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See detailChildhood Herpes Zoster-Triggered Guttate Psoriasis
FAILLA, Valérie ULg; NIKKELS, Nazli ULg; SABATIELLO, Murielle ULg et al

in Open Dermatology Journal (The) (2012), 6

Psoriasis is commonly triggered or exacerbated by various stress factors, certain drugs, or streptococcal throat infections. Viral infections such as HIV, CMV, chikungunya, or herpes simplex virus are ... [more ▼]

Psoriasis is commonly triggered or exacerbated by various stress factors, certain drugs, or streptococcal throat infections. Viral infections such as HIV, CMV, chikungunya, or herpes simplex virus are very uncommon triggers for psoriasis. Cases of varicella-triggered psoriasis are exceptional. A 7-year-old boy with a previous history of guttate psoriasis presented with generalized acute guttate psoriasis shortly after an extensive herpes zoster infection affecting the first and second left lumbar dermatomes. INF-alpha and granulocyte monocyte colony stimulating factor influence peripheral monocytes to transform into INF-dendritic cells (DC's), similar to those involved in psoriasis. These INF-DC's express toll-like receptors 7 and 8, which are responsive to viral single stranded RNA. Hence, viral infections and interferon (INF)-alpha may play a role in triggering psoriasis. [less ▲]

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See detailHerpes Simplex Virus Infections of the Nipple
EL HAYDERI, Lara ULg; CAUCANAS, Marie ULg; NIKKELS, Arjen ULg

in Open Dermatology Journal (The) (2012)

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably ... [more ▼]

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably underrecognized. Typical features include severe pain and erosive or ulcerated erythematous confluent clusters of lesions of the nipple and periareolar area. It is usually unilateral and not recurring. HSV infection of the nipple is originating from autoinoculation, sexual transmission or breastfeeding. Diagnosis is often delayed. The Tzanck smear is the most rapid and adequate method of dagnosis. Immunohistochemistry enables viral identification. The treatment relies on topical disinfection and oral antiviral therapy, such as aciclovir, famciclovir or valaciclovir. Scarring is uncommon. [less ▲]

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See detailChronic Idiopathic Penile Edema: Three Cases and a Review of the Literature
RATY, Laurent ULg; FAILLA, Valérie ULg; Andrianne, Robert ULg et al

in Open Dermatology Journal (The) (2011), 5

Abstract: Chronic idiopathic penile edema (CIPE) is an exceptional entity with disabling persistent lymphedema of the penis, affecting accessorily the scrotum and the pubis. The onset presents with ... [more ▼]

Abstract: Chronic idiopathic penile edema (CIPE) is an exceptional entity with disabling persistent lymphedema of the penis, affecting accessorily the scrotum and the pubis. The onset presents with recurrent swelling of the external genitalia, regressing spontaneously. After 2-3 years the swelling becomes progressively persistent. Mictional and erectile dysfunctions are not uncommon. A thorough work-up including RX, ultrasound examination, CT scanning, MRI imaging, serology and extensive blood testing should be performed to exclude underlying causes, including neoplastic, infectious, vascular and inflammatory diseases. CIPE is associated with significant psychological and functional impact. Surgical correction is the sole therapeutic option. Three patients with CIPE and a review of the literature are presented in order to increase awareness of this rare condition. [less ▲]

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