References of "Journal of Controlled Release"
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See detailChitosan nanoparticles for siRNA delivery: Optimizing formulation to increase stability and efficiency
Ragelle, Héloïse; Riva, Raphaël ULg; Vandermeulen, G. et al

in Journal of Controlled Release (2014), 176

This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii ... [more ▼]

This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio, chitosan physicochemical properties, PEGylation of chitosan as well as the addition of an endosomal disrupting agent and a negatively charged polymer was assessed. The gene silencing activity and cytotoxicity were evaluated on B16 melanoma cells expressing luciferase. We monitored the integrity and the size behavior of siRNA nanoparticles in human plasma using fluorescence fluctuation spectroscopy and single particle tracking respectively. The presence of PEGylated chitosan and poly(ethylene imine) was essential for high levels of gene silencing in vitro. Chitosan nanoparticles immediately released siRNA in plasma while the inclusion of hyaluronic acid and high amount of poly(ethylene glycol) in the formulation improved the stability of the particles. The developed formulations of PEGylated chitosan-based nanoparticles that achieve high gene silencing in vitro, low cytotoxicity and high stability in plasma could be promising for intravenous delivery of siRNA. [less ▲]

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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailHemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer
Kuznetsova, Natalia R.; Sevrin, Chantal ULg; Lespineux, David et al

in Journal of Controlled Release (2012)

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See detailDesign of reversibly core cross-linked micelles sensitive to reductive environment
Cajot, Sébastien ULg; Lautram, N.; Passirani, Catherine et al

in Journal of Controlled Release (2011), 152(1), 30-36

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in ... [more ▼]

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in order to build micellar drug delivery systems. Such azido groups being able to react by alkyne-azide 1,3 Huisgens cycloaddition (a click reaction) have been used further in order to cross-link the micelles via redox-sensitive disulfide bridges. This reversible cross-linking allows to prevent micelles dissociation at high dilution upon injection and to trigger their dissociation in more reductive environment, such as the cytosol. Copolymers having three different architectures, i.e. able to crosslink either the core or the shell of core-shell-corona system have been used to investigate their micellization, cross-linking and cross-linking reversibility. The stealthiness of these micelles crosslinked in the hydrophobic segment has also been studied in vitro. [less ▲]

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See detailHemocompatibility assessment of poly(2-dimethylamino ethylmethacrylate) (PDMAEMA)-based polymers
Cerda Cristerna, Bernardino Isaac ULg; Flores, Héctor; Pozos-Guillén, Amaury et al

in Journal of Controlled Release (2011), 153(3), 269-77

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA), a cationic polymer, has been widely reported as a nonviral carrier. Despite the fact that the cytotoxicity of this polymer has been extensively studied ... [more ▼]

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA), a cationic polymer, has been widely reported as a nonviral carrier. Despite the fact that the cytotoxicity of this polymer has been extensively studied, there is a lack of information about its blood compatibility. Hence, this work evaluates the hemocompatibility of free-form PDMAEMA homopolymers differing in molecular weight (Mw) with or without a poly(ethylene glycol) (PEG) sequence in the form of a palm tree-like structure. Poly(ethylenimine) (PEI) was used as a reference in order to compare its hemoreactivity. Hemagglutination, hemolysis, platelet number, blood coagulation, and the complement systems were assessed in normal human whole blood according to the ISO 10993-4. Results showed that Mw, concentration, and incubation time strongly affected the hemocompatibility of the polymers evaluated. Our in vitro observations highlight that PDMAEMA homopolymers interacted strongly with the surface of the red blood cells but not with the inner structure of the membrane, while PEI behaved in the opposite way. No clear correlation has been evidenced between PDMAEMA-induced hemagglutination, PEI-induced hemagglutination, and hemolysis. Interestingly, if these polyelectrolytes strongly affect the platelets and blood coagulation cascades in a dose dependent way, none of them significantly affects the complement system. Our work reveals new knowledge on the toxicology of 2 families of polycations largely explored for gene delivery and on their mechanisms of cellular and humoral interactions. [less ▲]

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See detailIncrement in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Cerda Cristerna, Bernardino Isaac ULg; Flores, Héctor; Pozos, Amaury et al

in Journal of Controlled Release (2010), 148(1), 30-31

Polycations are frequently reported to tailor drug delivery systems, there is still a need to better correlate theirmacromolecular features with their biocompatibility, in particular with blood. In this ... [more ▼]

Polycations are frequently reported to tailor drug delivery systems, there is still a need to better correlate theirmacromolecular features with their biocompatibility, in particular with blood. In this view, we have analysed the RBC aggregation and hemolysis response caused by poly (dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a free form, i.e. without their preliminary association with polyanionic drug. Our results highlight that the molecular weight of PDMAEMA significantly affects theRBC aggregationwithout inducing any hemolysis. [less ▲]

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See detailTargeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
Danhier, Fabienne; Vroman, Benoît; Lecouturier, Nathalie et al

in Journal of Controlled Release (2009), 140(2), 166-173

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our ... [more ▼]

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our PEGylated PLGA-based nanoparticles grafted with the RGD peptide or RGD-peptidomimetic (RGDp) would target the tumor endothelium and would further enhance the anti-tumor efficacy of PTX. The ligands were grafted on the PEG chain of PCL-b-PEG included in the nanoparticles. We observed in vitro that RGD-grafted nanoparticles were more associated to Human Umbilical Vein Endothelial cells (HUVEC) by binding to αvβ3 integrin than non-targeted nanoparticles. Doxorubicin was also used to confirm the findings observed for PTX. In vivo, we demonstrated the targeting of RGD and RGDp-grafted nanoparticles to tumor vessels as well as the effective retardation of TLT tumor growth and prolonged survival times of mice treated by PTX-loaded RGD-nanoparticles when compared to non-targeted nanoparticles. Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach. [less ▲]

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See detailPaclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
Danhier, Fabienne; Lecouturier, Nathalie; Vroman, Benoît et al

in Journal of Controlled Release (2009), 133(1), 11-17

The incorporation efficiency of PTX was higher with the nanoprecipitation technique. The release behavior of PTX exhibited a biphasic pattern characterized by an initial burst release followed by a slower ... [more ▼]

The incorporation efficiency of PTX was higher with the nanoprecipitation technique. The release behavior of PTX exhibited a biphasic pattern characterized by an initial burst release followed by a slower and continuous release. The in vitro anti-tumoral activity was assessed using the Human Cervix Carcinoma cells (HeLa) by the MTT test and was compared to the commercial formulation Taxol® and to Cremophor® EL. When exposed to 25 µg/ml of PTX, the cell viability was lower for PTX-loaded nanoparticles than for Taxol® (IC50 5.5 vs 15.5 µg/ml). Flow cytometry studies showed that the cellular uptake of PTX-loaded nanoparticles was concentration and time dependent. Exposure of HeLa cells to Taxol® and PTX-loaded nanoparticles induced the same percentage of apoptotic cells. PTX-loaded nanoparticles showed greater tumor growth inhibition effect in vivo on TLT tumor, compared with Taxol®. Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy. [less ▲]

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See detailSparing methylation of β-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro
Belhadj Salem, L.; Bosquillon, C.; Dailey, L. A. et al

in Journal of Controlled Release (2009), 136

Cyclodextrins (CDs) are promising solubility enhancers for inhaled drug delivery. However, they have dose-dependent effects on the respiratory epithelium, which may have advantages for permeability ... [more ▼]

Cyclodextrins (CDs) are promising solubility enhancers for inhaled drug delivery. However, they have dose-dependent effects on the respiratory epithelium, which may have advantages for permeability enhancement but also gives rise to safety concerns. In this study, the methyl thiazol tetrazolium (MTT) assay was used to compare a new sparingly methylated β-CD, Kleptose® Crysmeβ (Crysmeb) with the more established CD derivatives hydroxypropyl-γ-cyclodextrin (HPγCD), randomly methylated β-cyclodextrin (Rameb) and hydroxypropyl-β-cyclodextrin (HPβCD). The βCD derivatives affected cell metabolism in A549 cells in a concentration dependent manner with LDso of 56, 31 and 11 mM obtained for HPβCD, Crysmeb and Rameb, respectively. Calu-3 cells were less susceptible to βCD with an LDso of 25 mM being obtained for Rameb only. Permeability increases in Calu-3 cell layers were observed with βCD derivatives and a concentration dependency shown. The mechanism of permeability enhancement and its reversibility was investigated. Rameb produced an irreversible loss of cell layer barrier function at ≥25 mM, but perturbations of epithelial integrity were moderate and reversible in the case of HPβCD and Crysmeb (25-50 mM). Given its high solubilisation capacity, the low toxicity and transient absorption promoting properties, this study identifies Crysmeb as a promising adjuvant in formulations for inhalation. [less ▲]

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See detailPEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
Garinot, Marie; Fievez, Virginie; Pourcelle, Vincent et al

in Journal of Controlled Release (2007), 120(3), 195-204

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an ... [more ▼]

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an original method called "photografting" which covalently linked RGD peptides mainly on the PEG moiety of the PCL-PEG, included in the formulation. First, three non-targeted formulations with size and zeta potential adapted to M cell uptake and stable in gastro-intestinal fluids, were developed. Their transport by an in vitro model of the human Follicle associated epithelium (co-cultures) was largely increased as compared to mono-cultures (Caco-2 cells). RGD-labelling of nanoparticles significantly increased their transport by co-cultures. due to interactions between the RGD ligand and the I intregrins detected at the apical surface of co-cultures. In vivo studies demonstrated that RGD-labelled nanoparticles particularly concentrated in M cells. Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery. [less ▲]

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See detailHelodermin-loaded nanoparticles: Characterization and transport across an in vitro model of the follicle-associated epithelium
des Rieux, Anne; Fievez, Virginie; Momtaz, Maryam et al

in Journal of Controlled Release (2007), 118(3), 294-302

M cells represent a potential portal for oral delivery of peptides and proteins due to their high endocytosis abilities. An in vitro model of human FAE (co-cultures) was used to evaluate the influence of ... [more ▼]

M cells represent a potential portal for oral delivery of peptides and proteins due to their high endocytosis abilities. An in vitro model of human FAE (co-cultures) was used to evaluate the influence of M cells on the transport of free and encapsulated helodermin - a model peptide - across the intestinal epithelium. M cells enhanced transport of intact helodermin (18-fold, Papp 3 X 10(-6) cm s(-1)). As pegylation increased nanoparticle transport by M cells, helodermin was encapsulated in 200 mu nanoparticles containing PEG-b-PLA:PLGA 1:1. Stability of the selected formulation was demonstrated in simulated gastric and intestinal fluids. M cells increased the transport of helodermin encapsulated in these nanoparticles by a factor of 415, as compared to Caco-2 cells. Transport of free and encapsulated helodermin occurred most probably by endocytosis. In conclusion, M cells improved helodermin transport across the intestinal epithelium, confirming their high potential for oral delivery of peptides. [less ▲]

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See detailCopolymers of epsilon-caprolactone and quaternized epsilon-caprolactone as gene carriers
Vroman, Benoît; Mazza, Michaël; Fernandez, Manuela R et al

in Journal of Controlled Release (2007), 118(1), 136-144

New copolymers of E-caprolactone (CL) and gamma-bromo-epsilon-caprolactone quaternized by pyridine (Py + CL) were investigated as non-viral vectors for gene delivery. Copolymers with two molar ... [more ▼]

New copolymers of E-caprolactone (CL) and gamma-bromo-epsilon-caprolactone quaternized by pyridine (Py + CL) were investigated as non-viral vectors for gene delivery. Copolymers with two molar compositions (50 Py + CL/50 CL and 80 Py + CL/20 CL), each with a diblock or a random structure, were used to prepare nanoparticulate complexes with DNA. Average size and surface charge of the complexes and extent of the complexation were measured. The DNA condensation by the copolymers was analysed by a gel retardation assay. Cytotoxicity and transfection efficiency of the copolymers were also evaluated in HeLa cells and compared with polyethylenimme 50 kDa. The size of the polyplexes was approximately 200 nm. The zeta potential first increased with the copolymer/DNA charge ratio and became positive for charge ratios in the 2-4 range depending on the type of copolymer. DNA was completely condensed within the nanoparticles and the degree of interaction was very high. Cytotoxicity and transfection efficiency were found to be comparable to polyethylenimine 50 kDa. The experimental results suggest that the novel copolymers can be used as novel gene delivery vectors. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-410

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailOral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin
Evrard, Brigitte ULg; Chiap, Patrice ULg; De Tullio, Pascal ULg et al

in Journal of Controlled Release (2002), 85(1-3), 45-50

Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. ABZ has a very poor aqueous solubility. This study shows that hydroxypropyl ... [more ▼]

Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. ABZ has a very poor aqueous solubility. This study shows that hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is able to form inclusion complexes with ABZ and that is able to increase its aqueous solubility. A synergistic effect exists between HP-beta-CD and citric acid. The combination of HP-beta-CD (200 mM) and citric acid (50 mM) allows dissolution of more than 1.5 mg of ABZ per ml. The aim of this study is the in vivo evaluation in sheep of a solution of the inclusion complex of ABZ with HP-beta-CD in comparison with a suspension of the same drug. A significant (P<0.05) increase in the relative bioavailability is obtained with the solution containing the ABZ-HP-beta-CD complex as measured by ABZSO plasma levels. The area under the curve (AUC(0--> proportional, variant )) of the solution is 37% higher than that obtained with the suspension. Likewise the peak plasma concentration (C(max)) is twice that of the solution while the time to reach C(max) (T(max)) is reduced. [less ▲]

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailControl of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolisation materials
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Journal of Controlled Release (1996), 38(2-3), 109-122

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different ... [more ▼]

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different molecular weight have been combined. The basic concept relies upon the capability of the high molecular weight component (Mn: 65 000) to provide the microspheres with a high mechanical strength, whereas the low molecular weight component (Mn: 3500) should decrease the particle lifetime dramatically. It has been shown that changing the weight ratio of these two components is an efficient way to control the kinetics of the in vitro degradation of poly(DL-lactide) microspheres on the expected time scale. The microspheres have been prepared by the oil-in-water emulsion/evaporation process, and their final polymer content has been compared to the initial composition of the oil phase. They have also been analyzed by differential scanning calorimetry to know whether the two polymers form a monophase blend or not. Kinetics of the in vitro biodegradation has been estimated from the decrease in molecular weight of the constitutive poly(DL-lactide)s, the time-dependency of the microsphere weight and the observation of changes in the morphology by scanning electron microscopy. Progress in the hydrolysis of the ester groups has also been reckoned from the increasing acidity of the incubation medium and associated with the polymer. [less ▲]

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See detailMicroencapsulation by coacervation of poly(lactide-co-glycolide). IV. Effect of the processing parameters on coacervation and encapsulation
Nihant, N.; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Controlled Release (1995), 35(2-3), 117-125

Attention has been paid to phase separation of poly (lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of a silicone oil in order to promote protein microencapsulation. Since the process ... [more ▼]

Attention has been paid to phase separation of poly (lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of a silicone oil in order to promote protein microencapsulation. Since the process is very fast, the system is anytime out of equilibrium. The effect of the main processing parameters on the microencapsulation process has been analyzed and has highlighted that kinetics of the main encapsulation steps has a great effect on the characteristics of the final microspheres. These results have been discussed on the basis of a physico-chemical study of coacervation reported in previous papers of this series. [less ▲]

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See detailBiopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Evrard, Brigitte ULg; Delahaut, P.; Hubert, Philippe ULg et al

in Journal of Controlled Release (1995), 35

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the ... [more ▼]

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the rate constant for elimination (ke) for the intravenous solution was 0.18 h−1 compared to 0.10 h−1 for the oral aqueous solution. The absolute bioavailability of the oral solution was about 75%. A lipid matrix containing SMZ and a high density excipient is able to be retained in the reticulo-rumen and to produce a sustained release of the drug for at least 100 h provided that the mechanical strength of the bolus is sufficient. The pharmacokinetic data obtained with the lipid matrix show a release profile with two pulses due to both diffusion and erosion mechanisms. Plasma levels are maintained above the MIC of SMZ during 100 h with an absolute bioavailability of 51.7% [less ▲]

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See detailEffect of the emulsion stability on the morphology and porosity of semicrystalline poly-L-lactide micriparticles prepared by w/o/w double emulsion-evaporation
Schugens, Ch; Laruelle, N; Nihant, N et al

in Journal of Controlled Release (1994), 32

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