  18F LABELING OF BIOMOLECULES USING CLICK CHEMISTRY FOR PET APPLICATIONS : SYNTHETIC DEVELOPMENTSThonon, David  ; Flagothier, Jessica ; Paris, Jérôme et alin Drugs of the Future (2008, August), 33(A), 235 Detailed reference viewed: 60 (15 ULg) Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disordersDe Tullio, Pascal ; ; Florence, Xavier et alin Drugs of the Future (2006), 31 Detailed reference viewed: 8 (1 ULg)StrychnopentamineAngenot, Luc in Drugs of the Future (1986), 11(1), 42-44 Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of ... [more ▼] Strychnopentamine is a new alkaloid found in Strychnos usambarensis leaves. It is the first alkaloid with five amines found in a Strychnos species; a methylpyrrolidinic group is joined to a bnzene ring of the corynane part of the molecule.Antimitotic activity tests were carried out on cultured HW165 hepatoma, B16 melanoma and Ehrlich ascites cells.Strychnopentamine was more active than other indole alkaloids isolated from the same species.Preliminary experiments were then undertaken to search for a possible antitumor activity in animals (Ehrlich ascites tumor cells in mice).At a single dose of 2mg, a very marked regression was obvious but mice showed signs of intoxication. Other experiments must be carried out , in order to establish a more exact structure-activity relationship and to discover less toxic substances. [less ▲] Detailed reference viewed: 13 (1 ULg) |
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