References of "Medecine Sciences : M/S"
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See detailMémoire épisodique dans la maladie d’Alzheimer : Déclin de la remémoration consciente et de la familiarité ?
Simon, Jessica ULg; Bastin, Christine ULg

in Medecine Sciences : M/S (2014), 30

According to the dual-process recognition models, the retrieval of information from long-term memory is supported by recollection and familiarity. Alzheimer’s disease is consistently found to affect ... [more ▼]

According to the dual-process recognition models, the retrieval of information from long-term memory is supported by recollection and familiarity. Alzheimer’s disease is consistently found to affect recollection. As for familiarity, however, no consensus has been reached so far. Some studies are in favor of an early impairment of familiarity, while others are in favor of a preservation of familiarity in the mild and moderate stages of the disease. This lack of consensus can be partly explained by methodological differences between studies. We discuss three methodological dimensions: the type of recognition test, the type of paradigm for estimating familiarity and recollection, and the nature of the material used. These differences reveal the complex nature of familiarity which would be underlied by different mechanisms that may be selectively altered or preserved in the disease. [less ▲]

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See detailLa lumière comme stimulant de l’activité cognitive cérébrale
Vandewalle, Gilles ULg

in Medecine Sciences : M/S (2014), In press

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See detailLes proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese.
Lamour, Virginie; Nokin, Marie-Julie ULg; Henry, Aurélie ULg et al

in Medecine sciences : M/S (2013), 29(11), 1018-25

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix ... [more ▼]

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis. [less ▲]

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See detailPhysiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK
Dilly, Sébastien ULg; Poncin, Sylvie; Lamy, Cédric et al

in Medecine Sciences : M/S (2012), 28

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration ... [more ▼]

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration afterhyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to pass the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems. [less ▲]

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See detailL'ADN du soi, allie du systeme immunitaire pour la fonction adjuvante de l'alun
Marichal, Thomas ULg; Bureau, Fabrice ULg; Desmet, Christophe ULg

in Medecine Sciences : M/S (2012), 28(1), 31-3

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See detailLa neuro-imagerie: un outil diagnostique des etats de conscience alteree.
Thonnard, Marie ULg; Boly, Mélanie ULg; Bruno, Marie-Aurelie et al

in Medecine Sciences : M/S (2011), 27(1), 77-81

Vegetative and minimally conscious states diagnosis remained a major clinical challenge. New paradigms such as measurement of the global cerebral metabolism, the structural and functional integrity of ... [more ▼]

Vegetative and minimally conscious states diagnosis remained a major clinical challenge. New paradigms such as measurement of the global cerebral metabolism, the structural and functional integrity of fronto-parietal network, or the spontaneous activity in resting state have been shown to be helpful to disentangle vegetative from minimally conscious patients. Active neuroimagery paradigms also allow detecting voluntary and conscious activity in non-communicative patients. The implementation of these methods in clinical routine could permit to reduce the current high rate of misdiagnosis (40%). [less ▲]

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See detailLa neuro-imagerie: au-delà des images, une modélisation du fonctionnement cérébral humain
Maquet, Pierre ULg

in Medecine sciences : M/S (2011), 27(1), 5-6

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See detailHuntingtine, mitose et destinée cellulaire
Godin, Juliette ULg; Humbert, S.

in Medecine Sciences : M/S (2011), 27(2), 126-128

[No abstract available]

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See detailLes prions exploitent les communications neuro-immunitaires
Dorban, Gauthier; Antoine, Nadine ULg; Defaweux, Valérie ULg

in Medecine Sciences : M/S (2010), 26(6),

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See detailElongator orchestrates cerebral cortical neurogenesis
creppe, catherine; malinouskaya, lina; Volvert, Marie-Laure ULg et al

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

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See detailLes macrophages interstitiels, gardiens de l'homeostasie immune pulmonaire.
Bedoret, Denis; Bureau, Fabrice ULg; Desmet, Christophe ULg

in Medecine Sciences : M/S (2010), 26(3), 229-31

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See detailUn virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.
Schwartz, Christian; Le Douce, Valentin; Cherrier, Thomas ULg et al

in Medecine Sciences : M/S (2010), 26(2), 159-63

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing ... [more ▼]

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus. [less ▲]

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See detailUn virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.
Cherrier, Thomas ULg; Le Douce, Valentin; Redel, Laetitia et al

in Medecine Sciences : M/S (2010), 26(3), 291-5

The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the ... [more ▼]

The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary. [less ▲]

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See detailLes histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses.
Mottet, Denis ULg; Castronovo, Vincenzo ULg

in Medecine Sciences : M/S (2008), 24(8-9), 742-6

Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred ... [more ▼]

Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred different genes in cancer development. Today, the model has evolved: it has been demonstrated that malignancies can be initiated not only through genetic alterations but also through epigenetic deregulations. By altering the expression of gene involved in cell regulation, epigenetic alterations, such as histone acetylation, play a key role in the initiation and progression of neoplasm. It has been shown that an imbalance between the acelylated and deacetylated status of chromatin is significantly involved in the acquisition of a malignant phenotype. Thus, the modulation of the histone acetylation level by histone deacetylase (HDAC) inhibitors could lead to a genetic re-programmation in cancer cells that would favor apoptosis and prevent proliferation. The potential therapeutic value of several HDAC inhibitors for cancer patients has been evaluated in clinical assays with very promising outcome. Indeed, the first inhibitors available for patients has been recently approved for cancer patients tracing the way for a new class of promising anti-cancer therapy modalities. [less ▲]

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See detailVEGF111 : Dr Jekyll et Mr Hyde ?
Lambert, Charles ULg; Mineur, Pierre ULg; Nusgens, Betty ULg

in Medecine Sciences : M/S (2008), 24(6-7), 579-80

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See detailIngenierie tissulaire du parenchyme renal : une hypothese therapeutique ?
JOURET, François ULg; Pirson, Yves

in Medecine Sciences : M/S (2008), 24(6-7), 561-3

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See detailVertebrate origins: does the tunic make the man?
Delsuc, Frédéric; Baurain, Denis ULg; Philippe, Hervé

in Medecine Sciences : M/S (2006), 22(8-9, AUG-SEP), 688-690

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See detailGènes impliqués dans l'apoptose prostatique provoquée par un déficit androgénique
Bruyninx, Marc; Cornet, Anne ULg; Hennuy, Benoît ULg et al

in Medecine Sciences : M/S (1998), 14(5), 572-579

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See detailRésistance bactérienne aux beta-lactamines
Charlier, Paulette ULg; Coyette, Jacques ULg; Dehareng, Dominique ULg et al

in Medecine Sciences : M/S (1998), 14(5), 544-555

Detailed reference viewed: 102 (38 ULg)