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See detail16K Human Prolactin Inhibits Vascular Endothelial Growth Factor-Induced Activation of Ras in Capillary Endothelial Cells
D'Angelo, Gisela; Martini, Jean-François; Iiri, Taroh et al

in Molecular Endocrinology (Baltimore, Md.) (1999), 13(2), 692-704

Signaling pathways mediating the antiangiogenic action of 16K human (h)PRL include inhibition of vascular endothelial growth factor (VEGF)-induced activation of the mitogen-activated protein kinases (MAPK ... [more ▼]

Signaling pathways mediating the antiangiogenic action of 16K human (h)PRL include inhibition of vascular endothelial growth factor (VEGF)-induced activation of the mitogen-activated protein kinases (MAPK). To determine at which step 16K hPRL acts to inhibit VEGF-induced MAPK activation, we assessed more proximal events in the signaling cascade. 16K hPRL treatment blocked VEGF-induced Raf-1 activation as well as its translocation to the plasma membrane. 16K hPRL indirectly increased cAMP levels; however, the blockade of Raf-1 activation was not dependent on the stimulation of cAMP-dependent protein kinase (PKA), but rather on the inhibition of the GTP-bound Ras. The VEGF-induced tyrosine phosphorylation of the VEGF receptor, Flk-1, and its association with the Shc/Grb2/Ras-GAP (guanosine triphosphatase-activating protein) complex were unaffected by 16K hPRL treatment. In contrast, 16K hPRL prevented the VEGF-induced phosphorylation and dissociation of Sos from Grb2 at 5 min, consistent with inhibition by 16K hPRL of the MEK/MAPK feedback on Sos. The inhibition of Ras activation was paralleled by the increased phosphorylation of 120 kDa proteins comigrating with Ras-GAP. Taken together, these findings show that 16K hPRL inhibits the VEGF-induced Ras activation; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis. [less ▲]

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See detail16K human prolactin is an anti-lymphangiogenic factor in vitro and in vivo
Kinet, Virginie; Castermans, Karolien; Blacher, Silvia ULg et al

Poster (2010, March)

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See detail16K human prolactin is an anti-lymphangiogenic factor in vitro and in vivo
Kinet, Virginie; Castermans, Karolien; Blacher, Silvia ULg et al

Poster (2010, May 21)

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See detailThe 16OH/18OH and OD/OH isotope ratios in comet C/2002 T7 (LINEAR)
Hutsemekers, Damien ULg; Manfroid, Jean ULg; Jehin, Emmanuel ULg et al

in Astronomy and Astrophysics (2008), 490(Letters), 31-34

The [SUP]16[/SUP]OH/[SUP]18[/SUP]OH and OD/OH isotope ratios are measured in the Oort-Cloud comet C/2002 T7 (LINEAR) through ground-based observations of the OH A [SUP]2[/SUP]Σ[SUP]+[/SUP] - X [SUP]2 ... [more ▼]

The [SUP]16[/SUP]OH/[SUP]18[/SUP]OH and OD/OH isotope ratios are measured in the Oort-Cloud comet C/2002 T7 (LINEAR) through ground-based observations of the OH A [SUP]2[/SUP]Σ[SUP]+[/SUP] - X [SUP]2[/SUP]Π[SUB]i[/SUB] ultraviolet bands at 3063 à (0, 0) and 3121 à (1, 1) obtained with the Very Large Telescope (VLT) feeding the Ultraviolet-Visual Echelle Spectrograph (UVES). From the [SUP]16[/SUP]OH/[SUP]18[/SUP]OH ratio, we find [SUP]16[/SUP]O/[SUP]18[/SUP]O = 425 ± 55, equal within the uncertainties to the terrestrial value and to the ratio measured in other comets, although marginally smaller. We also estimate OD/OH from which we derive D/H = 2.5 ± 0.7à 10[SUP]-4[/SUP] in water. This value is compatible with the water D/H ratios evaluated in other comets and is marginally higher than the terrestrial value. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programme 073.C-0525). [less ▲]

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See detailA 17,900-year multi-proxy lacustrine record of Lago Puyehue (Chilean Lake District): introduction
De Batist, Marc; Fagel, Nathalie ULg; Loutre, Marie-France et al

in Journal of Paleolimnology (2008), 39(2), 151-161

This paper introduces the background and main results of a research project aimed at unravelling the paleolimnological and paleoclimatological history of Lago Puyehue (40 degrees S, Lake District, Chile ... [more ▼]

This paper introduces the background and main results of a research project aimed at unravelling the paleolimnological and paleoclimatological history of Lago Puyehue (40 degrees S, Lake District, Chile) since the Last Glacial Maximum (LGM), based on the study of several sediment cores from the lake and on extensive fieldwork in the lake catchment. The longest record was obtained in an 11-m-long piston core. An age-depth model was established by AMS C-14 dating, Pb-210 and Cs-237 measurements, identification of event-deposits, and varve-counting for the past 600 years. The core extends back to 17,915 cal. yr. BP, and the seismic data indicate that an open-lake sedimentary environment already existed several thousands of years before that. The core was submitted to a multi-proxy analysis, including sedimentology, mineralogy, grain-size, major geochemistry and organic geochemistry (C/N ratio, delta C-13), loss-on-ignition, magnetic susceptibility, diatom analysis and palynology. Along-core variations in sediment composition reveal that the area of Lago Puyehue was characterized since the LGM by a series of rapid climate fluctuations superimposed on a long-term warming trend. Identified climate fluctuations confirm a.o. the existence of a Late-Glacial cold reversal predating the northern-hemisphere Younger Dryas cold period by 500-1,000 years, as well as the existence of an early southern-hemisphere Holocene climatic optimum. Varve-thickness analyses over the past 600 years reveal periodicities similar to those associated with the El Nino Southern Oscillation and the Pacific Decadal Oscillation, as well as intervals with increased precipitation, related to an intensification of the El Nino impact during the southern-hemisphere equivalent of the Little Ice Age. [less ▲]

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See detailLe 17-butyrate d'hydrocortisone (Locoid), un trentenaire toujours innovateur.
Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(2), 128-30

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines ... [more ▼]

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines good efficiency and reduced risk of side effects. Its topical formulations have been enriched over time. The original Locoid lipocream and Locoid Crelo presentations confer remarkable qualities to the product. We report a synopsis of clinical and translational studies devoted to this unique dermocorticoid. [less ▲]

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See detail17-O-acetyl, 10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves
Cao, Martine ULg; Muganga, Raymond ULg; Tits, Monique ULg et al

Conference (2011, May 13)

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary ... [more ▼]

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity. [less ▲]

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See detail17-O-Acetyl,10-hydroxycorynantheol, a Selective Antiplasmodial Alkaloid Isolated from Strychnos usambarensis Leaves
Cao, Martine ULg; Muganga, Raymond ULg; Tits, Monique ULg et al

in Planta Medica (2011), 77

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary ... [more ▼]

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity. [less ▲]

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See detail17-O-Actetyl-10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves
Cao, Martine ULg; Muganga, Raymond ULg; Tits, Monique ULg et al

Conference (2011, December 13)

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary ... [more ▼]

In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity. [less ▲]

Detailed reference viewed: 24 (7 ULg)
See detail1798: contre les républicains français, une identité belge a posteriori
Raxhon, Philippe ULg; van Ypersele, Laurence

in Bruneel, Claude; Bernard, Bruno (Eds.) Les prémices de l'identité belge avant 1830? (2006)

Detailed reference viewed: 28 (3 ULg)
See detail17th Cognac Blues Passions
Sacré, Robert ULg

Article for general public (2010)

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See detail17β-estradiol levels in male zebra finch brain: combining Palkovits punch and an ultrasensitive radioimmunoassay
Charlier, Thierry ULg; Po, Kevin WL; Newman, Amy EM et al

in General and Comparative Endocrinology (2010), 167

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See detail18 F-labeled analogues of anti-tumor agent calixarene 0118
Läppchen, Tilman; Rossin, Raffaella; van Mourik, Tiemen et al

Conference (2013, May 14)

Calix[4]arene compound 0118 , a topomimetic of the antiangiogenic amphipathic peptide anginex targeting galectin-1, is currently in Phase I clinical trials with terminal cancer patients. Radiolabelled ... [more ▼]

Calix[4]arene compound 0118 , a topomimetic of the antiangiogenic amphipathic peptide anginex targeting galectin-1, is currently in Phase I clinical trials with terminal cancer patients. Radiolabelled analogues of compound 0118 may serve as a development tool in PK/PD studies of this class of calix[4]arene compounds, and may prove highly valuable for patient stratification and therapy monitoring. So far, such radiotracers have not been described. In this work, we have designed compound 0118 analogues containing a terminal alkyne functional group for introduction of an F-18 label via Cu(I)-catalyzed 1,3-dipolar cycloaddition of 2-[18F]fluoroethylazide. [less ▲]

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See detail18 kyr, 120 kyr & 5 Myr shortening rates along the front of the southern Tianshan Mountains (China),
Hubert, Aurelia ULg; Suppe, J; Wang, Xin et al

in Geological Society of America - Abstracts with Programs (1999, October), 31(7),

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See detailThe 18 September 1692 Earthquake in the Belgian Ardenne and its aftershocks
Alexandre, Pierre ULg; Kusman, David; Camelbeeck, Thierry et al

in Fréchet, J.; Meghraoui, M.; Stucchi, M. (Eds.) Historical Seismology. Interdisciplinary Studies of Past and Recent Earthquakes (2008)

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See detail[(18)F]p-MPPF: A radiolabeled antagonist for the study of 5-HT(1A) receptors with PET
Plenevaux, Alain ULg; Lemaire, Christian ULg; Aerts, Joël ULg et al

in Nuclear Medicine & Biology (2000), 27(5), 467-71

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A ... [more ▼]

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism. [less ▲]

Detailed reference viewed: 170 (37 ULg)