References of "Movement Disorders : Official Journal of the Movement Disorder Society"
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See detailBrain activation pattern related to gait disturbances in Parkinson's disease.
Cremers, Julien ULg; D'Ostilio, Kevin ULg; Stamatakis, Julien et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2012), 27(12), 1498-505

Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental ... [more ▼]

Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances. (c) 2012 Movement Disorder Society. [less ▲]

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See detailCharacterization of periodic upper limb movement disorder in a patient with restless arms syndrome.
Ruppert, Elisabeth; Cretin, Benjamin; Meyer, Christelle ULg et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2012), 27(11), 1459-61

BACKGROUND: Restless legs syndrome (RLS) and the frequently associated periodic limb movements (PLM) are common neurological disorders whose pathophysiology remains elusive. We report on the case of a 40 ... [more ▼]

BACKGROUND: Restless legs syndrome (RLS) and the frequently associated periodic limb movements (PLM) are common neurological disorders whose pathophysiology remains elusive. We report on the case of a 40-year-old patient presenting with severe restlessness in the upper limbs, a poorly known variant of RLS. CASE REPORT: Video-polysomnography was performed because of the associated poor sleep quality and daytime sleepiness evocative of PLM. An electromyogram of the extensor carpi radialis muscle was added. Remarkably, our patient had movements of repeated extension of the small finger that contrasted with the extension of the hallux, characteristic for PLM. Pramipexol was an effective treatment relieving the patient's upper limbs of discomfort and ameliorating her restless sleep. CONCLUSIONS: Involvement of the upper limbs in RLS is relatively common, but restlessness may be located on the upper limbs solely. One should be aware of the upper limb variant, and that treatment by dopaminergic agonists proves to be very efficient. [less ▲]

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See detailGait analysis using a wearable accelerometer system: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(S2), 355

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See detailAmbulatory monitoring of energy expenditure and physical activity levels using the SenseWear ArmbandTM system in Parkinson’s disease
Rodriguez de la Cruz, Carlos ULg; Bury, Thierry ULg; Le Scanff, Steren et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(S2), 355-356

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See detailGait analysis during an original walking test: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(Suppl 2), 355

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See detailAutomatic brain image reading for the differential diagnosis between atypical parkinsonian syndromes & Parkinson's disease
Garraux, Gaëtan ULg; Phillips, Christophe ULg; Lemaire, Christian ULg et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010), 25(7), 379-379

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See detailDe novo interstitial duplication 4q associated with sporadic young-onset dopa-responsive parkinsonism
Garraux, Gaëtan ULg; VANBELLINGHEN, Jean-François ULg; JAMAR, Mauricette ULg et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 138-139

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See detailUnified Freezing of Gait Rating Scale (UFOGS)
Cremers, Julien ULg; Garraux, Gaëtan ULg

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 432-433

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See detailA clinico-pathological report of SCA17 associated with a heterozygote small trinucleotide expansion
Garraux, Gaëtan ULg; Moonen, Gustave ULg; Deprez, Manuel ULg

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 12-12

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See detailEvidence for increased upper brain stem activity following STN-DBS in Parkinson's disease: An (18)FDG-PET study
Desoullieres, Aurélie; KASCHTEN, Bruno ULg; CREMERS, Julien ULg et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 186-187

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See detailModulation of cerebral functional interactions by cortical dopamine in health and Parkinson's disease
Garraux, Gaëtan ULg; Talagala, S.; Carson, R. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2007), 22(Suppl. 16), 478

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See detailAnterior cingulate, insula and parietal operculum commonly activated during motor and vocal ties in patients with Tourette syndrome: An event-related functional MRI study
Bohlhalter, Stephan; Goldfine, Andrew; Matteson, Sarah et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2004), 19(Suppl. 9), 1109

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See detailBrain Levels of Thiamine and Its Phosphate Esters in Friedreich's Ataxia and Spinocerebellar Ataxia Type 1
Bettendorff, Lucien ULg; Mastrogiacomo, Frank; LaMarche, J. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (1996), 11(4), 437-439

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we ... [more ▼]

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we measured levels of thiamine and its phosphate esters thiamine monophosphate (TMP) and thiamine diphosphate (TDP), in postmortem cerebellar and cerebral cortices of patients with Friedreich's ataxia (FA) and spinocerebellar ataxia type 1 (SCA1). Brain levels of free (nonphosphorylated) thiamine, TMP, TDP, and total thiamine in FA and SCA1 were, on average, not significantly different from control values. However, a nonsignificant trend was observed for slightly reduced levels of TDP and total thiamine in cerebellar cortex of the SCA1 patients, a finding that might be related to the severe neuronal damage in this brain area. We conclude that in FA, brain thiamine concentrations are normal, whereas in SCA1 the levels are, at most, only slightly reduced. [less ▲]

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