  Evidence for behavioral sensitization to cocaine in preweanling rat pups; Tirelli, Ezio  ; et alin Psychopharmacologia (1998), 138(2), 114-123 Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to ... [more ▼] Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to postnatal day 20 with 0, 5, 15, or 30 mg/kg cocaine hydrochloride and placed for 30 min in either the experimental chamber or home cage. On postnatal day 21 (test day), Ss were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲] Detailed reference viewed: 7 (1 ULg)Action of a new psychotropic drug (sulpiride) on avoidance behavior in ratsFontaine, Ovide ; ; Richelle, Marc in Psychopharmacologia (1974), 39 Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a sidman avoidance schedule. Doses ranging from 1 to 80mg/kg resulted on the animal recieving fever shocks. This ... [more ▼] Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a sidman avoidance schedule. Doses ranging from 1 to 80mg/kg resulted on the animal recieving fever shocks. This effect was not correlated with an increase of responding and seemed unrelated to the suppressing action abruptly observed at high doses (i.e. 150 to 200 mg/kg). These results differ from those classicaly obtained with other neuroleptics. [less ▲] Detailed reference viewed: 3 (0 ULg)Antagonisme des effets centraux et périphériques de la trémorine par deux sympathicolytiques: L'atropine et la scopolamineFontaine, Ovide ; Richelle, Marc in Psychopharmacologia (1967), 11 Detailed reference viewed: 6 (0 ULg)Behavioral effects of a prolonged treatment with small doses of morphine in cats; Richelle, Marc ; Fontaine, Ovide in Psychopharmacologia (1966), 9 Detailed reference viewed: 2 (0 ULg)Effet d'un traitement prolongé au chlordiazépoxide sur un conditionnement temporel chez le ratRichelle, Marc ; in Psychopharmacologia (1964), 5 Detailed reference viewed: 3 (0 ULg) |
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