New models for analyzing mast cell functions in vivo.
Marichal, Thomas ; ;
in Trends in Immunology (2012), 33(12), 613-25
In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that ... [more ▼]
In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that contribute to disease or help to maintain health. Although some of these roles were first suggested by analyses of MC products or functions in vitro, it is critical to determine whether, and under which circumstances, such potential roles actually can be performed by MCs in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of MCs and MC-associated products during biological responses in vivo, and comments on some of the similarities and differences in the results obtained with these newer versus older models of MC deficiency. [less ▲]Detailed reference viewed: 34 (1 ULg)
Epithelial metaplasia: an inadequate environment for antitumour immunity?
Delvenne, Philippe ; Hubert, Pascale ; Jacobs, Nathalie
in Trends in Immunology (2004), 25(4), 169-73Detailed reference viewed: 20 (3 ULg)
Lymphocyte Kinetics: The Interpretation Of Labelling Data
; ; et al
in Trends In Immunology (2002), 23(12),Detailed reference viewed: 12 (1 ULg)