  The Influence of Phylogenic Origin on the Occurrence of Brachycephalic Airway Obstruction Syndrome in a Large Retrospective StudyNjikam Nsangou, Ibrahim  ; ; et alin International journal of applied research in veterinary medicine (2009), 7(3), 138-143 Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily ... [more ▼] Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily affordable information of clinical significance. When this clinical information is enriched with knowledge on the phylogenetic origins, breed histories of the dog and adjusted for known biases, they may lead the way to more in depth genetic research. We illustrated here with a very complex disease, the brachycephalic airway obstruction syndrome (BAOS). No cases were reported in the boxer breed while almost half of the dogs from the other brachycephalic breeds of the same phylogenetic cluster were BAOS, making these breeds good candidates for further genetic studies. Critical issues to improve utility of clinical data for genetic studies are discussed along with methods to handle biases inherent to such type of studies. [less ▲] Detailed reference viewed: 98 (7 ULg) Cost-effectiveness analysis applied to the veterinary medicine: The economic value of packed cell value in the prognosis of horse surgical colicDetilleux, Johann ; Serteyn, Didier in International Journal of Applied Research in Veterinary Medicine (2005), 3(4), 309-318 Techniques of cost-effectiveness analyses were applied to determine whether or not it is economically efficient to measure the packed cell volume (PCV) on a colic horse before deciding on abdominal ... [more ▼] Techniques of cost-effectiveness analyses were applied to determine whether or not it is economically efficient to measure the packed cell volume (PCV) on a colic horse before deciding on abdominal surgery. The effects of this decision of uncertainty on the estimated values of the parameters (probability of survival after surgery, surgery costs, PCV positive predictive value, and length of survival after surgery) were considered along with the monetary values of collecting additional information on those parameters. The effects of uncertainty on the incremental net benefits of each alternative were depicted by tornado diagrams, cost-effectiveness acceptability curves, and posterior probability distributions. The worth of additional information was computed as the expected values of perfect and sampling information. Given previously published results, the best PCV cut-off point to distinguish between survivors and nonsurvivors was at 44%. At this threshold, the most economically effective alternative is to measure PCV before surgery providing the owner is willing to pay less than €672 for each year the horse survives. Uncertainty on probability of survival after surgery largely influenced the decision whether or not to measure the PCV, but one should spend at most €381 in research to reduce this uncertainty. A study of postoperative survival of 500 colic horses would ensure an expected gain of €370 associated with a reduction in uncertainty. [less ▲] Detailed reference viewed: 30 (5 ULg) |
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