See detail18 kyr, 120 kyr & 5 Myr shortening rates along the front of the southern Tianshan Mountains (China),
Hubert, Aurelia ULg; Suppe, J; Wang, Xin et al

in Geological Society of America - Abstracts with Programs (1999, October), 31(7),

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See detailThe 18 September 1692 Earthquake in the Belgian Ardenne and its aftershocks
Alexandre, Pierre ULg; Kusman, David; Camelbeeck, Thierry et al

in Fréchet, J.; Meghraoui, M.; Stucchi, M. (Eds.) Historical Seismology. Interdisciplinary Studies of Past and Recent Earthquakes (2008)

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See detail[(18)F]p-MPPF: A radiolabeled antagonist for the study of 5-HT(1A) receptors with PET
Plenevaux, Alain ULg; Lemaire, Christian ULg; Aerts, Joël ULg et al

in Nuclear Medicine & Biology (2000), 27(5), 467-71

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A ... [more ▼]

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism. [less ▲]

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See detail180 degrees Pinhole SPET with a tilted detector and OS-EM reconstruction: phantom studies and potential clinical applications
Seret, Alain ULg; Defrise, Michel ULg; Blocklet, Didier

in European Journal of Nuclear Medicine (2001), 28(12), 1836-1841

This study investigated the feasibility of ordered subsets expectation maximisation (OS-EM) reconstruction of pinhole single-photon emission tomography (SPET) acquired with a tilted detector head and a ... [more ▼]

This study investigated the feasibility of ordered subsets expectation maximisation (OS-EM) reconstruction of pinhole single-photon emission tomography (SPET) acquired with a tilted detector head and a 180 degrees orbit. Phantom and patient data were recorded using a standard single-head camera. Reconstructions were performed using a dedicated OS-EM algorithm. Reconstructed images of line, uniformity and Picker's thyroid phantoms showed that the geometry, physical size and uniformity of the radioactive objects were preserved. For the range of radius corresponding to the patient studies, the measured full-widths at half-maximum lay between 4.90+/-0.25 mm and 6.05+/-0.25 mm. Finally, the gain in resolution associated with the use of the pinhole collimator instead of a parallel-hole collimator was highlighted in a parathyroid exploration and in a shoulder bone study. [less ▲]

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See detail182 oral EORTC RADIOTHERAPY QUALITY ASSURANCE PLATFORM: ESTABLISHMENT OF AN INTEGRATED CENTRAL REVIEW FACILITY
GULYBAN, Akos ULg; Fenton, Paul A.; Fairchild, Alysa et al

in Radiotherapy & Oncology (2011), 99

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See detail1862. La librairie internationale Lacroix, Verboeckhoven & Cie publie Les Misérables de Victor Hugo. Le contrat du siècle
Durand, Pascal ULg

in Bertrand, Jean-Pierre; Biron, M.; Grutman, R. (Eds.) et al Histoire de la littérature belge (2003)

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See detail1897-1997 Les cent ans de la section des Eaux et Forêts
Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(4), 236-238

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See detail1897-1997, 100 ans de Chimie et Industries agricoles
Wathelet, Bernard ULg; Commission de Chimie et des Bio-industries

Book (2000)

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See detail18F LABELING OF BIOMOLECULES USING CLICK CHEMISTRY FOR PET APPLICATIONS : SYNTHETIC DEVELOPMENTS
Thonon, David ULg; Flagothier, Jessica ULg; Paris, Jérôme ULg et al

in Drugs of the Future (2008, August), 33(A), 235

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See detail18F labelling of Insulin via click chemistry
Paris, Jérôme ULg; Mercier, Frédéric ULg; Thonon, David ULg et al

Poster (2010, May 27)

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See detail(18F)FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas : correlation with histopathology.
WITHOFS, Nadia ULg; SIGNOLLE, N.; NZARAMBA, EM. et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1647

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See detail18f-Fdg Pet Imaging in Assessing Exudative Pleural Effusions
DUYSINX, Bernard ULg; Larock, Marie-Paule ULg; Nguyen, Delphine et al

in Nuclear Medicine Communications (2006), 27(12), 971-6

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural ... [more ▼]

BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases. METHODS: Whole-body 18F-FDG PET was performed in 79 patients with exudative pleurisy. Standard uptake values were normalized for body weight, body surface area, lean body mass (SUVbw, SUVbsa, SUVlbm) with and without correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001). Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The cut-off value for SUVbw which gave the best accuracy (82.3%) was 2.2. When comparing thoracic with extrathoracic primaries the highest accuracy (80.4%) was found for a cut-off value of 2.6. CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries. [less ▲]

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See detail18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneite and Functional Tumor Volume in a Multi-Cancer Site Patient Cohort
HATT, MAT; MAJDOUB, MOHAMED; VALLIERES, MARTIN et al

in Journal of Nuclear Medicine (The) (2015), 56(1), 38-44

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See detail18F-FDG Uptake Assessed by PET/CT in Abdominal Aortic Aneurysms Is Associated with Cellular and Molecular Alterations Prefacing Wall Deterioration and Rupture.
Courtois, Audrey ULg; Richelle, Betty ULg; Hustinx, Roland ULg et al

in Journal of Nuclear Medicine (The) (2013), 54

Rupture of abdominal aortic aneurysms (AAAs) leads to a significant morbidity and mortality in aging populations, and its prediction would be most beneficial to public health. Spots of positive uptake of ... [more ▼]

Rupture of abdominal aortic aneurysms (AAAs) leads to a significant morbidity and mortality in aging populations, and its prediction would be most beneficial to public health. Spots of positive uptake of 18F-FDG detected by PET are found in 12% of AAA patients (PET+), who are most often symptomatic and at high rupture risk. Comparing the 18F-FDG-positive site with a negative site from the same aneurysm and with samples collected from AAA patients with no 18F-FDG uptake should allow the discrimination of biologic alterations that would help in identifying markers predictive of rupture. METHODS: Biopsies of the AAA wall were obtained from patients with no 18F-FDG uptake (PET0, n = 10) and from PET+ patients (n = 8), both at the site of positive uptake and at a distant negative site of the aneurysmal wall. Samples were analyzed by immunohistochemistry, quantitative real-time polymerase chain reaction, and zymography. RESULTS: The sites of the aneurysmal wall with a positive 18F-FDG uptake were characterized by a strikingly increased number of adventitial inflammatory cells, highly proliferative, and by a drastic reduction of smooth muscle cells (SMCs) in the media as compared with their negative counterpart and with the PET0 wall. The expression of a series of genes involved in the maintenance and remodeling of the wall was significantly modified in the negative sites of PET+, compared with the PET0 wall, suggesting a systemic alteration of the aneurysmal wall. Furthermore, a striking increase of several matrix metalloproteinases (MMPs), notably the MMP1 and MMP13 collagenases, was observed in the positive sites, mainly in the adventitia. Moreover, PET+ patients were characterized by a higher circulating C-reactive protein. CONCLUSION: Positive 18F-FDG uptake in the aneurysmal wall is associated with an active inflammatory process characterized by a dense infiltrate of proliferating leukocytes in the adventitia and an increased circulating C-reactive protein. Moreover, a loss of SMC in the media and alterations of the expression of genes involved in the remodeling of adventitia and collagen degradation potentially participate in the weakening of the aneurysmal wall preceding rupture. [less ▲]

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See detail18F-fluoride PET/CT for assessing bone involvement in prostate and breast cancers
Withofs, Nadia ULg; Grayet, Benjamin ULg; Tancredi, Tino ULg et al

in Nuclear Medicine Communications (2011), 32(3), 168-176

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See detail18F-fluoro-L-tyrosine : a potential tracer for whole-body tumor imaging with PET.
HUSTINX, Roland ULg; LEMAIRE, C.; JERUSALEM, Guy ULg et al

in Journal of Nuclear Medicine (The) (2002), 43

Detailed reference viewed: 8 (1 ULg)