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See detailLes problèmes liés aux médicaments dans les officines belges
Huysmans; De Wulf, I; Foulon, V et al

in Journal de Pharmacie de Belgique (2014), 1

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to ... [more ▼]

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to investigate the frequency and nature of drug related problems detected by community pharmacists, 2/to inventories the frequency and nature of the interventions by community pharmacists on prescribed medicines, and 3/to evaluate whether there is a difference between DRP detection at the moment of dispensing versus in a quiet setting (a posteriori detection). METHOD: All trainees of the participating universities of Belgian were asked to contribute to a observational study. Participating pharmacists quantified DRP's and their interventions on prescribed medicines for 5 days. Registrations were made by using a web tool based on an adapted version of the classification list of PCNE. The registration took place in two phases, at the time of delivery as well as in an a posteriori verification of the prescriptions with the pharmaceutical record file of the patients. RESULTS: The study was conducted from November 2012 to April 2013 in 534 community-pharmacies with internship. During this period 9.869 prescriptions (15%) with at least one DRP were detected on a total of 64.962 prescriptions treated by tutor pharmacists. Since there could be more than one problem on a prescription, 15.952 DRP's were registered. 2.597 of the DRP's were detected by a posteriori verification. 75% of all problems had a technical cause and 37% were clinical in nature. Under the technical causes an incomplete prescription was the most common. The most frequently registered clinical causes were a drug interaction, an inopportune time of intake, a too high or too low dose and an unsuitable drug. Participating pharmacists solved almost 3 of the 4 detected DRP's. In more than half of the DRP's, the patient was verbally and/or written informed. In 44% of the a posteriori discovered problems, the pharmacist intervened. CONCLUSION: Pharmacist detected one or more DRP's with 15% of the prescriptions. Analysis of a prescription prior to dispensing the medicines therefore appears necessary. The active intervention of the pharmacist in 83% of the problems indicates that he contributes to the optimization of drug therapy with a potential increase in the quality of life of the patient and a reduction in the cost of healthcare. The a posteriori discovered DRP's demonstrate the need for pharmacist lead meditation reviews possibly together with the physician and/or patient. [less ▲]

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See detailAutomédication des céphalées fréquentes : étude dans les officines belges.
Mehuys, Els; Paemeleire, Koen; Van Hees, Thierry ULg et al

in Journal de Pharmacie de Belgique (2012), 2

AIM: This observational community pharmacy-based study aimed to investigate headache characteristics and medication use of persons with regular headache presenting for self-medication. METHODS ... [more ▼]

AIM: This observational community pharmacy-based study aimed to investigate headache characteristics and medication use of persons with regular headache presenting for self-medication. METHODS: Participants (n=1205) completed ii) a questionnaire to assess current headache medication and previous physician diagnosis, (ii) the ID Migraine Screener [ID-M] and (iii) the MIDAS questionnaire. RESULTS: Forty-four % of the study population (n=528) did not have a physician diagnosis of their headache, and 225 of them (225/528, 42.6%) were found to be ID-M positive. The most commonly used acute headache drugs were paracetamol (used by 62% of the study population), NSAIDs (39%) and combination analgesics (36%). Only 12% of patients physician-diagnosed with migraine used prophylactic migraine medication, and 25% used triptans. About 24% of our sample (n=292) chronically overused acute medication, which was combination analgesic overuse (n=166), simple analgesic overuse (n=130), triptan overuse (n=19), ergot overuse (n=6) and opioid overuse (n=51). Only 14.5% was ever advised to limit intake frequency of acute headache treatments. CONCLUSIONS: This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse among subjects seeking self-medication for regular headache. Community pharmacists have a strategic position in education and referral of these self-medicating headache patients. [less ▲]

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See detailEtude des performances d'appareils de melange Unguator pour la preparation magistrale a usage dermatologique
Stassen, T.; Piette, Marie ULg; Kinget, R. et al

in Journal de Pharmacie de Belgique (2006), 61(1), 1-10

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See detailFormulation of submicronic emulsions by using a high-pressure homogeniser
Roland, I; Evrard, Brigitte ULg; Erpicum, T et al

in Journal de Pharmacie de Belgique (2003), 57

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See detailInclusion of Piroxicam into Beta-Cyclodextrin by Means of Supercritical Carbon Dioxide: Thermal, Spectroscopic and Physicochemical Studies
Van Hees, Thierry ULg; Evrard, Brigitte ULg; Piel, Géraldine ULg et al

in Journal de Pharmacie de Belgique (2000), 55(1, Jan-Feb), 30-1

The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. The solubility piroxicam in supercritical CO2 was determined. The influence of the temperature ... [more ▼]

The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. The solubility piroxicam in supercritical CO2 was determined. The influence of the temperature, the pressure and the time of exposure on the inclusion rate were studied and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 150 bar of CO2. This complex was characterised by Differential Scanning Calorimetry and Fourier Transform Infrared Spectrometry. Supercritical carbon dioxide may prove to be a novel useful complexation method of non-polar drugs into beta-cyclodextrin. [less ▲]

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See detailLes propriétés de la glucosamine
Reginster, Jean-Yves ULg; Halkin, V

in Journal de Pharmacie de Belgique (2000), 55(5), 118-121

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See detailOptimization of a high performance thin layer chromatography method to quantify solanines in patatoes
Bodart, P.; Hubert, Philippe ULg; Angenot, Luc ULg et al

in Journal de Pharmacie de Belgique (1999), 54

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See detailStudy of adsorption effects in the analysis of pharmaceutical formulations by CE
Fotsing, L.; Fillet, Marianne ULg; Chiap, Patrice ULg et al

in Journal de Pharmacie de Belgique (1999), 54

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See detailA Comparative Study of the Antimycotic Activity of a Miconazole Hp-Beta Cyclodextrin Solution and a Surfactant Solution
Piel, Géraldine ULg; Hayette, Marie-Pierre ULg; Evrard, Brigitte ULg et al

in Journal de Pharmacie de Belgique (1999), 54(3, May-Jun), 87-8

The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market ... [more ▼]

The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market probably because of the toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing 10 mg of miconazole per ml (as the marketed solution), in combination with HP-beta cyclodextrin and lactic acid. The MIC of these two solutions were determined by broth microdilution method (following the NCCLS guidelines) against 15 yeasts and 16 filamentous fungi isolates. This study showed that MIC obtained with these two solutions are not significantly different. In vitro, the cyclodextrin solution has the same antimycotic activity as the Daktarin IV solution and can be proposed as a safe and effective parenteral solution to replace the previous surfactant solution. [less ▲]

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See detailEffects of Nimesulide and Indometacin on Cox-1 and Cox-2: A Comparative Study
de Leval, X.; Dogné, Jean-Michel ULg; Neven, P. et al

in Journal de Pharmacie de Belgique (1999), 54(3), 89-90

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have ... [more ▼]

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin. [less ▲]

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See detailRésolution préparative du pirlindole
De Tullio, Pascal ULg; Felekidis, Apostolos ULg; Liégeois, Jean-François ULg et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailConception et synthèses d’activateurs potentiels de canaux potassiques sensibles à l’ATP et bioisostères du BMS 180448
Khelili, S.; Pirotte, Bernard ULg; Dupont, L. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas
Masereel, B.; Ouedraogo, R.; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailDesign, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes
Somers, F.; Rogister, F.; Ouedraogo, R. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailRésolution préparative du pirlindol, journées franco-belges de pharmacochimie
De Tullio, Pascal ULg; Felikidis, A.; Liégeois, Jean-François ULg et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailQuantitative analysis of l-lysine n-acetylcysteinate and related compounds by LC-MS
Toussaint, B.; Ceccato, Attilio ULg; Hubert, Philippe ULg et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailAutomated determination of acyclovir in human plasma using solid phase extraction and liquid chromatography
Chiap, Patrice ULg; Planck, I.; Evrard, Brigitte ULg et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 17 (1 ULg)