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See detailInfection humaine par le virus B du singe en Afrique
Mafuko Nsabimana, Jean-Marie; Moutschen, Michel ULg; Thiry, Etienne ULg et al

in Santé : Cahiers d'Etude et de Recherches Francophones (2008), 18(1), 3-8

Simian herpes B virus or Cercopithecine herpesvirus 1 (CeHV-1) is enzootic (80% to 100%) in Asian monkeys of the genus Macaca but is also present in other monkey species. This virus, discovered in 1933 ... [more ▼]

Simian herpes B virus or Cercopithecine herpesvirus 1 (CeHV-1) is enzootic (80% to 100%) in Asian monkeys of the genus Macaca but is also present in other monkey species. This virus, discovered in 1933, is closely related to human herpesvirus 1 and human herpesvirus 2, responsible respectively for labial and genital herpes. CeHV-1 infection is generally asymptomatic or mild in monkeys but in humans it may lead to fulminant encephalomyelitis that has an 80% lethality rate without treatment. Infections in humans are usually attributed to animal bites or scratches or to percutaneous or mucosal inoculation with infected materials from asymptomatic monkeys. Although the incidence of human infection with CeHV-1 is low, until the availability of antiviral therapy its death rate made this virus a serious zoonotic threat. Even now, good knowledge of its clinical signs and risk factors is essential for only they allow early and swift antiviral therapy (acyclovir, valacyclovir, or famciclovir) and prevent severe disease or fatal outcome. This article describes the virus, the resulting disease in human and a suspected clinical case involving a woman bit by a vervet monkey (Cercopithecus aethiops) in Garamba National Park in the Democratic Republic of the Congo. [less ▲]

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See detailChimiosensibilité in vivo et in vitro de Plasmodium falciparum à Brazzaville (Congo)
Chandenier, Jacques; Ndounga, Mathieu; Carme, Bernard et al

in Santé : Cahiers d'Etude et de Recherches Francophones (1995), 5(1), 25-29

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to ... [more ▼]

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. The resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. Thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. This finding was further confirmed by a parallel in vitro analysis of sensitivity to chloroquine in Brazzaville. A chloroquine monitoring network is now being established throughout the country based on simplified WHO tests of 100 asymptomatic schoolchildren conducted every six months. The first results in 1993, from three Southern regions indicate that parasites are found in 20 to 60% of cases seven days after a standard 3 day treatment with 25 mg/kg, according to the region. The results of in vitro and in vivo tests are very variable. Indeed, the value of such results for these tests for national monitoring is questionable: a more reliable system of identifying true therapeutic failures would be better suited. [less ▲]

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