References of "Journal of Labelled Compounds & Radiopharmaceuticals"
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See detailTHE USEFULNESS OF AN ARTERIOVENOUS SHUNT COMBINED WITH A BETA MICROPROBE FOR THE MEASUREMENT OF INPUT FUNCTION IN RATS
Warnock, Geoffrey ULg; Goblet, David ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 106

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See detailUSE OF A BETA MICROPROBE SYSTEM AS AN AFFORDABLE TRANSLATIONAL TOOL COMPARED TO PET – EXAMPLES USING FDG AND 18F-FALLYPRIDE BINDING
Warnock, Geoffrey ULg; Goblet, David ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 55

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See detailTIME-DEPENDENT PREFERENTIAL IN VIVO D2 OCCUPANCY BY AMISULPRIDE IN THE MEDIAL STRIATUM – CONTINUOUS MEASUREMENT USING A BETA MICROPROBE SYSTEM
Warnock, Geoffrey ULg; Goblet, David ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 105

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See detailNew Improvements in the Enantioselective Synthesis of 2-[18F]Fluoro-L-Tyrosine and 6-[18F]Fluoro-L-Dopa
Libert, Lionel ULg; Lemaire, Christian ULg; Denoël, Thibaut ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 196

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See detailTertiary Alcohols to Avoid Evaporation in Fluorine-18 Labeling
Aerts, Joël ULg; Voccia, Samuel; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 204

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See detailFast and Reliable Method for the Preparation of Various [18F]Fluorobenzyl Halides
Lemaire, Christian ULg; Libert, Lionel ULg; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 178

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See detailUse of Organic Bases for 18F-Fluoride Anion Exchange Elution avoiding the Classical Azeotropic drying Step Before Labeling
Lemaire, Christian ULg; Aerts, Joël ULg; Voccia, Samuel et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 198

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See detailAre Ionic Liquid Useful for Fluorine-18 Labeling?
Aerts, Joël ULg; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 193

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See detailLarge Scale Preparation of [18]Fluoromethoxybenzyl Bromides, Key Precursors for 2-[18F]Fluoro-L-Tyrosine and 6-[18F]Fluoro-L-Dopa
Libert, Lionel ULg; Lemaire, Christian ULg; Wouters, Ludovic ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 292

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See detailModified Non-Ionic Solid Supports: a Way to High Activity Fluorine-18 Radiochemistry in Microfluidic Devices
Aerts, Joël ULg; Voccia, Samuel; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 12

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See detailSynthesis, quality control and in vivo evaluation of [I-123] rhTIMP-2, a potential tumour-imaging agent
Oltenfreiter, R.; Burvenich, I.; Staelens, L. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2005), 48(5), 387-396

Matrix metalloproteinases (MMPs) are enzymes involved in the turnover of the extracellular matrix. Their overexpression in tumours may provide a target for diagnostic imaging by using labelled MMP ... [more ▼]

Matrix metalloproteinases (MMPs) are enzymes involved in the turnover of the extracellular matrix. Their overexpression in tumours may provide a target for diagnostic imaging by using labelled MMP inhibitors. MMPs are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). The enhanced production of MT1-MMP, located on the surface of cells within or in the direct vicinity of the tumour, and the high affinity interaction between TIMP-2 and MT1-MMP suggested that TIMP-2 could be a potential agent for non-invasive monitoring of cancer MMP levels, diagnosis of primary and secondary tumours and tumour response to MMP inhibitor therapy. There is also evidence that I-125-rhTIMP-2 internalizes, which is an important feature for its possible use as a radiotherapeuticum if labelled with I-131. Labelling of rhTIMP-2 was performed using the iodogen method resulting in a radiochemical yield of 51.1 +/- 11.8% (n = 5) and a radiochemical purity of > 98%. The trichloroacetic acid (TCA) precipitability of I-123 rhTIMP-2 was 95.2%. SDS-PAGE confirmed the correct size (21 kDa) of the purified I-123 rhTIMP-2 without degradation. HPLC showed one radioactive peak with a retention time corresponding to the nonlabelled rhTIMP-2. In vivo biodistribution showed no long-term accumulation in organs and the possibility to accumulate in the tumour. These results show the potential of I-123 rhTIMP-2 as tumour-imaging agent. Copyright (c) 2005 John Wiley [less ▲]

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See detailNew Methods For Halogenation of [18F]Fluorinated Benzyl Derivatives.
Kech, C.; Lemaire, Christian ULg; Brichard, L. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2005), 48

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See detailEx Vivo Evaluation of p-[18F]D-MPPF for the Study of 5-HT1A Receptors.
Defraiteur, C.; Lemaire, Christian ULg; Luxen, André ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2005), 48

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See detailRadiochemical Synthesis of OCH2F-[18F]MPPF a New Analogue of p-[18F]MPPF for the Study of 5-HT1A Receptors.
Defraiteur, C.; Lemaire, Christian ULg; Luxen, André ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2005), 48

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See detailRadiochemical Synthesis of p-[18F]Desmethyl-MPPF (p-[18F]D-MPPF) for the Study of 5-HT1A Receptors
Defraiteur, Caroline; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2003, August), 46(S1), 157

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See detailSynthesis of [18F]fluorinated a-methyl-a-amino acids by phase transfer catalysis for potential PET application.
Wouters, L.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2003), 46

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See detailSimple device for the radiosynthesis of [carbonyl-11C]amides, esters and ketones using carbon-11 monoxide.
Brichard, L.; Del Fiore, G.; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2003), 46

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See detailRadiosynthesis of 7-[18F]fluoroindole derivatives.
Otabashi, Muhammad ULg; Giacomelli, Fabrice ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2003), 46

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See detailFast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Lemaire, Christian ULg; Damhaut, P.; Lauricella, Benjamino ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2002), 45(5), 435-447

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose ... [more ▼]

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley [less ▲]

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