Antimitotic and cytotoxic Activities of Guattegaumerine, a Bisbenzylisoquinoline Alkaloid

in Planta Medica (1987), 53

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine ... [more ▼]

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells. [less ▲]

Isolement et détermination de Structure de l' Afrocurarine

in Planta Medica (1984), 50(2), 131-133

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data ... [more ▼]

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data. The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research. [less ▲]

La strychnoxanthine, un alcaloide monoterpénique d'un nouveau type isolé à partir du Strychnos gossweileri

in Planta Medica (1984), 50(1), 93-95

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially ... [more ▼]

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially by (1)H NMR at 360 MHz. [less ▲]

La guattegaumerine, nouvel alcaloide bisbenzylisoquinoleinique de Guatteria gaumeri

in Planta Medica (1983), 49(9), 25-7

The aqueous-alcoholic extract of the bark of GUATTERIA GAUMERI (Mexican Annonaceae) is used for the treatment of cholelithiasis and hypercholesterolemia. Therefore it seems very interesting to perform a ... [more ▼]

The aqueous-alcoholic extract of the bark of GUATTERIA GAUMERI (Mexican Annonaceae) is used for the treatment of cholelithiasis and hypercholesterolemia. Therefore it seems very interesting to perform a phytochemical study of this drug in order to know its composition and to determine, if possible, all the active principles. We describe now the isolation of the main alkaloid named guattegaumerine. This new bisbenzylisoquinoline alkaloid has been assigned structure 1, on the basis of spectroscopic, chemical and chromatographic evidence. [less ▲]

Les alcaloides quaternaires majoritaires du Strychnos variabilis du Zaire

in Planta Medica (1981), 42(8), 371-4

Two quaternary alkaloids have been isolated from the root barks of STRYCHNOS VARIABILIS collected in Zaire. The structure of these alkaloids (mavacurine and fluorocurine) could be deduced from spectral ... [more ▼]

Two quaternary alkaloids have been isolated from the root barks of STRYCHNOS VARIABILIS collected in Zaire. The structure of these alkaloids (mavacurine and fluorocurine) could be deduced from spectral data: UV, MS, IR and (1)H NMR. Moreover, the stereochemistry could be assigned by (1)H NMR at 360 MHz. [less ▲]

Isolement d'un Nouvel Alcaloide (O-Acetylretuline) et d'un Triterpenoide (Friedeline) à partir du Strychnos henningsii du Zaire

in Planta Medica (1981), 41(3), 240-3

A new alkaloid (O-acetylretuline) has been isolated from barks and leaves of two samples of STRYCHNOS HENNINGSII collected in Zaire. A triterpenoid (friedelin) is also present in this African species of ... [more ▼]

A new alkaloid (O-acetylretuline) has been isolated from barks and leaves of two samples of STRYCHNOS HENNINGSII collected in Zaire. A triterpenoid (friedelin) is also present in this African species of Strychnos. [less ▲]

Nouveaux alcaloïdes des racines du Strychnos icaja

in Planta Medica (1979), 37

Strychnos icaja roots are used in Central Africa for the preparation of arrow and ordeal poisons. Amongst the very numerous bases present in these roots, we have isolated and identified six alkaloids ... [more ▼]

Strychnos icaja roots are used in Central Africa for the preparation of arrow and ordeal poisons. Amongst the very numerous bases present in these roots, we have isolated and identified six alkaloids. Apart from strychnine, we have obtained three alkaloids previously detected in the leaves:icajine, 19,20-alpha-epoxynovacine and 19,20-alpha-epoxy-15-hydroxynovacine. Moreover we have extracted dimeric alkaloids: symmetrical (bisnordihydrotoxiferine) as well as a new unsymmetrical one (sungucine). Finally it has been shown that the plant contained also various quaternary alkaloids and particularly Nb-methylstrychninium base which has been found for the first time. Phytochemical and pharmacological experiments are still under study. [less ▲]

Le Dolichantoside, un alcaloïde nouveau du Strychnos gossweileri

in Planta Medica (1978), 34

This paper reports about the isolation and structure determination of a new indole glucoalkaloid extracted from the roots of Strychnos gossweileri collected in Democratic Republic of Congo (Zaïre)

De nouveaux alcaloïdes quaternaires du Strychnos usambarensis

in Planta Medica (1975), 27(1), 24-30

We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are ... [more ▼]

We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are described: O-methyl-macusine B and O-methyl-dihydro-macusine B. It is not easy to discuss the origin of these last products that could take formation during the extraction. The purification is very laborious because Strychnos usambarensis contains more than sixty alkaloids. [less ▲]

Alcaloïdes des Loganiacées: sur l'isolement d'un nouvel alcaloïde à partir du Strychnos usambarensis

in Planta Medica (1973), 23(3), 226-232

Tha authors have isolated a new anhydronium base from Strychnos usambarensis. Its structure was elucidated thanks to the spectral data (UV,IR, MS and comparison with a synthetic product). Indeed the ... [more ▼]

Tha authors have isolated a new anhydronium base from Strychnos usambarensis. Its structure was elucidated thanks to the spectral data (UV,IR, MS and comparison with a synthetic product). Indeed the synthesis of the product was realized before the isolation from a plant ! Anhydronium bases are rare in Nature. [less ▲]