References of "Thérapie"
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See detailEvaluation de l'insulinosecretion et de l'insulinosensibilite
Scheen, André ULg

in Thérapie (2007), 62(4), 311-8

Insulin secretion and insulin sensitivity interact in concert to maintain glucose homeostasis. Various pathologies, especially type 2 diabetes, are characterized by defects in secretion and/or action of ... [more ▼]

Insulin secretion and insulin sensitivity interact in concert to maintain glucose homeostasis. Various pathologies, especially type 2 diabetes, are characterized by defects in secretion and/or action of insulin and numerous drugs are able to partially correct these two defects. Therefore, the assessment of insulin secretion and insulin sensitivity is of interest to guide the choice of pharmacological treatments and to evaluate their efficacy. It could be performed by studying the couple of fasting insulin/glucose plasma concentrations or by performing dynamic tests, which mainly use the administration of glucose. The intimate relationship between insulin secretion and insulin sensitivity requires either appropriate tests that open the homeostatic feedback loop ("glucose clamp"), or sophisticated modeling approaches ("HOMA", "minimal model"). Insulin secretion should ideally be measured according to the corresponding insulin sensitivity. Dynamic tests are generally more informative than static measurements in the fasting state. [less ▲]

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See detailRole de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Bajou, Khalid ULg; Devy, L.; Masson, Véronique ULg et al

in Thérapie (2001), 56(5, Sep-Oct), 465-72

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]

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See detailLa mémoire de travail : une approche neuropsychologique et par imagerie cérébrale
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Thérapie (2000), 55(4), 455-460

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible ... [more ▼]

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible for the storage and processing of the information stored in working memory. Many neuropsychological and functional imagery data are consistent with that formulation of working memory. Moreover, many cognitive tasks have been specifically designed to explore particular aspects of working memory functioning. Taken as a whole, these data confirm that the working memory model remains a useful theoretical framework to explore memory functioning both in normal subjects and in pathological conditions. [less ▲]

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See detailMagnesium et metabolisme glucidique.
Lefebvre, Pierre ULg; Paolisso, G.; Scheen, André ULg

in Thérapie (1994), 49(1), 1-7

The interrelationships between magnesium and carbohydrate metabolism have regained considerable interest over the last few years. Insulin secretion requires magnesium: magnesium deficiency results in ... [more ▼]

The interrelationships between magnesium and carbohydrate metabolism have regained considerable interest over the last few years. Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Furthermore, experimental magnesium deficiency reduces the tissues sensitivity to insulin. Subclinical magnesium deficiency is common in diabetes. It results from both insufficient magnesium intakes and increase magnesium losses, particularly in the urine. In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance. Furthermore, it may participate in the pathogenesis of diabetes complications and may contribute to the increased risk of sudden death associated with diabetes. Some studies suggest that magnesium deficiency may play a role in spontaneous abortion of diabetic women, in fetal malformations and in the pathogenesis of neonatal hypocalcemia of the infants of diabetic mothers. Administration of magnesium salts to patients with type 2 diabetes tend to reduce insulin resistance. Long-term studies are needed before recommending systematic magnesium supplementation to type 2 diabetic patients with subclinical magnesium deficiency. [less ▲]

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See detailAction du sulpiride sur le comportement operant chez l'animal
Fontaine, Ovide ULg; Hauglustaine, A.; Libon, P. et al

in Thérapie (1975), 30

Sulpiride, a new psychotropic drug with neuroleptic activity, was administrated to rats and cats, trained in operant conditioning programs using positive reinforcement (FI, DRL, VI-CER, Mult FR-Ext ... [more ▼]

Sulpiride, a new psychotropic drug with neuroleptic activity, was administrated to rats and cats, trained in operant conditioning programs using positive reinforcement (FI, DRL, VI-CER, Mult FR-Ext.). Under these conditions, sulpiride appear to be an original drug in that way that the psychopharmacological "profil" cannot be compared with that of psychotropic drugs of widely explored classes. At clinical doses (1 to 10-20 mg/kg) the authors found a better adjustment to discriminative stimuli that is not a secondary effect of modification in the rate of responding. [less ▲]

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