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See detailIDS iSYS automated intact procollagen-1-Nterminus pro-peptide assay: method evaluation and reference intervals in adults and children
Morovat, Alireza; Catchpole, Anthony; MEURISSE, Angélique ULg et al

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 2009-2018

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference ... [more ▼]

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference intervals for PINP in both adults and children. Methods: Assay imprecision, recovery and interference were studied. Serum and plasma values were compared, and PINP stability was assessed. Using 828 specimens, IDS iSYS intact PINP and Roche E170 total PINP values were compared. Specimens from 597 adults and 485 children and adolescents were used to establish reference intervals for intact PINP. Results: The method demonstrated good recovery and acceptable imprecision. The assay was unaffected by icterus and lipaemia, but haemolysis decreased measured PINP. Serum and plasma values were comparable. There was a non-linear relation between IDS intact and Roche total PINP values. Pre- and post-menopausal women had comparable PINP values, but there was a difference between women of different age groups. Serum PINP in men showed a decline in young age up to 45 years, but remained steady thereafter. Separate reference intervals were established for four age groups in women and for two age groups in men. Data for children were partitioned into four-year age groups, and these showed PINP to be high with no major gender differences until 12 years of age. Thereafter, values in females decreased in 13–16 years age groups and further in 17–20 years age groups, whereas PINP increased in boys of 13–16 years of age with a subsequent decline at 17–20 years. Conclusions: The IDS iSYS PINP intact assay appears to be reliable. We have established gender- and age-related reference intervals for children and adults based on a relatively large healthy North European population. [less ▲]

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See detailTechnical and clinical evaluation of the VITROS Immunodiagnostic Products 25-OH Vitamin D Total Assay - comparison with marketed automated immunoassays and a liquid chromatography - tandem mass spectrometry method
CAVALIER, Etienne ULg; ROUSSELLE, Olivier ULg; FERRANTE, Nunzio ULg et al

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 1983-1989

Background: The study was conducted to evaluate the technical and clinical performance of the VITROS ® Immunodiagnostic Products 25-OH Vitamin D Total Assay, and compare it with the performance of five ... [more ▼]

Background: The study was conducted to evaluate the technical and clinical performance of the VITROS ® Immunodiagnostic Products 25-OH Vitamin D Total Assay, and compare it with the performance of five marketed automated assays and a liquid chromatography/mass spectrometry reference method (LC-MS/MS). Methods: Three hundred patient serum samples were used to compare the correlation of the VITROS ® 25-OH Vitamin D Total Assay with both the other immunoassays and the LC-MS/MS method, using Passing-Bablok regression and Bland-Altman analyses. Concordance of the diagnosis of vitamin D status was calculated to test the agreement between the different assays. In addition, samples containing vitamin D2 were used to test the assay ’ s ability to detect the D2 form of the vitamin. Results and conclusions: These results from the VITROS ® 5-OH Vitamin D Total Assay generally correlated well with those from most of the marketed immunoassays. Cross-reactivity of the D2 form was calculated as being close to 100%. Additionally, we found substantial variability in performance amongst the various assays, which suggests the need for optimisation and recalibration of commercial methods. [less ▲]

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See detailStaging chronic kidney disease and estimating glomerular filtration rate: an opinion paper about the new international recommendations
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 1911-1917

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify ... [more ▼]

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify patients in CKD stages have been published. <br />In this opinion article, we will review and discuss <br />the most important guidelines proposed about CKD staging <br />and glomerular filtration rate (GFR) estimating. In <br />particular, we question the choice of fixed knot values <br />at 60 mL/min/1.73 m ² to define CKD. We also question <br />the strategies proposed to measure and use cystatin C <br />results. [less ▲]

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See detailThe diagnostic utility of folate receptor autoantibodies in blood
Sequeira, JM; RAMAEKERS, Vincent ULg; Quadros, EV

in Clinical Chemistry & Laboratory Medicine (2013), 51(3), 545-54

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See detailClinical recognition and aspects of the cerebral folate deficiency syndromes
RAMAEKERS, Vincent ULg; Sequeira, JM; Quadros, EV

in Clinical Chemistry & Laboratory Medicine (2013), 51(3), 497-511

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See detailEvaluation of the cross-reactivity of 25-hydroxyvitamin D2 on seven commercial immunoassays on native samples
LE GOFF, Caroline ULg; PEETERS, Stéphanie ULg; CRINE, Yannick ULg et al

in Clinical Chemistry & Laboratory Medicine (2012), 50(11), 2031-2

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See detailAberrant results observed with four immuno-assays for total and free prostate-specific antigen (PSA) determination: a case-report
CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2012), 50(3), 583-584

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See detailFatty acids and cardiovascular risk
LE GOFF, Caroline ULg; Leroy, Ludovic; Kaux, Jean-François ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailElevation of cardiac and oxidative stress biomarkers after a running activity in sedentary subjects
LE GOFF, Caroline ULg; Bury, Thierry ULg; Rodriguez de la Cruz, Carlos ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailVitamin D: clinical relevance, analytical issues
CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(s1), 66

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See detailCystatin C is a reliable marker for estimation of glomerular filtration rate in renal transplantation: validation of a new turbidimetric assay using monospecific sheep antibodies
Bargnoux, A. S.; Cavalier, Etienne ULg; Cristol, J. P. et al

in Clinical Chemistry & Laboratory Medicine (2011), 49(2), 265-70

Background: The potential use of Cystatin C was recently assessed in kidney transplantation. A new particle-enhanced turbidimetric immunoassay (PETIA) that uses sheep antibodies (Binding Site Human ... [more ▼]

Background: The potential use of Cystatin C was recently assessed in kidney transplantation. A new particle-enhanced turbidimetric immunoassay (PETIA) that uses sheep antibodies (Binding Site Human Cystatin C immunoassay) has been developed. Analytical performance of this new assay was evaluated. Clinical relevance was determined by comparison with a reference method in a cohort of kidney transplant patients. Patients and methods: First, the analytical performance of the Binding Site cystatin C kit was tested on SPAPLUS® and Hitachi® analyzers. Second, a comparison study was performed using SPAPLUS® analyzer against two other cystatin C methods (the Siemens-PENIA method on BNII® and the Dako-PETIA application on Olympus AU640®). Third, the glomerular filtration rate (GFR) was estimated using several predictive cystatin C- and creatinine-based equations and compared to GFR measured by an isotopic method (99mTc-DTPA). These predictive algorithms were analyzed with respect to bias, precision and accuracy. Results: Total intra-assay and inter-assay coefficients of variation were below 5%. Values obtained with the SPAPLUS® correlated with the Siemens-PENIA and the Dako-PETIA methods. The creatinine and cystatin C-based equation allowed reliable assessment of GFR in our population of renal transplantation. Conclusions: The use of algorithms based on cystatin C and creatinine could provide a reliable estimate of GFR in kidney transplantation. [less ▲]

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See detailValidation of the Abbott Architect 25(OH)-vitamin D assay
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; BEKAERT, Anne-Catherine ULg et al

in Clinical Chemistry & Laboratory Medicine (2011), 49(s1), 418

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See detailAnalytical validation of the Liaison Calcitonin_II-Gen (DiaSorin)
Cavalier, Etienne ULg; Carlisi, Ignazia ULg; Bekaert, Anne-Catherine ULg et al

in Clinical Chemistry & Laboratory Medicine (2011), 49(2), 271-275

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See detailAnalytical validation of the BAP OSTASE on Liaison (DiaSorin).
Cavalier, Etienne ULg; Rozet, Eric ULg; Carlisi, Ignazia ULg et al

in Clinical Chemistry & Laboratory Medicine (2010), 48(1), 67-72

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See detailMulticentre evaluation of the Tosoh HbA1c G8 analyser
Chapelle, Jean-Paul ULg; Teixeira, Jelda ULg; Maisin, Diane et al

in Clinical Chemistry & Laboratory Medicine (2010), 48(3), 365-371

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See detailInterpretation of serum parathyroid hormone concentrations in dialysis patients: what do the KDIGO guidelines change for the clinical laboratory?
Souberbielle, Jean-Claude; Cavalier, Etienne ULg; Jean, Guillaume

in Clinical Chemistry & Laboratory Medicine (2010), 48(6), 769-774

Detailed reference viewed: 43 (3 ULg)