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See detailNicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials
lukasova, Martina; Hanson, Julien ULg; Tunaru, Sorin et al

in Trends in Pharmacological Sciences (2011)

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See detailIs ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
Quertemont, Etienne ULg; Tambour, Sophie ULg

in Trends in Pharmacological Sciences (2004), 25(3), 130-134

Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many behavioral effects of ethanol. However, its precise role remains a matter of debate, with some researchers ... [more ▼]

Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many behavioral effects of ethanol. However, its precise role remains a matter of debate, with some researchers suggesting that acetaldehyde has no role in the effects of ethanol and others contending that ethanol is a pro-drug whose pharmacological action is mediated by acetaldehyde. Recent studies support a role for acetaldehyde in the stimulant, reinforcing, hypnotic and amnesic effects of ethanol, and, in particular, alcohol abuse and alcoholism. However, current evidence indicates that acetaldehyde is not involved in some of the major neurochemical effects of ethanol. It is therefore likely that ethanol and acetaldehyde molecules act synergistically to determine the multiple neurochemical and behavioral effects of alcohol consumption. [less ▲]

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See detailRecent Advances in the Pharmacology of Quaternary Salts of Bicuculline
Seutin, Vincent ULg; Johnson, S. W.

in Trends in Pharmacological Sciences (1999), 20(7), 268-270

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