Neurotrophic Factors: Past and Future

in Acta Neurologica Belgica (1996), 96(3), 203-18

Frontal lobe dementia presenting as personality disorder

in Acta Neurologica Belgica (1996), 96(2), 130-134

The early differential diagnosis of frontal lobe dementia is particularly difficult because changes of personality or behaviour overwhelm intellectual and cognitive impairments. We report the case of a ... [more ▼]

The early differential diagnosis of frontal lobe dementia is particularly difficult because changes of personality or behaviour overwhelm intellectual and cognitive impairments. We report the case of a patient presenting with paranoid personality disorder who refused to collaborate in neuropsychological testing. Initial functional imaging showed frontal hypometabolism that served as an early marker of frontal lobe dysfunction. [less ▲]

Substrats neurologiques de la mémoire de travail : étude physiologique par tomographie à émission de positons

in Acta Neurologica Belgica (1996), 96

Pathogenesis of migraine: the biobehavioural and hypoxia theories reconciled.

in Acta Neurologica Belgica (1994), 94(2), 79-86

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino ... [more ▼]

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino-vascular system. While this can be found in other headache disorders, the process leading ultimately to trigemino-vascular activation appears to characterize migraine. Between attacks, the migrainous brain has two functional abnormalities: a habituation defect in sensory processing, probably related to dysfunctioning transmitter (serotonin, noradrenaline) systems and a reduced mitochondrial energy reserve. Both abnormalities may be genetically determined and concur to favour biochemical shifts leading to the migraine attack as a primary protective mechanism of the brain. Such a model of migraine pathogenesis reconciles the biobehavioural and hypoxia theories and opens new therapeutic perspectives. [less ▲]

Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.

in Acta Neurologica Belgica (1991), 91(5), 288-95

Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young ... [more ▼]

Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young volunteers. Cortical atrophy or neuronal depopulation are unlikely to entirely explain this physiological phenomenon, and sub-cortico-cortical deactivation should play a role, analogous to that proposed in subcortical diseases. [less ▲]

Positron Emission Tomography in Degenerative Dementias

in Acta Neurologica Belgica (1989), 89(3-4, May-Oct), 150-155

Positron emission tomography demonstrates different abnormalities of cerebral metabolism or characteristic disturbances of neurotransmission systems in "cortical" and "subcortical" dementias. Those ... [more ▼]

Positron emission tomography demonstrates different abnormalities of cerebral metabolism or characteristic disturbances of neurotransmission systems in "cortical" and "subcortical" dementias. Those patterns may reflect the underlying anatomopathology, but may also give clues to the pathophysiology of a disease and its symptoms. [less ▲]

Persistent varicella-zoster virus infection in the nervous system: in vitro and in vivo models

in Acta Neurologica Belgica (1988), 88

Painful legs and moving toes: démembrement clinique et physiopathologique du syndrome

in Acta Neurologica Belgica (1983), 83

Corrélation entre le caractère épileptogène d'un foyer lésionnel et la présence dans celui-ci d'astrocytes activés (présentant une activité très intense des déshydrogénases et de l'alpha-glucan-phosphorylase). Etude chez l'homme et l'animal

in Acta Neurologica Belgica (1978), 78

A propos d'une uvéo-névraxite

in Acta Neurologica Belgica (1975), 75(6), 267-78

The authors describe a patient, suffering from recurring uveitis, buccal aphthous ulcers and meningo-myelitis. The diagnosis of Behcet's disease accounts for the whole clinical picture and has been ... [more ▼]

The authors describe a patient, suffering from recurring uveitis, buccal aphthous ulcers and meningo-myelitis. The diagnosis of Behcet's disease accounts for the whole clinical picture and has been confirmed by a cutaneous hypersensitivity to scratching. The authors stress the similarity between the neurological aspects of Behcet's disease and multiple sclerosis not only on the clinical side but also concerning the CSF composition (lympho-mono-plasmatocytic meningogram, increase and fractionation of gammaglobulins). The authors present a critical review of the evidence in favour of a viral aetiology. They put forward the clinical and experimental data in favour of an auto-immune aetiopathogeny. Treatment with corticosteroids associated with immunosuppressive drugs proved beneficial. [less ▲]