References of "European Journal of Dermatology"
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See detailDermo-epidermal stimulation elicited by a salicylic acid derivative: a comparison with salicylic acid and all trans-retinoic acid.
Pierard, Gérald ULg; Leveque, J.-L.; Rougier, A. et al

in European Journal of Dermatology (2002), 12(4), -

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See detailSubclinical speckled perifollicular melanosis of the scalp.
Petit, Ludivine; Saint Leger, Didier; Loussouarn, Genevieve et al

in European Journal of Dermatology (2002), 12(6), 565-8

Based on the clinical presentation of some skin pigmentation disorders it is thought that a bicompartmental functional system exists in the epidermal melanocyte population. It corresponds to the ... [more ▼]

Based on the clinical presentation of some skin pigmentation disorders it is thought that a bicompartmental functional system exists in the epidermal melanocyte population. It corresponds to the perifollicular and interfollicular compartments, respectively. The present study was undertaken looking for the presence of such a system on scalp unaffected by pigmentary disorders. The scalps of 100 men with incipient to severe androgenic alopecia were examined using a videocamera equipped with an internal ultraviolet light-emitting unit. The face, trunk and limbs were similarly examined in 45 of these adults and in 13 children of both sexes. In 92 men, a subclinical hypermelanosis was found as a speckled pattern centered on every single follicle. With increasing baldness severity, another epidermal hyperpigmentation pattern involving the interfollicular area was superimposed to the perifollicular pattern. These stereotyped patterns of subclinical melanoderma were also disclosed on the face of adults, but not in children. In addition, the spotty perifollicular pattern was discrete or not apparent on the other parts of the body. It is concluded that the perifollicular subclinical melanotic pattern is a regional characteristic of cephalic skin, perhaps related to the local production of melanocortins, particularly alpha-MSH by the pilosebaceous unit. [less ▲]

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See detailBreaking the Relentless Course of Hallopeau's Acrodermatitis by Dapsone
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in European Journal of Dermatology (1999), 9(2), 126-128

We report the case of a 74-year-old man who suffered for four years from recurrent generalized pustular eruptions associated with acrodermatitis continua of Hallopeau (ACH). Initial therapy using topical ... [more ▼]

We report the case of a 74-year-old man who suffered for four years from recurrent generalized pustular eruptions associated with acrodermatitis continua of Hallopeau (ACH). Initial therapy using topical corticosteroids, tars and PUVA failed to improve the acral lesions. The disease was also unresponsive to systemic therapy using corticosteroids, methotrexate, etretinate, acitretine and cyclosporin A. Serious side-effects were experienced with these drugs. A marked improvement of the generalized pustules was observed under treatment combining etretinate and methotrexate, without having any effect on the acropustulosis. During hospitalization, a topical tar therapy cleared the pustular rash. Again no effect was observed on the acral lesions. Disulone (DDS) therapy, initiated at a dose of 200 mg/day, completely cleared ACH after 4 weeks. The disease relapsed when the dose was reduced to 100 mg/day. Increasing the DDS to 150 mg/day was rapidly followed by a new clearance of the acral lesions. After a 3-month treatment, the patient has remained lesion free and no DDS-related side-effects have occurred. In conclusion, sulfones may be considered as an alternative therapeutic option in drug-resistant ACH. [less ▲]

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See detailHerpesviridae granulomas. Letter
Nikkels, Arjen ULg; Pierard, Gérald ULg

in European Journal of Dermatology (1996), 6(5), 394

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See detailVulvar basal cell carcinoma
Kharfi, M.; Mokhtar, I.; Fazaa, B. et al

in European Journal of Dermatology (1992), 2

Vulva is an uncommon localization for basal cell carcinomas. We report three cases and review the literature. There is often a long delay before patients seek medical attention for these lesions. Moreover ... [more ▼]

Vulva is an uncommon localization for basal cell carcinomas. We report three cases and review the literature. There is often a long delay before patients seek medical attention for these lesions. Moreover the clinical aspect is often indistinctive and misleading. The gross polymorphism of vulvar neoplasms therefore calls for biopsy of any suspicious areas. Surgical excision or Moh's chemotherapy are the treatments of choice for vulvar basal cell carcinomas. The recurrence rate remains quite high even when the lesion looks completely resected. [less ▲]

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