References of "European Journal of Nuclear Medicine and Molecular Imaging"
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See detailHow to scan who: the delicate balance between selecting the patient and selecting the imaging protocol.
Hustinx, Roland ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2016)

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See detail[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
WITHOFS, Nadia ULiege; Martinive, Philippe ULiege; VANDERICK, Jean ULiege et al

in European journal of nuclear medicine and molecular imaging (2016)

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]

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See detailFDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
LOVINFOSSE, Pierre ULiege; Janvary, Zsolt Levente; COUCKE, Philippe ULiege et al

in European journal of nuclear medicine and molecular imaging (2016)

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis. RESULTS: The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01). CONCLUSION: The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization. [less ▲]

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See detailNuclear medicine training in the European Union : 2015 Update
PRIGENT, ALAIN; HUSTINX, Roland ULiege; COSTA, DURVAL C.

in European Journal of Nuclear Medicine and Molecular Imaging (2015)

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See detailRadiolabelling of starch microparticles with Rhenium-188 for hepatocellular carcinoma’s therapy
Verger, Elise ULiege; Bouvier, Antoine; Benoit, Jean-Pierre et al

in European Journal of Nuclear Medicine and Molecular Imaging (2014, October), 41(Supplement 2), 443-444

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See detailSPECT/CT workflow and imaging protocols.
BECKERS, Catherine ULiege; Hustinx, Roland ULiege

in European journal of nuclear medicine and molecular imaging (2014), 41

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow ... [more ▼]

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow processes and the revision of original scheduling process and imaging protocols. In addition, the imaging protocol should be adapted for each individual patient, so that performing CT is fully justified and the CT procedure is fully tailored to address the clinical issue. Such refinements often occur before the procedure is started but may be required at some intermediate stage of the procedure. Furthermore, SPECT/CT leads in many instances to a new partnership with the radiology department. This article presents practical advice and highlights the key clinical elements which need to be considered to help understand the workflow process of SPECT/CT and optimise imaging protocols. METHODS: The workflow process using SPECT/CT is complex in particular because of its bimodal character, the large spectrum of stakeholders, the multiplicity of their activities at various time points and the need for real-time decision-making. RESULTS: With help from analytical tools developed for quality assessment, the workflow process using SPECT/CT may be separated into related, but independent steps, each with its specific human and material resources to use as inputs or outputs. This helps identify factors that could contribute to failure in routine clinical practice. At each step of the process, practical aspects to optimise imaging procedure and protocols are developed. A decision-making algorithm for justifying each CT indication as well as the appropriateness of each CT protocol is the cornerstone of routine clinical practice using SPECT/CT. CONCLUSION: In conclusion, implementing hybrid SPECT/CT imaging requires new ways of working. It is highly rewarding from a clinical perspective, but it also proves to be a daily challenge in terms of management. [less ▲]

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See detailFDG PET/CT in Crohn's disease : correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity
SABOURY, BABAK; SALAVATI, ALI; BROTHERS, ALEX et al

in European Journal of Nuclear Medicine and Molecular Imaging (2014), 41

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography ... [more ▼]

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT employing a new quantitative approach. METHODS: A total of 22 subjects (mean age 37) with CD who had undergone FDG PET/CT followed by ileocolonoscopy within 1 week were included in this analysis. The CD endoscopy index of severity (CDEIS) for various bowel segments was calculated. The CD activity index (CDAI) was evaluated, and fecal calprotectin was measured. On PET, regions with increased FDG uptake in large bowel were segmented with an adaptive contrast-oriented thresholding algorithm, and metabolically active volume (MAV), uncorrected mean standardized uptake value (SUVmean), partial volume-corrected SUVmean (PVC-SUVmean), SUVmax, uncorrected total lesion glycolysis (TLG = MAV x SUVmean), and PVC total lesion glycolysis (PVC-TLG = MAV x PVC-SUVmean) were measured. Global CD activity score (GCDAS) was calculated as the sum of PVC-TLG over all clinically significant FDG-avid regions in each subject. Correlations between regional PET quantification measures (SUVs, TLGs) and CDEIS were calculated. Correlations between the global PET quantification measure (GCDAS, global SUVs) with CDAI, fecal calprotectin, CDEIS, and CRP level were also calculated. RESULTS: SUVmax, PVC-SUVmean, and PVC-TLG significantly correlated with segment CDEIS subscores (r = 0.50, r = 0.69, and r = 0.31, respectively; p < 0.05). GCDAS significantly correlated with CDAI and fecal calprotectin (r = 0.64 and r = 0.51, respectively; p < 0.05). CONCLUSION: By employing this new quantitative approach, we were able to calculate indices of regional and global CD activity, which correlated well with both clinical and pathological disease activity surrogate markers. This approach may be of clinical importance in measuring both global disease activity and treatment response in patients with CD. [less ▲]

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See detailPrognostic value of FDG PET/CT in patients with hepatocellular carcinoma treated with liver transplantation.
GOVAERTS, L.; DETRY, Olivier ULiege; BLETARD, Noëlla ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2013), 2013(SUPPL), 287

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See detailAcute intramural haematoma of the ascending aorta
DURIEUX, Rodolphe ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2012), 39(8), 1368-1369

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See detailAcute intramural haematoma of the ascending aorta.
Govaerts, L.; WITHOFS, Nadia ULiege; DURIEUX, Rodolphe ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2012), 39(8), 1368-9

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See detailPhantom program analysis to assess the variability in PET image quantification between different PET-CT centres
Guiot, Thomas; Vanderlinden, Bruno; Wimana, Zéna et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 172

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See detailViability for the Siemens Ecat HR+ of the new stability test of PET scanners elaborated by the Belgian Hospital Physicist Association
Nguyen, Daniel ULiege; Dalemans, Christophe; Bahri, Mohamed Ali ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 174

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See detailQuantitative capabilities of the Siemens Symbia T6 SPECT-CT system with iterative Flash3D reconstruction
Nguyen, Daniel ULiege; Seret, Alain ULiege; Bernard, Claire ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 223

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See detail2-18F-Fluoro-L-tyrosine in the suspicion of recurrence of previously treated gliomas.
AGIUS, C.; NAMUR, Gauthier ULiege; COUTURIER, O. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011), 38(SUPPL), 219

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See detailAssessment of early therapeutic response in anti-TNFα refractory rheumatoid arthritis with FDG PET/CT.
FOSSE, P.; KAISER, Marie-Joëlle ULiege; NAMUR, Gauthier ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2010), 37(SUPPL), 211

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See detailPET/CT in head and neck cancer: an update.
Hustinx, Roland ULiege; Lucignani, Giovanni

in European Journal of Nuclear Medicine and Molecular Imaging (2010), 37(3), 645-51

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See detailNEMA NU1-2001 performance tests of Philips Brightview SPECT cameras
Seret, Alain ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2009, October), 36(S2), 408

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See detailWill high-resolution/high-sensitivity SPECT ensure that PET is not the only survivor in nuclear medicine during the next decade?
Seret, Alain ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2009), 36(3), 533

The future of SPECT and PET is discussed is the light of the most recent advances in SPECT and in the context of the supply in isotopes

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See detail99m Tc-MIBI pinhole SPECT in primary hyperparathyroidism: comparison with conventional SPECT, planar scintigraphy and ultrasonography
Carlier, Thomas; Oudoux, Aurore; Miraillé, Eric et al

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(3), 637-643

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See detailAttenuation and scatter correction accuracy of the microPET Focus 120 assessed with the NEMA NU-4 2008 phantom.
Bahri, Mohamed Ali ULiege; Plenevaux, Alain ULiege; Seret, Alain ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(S2), 193

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