References of "Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology"
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See detailContribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients
Ben Gacem, Riadh; Hachana, Mohamed Ridha ULg; Ziadi, Sonia et al

in Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology (2011)

Objective: The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. Methods: Breast carcinoma ... [more ▼]

Objective: The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. Methods: Breast carcinoma tissues (n=117) and available paired normal breast tissues (n=65) from Tunisian women who had no family history were investigated for the methylation status of BRCA1 and BRCA2 promoters using methylation-specific PCR. Breast specimens from women without carcinoma (16 fibroadenomas and 5 mastopathies) were used as control. Results: Hypermethylation of BRCA1 and BRCA2 promoters was detected respectively in 60.7% and 69.2% of the carcinoma tissues, and in only 7.7% and 4.6% of the paired normal breast tissues. None of the fibroadenomas and mastopathies showed hypermethylation. Correlations were found between BRCA1 and BRCA2 hypermethylation and decrease in their mRNA expression (p=0.02 and p=0.009, respectively). Moreover, BRCA1 methylation correlates with patients age (p=0.01) and triple negative (ER-, PR-, HER2-) tumors (p=0.01). Patients with methylated BRCA1 and/or BRCA2 had a significant prolonged survivals compared to those with unmethylated tumors (p=0.002). Conclusion: Our results suggest an important role of BRCA1 and BRCA2 promoter methylation in breast cancer development in the Tunisian population. [less ▲]

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See detailIncreased Sister Chromatid Exchange Frequencies Observed in a Cohort of Inhabitants of a Village Located at the Boundary of an Industrial Dumping Ground: Phase I
Laurent, C.; Lakhanisky, T.; Jadot, P. et al

in Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology (1993), 2(4, Jul-Aug), 355-62

Since the mid-eighties, a sand pit located at the boundary of Mellery, a small village in Belgium, has been used as a dumping ground for industrial waste. After a particularly dry summer, many people ... [more ▼]

Since the mid-eighties, a sand pit located at the boundary of Mellery, a small village in Belgium, has been used as a dumping ground for industrial waste. After a particularly dry summer, many people complained of very foul smells coming from the dumping ground. An analysis of the environmental atmosphere detected alkanes and chlorinated saturated and unsaturated hydrocarbons in various concentrations. Consequently, the Belgian Ministry of the Environment requested additional measurements from the dumping site and the surrounding regions. Given the hazards and possible ill health effects associated with simultaneous exposure to low levels of many chemicals, biomarkers of personal exposure were measured in a representative group of people living in this village. The cytogenetic consequences of daily exposure to a mixture of genotoxicants were measured by the Sister Chromatid Exchange assay. The study included a group of 51 environmentally exposed persons (including 11 children) and 52 controls. A significant increase in Sister Chromatid Exchange frequency was detected among the inhabitants of the village compared to that of the control group, especially among the children living in Mellery as compared to the matched control children. [less ▲]

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