Physiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK

in Medecine Sciences : M/S (2012), 28

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration ... [more ▼]

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration afterhyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to pass the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems. [less ▲]

L'ADN du soi, allie du systeme immunitaire pour la fonction adjuvante de l'alun.

in Medecine Sciences : M/S (2012), 28(1), 31-3

La neuro-imagerie: au-delà des images, une modélisation du fonctionnement cérébral humain

in Medecine sciences : M/S (2011), 27(1), 5-6

Elongator orchestrates cerebral cortical neurogenesis

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.

in Medecine Sciences : M/S (2010), 26(2), 159-63

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing ... [more ▼]

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus. [less ▲]

Les histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses.

in Medecine Sciences : M/S (2008), 24(8-9), 742-6

Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred ... [more ▼]

Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred different genes in cancer development. Today, the model has evolved: it has been demonstrated that malignancies can be initiated not only through genetic alterations but also through epigenetic deregulations. By altering the expression of gene involved in cell regulation, epigenetic alterations, such as histone acetylation, play a key role in the initiation and progression of neoplasm. It has been shown that an imbalance between the acelylated and deacetylated status of chromatin is significantly involved in the acquisition of a malignant phenotype. Thus, the modulation of the histone acetylation level by histone deacetylase (HDAC) inhibitors could lead to a genetic re-programmation in cancer cells that would favor apoptosis and prevent proliferation. The potential therapeutic value of several HDAC inhibitors for cancer patients has been evaluated in clinical assays with very promising outcome. Indeed, the first inhibitors available for patients has been recently approved for cancer patients tracing the way for a new class of promising anti-cancer therapy modalities. [less ▲]

Ingenierie tissulaire du parenchyme renal : une hypothese therapeutique ?

in Medecine Sciences : M/S (2008), 24(6-7), 561-3

Gènes impliqués dans l'apoptose prostatique provoquée par un déficit androgénique

in Medecine Sciences : M/S (1998), 14(5), 572-579

Régulation transcriptionnelle du gène de la prolactine humaine

in Medecine Sciences : M/S (1998), 14(580-587),

Le gène humain de la prolactine (hPRL) est exprimé essentiellement par l'antéhypophyse. L'analyse des éléments régulateurs de la transcription sur plus de 5 000 bases en amont du site de début de ... [more ▼]

Le gène humain de la prolactine (hPRL) est exprimé essentiellement par l'antéhypophyse. L'analyse des éléments régulateurs de la transcription sur plus de 5 000 bases en amont du site de début de transcription a montré l'importance du contrôle par le facteur de transcription Pit-1, spécifique de l'hypophyse, à côté de facteurs ubiquistes. Des hormones modulent l'expression du gène hPRL, transmettant leur signal par les voies intracellulaires de l'AMP cyclique et du calcium, relayées au niveau du promoteur proximal (-250/+1) essentiellement par les facteurs de transcription Pit-1 et AP-1. Les récepteurs nucléaires contrôlent aussi en partie la transcription de hPRL: le récepteur des oestrogènes l'active en se liant aux éléments de réponse distaux ; les récepteurs nucléaires des hormones thyroïdiennes et des glucocorticoïdes la répriment en interférant respectivement avec la fonction activatrice de AP-1 et de Pit-1. [less ▲]

Les spermatozoïdes ont-ils du nez ?

in Medecine Sciences : M/S (1994), 10