References of "European Journal of Nuclear Medicine and Molecular Imaging"
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See detailFDG PET/CT in Crohn's disease: correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity.
Saboury, Babak; Salavati, Ali; Brothers, Alex et al

in European journal of nuclear medicine and molecular imaging (2013)

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography ... [more ▼]

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT employing a new quantitative approach. METHODS: A total of 22 subjects (mean age 37) with CD who had undergone FDG PET/CT followed by ileocolonoscopy within 1 week were included in this analysis. The CD endoscopy index of severity (CDEIS) for various bowel segments was calculated. The CD activity index (CDAI) was evaluated, and fecal calprotectin was measured. On PET, regions with increased FDG uptake in large bowel were segmented with an adaptive contrast-oriented thresholding algorithm, and metabolically active volume (MAV), uncorrected mean standardized uptake value (SUVmean), partial volume-corrected SUVmean (PVC-SUVmean), SUVmax, uncorrected total lesion glycolysis (TLG = MAV x SUVmean), and PVC total lesion glycolysis (PVC-TLG = MAV x PVC-SUVmean) were measured. Global CD activity score (GCDAS) was calculated as the sum of PVC-TLG over all clinically significant FDG-avid regions in each subject. Correlations between regional PET quantification measures (SUVs, TLGs) and CDEIS were calculated. Correlations between the global PET quantification measure (GCDAS, global SUVs) with CDAI, fecal calprotectin, CDEIS, and CRP level were also calculated. RESULTS: SUVmax, PVC-SUVmean, and PVC-TLG significantly correlated with segment CDEIS subscores (r = 0.50, r = 0.69, and r = 0.31, respectively; p < 0.05). GCDAS significantly correlated with CDAI and fecal calprotectin (r = 0.64 and r = 0.51, respectively; p < 0.05). CONCLUSION: By employing this new quantitative approach, we were able to calculate indices of regional and global CD activity, which correlated well with both clinical and pathological disease activity surrogate markers. This approach may be of clinical importance in measuring both global disease activity and treatment response in patients with CD. [less ▲]

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See detailSPECT/CT workflow and imaging protocols.
Beckers, Catherine; Hustinx, Roland ULg

in European journal of nuclear medicine and molecular imaging (2013)

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow ... [more ▼]

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow processes and the revision of original scheduling process and imaging protocols. In addition, the imaging protocol should be adapted for each individual patient, so that performing CT is fully justified and the CT procedure is fully tailored to address the clinical issue. Such refinements often occur before the procedure is started but may be required at some intermediate stage of the procedure. Furthermore, SPECT/CT leads in many instances to a new partnership with the radiology department. This article presents practical advice and highlights the key clinical elements which need to be considered to help understand the workflow process of SPECT/CT and optimise imaging protocols. METHODS: The workflow process using SPECT/CT is complex in particular because of its bimodal character, the large spectrum of stakeholders, the multiplicity of their activities at various time points and the need for real-time decision-making. RESULTS: With help from analytical tools developed for quality assessment, the workflow process using SPECT/CT may be separated into related, but independent steps, each with its specific human and material resources to use as inputs or outputs. This helps identify factors that could contribute to failure in routine clinical practice. At each step of the process, practical aspects to optimise imaging procedure and protocols are developed. A decision-making algorithm for justifying each CT indication as well as the appropriateness of each CT protocol is the cornerstone of routine clinical practice using SPECT/CT. CONCLUSION: In conclusion, implementing hybrid SPECT/CT imaging requires new ways of working. It is highly rewarding from a clinical perspective, but it also proves to be a daily challenge in terms of management. [less ▲]

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See detailQuantitative capabilities of the Siemens Symbia T6 SPECT-CT system with iterative Flash3D reconstruction
Nguyen, Daniel ULg; Seret, Alain ULg; Bernard, Claire ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 223

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See detailViability for the Siemens Ecat HR+ of the new stability test of PET scanners elaborated by the Belgian Hospital Physicist Association
Nguyen, Daniel ULg; Dalemans, Christophe; Bahri, Mohamed Ali ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 174

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See detailPhantom program analysis to assess the variability in PET image quantification between different PET-CT centres
Guiot, Thomas; Vanderlinden, Bruno; Wimana, Zéna et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 172

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See detailPET/CT in head and neck cancer: an update.
Hustinx, Roland ULg; Lucignani, Giovanni

in European Journal of Nuclear Medicine and Molecular Imaging (2010), 37(3), 645-51

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See detailNEMA NU1-2001 performance tests of Philips Brightview SPECT cameras
Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2009, October), 36(S2), 408

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See detailWill high-resolution/high-sensitivity SPECT ensure that PET is not the only survivor in nuclear medicine during the next decade?
Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2009), 36(3), 533

The future of SPECT and PET is discussed is the light of the most recent advances in SPECT and in the context of the supply in isotopes

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See detail99m Tc-MIBI pinhole SPECT in primary hyperparathyroidism: comparison with conventional SPECT, planar scintigraphy and ultrasonography
Carlier, Thomas; Oudoux, Aurore; Miraillé, Eric et al

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(3), 637-643

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See detailHighlights of the annual congress of the European Association of Nuclear Medicine, Copenhagen 2007.
Knuuti, Juhani; Hustinx, Roland ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(3), 655-72

INTRODUCTION: The Annual Congress of the European Association of Nuclear Medicine took place in Copenhagen on October 13-17, 2007. The event is the major scientific and professional effort in the field of ... [more ▼]

INTRODUCTION: The Annual Congress of the European Association of Nuclear Medicine took place in Copenhagen on October 13-17, 2007. The event is the major scientific and professional effort in the field of nuclear medicine in Europe. The most important developments in the fields of instrumentation, radionuclide production, radiochemistry, radiotherapy, as well as the clinical imaging fields of neurology, cardiology, oncology, and general sciences were reported. OBJECTIVE: This paper emphasizes the major findings and trends at this important gathering. This review is, however, only a brief summary of the large amount of data discussed. [less ▲]

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See detailCyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies.
Lacan, Goran; Plenevaux, Alain ULg; Rubins, Daniel J. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(12), 2256-66

PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperaz ine ([(18)F]MPPF) for ... [more ▼]

PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperaz ine ([(18)F]MPPF) for binding to hydroxytryptamine(1A) (5-HT(1A)) receptors. Those increases were quantified in rat brain with in vivo microPET and ex vivo tissue studies. MATERIALS AND METHODS: Each Sprague-Dawley rat (n = 4) received a baseline [(18)F]MPPF microPET scan followed by second scan 2-3 weeks later that included cyclosporine pretreatment (50 mg/kg, i.p.). Maximum a posteriori reconstructed images and volumetric ROIs were used to generate dynamic radioactivity concentration measurements for hippocampus, striatum, and cerebellum, with simplified reference tissue method (SRTM) analysis. Western blots were used to semiquantify P-gp regional distribution in brain. RESULTS: MicroPET studies showed that hippocampus uptake of [(18)F]MPPF was increased after cyclosporine; ex vivo studies showed similar increases in hippocampus and frontal cortex at 30 min, and for heart and kidney at 2.5 and 5 min, without concomitant increases in [(18)F]MPPF plasma concentration. P-gp content in cerebellum was twofold higher than in hippocampus or frontal cortex. CONCLUSIONS: These studies confirm and extend prior ex vivo results (J. Passchier, et al., Eur J Pharmacol, 2000) that showed [(18)F]MPPF as a substrate for P-gp. Our microPET results showed that P-gp modulation of [(18)F]MPPF binding to 5-HT(1A) receptors can be imaged in rat hippocampus. The heterogeneous brain distribution of P-gp appeared to invalidate the use of cerebellum as a nonspecific reference region for SRTM modeling. Regional quantitation of P-gp may be necessary for accurate PET assessment of 5-HT(1A) receptor density when based on tracer uptake sensitive to P-gp modulation. [less ▲]

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See detailAttenuation and scatter correction accuracy of the microPET Focus 120 assessed with the NEMA NU-4 2008 phantom.
Bahri, Mohamed Ali ULg; Plenevaux, Alain ULg; Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(S2), 193

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See detailResolution Recovery Iterative Reconstruction For Human Pinhole SPECT: A Phantom Study.
Seret, Alain ULg; Andreyev, A.; Vanhove, Chistian et al

in European Journal of Nuclear Medicine and Molecular Imaging (2007, October 17), 34(S2), 236-237

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See detailContrast and sensitivity performances of Elscint, General Electric, Siemens and SMV multi-heads cameras.
Kirkove, Murielle ULg; Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2007, October), 34(S2), 345

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See detailF-18-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3
Beckers, Catherine ULg; Jeukens, Xavier; Ribbens, Clio ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(3), 275-280

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic ... [more ▼]

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic resonance imaging (MRI) and ultrasonography (US). Methods: Sixteen knees in 16 patients with active RA were assessed with PET, MRI and US at baseline and 4 weeks after initiation of anti-TNF-alpha treatment. All studies were performed within 4 days. Visual and semi-quantitative (standardised uptake value, SUV) analyses of the synovial uptake of FDG were performed. The dynamic enhancement rate and the static enhancement were measured after i.v. gadolinium injection and the synovial thickness was measured in the medial, lateral patellar and suprapatellar recesses by US. Serum levels of C-reactive protein (CRP) and metalloproteinase-3 (MMP-3) were also measured. Results: PET was positive in 69% of knees while MRI and US were positive in 69% and 75%. Positivity on one imaging technique was strongly associated with positivity on the other two. PET-positive knees exhibited significantly higher SUVs, higher MRI parameters and greater synovial thickness compared with PET-negative knees, whereas serum CRP and MMP-3 levels were not significantly different. SUVs were significantly correlated with all MRI parameters, with synovial thickness and with serum CRP and MMP-3 levels at baseline. Changes in SUVs after 4 weeks were also correlated with changes in MRI parameters and in serum CRP and MMP-3 levels, but not with changes in synovial thickness. Conclusion: F-18-FDG PET is a unique imaging technique for assessing the metabolic activity of synovitis. The PET findings are correlated with MRI and US assessments of the pannus in RA, as well as with the classical serum parameter of inflammation, CRP, and the synovium-derived parameter, serum MMP-3. Further studies are warranted to establish the place of metabolic imaging of synovitis in RA. [less ▲]

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See detailThe number of subsets required for OSEM reconstruction in nuclear cardiology
Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 231-231

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See detailEffect of diazepam on the efficacy of dual-phase FDG PET imaging.
Zhuang, Hongming; Hustinx, Roland ULg; Alavi, Abass

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 228-9230

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See detailIodide organification disorder in autonomous thyroid nodule.
Tang, B.; Corvilain, B.; Seret, Alain ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 351

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See detailComparison of noise, hot and cold contrast of eight tomographic camera models.
Seret, Alain ULg; Nguyen, Thibaut

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 282

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See detailImpact of the attenuation and scatter correction methods on hot and cold contrasts obtained with the Philips Gemini PET-scanner.
Seret, Alain ULg; Nguyen, T.; Bernard, Claire ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 316

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