References of "Acta Oto-Rhino-Laryngologica Belgica"
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See detailFunctional neuroimaging of auditory processing
Laureys, Steven ULg; Salmon, Eric ULg; Goldman, Serge et al

in Acta Oto-Rhino-Laryngologica Belgica (2003), 57(4), 267-273

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm ... [more ▼]

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm the spatial distribution of brain activation in temporal areas for the processing of simple acoustic stimuli. Brain activity is much more complex for words, and different networks can be recruited when phonological, lexical and semantic levels of processing are engaged. [less ▲]

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See detailProliferation generation of auditory hair cells in culture
Malgrange, B; Belachew, S; Thiry, Marc ULg et al

in Acta Oto-Rhino-Laryngologica Belgica (2002), 56

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See detailPharmacologic treatment of inner ear: from basic science to the patient.
Lefèbvre, Philippe ULg; Staecker, H.; Van de Water, T. et al

in Acta Oto-Rhino-Laryngologica Belgica (2002), 56(1), 45-9

Most of the deafness are of sensorineural origin and are characterized by a loss of hair cells and of spiral ganglion neurons. At the present time, hearing aids are the only treatment. However, in some ... [more ▼]

Most of the deafness are of sensorineural origin and are characterized by a loss of hair cells and of spiral ganglion neurons. At the present time, hearing aids are the only treatment. However, in some diseases of the inner ear, pharmacological treatment have been proposed and used successfully. In this paper, we will review some basic science aspects of the biology of the neurosensory structures of the inner ear, in particular of the auditory neurons, that lead to the rationale of some treatments for the inner ear diseases. Developmental studies, neuronal cell culture experiments, and analyses of gene knockout animals reveal a number of growth factors which are important for the rescue and repair of injured auditory neurons in the inner ear. These factors rescue the injured auditory neurons in vivo. Furthermore, perfusion of antioxydant to the cochlea prevented the hearing loss induced by cisplatin. These in vitro and in vivo experiments demonstrate that it is possible to manipulate the neurosensory structures of the inner ear and provide an effective treatment to prevent the degeneration of the neurons. The molecules or drugs can be administered locally to the inner ear through a direct perilymphatic perfusion or through the round window membrane. As an example, we will discuss the treatment of patients suffering from idiopathic sensorineural hearing loss which can be treated successfully by a perfusion through the round window membrane, improving their hearing threshold and their speech discrimination. [less ▲]

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See detailMorphological analysis of overproduction of hair cells and Deiters'cells in the E19 rat organ of Corti
Thiry, Marc ULg; Malgrange, B; Lefebvre, P

in Acta Oto-Rhino-Laryngologica Belgica (2002), 56

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See detailIntercellular Contacts between Germinal Center Cells. Mechanisms of Adhesion between Lymphoid Cells and Follicular Dendritic Cells
Louis, Edouard ULg; Philippet, B.; Cardos, B. et al

in Acta Oto-Rhino-Laryngologica Belgica (1989), 43(4), 297-320

Intercellular connections exist between germinal center cells especially between lymphoid cells and follicular dendritic cells (FDC). Even after isolation, FDC remain associated to lymphocytes and are ... [more ▼]

Intercellular connections exist between germinal center cells especially between lymphoid cells and follicular dendritic cells (FDC). Even after isolation, FDC remain associated to lymphocytes and are able, in a cell suspension, to establish new connections with others. Using human tonsillar cells or mouse lymph node cells we analysed these connections which were shown to be species-specific. Low temperature as well as absence of Ca++ and Mg++ in the culture medium reduced the adherence of fluorochrome-labeled lymphoid cells to FDC. Colchicine treatment did not impair the adherence, whereas cytochalasin B dit it; this was the first observation underlining the importance of microfibrils in FDC. Antibodies directed towards integrin molecules (LFA-1 alpha or beta chain, CD11a and CD18 respectively) reduced the adherence, others (anti-CR3 or anti-gp 150/95, CD11b and c respectively) did not influence it. Antibodies directed against MHC class II exerted no inhibitory action on the lymphoid cell adhesion to FDC. As, at ultrastructural level, gold-labeled immune complexes can be found between FDC and lymphoid cells, we examined the effect on cell adhesion of the addition of immune complexes to the cell suspensions. It only impaired the lymphoid cell adhesion when complement components were present. IgM complexes were then more inhibitory than IgG complexes. When antibodies against Fc IgG receptors (CD16) were added, the adhesion was strongly reduced whereas antibodies to Fc IgE (CD23) receptors had no influence. The antibody DRC1, specifically recognizing an antigen on human FDC reduced the attachment of cells to FDC. This antigen thus seems to play a role in the intercellular contacts; this is the first function ascribed to this FDC specific antigen. [less ▲]

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See detailFunctional study of human tonsillar follicular dendritic cells.
Simar, L. J.; Lilet, Chantal ULg; Heinen, Ernst ULg et al

in Acta Oto-Rhino-Laryngologica Belgica (1984), 38(3), 278-87

Follicular dendritic cells (FDC) isolated from human tonsils and adenoids appear as round clusters where the FDC surround lymphoid cells. Using fluorescein and colloidal gold labelled antibodies we ... [more ▼]

Follicular dendritic cells (FDC) isolated from human tonsils and adenoids appear as round clusters where the FDC surround lymphoid cells. Using fluorescein and colloidal gold labelled antibodies we determined their surface antigens, the immunoglobulins they fix and the cells they envelope. Isolated FDC react with specific anti-FDC antibodies but also with an anti-monocyte/macrophage antibody and with anti-HLA-DR antibodies. They retain IgG, IgM, IgA and IgE but not IgD immunoglobulins; this retention occurs, according to our results, via their Fc and C3b receptors. The cells they envelope are mainly B cells, but also occasionally T helper cells. T suppressor cells were only rarely found in contact with FDC. We suggest that FDC create a micro-environment favourable to the proliferation and differentiation of B cells during the humoral response. [less ▲]

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