References of "Planta Medica"
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See detailAntiinflammatory Prodelphinidins from Black Currant (Ribes nigrum) Leaves
Tits, Monique ULg; Angenot, Luc ULg; Damas, Jacques ULg et al

in Planta Medica (1991), 57(Supplement issue 2), 134

In a study to select anti-inflammatory medicinal plants, we have observed that extracts of Ribes nigrum significantly inhibited at a dose of 50mg/kg i.p. the carrageenan rat paw edema. We have now proved ... [more ▼]

In a study to select anti-inflammatory medicinal plants, we have observed that extracts of Ribes nigrum significantly inhibited at a dose of 50mg/kg i.p. the carrageenan rat paw edema. We have now proved that the most active fractions contained proanthocyanidins . In the present study, we report on the isolation of three bioactive compounds: two prodelphinidins dimers and a new trimeric one. [less ▲]

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See detailMatadine: a New Anhydronium Base from Strychnos gossweileri
Quetin-Leclercq, J.; Warin, R.; Delaude, C. et al

in Planta Medica (1990), 56

Matadine was isolated from the root bark of Strychnos gossweileri collected by one of us (C.D.) in Matadi (Congo).We describe here the isolation and structure detrmination of a new anhydronium base to ... [more ▼]

Matadine was isolated from the root bark of Strychnos gossweileri collected by one of us (C.D.) in Matadi (Congo).We describe here the isolation and structure detrmination of a new anhydronium base to which we have given the trivial name of matadine. [less ▲]

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See detailAntimitotic and cytotoxic Activities of Guattegaumerine, a Bisbenzylisoquinoline Alkaloid
Quetin-Leclercq, Joëlle; Gillet, Marie-Claire ULg; Bassleer, Roger et al

in Planta Medica (1987), 53

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine ... [more ▼]

Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells. [less ▲]

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See detailDolichantoside, Main Alkaloid from Stem Bark of Strychnos Tricalysioides
Leclercq, Joëlle; Angenot, Luc ULg

in Planta Medica (1984), 50(5), 457-8

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference ... [more ▼]

The bark of Strychnos tricalysioides from Cameroon has been studied. The main alkaloid (present in a minute amount) was identified to dolichantoside (TLC, UV, IR and CD) and compared to a reference compound previously isolated in our laboratory from Strychnos gossweileri root bark. [less ▲]

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See detailIsolement et détermination de Structure de l' Afrocurarine
Caprasse, M.; Angenot, Luc ULg; Tavernier, D. et al

in Planta Medica (1984), 50(2), 131-133

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data ... [more ▼]

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data. The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research. [less ▲]

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See detailIsolement de Nb-méthylantirhine, malindine et isomalindine à partir du Strychnos Usambarensis
Caprasse, M.; Tavernier, D.; Anteunis, M. J. et al

in Planta Medica (1984), 50(1), 27-30

Three quaternary alkaloids have been isolated from root barks of STRYCHNOS USAMBARENSIS Gilg from Rwanda: malindine, isomalindine and Nb-methyl-antirhine. The structure elucidation and the stereochemistry ... [more ▼]

Three quaternary alkaloids have been isolated from root barks of STRYCHNOS USAMBARENSIS Gilg from Rwanda: malindine, isomalindine and Nb-methyl-antirhine. The structure elucidation and the stereochemistry of the new isomalindine has been proposed based on its spectral data and their comparison with those of malindine, its isomer. [less ▲]

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See detailLa strychnoxanthine, un alcaloide monoterpénique d'un nouveau type isolé à partir du Strychnos gossweileri
Coune, C.; Tavernier, D.; Caprasse, M. et al

in Planta Medica (1984), 50(1), 93-95

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially ... [more ▼]

Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially by (1)H NMR at 360 MHz. [less ▲]

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See detailEtude complémentaire de la cytotoxicite de la mélinonine F, alcaloide dérive de la beta-carboline
Bassleer, Roger ULg; Marnette, J. M.; Wiliquet, P. et al

in Planta Medica (1983), 49(11), 158-161

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A ... [more ▼]

The cellular effects of melinonine F, an alkaloid isolated from STRYCHNOS MELINONIANA (South America) and STRYCHNOS USAMBARENSIS (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA IN VITRO. [less ▲]

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See detailLa guattegaumerine, nouvel alcaloide bisbenzylisoquinoleinique de Guatteria gaumeri
Dehaussy, H.; Tits, Monique ULg; Angenot, Luc ULg

in Planta Medica (1983), 49(9), 25-7

The aqueous-alcoholic extract of the bark of GUATTERIA GAUMERI (Mexican Annonaceae) is used for the treatment of cholelithiasis and hypercholesterolemia. Therefore it seems very interesting to perform a ... [more ▼]

The aqueous-alcoholic extract of the bark of GUATTERIA GAUMERI (Mexican Annonaceae) is used for the treatment of cholelithiasis and hypercholesterolemia. Therefore it seems very interesting to perform a phytochemical study of this drug in order to know its composition and to determine, if possible, all the active principles. We describe now the isolation of the main alkaloid named guattegaumerine. This new bisbenzylisoquinoline alkaloid has been assigned structure 1, on the basis of spectroscopic, chemical and chromatographic evidence. [less ▲]

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See detailEffets de trois Alcaloides Extraits du Strychnos usambarensis sur des Cellules Cancereuses en Culture
Bassleer, Roger ULg; Gillet, Marie-Claire ULg; Massart, B. et al

in Planta Medica (1982), 45(6), 123-6

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours ... [more ▼]

The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours cultivated IN VITRO (B 16 mouse melanoma cells, mouse Ehrlich tumour cells ELT, HW 165 rat hepatoma). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated. [less ▲]

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See detailLes alcaloides quaternaires majoritaires du Strychnos variabilis du Zaire
Tits, Monique ULg; Franz, Michel ULg; Tavernier, D. et al

in Planta Medica (1981), 42(8), 371-4

Two quaternary alkaloids have been isolated from the root barks of STRYCHNOS VARIABILIS collected in Zaire. The structure of these alkaloids (mavacurine and fluorocurine) could be deduced from spectral ... [more ▼]

Two quaternary alkaloids have been isolated from the root barks of STRYCHNOS VARIABILIS collected in Zaire. The structure of these alkaloids (mavacurine and fluorocurine) could be deduced from spectral data: UV, MS, IR and (1)H NMR. Moreover, the stereochemistry could be assigned by (1)H NMR at 360 MHz. [less ▲]

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See detailLes Alcaloides majoritaires du Strychnos scheffleri du Zaire
Caprasse, M.; Angenot, Luc ULg

in Planta Medica (1981), 42(8), 364-70

Leaves and stem barks of S. SCHEFFLERI G ILG afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and ... [more ▼]

Leaves and stem barks of S. SCHEFFLERI G ILG afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and strychnofendlerine) have been isolated from leaf material while stem barks yielded one tertiary monomer (desacetylisoretuline), one tertiary symmetrical dimer (bis-nordihydrotoxiferine) and two quaternary monomers (mavacurine and fluorocurine). [less ▲]

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See detailIsolement d'un Nouvel Alcaloide (O-Acetylretuline) et d'un Triterpenoide (Friedeline) à partir du Strychnos henningsii du Zaire
Angenot, Luc ULg; Tits, Monique ULg

in Planta Medica (1981), 41(3), 240-3

A new alkaloid (O-acetylretuline) has been isolated from barks and leaves of two samples of STRYCHNOS HENNINGSII collected in Zaire. A triterpenoid (friedelin) is also present in this African species of ... [more ▼]

A new alkaloid (O-acetylretuline) has been isolated from barks and leaves of two samples of STRYCHNOS HENNINGSII collected in Zaire. A triterpenoid (friedelin) is also present in this African species of Strychnos. [less ▲]

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See detailAction neuromusculaire et cardiaque d'un extrait alcaloïdique de Strychnos icaja
Kambu, K.; Kaba, S.; Cambier, E. et al

in Planta Medica (1980), 40

Strychnos icaja is a well-known tetanizing poison, containing strychnine and 12-hydroxy-derivative amongst many other alkaloids. We have studied quaternary alkaloids of S. icaja root barks, which exhibit ... [more ▼]

Strychnos icaja is a well-known tetanizing poison, containing strychnine and 12-hydroxy-derivative amongst many other alkaloids. We have studied quaternary alkaloids of S. icaja root barks, which exhibit a prononced muscle-relaxant effect and a high cardiotoxicity. Our expriments prove that the pharmacological action of S. icaja aqueous extract is different from that of S. nux-vomica extract. Therefore none African Strychnos species shows an exclusively strychnine-like effect in all its extracts. [less ▲]

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See detailNouveaux alcaloïdes des racines du Strychnos icaja
Kambu, Kabangu; Coune, Claude; Angenot, Luc ULg

in Planta Medica (1979), 37

Strychnos icaja roots are used in Central Africa for the preparation of arrow and ordeal poisons. Amongst the very numerous bases present in these roots, we have isolated and identified six alkaloids ... [more ▼]

Strychnos icaja roots are used in Central Africa for the preparation of arrow and ordeal poisons. Amongst the very numerous bases present in these roots, we have isolated and identified six alkaloids. Apart from strychnine, we have obtained three alkaloids previously detected in the leaves:icajine, 19,20-alpha-epoxynovacine and 19,20-alpha-epoxy-15-hydroxynovacine. Moreover we have extracted dimeric alkaloids: symmetrical (bisnordihydrotoxiferine) as well as a new unsymmetrical one (sungucine). Finally it has been shown that the plant contained also various quaternary alkaloids and particularly Nb-methylstrychninium base which has been found for the first time. Phytochemical and pharmacological experiments are still under study. [less ▲]

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See detailNouveaux alcaloïdes bis-indoliques dans l'écorce des racines du Streychnos variabilis
Tits, Monique ULg; Angenot, Luc ULg

in Planta Medica (1978), 34

New bis-indole alkaloids (strychnobiline and isostrychnobiline) were extracted from roots of Strychnos variabilis. The plane structures of these alkaloids have been elucidated. Nordihydrotoxiferine is ... [more ▼]

New bis-indole alkaloids (strychnobiline and isostrychnobiline) were extracted from roots of Strychnos variabilis. The plane structures of these alkaloids have been elucidated. Nordihydrotoxiferine is also present in this African species of Strychnos. [less ▲]

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See detailLe Dolichantoside, un alcaloïde nouveau du Strychnos gossweileri
Coune, Claude; Angenot, Luc ULg

in Planta Medica (1978), 34

This paper reports about the isolation and structure determination of a new indole glucoalkaloid extracted from the roots of Strychnos gossweileri collected in Democratic Republic of Congo (Zaïre)

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See detailVogeloside et acide secologanique, glucosides secoiridoides d'Anthocleista vogelii
Chapelle, Jean-Paul ULg

in Planta Medica (1976), 29(3), 268-74

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See detailDe nouveaux alcaloïdes quaternaires du Strychnos usambarensis
Angenot, Luc ULg

in Planta Medica (1975), 27(1), 24-30

We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are ... [more ▼]

We have isolated and identified three quaternary monomeric indole alkaloids from barks of Strychnos usambarensis roots. Besides Macusine B, previously found in Strychnos toxifera, two new products are described: O-methyl-macusine B and O-methyl-dihydro-macusine B. It is not easy to discuss the origin of these last products that could take formation during the extraction. The purification is very laborious because Strychnos usambarensis contains more than sixty alkaloids. [less ▲]

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See detailConstituants chimiques des feuilles d'Anthocleista vogelii
Chapelle, Jean-Paul ULg

in Planta Medica (1974), 26(4), 301-4

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