References of "Journal of Gravitational Physiology : A Journal of the International Society for Gravitational Physiology"
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See detailTHE FUNCTION OF HMG-BOX TRANSCRIPTION FACTORS Sox4a AND Sox4b IN ZEBRAFISH BONE DEVELOPMENT AND HOMEOSTASIS.
Aceto, Jessica ULg; Motte, Patrick ULg; Martial, Joseph ULg et al

in Journal of Gravitational Physiology : A Journal of the International Society for Gravitational Physiology (2008), 15

In mammals, the Sox4 gene is involved in development of endocardial crests, the brain, the lung, teeth, gonads and lymphocytes. Recently, Sox4 was shown to control bone mass and mineralization in mice. In ... [more ▼]

In mammals, the Sox4 gene is involved in development of endocardial crests, the brain, the lung, teeth, gonads and lymphocytes. Recently, Sox4 was shown to control bone mass and mineralization in mice. In zebrafish, two homologs for the mammalian Sox4 are present, sox4a and sox4b. Here we investigate the function of the sox4a and sox4b genes in cartilage and bone development in zebrafish. Therefore, we focus our attention on the first bone structures to be formed, the head skeleton and more precisely the pharyngeal cartilage. We show that both genes are expressed in the pharyngeal region, albeit at different time points during development. Double in situ hybridization experiments are used to exactly define the particular tissues where they are expressed. Furthermore, microinjection experiments of antisense oligonucleotides are used to block translation of these specific genes and to define their precise function during cartilage and bone development. [less ▲]

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See detailMicrogravity-induced matrix remodelling is linked to reduction in tension of human dermal fibroblasts
Guignandon, A.; Lambert, Charles ULg; Réga, Georgette et al

in Journal of Gravitational Physiology : A Journal of the International Society for Gravitational Physiology (2005), 12(1),

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See detailRole of the RhoGTPases in the cellular receptivity and reactivity to mechanical signals including microgravity
Nusgens, Betty ULg; Chometon, G.; Guignandon, Alain et al

in Journal of Gravitational Physiology : A Journal of the International Society for Gravitational Physiology (2005), 12(1), 269-270

The small G proteins of the Rho Family (RhoGTPases) are key operators in the signaling arising from extracellular matrix through integrin receptors and from membrane receptors for soluble ligands. FLight ... [more ▼]

The small G proteins of the Rho Family (RhoGTPases) are key operators in the signaling arising from extracellular matrix through integrin receptors and from membrane receptors for soluble ligands. FLight data show that microgravity affects cell architecture and gene expression leading us to assume that the signaling pathways(s) involving the RhoGTPAses might disturbed in a weightlessness environment. TO test this hypothesis in microgravityu, we created genetically engineered human fibroblasts that will be used in Biolab on the ISS. [less ▲]

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