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See detailThe NF-κ B-independent functions of IKK subunits in immunity and cancer
Chariot, Alain ULg

in Trends in Cell Biology (2009), 19

The IKK complex is involved in transcriptional activation by phosphorylating the inhibitory molecule IkBa, a modification that triggers its subsequent degradation, allowing activation of NF-kB ... [more ▼]

The IKK complex is involved in transcriptional activation by phosphorylating the inhibitory molecule IkBa, a modification that triggers its subsequent degradation, allowing activation of NF-kB. Importantly, recent reports indicate that multiple cytoplasmic and nuclear proteins distinct from the NF-kB/IkB proteins are phosphorylated by the catalytic subunits of the IKK complex, IKKa or IKKb. Here we describe how the IKK subunits can play crucial roles in allergy, inflammation, immunity by targeting proteins such as SNAP23 and IRF7 but also in cancer by phosphorylating key molecules such as p53, TSC1 and FOXO3a through NF-kB-independent pathways. Thus, these recent findings considerably widen the biological roles played by these kinases and suggest that a full understanding of the biological roles played by IKKa and IKKb requires an exhaustive characterization of their substrates. [less ▲]

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See detailBirth of a nucleolus: the evolution of nucleolar compartments.
Thiry, Marc ULg; Lafontaine, Denis L J

in Trends in Cell Biology (2005), 15(4), 194-9

In eukaryotes, ribosome synthesis largely takes place in a specialized nuclear domain - the nucleolus. It has recently become apparent that this organelle is involved in the biogenesis of most cellular ... [more ▼]

In eukaryotes, ribosome synthesis largely takes place in a specialized nuclear domain - the nucleolus. It has recently become apparent that this organelle is involved in the biogenesis of most cellular ribonucleoprotein particles (RNPs), as well as in cell-cycle regulation, making it central to gene expression. The field has traditionally acknowledged that each nucleolus is organized in three morphologically distinct compartments. Here, however, we discuss our view that in fact many eukaryotes have bipartite nucleoli. We propose that, during evolution, a third nucleolar compartment emerged at the transition between the anamniotes and the amniotes, following a substantial increase in size of the rDNA intergenic region. We believe that these conclusions have important implications for understanding the structure-function relationships within this key cellular organelle. [less ▲]

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See detailPictures in cell biology. Spatial dynamics of rRNAs.
Thiry, Marc ULg; Cheutin, T.; O'Donohue, M. F. et al

in Trends in Cell Biology (2001), 11(4), 147

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See detailStructure, function and assembly of the nucleolus.
Scheer, U.; Thiry, Marc ULg; Goessens, Guy ULg

in Trends in Cell Biology (1993), 3(7), 236-41

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins ... [more ▼]

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis. [less ▲]

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