References of "Annales de Dermatologie et de Vénéréologie"
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See detailCOMPLICATIONS DERMATOLOGIQUES DES TATOUAGES DEFINITIFS ET TEMPORAIRES
CAUCANAS, MARIE; EL HAYDERI, Lara ULg; LEBAS, Eglantine ULg et al

in Annales de Dermatologie et de Vénéréologie (2011)

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See detailAcide Hyaluronique et matrice extracellulaire : une molécule primitive ?
Nusgens, Betty ULg

in Annales de Dermatologie et de Vénéréologie (2010), 137(supplément 1), 3-8

Hyaluronic acid, or hyaluronan, is a polymer made of the repetition of a unique disaccharidic unit, D-glucuronic acid and D-N-acetylglucosamine, that can reach a molecular mass of 10(7) daltons. This ... [more ▼]

Hyaluronic acid, or hyaluronan, is a polymer made of the repetition of a unique disaccharidic unit, D-glucuronic acid and D-N-acetylglucosamine, that can reach a molecular mass of 10(7) daltons. This primitive polymer has emerged as a remarkable extracellular matrix component by its viscoelastic properties, its hygroscopic capacities and the diversity of cell processes it controls. Identified in all vertebrate tissues, more than 50% of acid hyaluronic of the organism is present in skin. Having no protein core, its synthesis is performed through a unique process, depending on enzymatic activity of hyaluronan synthases acting at the internal face of the plasmatic membrane and extruding the nascent polymer to the extracellular medium. This polymer constitutes a scaffold on which a large number of sulfated proteoglycans, up to one hundred, can be linked. These supramolecular structures of considerable size are able to entrap large amounts of water and ions to provide tissues with hydration and turgescence. Hyaluronic acid is recognized by cell membrane receptors, notably CD44 which is the best known. Interaction of hyaluronic acid with its receptors triggers several intracellular signaling pathways regulating proliferation, migration and differentiation. Cell response is largely influenced by the size of the polymer and by that of the fragments generated upon degradation by hyaluronidases or free radicals. Hyaluronic acid is metabolically very active, as, for example, its half-life in skin is less than one day. Detected in epidermis where it could play a role in the control of proliferation and differentiation of basal cells, it is however prominent in dermis in association with versican. The remarkable physicochemical properties of hyaluronic acid as well as the diversity of biological processes it controls largely surpass the primitive character of this polymer. [less ▲]

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See detailLe botryomycome.
Wauters, Odile ULg; Sabatiello, Murielle ULg; Nikkels, Nazli ULg et al

in Annales de Dermatologie et de Vénéréologie (2010), 137(3), 238-42237243

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See detailLe systeme vasculaire lymphatique: etats des connaissances et implications dermatologiques potentielles.
Henno, Audrey ULg; Lapiere, ChM; Nusgens, Betty ULg et al

in Annales de Dermatologie et de Vénéréologie (2008), 135(10), 704-9

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See detailUn ongle d'inclusion: une complication de la cure chirurgicale d'ongle incarne selon la technique de Zadik
Vanhooteghem, Olivier ULg; Henrijean, A.; André, Jean-François ULg et al

in Annales de Dermatologie et de Vénéréologie (2006), 133(12), 1009-10

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See detailLipolyse electromagnetique et lipoatrophie semi-circulaire des cuisses
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2006), 133(6-7, Jun-Jul), 577-80

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a ... [more ▼]

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a status of administrative employee. OBSERVATION: The older etiopathogenic hypotheses give way to a newer one implying the electromagnetic fields generated by computers and their wirings. The resulting modifications in the intrinsic bioelectrical properties of the skin could influence the biology of macrophages exhibiting lipophagic activity in the hypodermis. The electroactivation of these cells could lead to TNF-alpha release. DISCUSSION: The semicircular lipoatrophy of the thighs is a problem that may affect an employee out of two. Rather than hoping an efficaceous drug therapy, prevention must be advocated by adapting the work conditions related to the use of computerized devices. [less ▲]

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See detailCheloide et cicatrice hypertrophique
Mostinckx, S.; Vanhooteghem, Olivier ULg; Richert, Bertrand ULg et al

in Annales de Dermatologie et de Vénéréologie (2005), 132(4), 384-7

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See detailHistomycologie unguéale
Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Annales de Dermatologie et de Vénéréologie (2003), 130

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The ... [more ▼]

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The location of and the density in fungal cells is variable. In some instances, these aspects remain clinically unsuspected. In vivo confocal microscopy can bring the same information. Computerized image analysis of histological sections is the most performant means for quantifying the fungal load. Immunohistochemistry brings information about the identity of the fungus or the association of different fungi present in the nail plate. Mixed infections may be unifocal or located at different levels in the nail apparatus. The viability of fungi as assessed by vital stains can be assessed under the microscope and quantified by flow cytometry. The different facets of nail histomycology are complementary and shed some light on aspects sometimes unsuspected of onychomycoses. [less ▲]

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See detailVasculite pustuleuse severe et polymorphe induite par le losartan
Pierard Franchimont, C.; Henry, Frédérique ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2001), 128(10, Pt 1), 1040-2

INTRODUCTION: We report a case of severe pustular vasculitis most probably due to losartan (Cozaar) which is an antihypertensive drug inhibiting the receptors for angiotensin II. CASE REPORT: A 64-year ... [more ▼]

INTRODUCTION: We report a case of severe pustular vasculitis most probably due to losartan (Cozaar) which is an antihypertensive drug inhibiting the receptors for angiotensin II. CASE REPORT: A 64-year-old woman, suffering from hypertension, developed a widespread and rapidly evolving bullous and pustular eruption without any other clinical sign. Leucocytoclastic vasculitis and junctional blisters were present with deposits of both IgA and IgG at these sites. Withdrawal of losartan, which was the only drug taken by the patient, and tapered corticotherapy cleared the lesions. The rash left a prominent mottled hyperpigmentation. It did not recur during the following months despite the presence of antineutrophil cytoplasmic antibodies. DISCUSSION: So far only a few cutaneous side effects have been reported following losartan intake. This drug was the likely culprit in the present case. Vasculitis was extremely severe and polymorphous. [less ▲]

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See detailOsteo-onychodysplasie héréditaire (Nail Patella Syndrome)
Vanhooteghem, Olivier ULg; Henrijean, A.; Richert, Bertrand ULg et al

in Annales de Dermatologie et de Vénéréologie (2001), 128(10, Pt 1), 1063-7

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See detailSeuil liminaire de la perception d'un etirement cutane
Martalo, O.; Henry, Frédérique ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2001), 128(2), 119-22

BACKGROUND: Cutaneous sensorial perception is complex and proves to be difficult to quantify. Skin sensitivity to mechanical distension is largely unexplored. We have developed an original method aimed at ... [more ▼]

BACKGROUND: Cutaneous sensorial perception is complex and proves to be difficult to quantify. Skin sensitivity to mechanical distension is largely unexplored. We have developed an original method aimed at quantifiying these physiological parameters.VOLUNTEERS AND METHODS: The study was performed on 24 adult volunteers aged 20 to 50 years. A Cutometer SEM 474 equipped with 2 and 4 mm diameter probes was used to exert a progressive or a steep suction on the cheeks. The intensities of both the suction and the skin deformation observed at the earliest moment the traction was perceived by the volunteers were recorded.RESULTS: The liminar sensorial detection under progressive suction force was 1.5 times lower when using the 4 mm probe than the 2 mm probe. Suction necessary for liminar sensation was 7 times lower under steep suction than in response to the progressive mode. The skin deformation corresponding to the liminar sensorial perception was almost constant (C=0.5 p. 100) for each subject. By contrast, a large inter individual heterogeneity unrelated to age was present.COMMENTS: Sensitivity of facial skin to stretching can be explored using a precise suction method. Perception is more related to the rate of traction than to the surface area submitted to suction. Cutaneous deformation, nearly constant for each individual, appears to be the main parameter. Steep and progressive suctions appear to stimulate distinct types of mechanoreceptors. The presently described method can be applied in cosmetology and in functional investigation of various diseases such as diabetes, acromegaly and atopic dermatitis among others. [less ▲]

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See detailDermatite actinique chronique severe traitee par ciclosporine: 2 cas
Paquet, Philippe ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2001), 128(1), 42-5

INTRODUCTION: The treatment of the severe forms of photodermatoses often requires potent systemic immunosuppressive drugs. We report two patients suffering from severe photodermatitis successfully treated ... [more ▼]

INTRODUCTION: The treatment of the severe forms of photodermatoses often requires potent systemic immunosuppressive drugs. We report two patients suffering from severe photodermatitis successfully treated with oral cyclosporine. CASES REPORT: A 58-year-old man developed severe pruritic eczematous reactions for several years on light-exposed and light-protected skin following each sun exposure. A 66-year-old man showed similar lesions restricted to the head and neck. The clinical presentation and evolution as well as histologic, immunohistologic, allergologic and photobiologic assessments suggested the diagnosis of actinic reticuloid and persistent light reactivity, respectively. The lesions of both patients did not respond to a high dose regimen of systemic corticosteroids (methylprednisolone 1 mg/kg/day) for several weeks. The severity of cutaneous lesions and pruritus required another potent immunosuppressive treatment. Oral cyclosporine at the maximum daily dose of 4 mg/kg was given for three months. A rapid improvement of the pruritus and skin lesions occurred in the two patients, without significant side-effect. The first patient experienced recurrent lesions after termination of cyclosporine treatment during summer time. The other patient did not develop new skin eruption for 3 years after stopping the initial treatment with cyclosporine. DISCUSSION: Low-dose oral cyclosporine is a quick-acting and well tolerated symptomatic treatment of severe photodermatoses resistant to other systemic immunosuppressive drugs. However, therapeutic results do not consistently exhibit long-standing remanent effect. [less ▲]

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See detailLes recherches sur la biologie moléculaire du virus de la varicelle et du zona (VZV) ont-elles des applications cliniques ?
Rentier, Bernard ULg

in Annales de Dermatologie et de Vénéréologie (1997), 124(Suppl. 2), 4-8

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See detailVaricelle létale. Etude immunohistochimique et par hybridation in situ
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Sadzot-Delvaux, Catherine ULg et al

in Annales de Dermatologie et de Vénéréologie (1994), 121(2), 113-117

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the ... [more ▼]

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the glycoprotein gpI specific for VZV and its corresponding nucleic acids found in multiple foci of most tissues and organs, except in the brain and paravertebral sympathetic ganglia. [less ▲]

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See detailTrichosporonose des immunodéprimés
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Rurangirwa, A. et al

in Annales de Dermatologie et de Vénéréologie (1990), 117(11), 856-8

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See detailDendrocytes et cellules dendritiques épidermiques au cours du photovieillissement
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Nikkels, Arjen ULg et al

in Annales de Dermatologie et de Vénéréologie (1990), 117(12), 965-967

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See detailAngiotropic lymphoma of proliferating systematized angioendotheliomatosis type
Pierard, Gérald ULg; Soyeur-Broux, Monique ULg; FRIDMAN, Viviana ULg et al

in Annales de Dermatologie et de Vénéréologie (1988), 115(3), 333-336

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