References of "Annals of the Rheumatic Diseases"
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See detailLong-term treatment of postmenopausal osteoporotic women with strontium ranelate : results at 10 years
Reginster, Jean-Yves ULg; Kaufman, J. M.; Devogelaer, J. D. et al

in Annals of the Rheumatic Diseases (2011), 70(S3), 167

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See detailMitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis.
Rego-Perez, I.; Fernandez-Moreno, M.; Deberg, Michelle ULg et al

in Annals of the Rheumatic Diseases (2011), 70(4), 646-52

OBJECTIVE: To analyse the influence of mitochondrial DNA haplogroups, as well as the radiographic grade, on serum levels of proteolytic enzymes in patients with osteoarthritis (OA). METHODS: Serum levels ... [more ▼]

OBJECTIVE: To analyse the influence of mitochondrial DNA haplogroups, as well as the radiographic grade, on serum levels of proteolytic enzymes in patients with osteoarthritis (OA). METHODS: Serum levels of metalloproteinase-1 (MMP-1), MMP-3, MMP-13, myeloperoxidase and cathepsin K were analysed in 73 patients with OA and 77 healthy controls carrying the haplogroups J, U and H, by ELISA. Knee and hip radiographs were classified according to Kellgren and Lawrence (K/L) scoring from grade 0 to grade IV. Non-parametric and multiple regression analyses were performed to test the effects of clinical variables, including gender, age, smoking status, diagnosis, haplogroups and radiological K/L grade on serum levels of these enzymes. RESULTS: A significant influence of the haplogroups on the serum levels of MMP-3 and MMP-13 was detected (p=0.027 and p=0.035, respectively). Patients with OA with haplogroup H showed higher serum levels of MMP-3 than healthy controls. Serum levels of MMP-13 were significantly higher in patients with OA (p<0.001), and carriers of the haplogroup J showed lower levels than H carriers. Besides, levels of MMP-13 were proportionally higher in radiological groups B (K/L grade II and III) and C (K/L grade IV) than in group A (K/L grade 0 and I) (p=0.005). CONCLUSIONS: This study shows that haplogroups have a significant influence on serum levels of MMP-3 and MMP-13. The influence of the haplogroups on serum levels of MMP-3 is clearly dependent on the diagnosis, whereas the influence of the haplogroups on serum levels of MMP-13 is independent of diagnosis. [less ▲]

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See detailEffects of original rehabilitation programs in patients with fibromyalgia syndrome
Maquet, Didier ULg; BRONFORT, Stéphanie ULg; LECART, Marie-Paule ULg et al

in Annals of the Rheumatic Diseases (2010, June), 69(Suppl 3), 706

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See detailEffects of an original training program in healthy elderly subjects
Maquet, Didier ULg; BRONFORT, Stéphanie ULg; LECART, Marie-Paule ULg et al

in Annals of the Rheumatic Diseases (2010, June), 69(Suppl 3), 313

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See detailPreparing new regulatory guidelines: the role of the Group for the Respect of Ethics and Excellence in Science (GREES)
Reginster, Jean-Yves ULg

in Annals of the Rheumatic Diseases (2010, June), 69(Suppl.3), 42

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See detailHealth-related quality of life after total knee or hip replacement: a 7-year prospective study
Bruyère, Olivier ULg; Vanoverberghe, Marie ULg; Neuprez, Audrey ULg et al

in Annals of the Rheumatic Diseases (2010, June), 69(Suppl.3), 469

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See detailClinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
Conaghan, P. G.; D'Agostino, M. A.; Le Bars, M. et al

in Annals of the Rheumatic Diseases (2010), 69

OBJECTIVES: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. METHODS: This was a 3-year prospective study of a ... [more ▼]

OBJECTIVES: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. METHODS: This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan-Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. RESULTS: Of the 600 original patients, 531 (88.5%), mean age 67+/-10 years, mean disease duration 6.1+/-6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0-4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade > or =III vs <III, hazards ratio (HR) = 4.08 (95% CI 2.34 to 7.12), p<0.0001); ultrasonographic knee effusion (> or =4 mm vs <4 mm) (HR = 2.63 (95% CI 1.70 to 4.06), p<0.0001); knee pain intensity on a 0-100 mm visual analogue scale (> or =60 vs <60) (HR = 1.81 (95% CI 1.15 to 2.83), p=0.01) and disease duration (> or =5 years vs <5 years) (HR=1.63 (95% CI 1.08 to 2.47), p=0.02). Clinically detected effusion and US synovitis were not associated with joint replacement in the univariate analysis. CONCLUSION: Longitudinal evaluation of this OA cohort demonstrated significant progression to joint replacement. In addition to severity of radiographic damage and pain, US-detected effusion was a predictor of subsequent joint replacement. [less ▲]

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See detailMitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis.
Rego-Perez, I.; Fernandez-Moreno, M.; Deberg, Michelle ULg et al

in Annals of the Rheumatic Diseases (2010), 69(5), 910-7

OBJECTIVE: To analyse the influence of mitochondrial DNA (mtDNA) haplogroups on serum levels of molecular biomarkers in patients with osteoarthritis (OA). METHODS: Serum levels of molecular biomarkers of ... [more ▼]

OBJECTIVE: To analyse the influence of mitochondrial DNA (mtDNA) haplogroups on serum levels of molecular biomarkers in patients with osteoarthritis (OA). METHODS: Serum levels of molecular biomarkers of cartilage metabolism (collagen type II markers: C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix (C2C), collagen type II (Coll2-1, and its nitrated form, Coll2-1NO(2)), procollagen type II (CPII)), synovial metabolism (hyaluronic acid (HA)) and cartilage and synovial turnover (cartilage glycoprotein 39 (YKL-40)) were analysed in 73 patients with OA and 77 healthy controls using ELISAs. All participants had been previously genotyped for the mtDNA haplogroups J, U and H. Non-parametric and multivariate analysis were performed to test the effects of the clinical variables, including gender, age, smoking status, diagnosis, mtDNA haplogroups and radiological Kellgren and Lawrence (K/L) grade on the serum levels of the molecular markers. RESULTS: Non-parametric analysis found increased serum levels of HA in patients with OA, while the values for C2C and the C2C/CPII ratio were significantly higher in the healthy controls. A multiple regression analysis showed a relationship between the mtDNA haplogroups and serum levels of the typical collagen type II markers. Carriers of the mtDNA haplogroup H had higher levels while carriers of the mtDNA haplogroup J showed lower levels. Statistically significant interactions between mtDNA haplogroups and diagnosis and between mtDNA haplogroups and radiological K/L grade in the serum levels of molecular markers were also found. CONCLUSION: A new role for mtDNA haplogroups emerges from this work. The results suggest that the mtDNA haplogroups interact significantly with the serum levels of OA-related molecular markers, suggesting the possibility of their use as a complementary assay with these molecular markers. [less ▲]

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See detailThe clinical and economic burden of nonadherence with oral bisphosphonates in osteoporotic patients
Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg; Reginster, Jean-Yves ULg

in Annals of the Rheumatic Diseases (2009, June), 68(S3), 667

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See detailInhibition of radiographic progression with combination etanercept and methotrexate in patients with moderately active rheumatoid arthritis previously treated with monotherapy
van der Heijde, D.; Burmester, G.; Melo-Gomes, J. et al

in Annals of the Rheumatic Diseases (2009), 68(7), 1113-1118

OBJECTIVE: To determine the effect of changing from etanercept or methotrexate monotherapy to etanercept plus methotrexate combination therapy on radiographic progression in rheumatoid arthritis (RA ... [more ▼]

OBJECTIVE: To determine the effect of changing from etanercept or methotrexate monotherapy to etanercept plus methotrexate combination therapy on radiographic progression in rheumatoid arthritis (RA) patients. METHODS: Patients enrolled in this 1-year open-label study previously completed a 3-year blinded study in which they received methotrexate or etanercept monotherapy or the combination of both. All patients received the combination of etanercept 25 mg subcutaneously twice weekly plus oral methotrexate up to 20 mg/week. The primary radiographic endpoint was a change in modified total Sharp score (TSS), as assessed by blinded readers. RESULTS: At baseline, patients previously receiving methotrexate monotherapy (etanercept-added, n = 52) or etanercept monotherapy (methotrexate-added, n = 68) had moderate disease activity levels (mean disease activity score (DAS) of 2.6 and 2.5, respectively), whereas patients previously receiving combination therapy (n = 90) had a low disease activity level (mean DAS of 2.0). The addition of etanercept to methotrexate monotherapy resulted in a significant reduction in radiographic progression (p<0.05). Mean TSS changes in the previous year versus the current year were +1.79 versus +0.25 for the etanercept-added group (p<0.05); +0.51 versus -0.18 for the methotrexate-added group (NS) and +0.42 versus +0.24 for the combination group (NS). CONCLUSION: In these RA patients with on average moderate disease activity despite previous methotrexate monotherapy, combination treatment with etanercept and methotrexate inhibited radiographic progression and improved radiographic outcomes. These data, in conjunction with the previously published clinical data, support the use of combination therapy in RA patients with moderate disease activity. [less ▲]

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See detailBiomarkers and HLA typing in erosive and non erosive osteoarthritis of the hands
Frigato, M; Ramonda, R; Henrotin, Yves ULg et al

in Annals of the Rheumatic Diseases (2009), 68(Suppl.3), 473

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See detailEffects of iron depletion on articular biomarkers and joint symptoms in patients with genetic hemochromatosis: a prospective, longitudinal study.
Richette, P; Eymard, C; Deberg, M et al

in Annals of the Rheumatic Diseases (2009), 68(Suppl 3), 679

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See detailInformation delivery to patients with acute low back pain: a longitudinal observational randomized survey
Marty, M; Moyse, D; Bazin, T et al

in Annals of the Rheumatic Diseases (2009), 68(Suppl 3), 700

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See detailThe serum levels of biomarkers are related with mitochondrial DNA haplogroups in knee OA patients
Rego, I; Fernandez, M; Deberg, M et al

in Annals of the Rheumatic Diseases (2009), 68(Suppl 3), 290

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See detailSimilar non-vertebral antifracture efficacy demonstrated with monthly ibandronate versus weekly bisphosphonate therapy: A retrospective cohort study
Reginster, Jean-Yves ULg; Barr, C. E.; Blumentals, W. A. et al

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 539

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See detailRelationship between long-term changes in femoral neck bone mineral density and hip fracture incidence in untreated postmenopausal osteoporotic women
Bruyère, Olivier ULg; Brandi, M.; Vellas, B. et al

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 403

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See detailAssociation between lumbar disc degeneration and biochemical markers of bone and cartilage remodelling
Bruyère, Olivier ULg; Collette, Julien ULg; Christiansen, F. et al

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 231

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See detailPrevalence of vitamin D inadequacy in institutionalized osteoporotic postmenopausal women
Bruyère, Olivier ULg; Delhez, M.; Collette, Julien ULg et al

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 403

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