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See detailChronic mucocutaneous herpes simplex virus and varicella zoster virus infections
Wauters, Odile ULg; Lebas, Eglantine ULg; Nikkels, Arjen ULg

in Journal of the American Academy of Dermatology (2012)

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See detailThe Tzanck smear: heading the right way!
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Journal of the American Academy of Dermatology (2009), 61(1), 152-3

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See detailRetronychia: Proximal ingrowing of the nail plate
De Becker, D. A. R.; Richert, Bertrand ULg; Duhart, E. et al

in Journal of the American Academy of Dermatology (2008), 58

Background: Proximal nail fold inflammation can be caused by many diseases and has not previously been recognized as a result of posterior embedding of the nail. We describe a new pattern of ingrowth that ... [more ▼]

Background: Proximal nail fold inflammation can be caused by many diseases and has not previously been recognized as a result of posterior embedding of the nail. We describe a new pattern of ingrowth that we have termed retronychia (‘‘retro’’—Latin for backwards; ‘‘onychia’’—Greek for nail). The term describes a combination of proximal nail plate ingrowth into the proximal nail fold which is associated with multiple generations of nail plate misaligned beneath the proximal nail. Objective: To describe a new pattern of nail ingrowth which causes a specific form of proximal nail fold paronychia. Methods: Collective cases were reported to a European Nail Society expert group. Results: Persistent proximal nail fold inflammation can result from an episode of trauma that disturbs longitudinal nail growth and results in reverse embedding of the nail plate. This can cause pain, inflammation, and granulation tissue formation, and is typically relieved by avulsion and antiinflammatory treatment. Limitations: We cannot demonstrate causality between the proposed precipitants and the clinical features. Conclusion: Retroncyhia represents proximal ingrowth of the nail that occurs when the nail embeds backwards into the proximal nail fold. Nail plate avulsion with supplementary medical management is curative. [less ▲]

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See detailEffect of a single dose of R126638 in seborrheic dermatitis
Ausma, J.; Henry, Frédérique ULg; Borgers, M. et al

in Journal of the American Academy of Dermatology (2005, March), 52(3, ,Suppl. S), 125

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See detailThe activity of R126638, a new triazole antifungal, as assessed by corneofungimetry
Ausma, J.; Pierard-Franchimont, Claudine ULg; Borgers, M. et al

in Journal of the American Academy of Dermatology (2005, March), 52(3, Suppl. S), 129

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See detailFatal outcome of herpes simplex virus superinfection of Darier disease
Nikkels, Arjen ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Journal of the American Academy of Dermatology (2005, March), 52(3, Suppl. S), 132

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See detailPeriungual lipoma: About three cases
Richert, Bertrand ULg; André, J.; Choffray, Alexandre ULg et al

in Journal of the American Academy of Dermatology (2004), 51(2 Suppl), 91-93

Lipomas are one of the most common benign soft tissue tumors. The usual development sites are the neck, the torso, and the legs. Lipomas of the nail unit are extremely rare. Only five cases have been ... [more ▼]

Lipomas are one of the most common benign soft tissue tumors. The usual development sites are the neck, the torso, and the legs. Lipomas of the nail unit are extremely rare. Only five cases have been reported tip to now. four in subungual locations and one in the lateral nail fold. We report three cases of peri-Lingual lipomas, one on the digit and two on the toes. Two of them exhibited the histological features of perisudoral lipomas. [less ▲]

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See detailAtypical recurrent varicella in 4 patients with hemopathies.
Nikkels, Arjen ULg; Simonart, Thierry; Kentos, Alain et al

in Journal of the American Academy of Dermatology (2003), 48(3), 442-7

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with ... [more ▼]

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for alpha-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. [less ▲]

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See detailEffectors of Inflammation in Actinic Prurigo
Arrese, J. E.; Dominguez-Soto, L.; Hojyo-Tomoka, M. T. et al

in Journal of the American Academy of Dermatology (2001), 44(6), 957-61

BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the ... [more ▼]

BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo. [less ▲]

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See detailShingles Developing within Recent Surgical Scars
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Journal of the American Academy of Dermatology (1999), 41(2, Pt 2), 309-311

Occurrence of varicella and recurrence of herpes simplex on traumatized sites of the skin are well-described events. By contrast, herpes zoster occurring specifically at the site of previously injured ... [more ▼]

Occurrence of varicella and recurrence of herpes simplex on traumatized sites of the skin are well-described events. By contrast, herpes zoster occurring specifically at the site of previously injured skin has not yet been reported. Two patients are presented who developed shingles limited to skin on and around recent surgical scars. Varicella zoster virus was identified using immunohistochemistry on skin biopsy specimens and Tzanck smears. We suspect that the occurrence of herpes zoster involving surgical scars is usually misdiagnosed and therefore unrecognized. Whether shingles adjacent to scars represents a coincidental event or is specifically triggered by local injury is unknown. [less ▲]

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See detailQuantification of skin color in patients undergoing maintenance hemodialysis
Deleixhe-Mauhin, F.; Krzesinski, Jean-Marie ULg; Rorive, Georges ULg et al

in Journal of the American Academy of Dermatology (1992), 27(6), 950-953

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin ... [more ▼]

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin. Objective: Our purpose was to conduct a comparative cross-sectional study of white patients with distinct diseases that modify their skin color. Methods: A reflected-light colorimeter was used to compare the color of the forehead and forearms of 61 white patients receiving hemodialysis with that of matched controls and of patients with anemia or icterus. Results: Significant differences were found in both reflectance and chromaticity between these groups of patients. Duration of hemodialysis and use of erythropoietin did not significantly influence the colorimetric measurements. Conclusion: The use of a color-reflectance meter allows precise evaluation of subtle changes in skin color and may be used to monitor several diseases. [less ▲]

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