References of "Vox Sanguinis"
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See detailSimultaneous passenger lymphocyte syndrome and multiple alloimmunization against donor's blood group antigens after liver transplantation
MONFORT, Mélanie ULg; HONORE, Pierre ULg; GOTHOT, André ULg et al

in Vox Sanguinis (2015), 109

Background If “passenger lymphocyte syndrome” (PLS) is a well-recognized complication in ABO mismatched solid organ transplantation, the coexistence of this reaction with recipient’s alloimmunisation ... [more ▼]

Background If “passenger lymphocyte syndrome” (PLS) is a well-recognized complication in ABO mismatched solid organ transplantation, the coexistence of this reaction with recipient’s alloimmunisation against multiple antigens expressed on the residual red blood cells in the graft is less common and unpredictable. Methods The receiver of an ABO minor mismatch liver graft from a cadaveric donor developed hemolytic anemia within 2 weeks after transplantation. The organ donor was of blood group O D+C+c+E+e+ K+k+ Le(a+b-) and the recipient, A1 D-C-c+E-e+ K-k+ Le(a-b-). The donor and recipient were both tested for irregular antibodies. Elution was performed on the recipient’s red blood cells (RBCs). Results None of the recipient and donor had irregular alloantibodies at the time of transplantation. On day 10, anti-A antibodies was detected in the recipient’s serum and eluted from his RBCs. At the same time, the patient developed multiple alloantibodies: anti-D, anti-C, anti-E, anti-K and anti-Lea against the donor’s erythrocyte antigens. Conclusion Although serological analysis and hemolytic parameters confirmed the diagnosis of PLS which required transfusion support, no sign of graft damage due to recipient’s immune reaction was detected. This case illustrates the required follow-up of the recipient after transplantation. [less ▲]

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See detailCord blood banking
Brand, A.; Rebulla, P.; Engelfriet, C. P. et al

in Vox Sanguinis (2008), 95

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See detailInternational forum. Use of umbilical cord blood progenitor cells as an alternative for bone marrow transplantation.
Engelfriet, C. P.; Reesink, H. W.; Wagner, J. E. et al

in Vox Sanguinis (2002), 83(2), 172-87

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See detailHemovigilance: Clinical Tolerance of Solvent-Detergent Treated Plasma
Baudoux, Etienne ULg; Margraff, U.; Coenen, Alain ULg et al

in Vox Sanguinis (1998), 74(Suppl 1), 237-9

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates ... [more ▼]

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates). METHODS: Adverse events (AEs) related to the use of blood products at the Blood Transfusion Center (BTC) are routinely collected through a formalised system of hemovigilance. All AEs reported are entered into a safety data base which was used for the study. All AEs reported during a one-year period to the BTC were retrospectively re-assessed and descriptive statistics calculated. RESULTS: 5064 units of SD treated plasma were transfused to 894 recipients during the study period at the occasion of 1553 transfusions. No AE associated to SD treatment plasma was reported during that period. In contrast, during the same period, 485 AEs associated with the use of red blood cell concentrates (RBCC) were reported in 251 patients at the occasion of 262 transfusions. 2.1% (251/11,748) of the patients transfused with RBCC experienced one or more AEs. The incidence of AEs per unit transfused was 1.3% (485/37,332), and 2.4% (485/20,460) of RBCC transfusions were associated with one or more AEs. 142 AEs associated with the use of platelet concentrate (PC) were observed in 69 patients at the occasion of 73 transfusions. 4.2% (69/1645) of patients transfused with PC experienced one or more AEs. The incidence of AEs per unit transfused was 1.1% (142/12,772), and 2.8% (142/5034) of PC transfusions were associated with one or more AEs. All reported AEs were classified and non serious. The most frequently observed AEs were fever, chills and rashes which accounted for roughly 64% of all reported AEs. CONCLUSION: As for the overall clinical tolerance of red cell and platelet concentrates, the results of this study are in complete agreement with the published literature. The study also confirms the extremely good tolerability of SD treated plasma in comparison with other labile blood products. [less ▲]

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See detailAbsence of seroconversion in a PCR positive person 18 months after transfusion of HIV infected blood
Vaira, Dolorès ULg; François-Gérard, C.; Rentier, Bernard ULg et al

in Vox Sanguinis (1989), 57(3), 220-221

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