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See detailComparison of the platelet concentrations obtained in platelet-rich plasma (PRP) between the GPS™ II and GPS™ III systems
Kaux, Jean-François ULg; Le Goff, Caroline ULg; Renouf, Julien et al

in Pathologie Biologie (2011), 59(5), 275-277

Introduction Platelet growth factors are known for their ability to speed up tissue healing (bone, skin, tendons, muscle). Various techniques make it possible to collect this platelet-rich plasma or PRP ... [more ▼]

Introduction Platelet growth factors are known for their ability to speed up tissue healing (bone, skin, tendons, muscle). Various techniques make it possible to collect this platelet-rich plasma or PRP. Methods This study compares the platelet concentrations obtained from five patients using GPS™ III, which has recently come onto the market, with those obtained using GPS™ II. Results and conclusion We obtain a platelet concentration that is six to nine times greater with GPS ™ II and GPS™ III, but there is no significant difference between the concentrations of PRP obtained with the two systems. [less ▲]

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See detailEtude comparative de 5 techniques de préparation plaquettaire (Platelet-Rich Plasma)
Kaux, Jean-François ULg; Le Goff, Caroline ULg; Seidel, Laurence ULg et al

in Pathologie Biologie (2011), 59

Aim of the study: Injections of platelet-rich plasma (PRP) constitute a new therapeutic for treating chronic tendinopathies. The injection being carried out in the tendon, the volume of PRP should thus be ... [more ▼]

Aim of the study: Injections of platelet-rich plasma (PRP) constitute a new therapeutic for treating chronic tendinopathies. The injection being carried out in the tendon, the volume of PRP should thus be minimal (to decrease the intra-tendinous pressure and to minimize pain). This PRP should also have a raised platelet count. The quantity of released growth factors could be related to the system of preparation employed. We thus carried out a comparative study of 5 techniques of preparation of PRP described in the literature. Patients and methods: Samples of venous blood were taken among 5 patients in order to compare 5 techniques of preparation of PRP: University Hospital of Liège technique, Curasan® PRP Kit, Plateltex®, GPS® and RegenLab®. Results: The various techniques make it possible to obtain more important platelet concentration than in blood, with variable volumes (0,3 mL to 6 mL). The number of platelets/microlitre appears higher with Plateltex® and obtains smallest volume of PRP. The other techniques also give small volumes excepted for the GPS® II. The number of collected platelets with this technique appears thus higher. The best collect efficiency is obtained with RegenLab®. Conclusion: The technique Plateltex® makes it possible to collect the highest concentration of platelets in the smallest volume available. [less ▲]

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See detailIntroduction a l'analyse spectrale des reseaux microvasculaires du melanome cutane primitif.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Pathologie Biologie (2010), 60

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically ... [more ▼]

Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically increase when the primary neoplasm reaches about one millimeter thick. It is believed that angiogenesis and lymphangiogenesis associated with cutaneous melanoma potentially influence the neoplastic progression of the primary tumor and its metastases. In some instances, both the intratumoral and peritumoral microvasculature are correlated to booming of the tumoral growth fraction. In addition, the vascular network serves as a migration path for the intravascular and perivascular neoplastic spread. Hence, the quantification of the microvasculature might help establishing a prognostic factor of evolution. Among the available methods, spectral analysis of immunohistochemical sections highlighting vessels helps defining the microvasculature distribution. The benefit of using spectral analysis is discussed and the modalities of application of this analytical method are scrutinized. [less ▲]

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See detailChronophysiologie circadienne du cuir chevelu
Franchimont, Claudine ULg; Henry, Frédérique ULg; Loussouarn, Geneviève et al

in Pathologie Biologie (2007), 55

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See detailCalcitonine et vieillissement osseux
Reginster, Jean-Yves ULg

in Pathologie Biologie (1997), 45(1), 52-6

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (> or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss at trabecular and cortical sites. A similar benefit is obtained following parenteral or nasal administration of the drug. Long-term administration of nasal salmon calcitonin induces a significant dose-dependent gain of bone at the lumbar spine, whereas discontinuous therapy with a ratio of 1:2 or 2:3 between the treatment and nontreatment periods is the best regimen for cortical bone. Epidemiological, retrospective, and prospective studies provide a convergent network of evidence that calcitonin administration in osteoporosis contributes to reduce significantly the frequency of subsequent fractures, both in the spine and in the hip. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect, reduces the duration of bed confinement, and decreases the number of concomitant analgesic medications. The well-demonstrated effects of nasal calcitonin permit it to be considered as a highly rational solution for the prevention and the treatment of postmenopausal osteoporosis. [less ▲]

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See detailUtilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale. Application chronopharmacologique
Milis, G.; Grandfils, Christian ULg; Flandroy, P. et al

in Pathologie Biologie (1996), 44(3), 208-11

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those ... [more ▼]

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those cisplatin loaded microspheres, some concentration peaks at the best tolerance time. The cancer is than more hit, by the high local anticancer drug concentration, and doses chronomodulations preserve the patient by following his tolerance. The experimentation on cancerous mice show that this technique could lead to great survival increases. Such a protocol might usefuly improve the anticancer therapy. [less ▲]

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See detailLes cellules dendritiques folliculaires: phenotype, origine et fonctions.
Heinen, Ernst ULg

in Pathologie Biologie (1995), 43(10), 848-57

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic ... [more ▼]

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic cells presenting antigens to T cells. They are long-lived and derived from local mesenchymal cells. Their complex cytoplasmic extensions, covered with dendrites, are intermingled in a network which surrounds germinal B and T cells. On their surface, receptors fix immune complexes without endocytosis and adhesion molecules ensure close contacts to the lymphoid cells. FDC influence the migration, activation, proliferation, survival and differentiation of B cells into memory cells and probably act also on the germinal center T cells. [less ▲]

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See detailExamens electrophysiologiques dans la migraine.
Schoenen, Jean ULg

in Pathologie Biologie (1992), 40(4), 293-304

This article is a critical review of standard electroencephalography (EEG), brain mapping, evoked potential, and electromyography (EMG) studies carried out in various forms of migraine during and between ... [more ▼]

This article is a critical review of standard electroencephalography (EEG), brain mapping, evoked potential, and electromyography (EMG) studies carried out in various forms of migraine during and between attacks. With the exception of contingent negative variation, the exteroceptive silent period of the temporalis muscle, and possibly fast activity in response to visual stimuli, which are useful for the differential diagnosis of functional headache, the main value of electrophysiologic studies is to provide insight into the pathophysiology of the disease. Results of the different methods consistently indicate that the brain of migraine patients is characterized by hypersensitivity to some forms of stimuli between attacks and by, often focal, hypoactivity during attacks. [less ▲]

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See detailUtilisation en scintillation liquide du Triton X-100 pour le comptage à haut rendement du radiofer plasmatique
Fillet, Georges ULg

in Pathologie Biologie (1972), 20

A new method for liquid scintillation counting of plasma 59Fe is presented. Using Triton X-100 as an emulsifying agent at 4°C, the efficiency is in the 81-83% range and is five times greater than that ... [more ▼]

A new method for liquid scintillation counting of plasma 59Fe is presented. Using Triton X-100 as an emulsifying agent at 4°C, the efficiency is in the 81-83% range and is five times greater than that achieved with crystal sytems. Without previous manipulation, volumes as great as 4 ml of plasma may be directly incorporated into the scintillation medium and counted with good reproducibility. Bleaching procedure and quench correction are discussed. The method allows a more precise study of iron kinetics and erythropoiesis in humans. [less ▲]

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