References of "Journal of Endocrinological Investigation"
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See detailResistant prolactinomas
Vasilev, V.; Daly, Adrian ULg; VROONEN, Laurent ULg et al

in Journal of Endocrinological Investigation (2011), 34

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See detailThe R304X mutation of the Aryl hydrocarbon receptor Interacting Protein gene in familial isolated pituitary adenomas: mutational Hot-Spot or founder effect?
Occhi, G.; Jaffrain-Rea, M. L.; Trivellin, G. et al

in Journal of Endocrinological Investigation (2010), 33

Background: Mutations in the Aryl hydrocarbon receptor Interacting Protein (AIP) gene have been described in about 15% of kindreds with Familial Isolated Pituitary Adenomas (FIPA) and in a minority of ... [more ▼]

Background: Mutations in the Aryl hydrocarbon receptor Interacting Protein (AIP) gene have been described in about 15% of kindreds with Familial Isolated Pituitary Adenomas (FIPA) and in a minority of early onset sporadic pituitary adenomas (PA). Among the AIP mutations reported so far, the R304X (AIPR304X) represents, together with the "Finnish mutation" Q14X, the most common one. Methods: Three AIPR304X Italian families, including a newly reported kindred, have been genotyped for 12 genetic markers surrounding the AIP gene in order to look for a potential founder effect in Italy. Disease penetrance and genotype-phenotype correlations were also addressed. Results: Analysis of chromosome 11' genetic markers revealed a common haplotype in two AIPR304X kindreds originating from central Italy. Overall, seventeen mutations carriers were identified, including 7 patients and 10 unaffected subjects, respectively, arguing in this case for a disease penetrance of 41%. Mean age at diagnosis was 19.1+/-6.7 years-old, with females tending to be older than males. Though most PA were somatotropinomas (6/7), a great variability in disease severity was observed, even between subjects sharing the same at-risk haplotype. Conclusion: These data provide strong evidence for a new founder effect of the AIPR304X mutation in central Italy and the observed variations in disease severity point out the role of additional genetic or environmental factors in such kindreds. [less ▲]

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See detailPrevalence of double pituitary adenomas in a surgical series: Clinical, histological and genetic features.
Magri, F.; Villa, C.; Locatelli, D. et al

in Journal of Endocrinological Investigation (2010), 33(5), 325-31

BACKGROUND: The term double pituitary adenomas (DPA) is usually referred to those rare lesions showing two distinct cellular components. Genetic background may sustain the proliferation of more than one ... [more ▼]

BACKGROUND: The term double pituitary adenomas (DPA) is usually referred to those rare lesions showing two distinct cellular components. Genetic background may sustain the proliferation of more than one cell at the same time but no information is available on the presence of aip mutations in these patients. AIM: We report the prevalence and the endocrinological, neuroradiological, histopathological and genetic features of DPA detected in a large surgical series. The contribution of pituitary transcription factor immunostains in DPA was also evaluated. SUBJECTS AND METHODS: One-hundred-forty-four patients undergoing surgery for tumors of the sellar region were evaluated. Histopathology, immunohistochemistry and the mutational analysis for the entire coding region of the AIP and MEN1 genes were performed. RESULTS: One-hundred-seventeen patients out of 144 had a pituitary adenoma. DPA was found in 3 (2.6%) out of 117 patients with pituitary adenoma. Immunohistochemistry and transcription factors analysis demonstrated two not yet described histotype associations in DPA. The coexistence of somatotroph-lactotroph and silent mammosomatotroph histotype in 1 case and the coexistence of sparsely granulated lactotroph and null cell adenomas in the remaining two cases were first identified. Sequencing data for the coding region of the aip and the menin gene resulted in wild type sequences in all patients with DPA. CONCLUSIONS: The prevalence of DPA observed in our unselected surgical series is not negligible (2.6%). Furthermore, the evaluation of the treatment outcome would suggest that the clinical management of DPAs requires a careful diagnostic approach and follow- up. [less ▲]

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See detailAn overview of the epidemiology and genetics of acromegaly.
Daly, Adrian ULg; Petrossians, Patrick ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (2005), 28(11 Suppl International), 67-69

Historical data indicate that pituitary tumors represent 10% of intracranial tumors, while adenomas are noted in approximately 14-23% of normal subjects on autopsy or magnetic resonance imaging (MRI ... [more ▼]

Historical data indicate that pituitary tumors represent 10% of intracranial tumors, while adenomas are noted in approximately 14-23% of normal subjects on autopsy or magnetic resonance imaging (MRI). About 2.5% of these tumors stain positive for GH in histopathologic studies. In contrast, the prevalence of clinically diagnosed acromegaly is lower at 36-69 per million population. Ongoing studies indicate that the actual prevalence of acromegaly in the community may be higher than previous epidemiologic data suggest. Acromegaly can occur both sporadically and in the setting of familial conditions, such as multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). Isolated familial somatotropinoma has been described and newer data suggest that acromegaly may also occur in non-MEN1/CNC families in combination with other pituitary tumor phenotypes. [less ▲]

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See detailACTH-Related peptide-secreting silent corticotroph adenomas of the pituitary
abs, r; Smets, G.; klöppel, G. et al

in Journal of Endocrinological Investigation (1993), 16

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See detailThe treatment of prolactinomas with cabergoline : results in 56 patients
Demez, Pierre ULg; Verhaert, G.; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1993), 16

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See detailPresurgical octreotide treatment in acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1993), 16(1-8), 137

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See detailAlteration of fetal development and hormonal status after dam treatment with anti-insulin like growth factor-I monoclonal antibodies in rat.
Renaville, Robert ULg; Devolder, Anne; Sneyers, Myriam et al

in Journal of Endocrinological Investigation (1992), 15(suppl 4), 85

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See detailVariability in the bovine GH receptor amino acid sequence
Sneyers, Myriam; Renaville, Robert ULg; Devolder, Anne et al

in Journal of Endocrinological Investigation (1992), 15(suppl 4), 59

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See detailThe thymic education of developing T cells in self neuroendocrine principles
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Journal of Endocrinological Investigation (1992), 15

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See detailCoexistence of Cushing's disease with uninodular adrenal hyperplasia.
Nobels, F.; Abs, R.; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991)

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See detailMedico-surgical treatment of acromegaly.
Stevenaert, Achille ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991)

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See detailAcute effects of Parlodel-LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma.
Abs, R.; Parizel, P. M.; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1991), 14(2), 135-8

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration ... [more ▼]

A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration of the vision was detected five years later and tumor regrowth was evidenced. The patient was treated with the long-acting and repeatable form of bromocriptine (Parlodel-LAR). Three days after the first intramuscular injection it already resulted in an important improvement of the visual field defects. Serum FSH concentration was suppressed during a prolonged period, but no change in the size of the pituitary adenoma was recorded on CT scan. Long-term oral treatment with bromocriptine resulted in a sustained suppression of the serum FSH levels, without further visual improvement, but with a significant reduction of the volume of the adenoma. The rapid and prolonged effect of Parlodel-LAR upon the FSH secretion, with a possible correction of the visual field defects and a reduction of the tumor mass, could make this medication appropriate as adjunctive treatment in some gonadotroph cell adenomas. [less ▲]

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See detailAcromegaly, multinodular goiter, and silent polyostotic fibrous dysplasia : a variant of the Mc Cune Albright syndrome.
Abs, R.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1990), 13(8), 671-675

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident ... [more ▼]

A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident. The presence of a pituitary mass and the secretory dynamics of growth hormone and prolactin were suggestive of a mammosomatotroph cell adenoma. A toxic multinodular goiter was also associated, but unique was the spontaneous normalization of the thyroid function. Unusual was the silent evolution of the polyostotic fibrous dysplasia, which was only fortuitously discovered during magnetic resonance imaging of the pituitary region. Treatment of the acromegaly with the long-acting somatostatin analogue octreotide resulted in an important inhibition of the GH secretion and in a reduction of the volume of the pituitary adenoma. [less ▲]

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See detailA follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine.
Abs, R.; Beckers, Albert ULg; De Longueville, M.

in Journal of Endocrinological Investigation (1990), 13

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See detailThyrotropin-secreting pituitary adenomas : report of 7 cases.
Beckers, Albert ULg; Abs, R.; Mahler, C. et al

in Journal of Endocrinological Investigation (1990)

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See detailGonadotropin secretion in the bovine : localization of LH and FSH in pituitaries by electron microscopy.
Bastings, E.; Beckers, Albert ULg; Reznik, M. et al

in Journal of Endocrinological Investigation (1990)

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See detailCyclical Cushing's disease and its successful control under sodium valproate.
Beckers, Albert ULg; Stevenaert, Achille ULg; Pirens, G. et al

in Journal of Endocrinological Investigation (1990), 13(11), 923-9

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical ... [more ▼]

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. [less ▲]

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See detailThe physiology of pituitary and placental GH secretion during pregnancy in acromegalic as compared to normal women.
Beckers, Albert ULg; Frankenne, F.; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1989)

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