References of "International Journal of Cancer = Journal International du Cancer"
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See detailAlterations of the basement membrane and connective tissue antigens in human metastatic lymph nodes.
Burtin, P.; Chavanel, G.; Foidart, Jean-Michel ULg et al

in International Journal of Cancer = Journal International du Cancer (1983), 31(6), 719-26

Antigens of the basement membrane (type-IV collagen and laminin) and the connective tissue (type-III collagen and fibronectin) were studied by immunofluorescence in 16 lymph nodes draining colorectal ... [more ▼]

Antigens of the basement membrane (type-IV collagen and laminin) and the connective tissue (type-III collagen and fibronectin) were studied by immunofluorescence in 16 lymph nodes draining colorectal carcinomas and 6 lymph nodes draining breast carcinomas. A comparison was also made between 7 primary colorectal carcinomas and 9 lymph nodes draining these tumors. Anti-type-IV collagen and anti-laminin rarely stained the basement membrane of metastatic tumors. In contrast, we detected type-IV collagen in the peritumoral stroma, although similar images were rarely seen in primary tumors. When tumoral cells were in the vicinity of lymphoid cells, they were occasionally separated by a barrier stained by the four antisera, or only by antifibronectin and anti-type-III collagen. In other cases no barrier was observed between both types of cells which were in close contact. On the whole the above alterations were more marked in the lymph nodes draining breast carcinomas, in comparison to those draining colorectal carcinomas. Tumor cells were never stained by anti-type-IV collagen or antilaminin serum. Some cells found either in the lymphoid or in the tumor area of metastatic lymph nodes were stained not only by these antisera, but also by a monoclonal antibody against Willebrand Factor, which is a marker of endothelial cells. Thus the labelled cells were characterized as being derived from the capillary wall. [less ▲]

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Peer Reviewed
See detailAntigens of the basement membrane and the peritumoral stroma in human colonic adenocarcinomas: an immunofluorescence study.
Burtin, P.; Chavanel, G.; Foidart, Jean-Michel ULg et al

in International Journal of Cancer = Journal International du Cancer (1982), 30(1), 13-20

Twenty colonic adenocarcinomas were studied by immunofluorescence with antisera against components of the basement membrane: type IV collagen, laminin and heparan sulfate-rich proteoglycan, as well as ... [more ▼]

Twenty colonic adenocarcinomas were studied by immunofluorescence with antisera against components of the basement membrane: type IV collagen, laminin and heparan sulfate-rich proteoglycan, as well as antisera against antigens of the connective tissue: type-III collagen, fibronectin and hyaluronectin. Marked alterations of the basement membranes were consistently observed on staining with each one of the first three antisera. In contrast, staining of the normal components of connective tissue was in most cases as intense as in normal colonic mucosa. Hyaluronectin, a marker of peritumoral stroma, was found to be present in 12 out 15 tumors studied. [less ▲]

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