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See detailCyclical Cushing's disease and its successful control under sodium valproate.
Beckers, Albert ULg; Stevenaert, Achille ULg; Pirens, G. et al

in Journal of Endocrinological Investigation (1990), 13(11), 923-9

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical ... [more ▼]

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. [less ▲]

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See detailThe physiology of pituitary and placental GH secretion during pregnancy in acromegalic as compared to normal women.
Beckers, Albert ULg; Frankenne, F.; Stevenaert, Achille ULg et al

in Journal of Endocrinological Investigation (1989)

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See detailEffect of transsphenoidal surgery on the LH pulsatility in women with microprolactinomas.
Beckers, Albert ULg; Stevenaert, Achille ULg; Vandalem, J. L. et al

in Journal of Endocrinological Investigation (1985)

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See detailOxytocin secretion by bovine granulosa cells: regulation and interactions with steroidogenesis
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Hustin, Jean et al

in Journal of Endocrinological Investigation (1985), 8 (Suppl. 3)

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See detailCushing's disease : episodic pattern of hypersecretion with two distinct rhythms
Beckers, Albert ULg; Stevenaert, Achille ULg; Hennen, G.

in Journal of Endocrinological Investigation (1985)

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See detailOxytocin secretion by bovine granulosa cells: regulation and interactions with steroidogenesis
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Hustin, Jean et al

in Journal of Endocrinological Investigation (1985), 8

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See detailEffect of transphenoidal surgery on the LH pulsatility in women with microprolactinomas
Stevenaert, Achille ULg; Beckers, Albert ULg; vandalem, jl et al

in Journal of Endocrinological Investigation (1985)

Detailed reference viewed: 4 (0 ULg)