References of "Annals of Neurology"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA role for the default mode network in the bases of disorders of consciousness.
Fernandez-Espejo, Davinia; Soddu, Andrea ULg; Cruse, Damian et al

in Annals of Neurology (2012), 72(3), 335-43

OBJECTIVE: Functional connectivity in the default mode network (DMN) is known to be reduced in patients with disorders of consciousness, to a different extent depending on their clinical severity ... [more ▼]

OBJECTIVE: Functional connectivity in the default mode network (DMN) is known to be reduced in patients with disorders of consciousness, to a different extent depending on their clinical severity. Nevertheless, the integrity of the structural architecture supporting this network and its relation with the exhibited functional disconnections are very poorly understood. We investigated the structural connectivity and white matter integrity of the DMN in patients with disorders of consciousness of varying clinical severity. METHODS: Fifty-two patients--19 in a vegetative state (VS), 27 in a minimally conscious state (MCS), and 6 emerging from a minimally conscious state (EMCS)--and 23 healthy volunteers participated in the study. Structural connectivity was assessed by means of probabilistic tractography, and the integrity of the resulting fibers was characterized by their mean fractional anisotropy values. RESULTS: Patients showed significant impairments in all of the pathways connecting cortical regions within this network, as well as the pathway connecting the posterior cingulate cortex/precuneus with the thalamus, relative to the healthy volunteers. Moreover, the structural integrity of this pathway, as well as that of those connecting the posterior areas of the network, was correlated with the patients' behavioral signs for awareness, being higher in EMCS patients than those in the upper and lower ranges of the MCS patients, and lowest in VS patients. INTERPRETATION: These results provide a possible neural substrate for the functional disconnection previously described in these patients, and reinforce the importance of the DMN in the genesis of awareness and the neural bases of its disorders. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Full Text
Peer Reviewed
See detailPrimary central nervous system lymphoma in a patient treated with Natalizumab.
Phan-Ba, Rémy ULg; Bisig, Bettina ULg; Deprez, Manuel ULg et al

in Annals of Neurology (2011), 69(6), 1060-1

Detailed reference viewed: 60 (15 ULg)
Full Text
Peer Reviewed
See detail18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial.
Vandenberghe, R.; Van Laere, K.; Ivanoiu, A. et al

in Annals of Neurology (2010), 68(3), 319-329

Objective: The most widely studied positron emission tomography ligand for in vivo -amyloid imaging is 11CPittsburgh compound B (11C-PIB). Its availability, however, is limited by the need for an on-site ... [more ▼]

Objective: The most widely studied positron emission tomography ligand for in vivo -amyloid imaging is 11CPittsburgh compound B (11C-PIB). Its availability, however, is limited by the need for an on-site cyclotron. Validation of the 18F-labeled PIB derivative 18F-flutemetamol could significantly enhance access to this novel technology. Methods: Twenty-seven patients with early-stage clinically probable Alzheimer disease (AD), 20 with amnestic mild cognitive impairment (MCI), and 15 cognitively intact healthy volunteers (HVs) above and 10 HVs below 55 years of age participated. The primary endpoint was the efficacy of blinded visual assessments of 18F-flutemetamol scans in assigning subjects to a raised versus normal uptake category, with clinical diagnosis as the standard of truth (SOT). As secondary objectives, we determined the correlation between the regional standardized uptake value ratios (SUVRs) for 18F-flutemetamol and its parent molecule 11C-PIB in 20 of the AD subjects and 20 of the MCI patients. We also determined test-retest variability of 18F-flutemetamol SUVRs in 5 of the AD subjects. Results: Blinded visual assessments of 18F-flutemetamol scans assigned 25 of 27 scans from AD subjects and 1 of 15 scans from the elderly HVs to the raised category, corresponding to a sensitivity of 93.1% and a specificity of 93.3% against the SOT. Correlation coefficients between cortical 18F-flutemetamol SUVRs and 11C-PIB SUVRs ranged from 0.89 to 0.92. Test-retest variabilities of regional SUVRs were 1 to 4%. Interpretation: 18F-Flutemetamol performs similarly to the 11C-PIB parent molecule within the same subjects and provides high test-retest replicability and potentially much wider accessibility for clinical and research use. [less ▲]

Detailed reference viewed: 48 (9 ULg)
Full Text
Peer Reviewed
See detailIncreased midbrain gray matter in Tourette's syndrome
Garraux, Gaëtan ULg; Goldfine, Andrew; Bohlhalter, Stephan et al

in Annals of Neurology (2006), 59(2), 381-385

Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased ... [more ▼]

Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS. [less ▲]

Detailed reference viewed: 27 (1 ULg)
Full Text
Peer Reviewed
See detailChanges in brain anatomy in focal hand dystonia
Garraux, Gaëtan ULg; Bauer, Andrew; Hanakawa, Takashi et al

in Annals of Neurology (2004), 55(5), 736-739

No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter ... [more ▼]

No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter in the hand representation area of primary somatosensory and, to a lesser extent, primary motor cortices in 36 patients with unilateral FHD compared with 36 controls. The presence of anatomical changes in the perirolandic cortex for the unaffected hand as well as that for the affected hand suggests that these disturbances may be, at least in part, primary. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailRetrograde reactions of Clarke's nucleus neurons after human spinal cord injury
Schmitt, Andreas B.; Breuer, Sebastien; Polat, Leyla et al

in Annals of Neurology (2003), 54(4), 534-539

Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration ... [more ▼]

Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailSubclinical cerebellar impairment in the common types of migraine: a three-dimensional analysis of reaching movements.
Sandor, P. S.; Mascia, A.; Seidel, L. et al

in Annals of Neurology (2001), 49(5), 668-72

Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum ... [more ▼]

Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca2+ channel genes in the common types of migraine needs to be investigated by genetic analyses. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Peer Reviewed
See detailA locus for febrile seizures (FEB3) maps to chromosome 2q23-24.
Peiffer, A.; Thompson, J.; Charlier, Carole ULg et al

in Annals of Neurology (1999), 46(4), 671-8

Febrile seizures are the most common form of childhood seizures, occurring in 2% to 5% of North American children. We report a large Utah family with 21 members affected by febrile seizures inherited as ... [more ▼]

Febrile seizures are the most common form of childhood seizures, occurring in 2% to 5% of North American children. We report a large Utah family with 21 members affected by febrile seizures inherited as an autosomal dominant trait. All had generalized tonic-clonic seizures with onset associated with fever, consistent with the consensus febrile seizure phenotype, and none had febrile seizures beyond 6 years of age. Eighteen affected individuals had recurrent febrile seizures. Eight individuals developed afebrile seizures between ages 5 and 13 years. Afebrile seizures consisted of generalized tonic-clonic, generalized tonic, generalized atonic, simple partial, and partial complex seizure types and were associated with abnormal electroencephalographic findings in 5 individuals, all of whom were intellectually normal. We undertook linkage analysis in this family, defining the disease phenotype as febrile seizures alone. Linkage analysis in epilepsy candidate gene/loci regions failed to show evidence for linkage to febrile seizures. However, a genomewide scan and subsequent fine mapping revealed significant evidence for a new febrile seizure locus (FEB3) on chromosome 2q23-24 with linkage to the marker D2S2330 (LOD score 8.08 at theta = 0.001). Haplotype analysis defined a critical 10-cM region between markers D2S141 and D2S2345 that contains the FEB3 locus. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailElectrophysiological classification of Guillain-Barré Syndrome: clinical associations and outcome
Hadden, R. D. M.; Cornblath, D. R.; Hughes, R. A. C. et al

in Annals of Neurology (1998)

Detailed reference viewed: 31 (2 ULg)
Full Text
Peer Reviewed
See detailInterictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Afra, Judit; Mascia, Adolores; GERARD, Pascale ULg et al

in Annals of Neurology (1998), 44(2), 209-15

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks ... [more ▼]

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks. By using a 13-cm circular coil placed over the vertex and recordings of the first dorsal interosseus muscle, we measured thresholds (at rest and during contraction), amplitudes of motor evoked potentials and cortical silent periods. Paired stimulations with short (1-20 msec) interstimulus intervals were performed to assess intracortical inhibition. The visual cortex was stimulated with the same coil placed over the occipital scalp (7 cm above the inion) and the prevalence and threshold of phosphene production was determined. In patients with migraine with aura, motor thresholds during isometric contraction were significantly higher, whereas the prevalence of stimulation-induced phosphene production was lower compared with healthy controls. These changes were not correlated with attack frequency or disease duration. No differences were found between subject groups in thresholds at rest, motor evoked potential amplitudes, cortical silent periods, or response curves after paired stimuli. These results are in favor of cortical hypoexcitability rather than hyperexcitability in patients with migraine with aura between attacks. [less ▲]

Detailed reference viewed: 31 (6 ULg)
Full Text
Peer Reviewed
See detailBrain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease.
Mastrogiacomo, Frank; Bettendorff, Lucien ULg; Grisar, Thierry ULg et al

in Annals of Neurology (1996), 39

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

Detailed reference viewed: 13 (2 ULg)
Peer Reviewed
See detailLeber-associateddystonia with putamen necrosis
Van Coster, R.; Misson, Jean-Paul ULg; Meire, F. et al

in Annals of Neurology (1994)

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailThe Audiospinal Reaction in Parkinsonian Patients Reflects Functional Changes in Reticular Nuclei
Delwaide, Paul ULg; PEPIN, Jean-Louis ULg; Maertens De Noordhout, Alain ULg

in Annals of Neurology (1993), 33(1), 63-9

Audiospinal facilitation using the soleus H-reflex as a test was compared in 16 control subjects and 23 parkinsonian patients. In the patients, facilitation was significantly reduced during the 75 to 150 ... [more ▼]

Audiospinal facilitation using the soleus H-reflex as a test was compared in 16 control subjects and 23 parkinsonian patients. In the patients, facilitation was significantly reduced during the 75 to 150 msec after the conditioning stimulation. This reduction was seen bilaterally even in patients with a hemisyndrome. It was corrected by L-dopa but not by anticholinergic agents. Facilitation at the 75-msec delay showed an inverse linear correlation with the bradykinesia intensity (r = -0.7, p < 0.01). The results argue in favor of a reduced excitability of the nucleus reticularis pontis caudalis from which a reticulospinal tract emanates as effector of the audiospinal facilitation. This would represent another example of dysfunction of reticular nuclei in Parkinson's disease. [less ▲]

Detailed reference viewed: 15 (9 ULg)
Full Text
Peer Reviewed
See detailFacilitation of Responses to Motor Cortex Stimulation: Effects of Isometric Voluntary Contraction
Maertens De Noordhout, Alain ULg; PEPIN, Jean-Louis ULg; GERARD, Pascale ULg et al

in Annals of Neurology (1992), 32(3), 365-70

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over ... [more ▼]

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over the cervical column and by electric and magnetic percutaneous stimulation of the motor cortex. No significant difference was found between the degrees of facilitation of the responses to any of the stimuli. Using collision techniques, we also showed that the pyramidal fibers activated by spinal and cortical stimuli are the same. Facilitation induced by isometric contraction (20% maximum) was of similar or greater magnitude than that found with constant vibration of the tendon of the target muscle. In cases where vibration and contraction had equal facilitatory effects, there was no further facilitation of the responses when both conditions were applied together. These findings indicate that the facilitatory effect of isometric contraction of the target muscle essentially originates at a spinal level rather than in the motor cortex. [less ▲]

Detailed reference viewed: 15 (6 ULg)
Full Text
Peer Reviewed
See detailShort-latency autogenic inhibition in patients with Parkinsonian rigidity.
Delwaide, Paul ULg; PEPIN, Jean-Louis ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Annals of Neurology (1991), 30(1), 83-9

The spinal Ib interneuron efficacy has been compared in 11 control subjects and 19 patients with parkinsonian rigidity. In normal subjects, gastrocnemius medialis nerve stimulation induces an inhibition ... [more ▼]

The spinal Ib interneuron efficacy has been compared in 11 control subjects and 19 patients with parkinsonian rigidity. In normal subjects, gastrocnemius medialis nerve stimulation induces an inhibition of the soleus H reflex for 3 to 8 msec with a peak at 5 msec of 83.72 +/- 7.28% of the control value of H reflex. In parkinsonian patients, inhibition is reduced or even replaced by facilitation, which also peaks at 5 msec. The departures from normal values correlate with rigidity intensity assessed by the Webster scale. Increase in rigidity is associated, first, with a reduction of inhibition and, from a score of 2 or more, with facilitation replacing the normal inhibition. In addition to providing an electrophysiological index of rigidity, reduction in autogenic inhibition might be one of the neurophysiological mechanisms underlying rigidity. In association with the known hyperactivity of the Ia inhibitory interneuron in Parkinson's disease, reduction of activity of Ib interneuron could be explained by an increased activity in the reticularis gigantocellularis nucleus; its efferent tracts both inhibit Ib interneurons and activate Ia interneurons. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailCorrelation of phasic muscle strength and corticomotoneuron conduction time in multiple sclerosis.
van der Kamp, W.; MAERTENS DE NOORDHOUT, Alain ULg; Thompson, P. D. et al

in Annals of Neurology (1991), 29(1), 6-12

Central motor conduction times for the adductor pollicis muscle, the twitch force of that muscle to scalp magnetic motor cortex stimulation, and the maximum force of phasic voluntary contraction of the ... [more ▼]

Central motor conduction times for the adductor pollicis muscle, the twitch force of that muscle to scalp magnetic motor cortex stimulation, and the maximum force of phasic voluntary contraction of the same muscle were measured in 15 patients with multiple sclerosis. Two tests of manual dexterity of the same hand also were studied: the Purdue pegboard test, and the maximal frequency of a scissors movement of the thumb and index finger. The patients had normal strength or minimal weakness of the intrinsic muscles of the hand on clinical examination. The mean central motor conduction times for the adductor pollicis muscle for the patients were longer than normal, the peak twitch force of the adductor pollicis muscle evoked by cortical stimulation and the maximum force of a phasic voluntary contraction of the adductor pollicis muscle were smaller than normal. There were strong correlations between all these measures. Central motor conduction time in the patients was inversely correlated with voluntary phasic force and the twitch force after cortical stimulation. That is, the longer the central motor conduction time, the weaker the force. Prolonged central motor conduction time is likely to be accompanied by conduction block in corticomotoneuron pathways. The correlation of central motor conduction time with voluntary phasic force and the twitch force most likely reflects the degree of conduction block and temporal dispersion rather than delay in conduction per se. These results indicate that objective assessments of phasic muscle strength may reveal correlations with central motor conduction time that are not evident on conventional clinical examination which assesses tonic muscle contraction strength.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

Detailed reference viewed: 17 (5 ULg)
Full Text
Peer Reviewed
See detailA disorder of axonal development, necrotizing myopathy, cardiomyopathy and cataracts: A new familial disorder
Lyon, Gilles; Arita, Frenando; Le Galloudec, Eric et al

in Annals of Neurology (1990), 27

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailEffects of beta blockade on contingent negative variation in migraine.
MAERTENS DE NOORDHOUT, Alain ULg; Timsit-Berthier, M.; Timsit, M. et al

in Annals of Neurology (1987), 21(1), 111-112

Detailed reference viewed: 12 (6 ULg)