References of "Journal de Gynécologie, Obstétrique et Biologie de la Reproduction"
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See detailInfluence of HIV-1 and placental malaria co-infection on newborn biometry and Apgar scores in Kinshasa Democratic Republic of Congo
Modia O'Yandjo, A.; Foidart, Jean-Michel ULg; RIGO, Jacques ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2011), 40(5), 460-4

Objective The aim of this study was to assess the impact of HIV-1 and placental malaria co-infection on newborn biometry and Apgar scores. Methods 146 HIV-1 infected and 149 HIV-1 uninfected consent ... [more ▼]

Objective The aim of this study was to assess the impact of HIV-1 and placental malaria co-infection on newborn biometry and Apgar scores. Methods 146 HIV-1 infected and 149 HIV-1 uninfected consent mothers and their newborns were recruited. Placental biopsies examination confirmed the presence or absence of placental malaria. Birth weight (BW), placental weight, cranial circumference, brachial perimeter, height, Body Mass Index (BMI) and Apgar scores at 1’, 5’, 10’ were taken. The Chi2 test and t -Student test were used for data statistical analysis. Results The global placental malarial infection prevalence was 72% but was 91% in HIV-1 infected vs. 53.7% in HIV-1 uninfected mothers (p <0.0001). The mean BW of HIV-1 co-infected mother’s newborns was slightly inferior to that of HIV-1 uninfected mother’s babies (3,033±524g vs. 3,236±565g) but this difference was not statistically significant (p >0.05). No other significant biometric differences were noted (p >0.05). But, the co-infection influenced negatively Apgar scores at 5’ (p <0.05). Conclusion HIV-1 co-infected mothers were more frequently exposed to placental malaria infection. The co-infection reduced the Apgar scores taken at the fifth minute. [less ▲]

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See detailA rare case of placental choriangioma associated with neonatal diffuse hemangomatosis.
Capelle, Xavier ULg; Syrios, Petros ULg; Chantraine, Frédéric ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2009), 38(3), 246-249

Placental chorioangioma is a benign vascular tumor. Lesions larger than 4cm may cause fetal and maternal complications. Its association with disseminated neonatal hemangiomatosis is rarely described. We ... [more ▼]

Placental chorioangioma is a benign vascular tumor. Lesions larger than 4cm may cause fetal and maternal complications. Its association with disseminated neonatal hemangiomatosis is rarely described. We report a case of a large chorioangioma associated with an hydrops foetalis and disseminated neonatal hemangiomatosis. The relationship between placental chorioangioma and hemangioma is briefly discussed. [less ▲]

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See detailDétermination d'un index prédictif de la preeclampsie en préconceptionnel et propositions thérapeutiques de prévention primaire
Emonts, Patrick ULg; Seaksan, Sontera; Seidel, Laurence ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2008), 37(5), 469-476

Objective To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary ... [more ▼]

Objective To derive a prediction index based on the most salient history, laboratory and clinical parameters for identifying women at high risk of developing preeclampsia (PE) and to suggest a primary prevention. Material and method Non-pregnant women with a history of PE (n =101) were compared to non-pregnant parous women with a history of one or more successful normotensive pregnancies (n =50) but with comparable age, gestation and parity profiles. The parameters included history and clinical examination; laboratory studies (hemostasis, coagulation, vitamins); and morphological and functional tests (cardiovascular and renal functions). Stepwise logistic regression analysis was applied to develop a three step PE prediction index based on the most discriminant parameters. Strategies to prevent PE in the high-risk group are described. Results Identification of women at high risk of PE can be done efficiently (88% sensitivity and specificity) using a predictive index based on a simple history, laboratory, clinical and functional information. Stategies to prevent PE in our high-risk group have given encouraging results during next pregnancy. Conclusion Our study gives a predictive index of PE outside of pregnancy and possibilities to do a primary prevention. [less ▲]

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See detailGestion antenatale et issue postnatale des foetus atteints de laparoschisis
Capelle, Xavier ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2007), 36(5), 486-95

OBJECTIVES: To assess the relevance and the quality of gastroschisis's care in a mid level referral centre. METHOD: A retrospective analysis was performed for infants diagnosed or born with gastroschisis ... [more ▼]

OBJECTIVES: To assess the relevance and the quality of gastroschisis's care in a mid level referral centre. METHOD: A retrospective analysis was performed for infants diagnosed or born with gastroschisis between 1992 and 2003 at the Citadelle hospital, Department of Obstetrics and Gynaecology, University of Liege. RESULTS: Twenty-four cases of gastroschisis were identified. For 22 of them (92%) antenatal sonographic diagnosis was performed at a mean gestational age of 23 weeks. Antenatal diagnosis did not allow to identify additional malformation or chromosomal anomaly. Postnatal diagnosis allows to identify 3 infants with minor cardiac anomalies without functional consequence and one X fragile syndrome. One pregnancy was electively terminated at 24 weeks and one late intrauterine death was reported at 35 weeks. Bowel atresia, stenosis or ischemia were present at birth for 8 cases (33%). Out of 24 cases 22 were live born. 10 infants out of 22 (45%) underwent uncomplicated primary surgical repair. Three infants out of 22 (14%) underwent delayed closure without complications. Nine infants out 22 (41%) underwent multiple surgery (2 to 6). In this group all had postnatal complications, some with multisystem complications, including 3 deaths, 6 with infectious complications, 5 with gastrointestinal complications and 2 with genitourinary or haematological complications. Hospital stay range from 19 to 378 days (median, 51 days). Length of stay and time to full enteral feeding were longer if oligohydramnios or sonographic signs of intestinal damage were found. Among infants born before 35 weeks, only those with intestinal damage at birth had length of stay or time to full enteral feeding longer. Out of 22 live born infants 19 survived (86%) after one year. Survival rate without handicap due to gastroschisis is 84%. CONCLUSION: Sonographic examination is a valid method for prenatal diagnosis and surveillance. Our survival rate agrees with recent data in the literature. It has to be noticed that hospital stay is lengthy and complications are frequent. The most important prognostic factor is the condition of the bowel at birth and there is no antenatal means to predict severe damage. [less ▲]

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See detailL'endometriose extragenitale
Nisolle, Michelle ULg; Pasleau, Françoise ULg; Foidart, Jean-Michel ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2007), 36(2), 173-8

Parietal, appendiceal, pleuropulmonary and diaphragmatic endometriosis represent 5% of endometriosis cases. Diagnosis and management of these extra-genital localisations are described according to the ... [more ▼]

Parietal, appendiceal, pleuropulmonary and diaphragmatic endometriosis represent 5% of endometriosis cases. Diagnosis and management of these extra-genital localisations are described according to the literature. Parietal endometriosis usually requires large resection of the tumor. Appendiceal endometriosis is frequently observed in cases of digestive endometriosis. Induration or rigidity of the appendix due to the presence of deep infiltrating endometriosis justifies appendicectomy. Thoracic and diaphragmatic endometriosis is characterized by the presence of typical symptoms during the perimenstrual periode. Medical treatment obtaining therapeutic amenorrhea is firstly administered and surgery is indicated in cases of symptoms recurrence. [less ▲]

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See detailLe calcium et la vitamine D dans la prise en charge de l'ostéoporose
Rizzoli, R.; Boonen, S.; Brandi, M. L. et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2007), 36(6), 615-617

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See detailUtilisation en routine clinique du genotypage foetal RHD sur plasma maternel: bilan de deux ans d'activite
Minon, J. M.; Schaaps, Jean-Pierre ULg; Retz, M. C. et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2005), 34(5), 448-53

OBJECTIVES: To evaluate the predictive value of RHD fetal genotype in maternal plasma of Rh D negative mothers after 10 weeks of gestation in a clinical use. MATERIAL AND METHOD: Prospective, comparative ... [more ▼]

OBJECTIVES: To evaluate the predictive value of RHD fetal genotype in maternal plasma of Rh D negative mothers after 10 weeks of gestation in a clinical use. MATERIAL AND METHOD: Prospective, comparative study between fetal RHD genotyping in maternal plasma, with amplification of exons 4,5,10 of the RHD gene, by real-time multiplex PCR, and Rh D serology at birth, in 218 pregnancy and their 223 babies, between November 2002 and 2004. RESULTS: Combining the amplification of three exons, the concordance rate of fetal Rh D genotyping in maternal plasma and baby phenotyping at delivery was 100%. Four women whose the babies were Rh D negative were positive for RHD exon 10 during pregnancy. This positivity was, in three cases, correlated with the presence of RHDpsi pseudogene and in last case, with a haplotype Cdes (r's). RHD genotyping was performed for five twin pregnancies. CONCLUSION: Multiplex PCR using maternal plasma provides perfect prenatal prediction of fetal RHD gene. These results confirm that this non invasive procedure is the preferred method for assessing Rh D fetal status in Rh negative mothers. Using this method for two years in routine practice has led us to modify our management scheme for sensitized Rh D-negative pregnant women. [less ▲]

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See detailLe streptocoque du groupe B en clinique antenatale et en salle de travail: un probleme d'attitude systematique
Lorquet, Sophie ULg; Melin, Pierrette ULg; Minon, Jean-Marc et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2005), 34(2), 115-27

OBJECTIVES: We wanted to evaluate the compliance to the local recommendations, similar to the CDC (Centers for Disease Control and prevention) recommendations launched in 1996, for the prevention of ... [more ▼]

OBJECTIVES: We wanted to evaluate the compliance to the local recommendations, similar to the CDC (Centers for Disease Control and prevention) recommendations launched in 1996, for the prevention of perinatal group B streptococcal (GBS) disease in the clinical practice of a academic maternity and to identify the causes of missed screening and antibiotic prophylaxis. MATERIALS AND METHODS: Retrospective study of 1249 consecutive pregnancies between 1st January and 31th August 2002. The screening methods for GBS colonisation were the culture of rectovaginal swabs collected between 35 and 37 weeks and/or a rapid antigenic screening performed on a vaginal swab collected at the patient's admission for labor. RESULTS: Rate of global screening was very high (97.8%): 28.8% of antenatal screening versus 90.3% during labor. An appropriate antibiotic prophylaxis was administered to only one-third of positive women when the screening was performed at admission to the labor room, whereas two-thirds of GBS-positive women screened between 35 and 37 weeks received their antibiotic prophylaxis. 2.4%o of the newborns were infected and 2.9% were colonized. Among the different risk factors, intrapartum fever was more often associated with maternal GBS colonisation. The observed sensitivity of the rapide antigenic test was 20.4%. CONCLUSION: Compliance to guidelines is sometimes difficult in the clinical practice of an academic maternity. In our hands the rapid test for GBS screening had low sensitivity. The analysis of these data led to introducing a computerized algorithm in our maternity to improve the prevention of perinatal group B streptococcal disease. [less ▲]

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See detailMethodologie de l'enquete MISSION (Menopause, rISque de cancer du SeIn, mOrbidite et prevaleNce).
Chevallier, T.; Daures, J*-P; Micheletti, M*-C et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2005), 34(7 Pt 1), 658-65

OBJECTIVE: The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to ... [more ▼]

OBJECTIVE: The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to determine the prevalence of breast cancer and global morbidity in France among menopausal women treated or not with hormone replacement therapy (HRT) and followed by a gynecologist. MATERIAL AND METHOD: 6600 menopausal women [3300 with HRT -- ie for estrogen: only estradiol via oral or transdermal administration; for progestogen: natural progesterone or assimiled or one pregnane derived (excluding medroxyprogesterone acetate) or non-pregnane derived -- and 3300 without HRT] will be enrolled in France between January 5 2004 and February 28 2005 by 825 gynecologists, members or not of the National Federation of Medical Gynecologists (FNCGM). This study design is a historico-prospective with case randomization. MISSION is conducted by a Theramex-Merck Laboratories initiative in collaboration with a WHO (World Health Organization) Collaborating Center for Public Health Aspects of Rheumatic Diseases and a multidisciplinary expert group. CONCLUSION: First results of this study will contribute to better knowledge of women health. [less ▲]

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See detailMéthodologie de l'enquête MISSION (Ménopause, risque de cancer du sein, morbidité et prévalence)
Chevalier, T.; Daures, J. P.; Micheletti, M. C. et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2005), 34(7-C1), 658-665

Objective. The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to ... [more ▼]

Objective. The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to determine the prevalence of breast cancer and global morbidity in France among menopausal women treated or not with hormone replacement therapy (HRT) and followed by a gynecologist. Material and method. 6600 menopausal women [3300 with HRT — ie for estrogen: only estradiol via oral or transdermal administration; for progestogen: natural progesterone or assimiled or one pregnane derived (excluding medroxyprogesterone acetate) or non-pregnane derived — and 3300 without HRT] will be enrolled in France between January 5 2004 and February 28 2005 by 825 gynecologists, members or not of the National Federation of Medical Gynecologists (FNCGM). This study design is a historico-prospective with case randomization. MISSION is conducted by a Theramex-Merck Laboratories initiative in collaboration with a WHO (World Health Organization) Collaborating Center for Public Health Aspects of Rheumatic Diseases and a multidisciplinary expert group. Conclusion. First results of this study will contribute to better knowledge of women health. [less ▲]

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See detailL'implantation : premier dialogue entre la mère et l'embryon
PERRIER d'HAUTERIVE, Sophie ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2004), 33

Implantation : the first maternal-embryo crosstalk. Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to obtain successful pregnancies ... [more ▼]

Implantation : the first maternal-embryo crosstalk. Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to obtain successful pregnancies. It is of prime importance to determine the characteristic features of a receptive endometrium. Embryo implantation is a complex event involving apposition followed by the adhesion of the blastocyst to the maternal endometrium, and finally the invasion of this endometrium. Though implantation could occur in any human tissue, the endometrium is the only tissue where embryo implantation cannot occur except during a restricted period called the “implantation window”. During this window, the endometrium is highly receptive to the embryo. Maternal-embryo crosstalk is favored by the implantation window. The molecular basis of the implantation window remains to be defined In the present study, we investigated the role of hCG, TGFß1, IGF1 and IGF2 in the secretion of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) by human epithelial endometrial cells in culture. Epithelial endometrial cells were obtained from endometrial biopsy in 28 fertile women. HCG and TGFß1 added to primary cultures of human epithelial endometrial cells showed a stimulatory effect on LIF secretion and a reducing effect on IL-6 secretion. All these findings suggest a role for hCG and TGFß1 in human embryo implantation. [less ▲]

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See detailEndometriose stade I et II: implications physiopathologiques, cliniques et therapeutiques
Nisolle, Michelle ULg; Nervo, Patricia ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2003), 32(8, Pt 2), 11-4

Stage I and II endometriosis is defined by a r-AFS score respectively ranging from 1 to 5 and from 6 to 15. This mild, superficial endometriosis is a very common pathology occurring in infertile women ... [more ▼]

Stage I and II endometriosis is defined by a r-AFS score respectively ranging from 1 to 5 and from 6 to 15. This mild, superficial endometriosis is a very common pathology occurring in infertile women. Nevertheless, these women with stage I/II endometriosis have usually few pelvic pain. This review summarizes the recent literature concerning new data on the pathogenesis of peritoneal endometriosis and its clinical management. Retrograde menstruation, peritoneal adhesion of shed endometrial tissue, and outgrowth of endometrial cells, glands and stroma, are essential elements in the pathogenesis of endometriosis according to Sampson's classic implantation theory. Nevertheless, exact pathophysiology of endometriosis remains unknown. Superficial endometriotic lesions observed by laparoscopy have to be treated. Surgical procedure is not difficult for stage I and II of endometriosis. Surgical procedure remains controversial. Carbon dioxide (CO2) Laser can be used for laparoscopic destruction of endometriosis. Newer procedures, such as SurgiTouch (Lumenis), are more effective in vaporization and decrease the risk thermal damage of contiguous structures. The monopolar scissors can also be used in order to excise the peritoneal endometriotic lesions. Medical treatment may be usefull if surgical treatment is not complete or if the pelvic cavity is hypervascularized. In these cases, Gonadotropin-Releasing Hormone agonists (Gn-RHa) are the most common and effective treatment. [less ▲]

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See detailTraitement hormonal de la menopause: traitement hormonal substitutif classique ou tibolone?
Reginster, Jean-Yves ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2002), 31(6), 541-9

OBJECTIVE: Our purpose was to review with critical analysis, data from randomized controlled clinical trials comparing the effects on bone of conventional hormone replacement therapy (HRT) and tibolone ... [more ▼]

OBJECTIVE: Our purpose was to review with critical analysis, data from randomized controlled clinical trials comparing the effects on bone of conventional hormone replacement therapy (HRT) and tibolone. Their respective effects on bone were also reviewed and summarized. Materials and methods. Medline via PubMed was searched using a combination of the following key words "tibolone, estrogens and bone" to identify all randomized controlled trials tibolone versus HRT (1960-2001). RESULTS: Six randomized controlled trials that have been carried out to compare effects of tibolone and conventional HRT on prevention of postmenopausal bone loss were identified. Only one of these trials has been performed with a correct methodology (double-blind and with an adequate duration). In this trial over 2 years, the highest significant increase from baseline in bone mineral density (BMD) at all sites was observed with HRT; in addition, HRT showed a significantly greater increase in BMD at lumbar spine than tibolone. Randomized placebo-controlled trials have demonstrated that tibolone produces positive effects on BMD. Nevertheless, no clinical convincing data are available to support its efficacy in the prevention of osteoporotic fractures. The positive impact on BMD of conventional HRT to prevent postmenopausal bone loss and to treat established osteoporosis has been shown by many randomized controlled trials. Regarding fracture risk prevention, some clinical and epidemiological data suggest that HRT initiated in early or late postmenopause may prevent fractures if it is administered at standard doses and continued for a long time. CONCLUSION: HRT is always the reference treatment of postmenopausal symptoms related to estrogen deficiency. [less ▲]

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See detailLa fenetre implantatoire
Perrier D'Hauterive, Sophie ULg; Charlet, Jeanne de Chantal ULg; Goffin, Frédéric ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2002), 31(5), 440-55

BACKGROUND: Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this endometrium. Though implantation ... [more ▼]

BACKGROUND: Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this endometrium. Though implantation could occur in any human tissue, the endometrium is the only tissue where embryo implantation cannot occur except during a restricted period called the implantation window. During this window, the endometrium is highly receptive to the embryo. MATERIAL: and methods. We reviewed the literature concerning the different factors involved in improved endometrial receptivity and implantation. RESULTS: Maternal - embryo crosstalk is favored by the implantation window. Endometrial receptivity results from the acquisition of ligands or receptors facilitating apposition, then adhesion of the embryo, or from the loss of components preventing it. The molecular basis of the implantation window remains to be defined. CONCLUSION: Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to successful pregnancy. It is of prime importance to determine the characteristic features of a receptive endometrium and, among the many markers proposed by in vitro studies, to analyze in humans those demonstrated by knock-out experiments to play a crucial role in mice. [less ▲]

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See detailLa fenêtre implantatoire
PERRIER d'HAUTERIVE, Sophie ULg; Charlet-Renard, Jeanne de Chantal ULg; Goffin, Frédéric ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2002), 31(5), 440-55

The implantation window. Background. Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this ... [more ▼]

The implantation window. Background. Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this endometrium. Though implantation could occur in any human tissue, the endometrium is the only tissue where embryo implantation cannot occur except during a restricted period called the implantation window. During this window, the endometrium is highly receptive to the embryo. Material and methods. We reviewed the literature concerning the different factors involved in improved endometrial receptivity and implantation. Results. Maternal - embryo crosstalk is favored by the implantation window. Endometrial receptivity results from the acquisition of ligands or receptors facilitating apposition, then adhesion of the embryo, or from the loss of components preventing it. The molecular basis of the implantation window remains to be defined. Conclusion. Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to successful pregnancy. It is of prime importance to determine the characteristic features of a receptive endometrium and, among the many markers proposed by in vitro studies, to analyze in humans those demonstrated by knock-out experiments to play a crucial role in mice. [less ▲]

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See detailRegrets apres sterilisation tubaire
Nervo, Patricia ULg; Bawin, L.; Foidart, Jean-Michel ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2000), 29(5), 485-91

OBJECTIVE: To examine thoroughly the profile and motivations of a group of women who regretted sterilization so much that they were prepared to undergo reversal microsurgery or in vitro fertilization ... [more ▼]

OBJECTIVE: To examine thoroughly the profile and motivations of a group of women who regretted sterilization so much that they were prepared to undergo reversal microsurgery or in vitro fertilization treatment. MATERIAL: and methods. The study followed one hundred women from their first consultation for a period of 3 years in order to analyze the outcome of their initial decision. RESULTS: Analysis of the circumstances at the time of the sterilization indicate 3 main factors which later caused the women to regret the decision Three years after the initial consultation, 69% of the patients have withdrawn from further investigation and /or treatment for different reasons analyzed in this study. 17 of the patients have undergone reversal microsurgery and 14 have attempted one or more in vitro fertilization treatments. Of these 31 patients, 12 (38.7%) have given birth to at least one child. CONCLUSION: These results sufficiently prove that tubal sterilization is worthy of consideration as much by the patient as by the physician as a method of irreversible contraception despite the developments in tubal microsurgery or in medically assisted procreation. [less ▲]

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See detailLa chirurgie mammaire supraconservatrice
Lifrange, Eric ULg; Colin, Claude ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2000), 29(3), 285-7

Currently, 30% of the breast biopsies are performed for patients with nonpalpable lesions. The surgical management of these lesions had to evolve to a better three-dimensional targeting and a reduction of ... [more ▼]

Currently, 30% of the breast biopsies are performed for patients with nonpalpable lesions. The surgical management of these lesions had to evolve to a better three-dimensional targeting and a reduction of the tissue traumatism. The ABBI procedure allows the percutaneous one bloc excision of suspicious mammographically detected lesions with a diameter of less than 2cm. We prospectively evaluated this procedure as a therapeutic tool. Of the 10 malignant lesions with a pathologic size <10mm, 9 (90%) were completely resected with the ABBI device (no residual disease at re-excision of the biopsy site). The results of this preliminary study suggest a potential therapeutic role of the ABBI procedure in the therapeutic arsenal against mammary lesions. [less ▲]

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See detailEvaluation du rôle préventif des oestroprogestatifs et des thérapeutiques non hormonales dans le cadre de l'ostéoporose postménopausique
Reginster, Jean-Yves ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1996), 25(7), 677-83

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of ... [more ▼]

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of osteoporosis is based on efforts to reach a maximal peak bone mass at the end of the growth period and, subsequently, at the time of menopause. No pharmacological intervention is considered at this stage. Biologically, hormone replacement therapy induces a correction of the biochemical changes observed in markers of bone remodeling at the time of the menopause. A systematic screening of asymptomatic postmenopausal women followed by the induction of hormonal replacement therapy in high risk subjects appears to be an interesting cost/benefit strategy in terms of reasonable attribution of health resources. Nasal administration of calcitonin fully prevents the trabecular bone loss observed during the first years of menopause. Notwithstanding, the exact dose of nasal calcitonin able to prevent bone loss remains to be fully elucidated. Bisphosphonates inhibit bone resorption. Tiludronate prevents trabecular postmenopausal bone loss. The use of selectif estrogen receptor modulators is based on a possible differential action of these molecules, at the level of the estrogenic receptors, depending of the tissue considered. Several direct inhibitors of osteoclastic resorption are also under development. Their main target is either to prevent the linkage of osteoclasts to the bone matrix or to prevent the acidification of bone matrix required to induce the resorption process. [less ▲]

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See detailCancers épithéliaux de l'ovaire. Acquisitions récentes
van den Brule, F. A.; Lambotte, René ULg; Castronovo, Vincenzo ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1995), 24(3), 241-52

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by ... [more ▼]

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by the lack of a well defined precursor lesion, the lack of knowledge about tumour progression, and by the relative inaccessibility of the ovaries in the abdominal cavity. Recent studies using experimental models allow us to better define the fundamental mechanisms of carcinogenesis from the serous ovarian cells and of invasion of the abdominopelvic cavity by proximity. This review article tries to update on epidemiology, genetic syndromes, biology, screening, and therapy of these epithelial tumours, and about the new directions taken by basic and clinical research. We will present data concerning oncogenes and tumour suppressor genes involved in epithelial ovarian tumours, regulation of tumour cells by growth factors, genes involved in tumour invasion, and mechanisms used by the cancer cell to resist to therapies. Non-epithelial ovarian tumours will not be examined in this manuscript. [less ▲]

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See detailHématome extradural cervical spontané de la femme enceinte
Mahieu, X.; Kridelka, Frédéric ULg; Pintiaux, Axelle ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(1), 99-102

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The ... [more ▼]

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The patient underwent first a caesarean and thereafter a prompt spinal surgical decompression. Complete sensory-motor recovery occurred after 48 hours. Differential diagnosis of cord compression, etiology of bleeding, conditions of recovery after surgery are discussed. [less ▲]

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