Matadine, a cytotoxic alkaloid from Strychnos gossweileri

in Phytochemistry (1991), 30(5), 1697-1700

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on ... [more ▼]

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells. [less ▲]

Venecurine, an Indole Alkaloid from Curare

in Phytochemistry (1989), 28(9), 2221-2223

A new quaternary indole alkaloid, venecurine, has been isolated by chromatographic techniques from a curare obtained from the Hoti tribe of Venezuela. Elucidation of its structure is based mainly on 2D ... [more ▼]

A new quaternary indole alkaloid, venecurine, has been isolated by chromatographic techniques from a curare obtained from the Hoti tribe of Venezuela. Elucidation of its structure is based mainly on 2D-NMR studies. Concurrently with the structural work, frog bioassays were carried out. The curare and venecurine exhibit the same type of activity that is relatively low as compared with the dimeric curarizing alkaloids.These results may be an indication that the sample of curare investigated was a weak one intended to be used for capturing rather than killing animals. [less ▲]

Strychnochromine, an unusual C18 indoline alkaloid from Strychnos gossweileri

in Phytochemistry (1988), 27(2), 595-597

Through a combination of spectroscopic techniques (UV, IR, MS, 1H and 13C NMR) it has been possible to propose a plane structure and the relative configuration of strychnochromine a dextrorotatory ... [more ▼]

Through a combination of spectroscopic techniques (UV, IR, MS, 1H and 13C NMR) it has been possible to propose a plane structure and the relative configuration of strychnochromine a dextrorotatory alkaloid isolated from the root bark of Strychnos gossweileri. [less ▲]

Isolation and Purification of Panarine, a Quaternary Alkaloid from a Venezuelian Curare

in Phytochemistry (1988), 27(12), 4002-4004

High Speed Counter Current Chromatography (HSCCC) has been used to isolate and purify two quaternary alkaloids from a sample of curare prepared by the Panare Indians of Estado Bolivar, Venezuela. One of ... [more ▼]

High Speed Counter Current Chromatography (HSCCC) has been used to isolate and purify two quaternary alkaloids from a sample of curare prepared by the Panare Indians of Estado Bolivar, Venezuela. One of the compounds is the known base Macusine B. The other one is a new but related base named panarine. Its structure has been established unequivocally by spectral and X-ray cristallographic analysis. [less ▲]

Four acylated flavonol glycosides from leaves of Strychnos variabilis

in Phytochemistry (1987), 26(12), 3331-3334

Four new acylated flavonol glycosides have been isolated and identified from the leaves of Strychnos variabilis: quercetin3-(4"-trans-p-coumaroyl) robinobioside-7-glucoside (variabiloside A) and its cis ... [more ▼]

Four new acylated flavonol glycosides have been isolated and identified from the leaves of Strychnos variabilis: quercetin3-(4"-trans-p-coumaroyl) robinobioside-7-glucoside (variabiloside A) and its cis derivative ( variabiloside B), kaempferol3-(4"-trans-p-coumaroyl)robinobioside-7-glucoside (variabiloside C) and its cis-derivative ( variabiloside D). [less ▲]

Flavonol glycosides from leaves of Strychnos variabilis

in Phytochemistry (1986), 25(2), 563-564

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter ... [more ▼]

Quercetin 3-O-galactoside, quercetin 3-O-robinobioside and kaempferol 3-O-robinobioside were obtained from the leaves of Strychnos variabilis. These flavonoids were isolated by DCCC (Droplet Counter Current Chromatography). YThe structures were established by TLC (co-chromatography), UV, NMR ,FAB-MS, hydrolytic and chemical methods. [less ▲]

13C NMR des alcaloïdes des Strychnos: les dérivés de l'harmane et de l'usambarensine

in Phytochemistry (1980), 19

13C NMR spectra of some tertiary and quaternary alkaloids are recorded and the signals assigned. Graphic interpretation of off-resonance spectra and substituent shielding effects together with the effect ... [more ▼]

13C NMR spectra of some tertiary and quaternary alkaloids are recorded and the signals assigned. Graphic interpretation of off-resonance spectra and substituent shielding effects together with the effect of Nb-methylation are utilized in the spectral interpretations. [less ▲]

Alkaloids from Strychnos usambarensis: revised structure for usambarine

in Phytochemistry (1978), 17(9), 1687-1689

La désacétylrétuline extraite du Strychnos variabilis

in Phytochemistry (1975), 14

Desacetylretuline has been extracted from the rootbark of Strychnos variabilis collected in Congo (Zaïre). The structure determinatiion was deduced from spectral data (UV,IR, MS, NMR, and CD).It is the ... [more ▼]

Desacetylretuline has been extracted from the rootbark of Strychnos variabilis collected in Congo (Zaïre). The structure determinatiion was deduced from spectral data (UV,IR, MS, NMR, and CD).It is the first time that this alkaloid is found in Nature. [less ▲]

Etude chimiotaxonomique dans les genres Macrotyloma, Dolichos et Pseudovigna

in Phytochemistry (1972), 12